Behavioural and neurochemical adaptations to nicotine in rats: influence of NMDA antagonists

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

The rat brain in stereotaxic coordinates

1983 • 28,962 citations

A psychomotor stimulant theory of addiction.

1987 • 2,704 citations

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

1986 • 1,814 citations

Inhibition of Morphine Tolerance and Dependence by the NMDA Receptor Antagonist MK-801

1991 • 1,212 citations

Catecholamine innervation of the basal forebrain IV. Topography of the dopamine projection to the basal forebrain and neostriatum

1978 • 1,160 citations

Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels.

1988 • 747 citations

Nicotine preferentially stimulates dopamine release in the limbic system of freely moving rats

1986 • 693 citations

Autoradiographic evidence for nicotine receptors on nigrostriatal and mesolimbic dopaminergic neurons

1985 • 527 citations

Blockade of “reverse tolerance” to cocaine and amphetamine by MK-801

1989 • 484 citations

The effects of nicotine on locomotor activity in non‐tolerant and tolerant rats

1983 • 457 citations

The effects of acute and repeated nicotine treatment on nucleus accumbens dopamine and locomotor activity

1992 • 428 citations

Evidence that mesolimbic dopaminergic activation underlies the locomotor stimulant action of nicotine in rats.

1988 • 313 citations

In Vivo Regulation of [³H]Acetylcholine Recognition Sites in Brain by Nicotinic Cholinergic Drugs

1985 • 283 citations

Time course study of the effects of chronic nicotine infusion on drug response and brain receptors.

1985 • 271 citations

Repeated administration of MK-801 produces sensitization to its own locomotor stimulant effects but blocks sensitization to amphetamine

1991 • 238 citations

Amphetamine behavioral sensitization and the excitatory amino acids

1990 • 188 citations

Development of both conditioning and sensitization of the behavioral activating effects of amphetamine is blocked by the non-competitive NMDA receptor antagonist, MK-801

1993 • 180 citations

MK-801 potently inhibits alcohol withdrawal seizures in rats

1990 • 169 citations

Locomotor activity in rats after administration of nicotinic agonists intracerebrally

1990 • 158 citations

The NMDA receptor antagonist MK-801 prevents long-lasting non-associative morphine tolerance in the rat

1992 • 155 citations

Chronic nicotine and locomotor activity: influences of exposure dose and test dose

1987 • 145 citations

Development and expression of sensitization to cocaine's reinforcing properties: role of NMDA receptors

1993 • 135 citations

The anticonvulsant MK-801 interacts with peripheral and central nicotinic acetylcholine receptor ion channels.

1990 • 130 citations

Nicotine tolerance in rats; role of dose and dose interval

1974 • 121 citations

The occurrence of tolerance to a central depressant effect of nicotine

1972 • 120 citations

Synthesis and NMD A Antagonistic Properties of the Enantiomers of 4‐(3‐phosphonopropyl)piperazine‐2‐carboxylic acid (CPP) and of the unsaturated analogue (E)‐4‐(3‐phosphonoprop‐2‐enyl)piperazine‐2‐carboxylic acid (CPP‐ene)

1989 • 109 citations

MK‐801 inhibition of nicotinic acetylcholine receptor channels

1991 • 94 citations

MK-801 attenuates the dopamine-releasing but not the behavioral effects of methamphetamine: an in vivo microdialysis study

1991 • 92 citations

Tolerance to nicotine following chronic treatment by injections: a potential role for corticosterone

1992 • 75 citations

MK801 attenuates behavioural adaptation to chronic nicotine administration in rats

1992 • 72 citations

Influence of tetrodotoxin and calcium on changes in extracellular dopamine levels evoked by systemic nicotine

1993 • 68 citations

Conditioned tolerance to the anorectic and corticosterone-elevating effects of nicotine

1991 • 62 citations

Effects of repeated MK-801 on ambulation in mice and in sensitization following methamphetamine

1992 • 38 citations

The development of pharmacological tolerance to the effect of nicotine on schedule-controlled responding in mice

1982 • 38 citations

Acute effects of nicotine injection into the nucleus accumbens on locomotor activity in nicotine-naive and nicotine-tolerant rats

1990 • 21 citations

Aversive environmental stimuli as a factor in the psychostimulant response to nicotine

1989 • 19 citations

Discrimination of agonist-antagonist mixtures

1993 • 13 citations

Discriminative stimulus effects of the nicotine antagonist mecamylamine in rats

1993 • 9 citations

Locomotor activity after nicotine infusions into the fourth ventricle of rats

1994 • 8 citations

Studies on the Role of Mesolimbic Dopamine in Behavioural Responses to Chronic Nicotine

1991 • 8 citations