Alkylation and Oxidative Damages to DNA: Constitutive and Inducible Repair Systems

GLUTATHIONE

1983 • 5,487 citations

Dietary Carcinogens and Anticarcinogens

1983 • 3,028 citations

Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli

1984 • 1,608 citations

Positive control of a regulon for defenses against oxidative stress and some heat-shock proteins in Salmonella typhimurium

1985 • 1,025 citations

Artificial transmutation of the gene

1996 • 966 citations

Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats

1985 • 829 citations

Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli.

1984 • 743 citations

A new pathway for DNA repair in Escherichia coli

1977 • 705 citations

The origin of human cancers

1981 • 653 citations

New Tn10 derivatives for transposon mutagenesis and for construction of lacZ operon fusions by transposition

1984 • 613 citations

Chemical Changes Induced in DNA by Ionizing Radiation

1985 • 570 citations

Repair of alkylated DNA in Escherichia coli. Methyl group transfer from O6-methylguanine to a protein cysteine residue.

1980 • 438 citations

In vivo mutagenesis by O6-methylguanine built into a unique site in a viral genome.

1984 • 437 citations

Inducible repair of oxidative DNA damage in Escherichia coli

1983 • 415 citations

Chemical Mutagenesis

1982 • 366 citations

DNA N-glycosylases and UV repair

1980 • 307 citations

Mutagenesis of the replication point by nitrosoguanidine: Map and pattern of replication of the Escherichia coli chromosome

1968 • 297 citations

Induction of a DNA glycosylase for N-methylated purines is part of the adaptive response to alkylating agents

1982 • 287 citations

Adaptation to alkylation resistance involves the induction of a DNA glycosylase

1982 • 283 citations

Repair of DNA double-strand breaks in Escherichia coli, which requires recA function and the presence of a duplicate genome

1977 • 240 citations

An adaptive response of E. coli to low levels of alkylating agent: Comparison with previously characterised DNA repair pathways

1977 • 225 citations

Escherichia coli xth mutants are hypersensitive to hydrogen peroxide

1983 • 223 citations

Inducible repair of O-alkylated DNA pyrimidines in Escherichia coli.

1984 • 223 citations

Active site and complete sequence of the suicidal methyltransferase that counters alkylation mutagenesis.

1985 • 221 citations

Endonuclease III (nth) mutants of Escherichia coli.

1985 • 196 citations

Genetic mapping of katF, a locus that with katE affects the synthesis of a second catalase species in Escherichia coli

1984 • 187 citations

groEL and dnaK genes of Escherichia coli are induced by UV irradiation and nalidixic acid in an htpR+-dependent fashion.

1984 • 178 citations

Suicide inactivation of the E. coli O6-methylguanine-DNA methyltransferase.

1982 • 178 citations

Isolation and initial characterization of glutathione-deficient mutants of Escherichia coli K 12

1975 • 173 citations

Repair of alkylated DNA in Escherichia coli. Physical properties of O6-methylguanine-DNA methyltransferase.

1982 • 172 citations

Enzyme action at 3' termini of ionizing radiation-induced DNA strand breaks.

1983 • 171 citations

Isolation of catalase-deficient Escherichia coli mutants and genetic mapping of katE, a locus that affects catalase activity

1984 • 165 citations

Induction of resistance to alkylating agents in E. coli: the ada+ gene product serves both as a regulatory protein and as an enzyme for repair of mutagenic damage.

1984 • 162 citations

Isolation and characterization of Escherichia coli K-12 mutants unable to induce the adaptive response to simple alkylating agents

1979 • 160 citations

Genetic mapping of katG, a locus that affects synthesis of the bifunctional catalase-peroxidase hydroperoxidase I in Escherichia coli

1985 • 148 citations

Methyl phosphotriesters in alkylated DNA are repaired by the Ada regulatory protein ofE. coli

1985 • 139 citations

Thymine lesions produced by ionizing radiation in double-stranded DNA

1985 • 138 citations

Purification and structure of the intact Ada regulatory protein of Escherichia coli K12, O6-methylguanine-DNA methyltransferase.

1985 • 124 citations

Molecular cloning of a gene which regulates the adaptive response to alkylating agents in Escherichia coli

1983 • 110 citations

Toxicity and mutagenicity of plumbagin and the induction of a possible new DNA repair pathway in Escherichia coli

1985 • 101 citations

Isolation of mutants of Escherichia coli with increased resistance to alkylating agents: Mutants deficient in thiols and mutants constitutive for the adaptive response

1980 • 95 citations

Induction and autoregulation of ada, a positively acting element regulating the response of Escherichia coli K-12 to methylating agents

1985 • 87 citations

Induction of specific Escherichia coli genes by sublethal treatments with alkylating agents.

1984 • 82 citations

O6-methylguanine-DNA methyltransferase in wild-type and ada mutants of Escherichia coli

1982 • 70 citations

Cellular glutathione is a key to the oxygen effect in radiation damage

1978 • 66 citations

Inducible repair of phosphotriesters in Escherichia coli.

1983 • 64 citations

Urea-DNA glycosylase in mammalian cells

1983 • 62 citations

Efficiency of the adaptive response of Escherichia coli to alkylating agents

1980 • 61 citations

Genetic mapping of ada and adc mutations affecting the adaptive response of Escherichia coli to alkylating agents

1982 • 44 citations

The incorporation of O⁶-methyldeoxyguanosine and O⁴-methyldeoxythymidine monophosphates into DNA by DNA polymerases I and α

1983 • 39 citations

Death of an enzyme: suicide repair of DNA

1983 • 27 citations