Transducin: A Signaling Switch Regulated by Guanine Nucleotides

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

Induction by cyclic GMP of cationic conductance in plasma membrane of retinal rod outer segment

1985 • 1,213 citations

Cyclic GMP Cascade of Vision

1986 • 1,168 citations

G Proteins: A Family of Signal Transducers

1986 • 975 citations

TUMOR NECROSIS, CACHEXIA, SHOCK, AND INFLAMMATION: A COMMON MEDIATOR

1988 • 814 citations

The Molecular Basis of Visual Excitation

1968 • 813 citations

Phosphodiesterase activation by photoexcited rhodopsin is quenched when rhodopsin is phosphorylated and binds the intrinsic 48-kDa protein of rod outer segments.

1986 • 781 citations

Flow of information in the light-triggered cyclic nucleotide cascade of vision.

1981 • 740 citations

Highly cooperative feedback control of retinal rod guanylate cyclase by calcium ions

1988 • 634 citations

Structure of the GDP Domain of EF-Tu and Location of the Amino Acids Homologous to ras Oncogene Proteins

1985 • 626 citations

Light- and GTP-regulated interaction of GTPase and other proteins with bovine photoreceptor membranes

1980 • 561 citations

The role of guanosine 5′-triphosphate in polypeptide chain elongation

1978 • 559 citations

The hyporheic habitat of river ecosystems

1988 • 536 citations

Homologies Between Signal Transducing G Proteins and ras Gene Products

1984 • 500 citations

Characterization of transducin from bovine retinal rod outer segments. I. Separation and reconstitution of the subunits.

1983 • 492 citations

Pertussis toxin-catalyzed ADP-ribosylation of transducin. Cysteine 347 is the ADP-ribose acceptor site.

1985 • 457 citations

Isolation and characterization of cGMP phosphodiesterase from bovine rod outer segments.

1979 • 448 citations

Four additional members of the ras gene superfamily isolated by an oligonucleotide strategy: molecular cloning of YPT-related cDNAs from a rat brain library.

1987 • 403 citations

Structural details of the binding of guanosine diphosphate to elongation factor Tu from E. coli as studied by X-ray crystallography.

1985 • 396 citations

Photolyzed rhodopsin catalyzes the exchange of GTP for bound GDP in retinal rod outer segments.

1980 • 391 citations

Light-induced reduction of cytoplasmic free calcium in retinal rod outer segment

1985 • 381 citations

Electrogenic Na–Ca exchange in retinal rod outer segment

1984 • 346 citations

Purification and characterization of the gamma regulatory subunit of the cyclic GMP phosphodiesterase from retinal rod outer segments.

1982 • 336 citations

Molecular biology of the visual pigments

1986 • 335 citations

Characterization of transducin from bovine retinal rod outer segments. II. Evidence for distinct binding sites and conformational changes revealed by limited proteolysis with trypsin.

1983 • 331 citations

ADP-ribosylation of transducin by pertussis toxin blocks the light-stimulated hydrolysis of GTP and cGMP in retinal photoreceptors.

1984 • 327 citations

Light-regulated binding of rhodopsin kinase and other proteins to cattle photoreceptor membranes

1978 • 313 citations

Primary structure of the α-subunit of transducin and its relationship to ras proteins

1985 • 291 citations

Sequence of the Alpha Subunit of Photoreceptor G Protein: Homologies Between Transducin, ras , and Elongation Factors

1985 • 276 citations

THE MOLECULAR MECHANISM OF VISUAL EXCITATION AND ITS RELATION TO THE STRUCTURE AND COMPOSITION OF THE ROD OUTER SEGMENT

1987 • 264 citations

A single amino acid substitution in rhodopsin (lysine 248—-leucine) prevents activation of transducin.

1988 • 260 citations

Complex formation between metarhodopsin II and GTP‐binding protein in bovine protoreceptor membranes leads to a shift of the photoproduct equilibrium

1982 • 259 citations

ATP mediates rapid reversal of cyclic GMP phosphodiesterase activation in visual receptor membranes

1980 • 251 citations

Identification of receptor contact site involved in receptor–G protein coupling

1987 • 249 citations

Interactions between photoexcited rhodopsin and GTP-binding protein: kinetic and stoichiometric analyses from light-scattering changes.

1981 • 247 citations

RELATIONSHIPS BETWEEN CHEMICAL AND MECHANICAL EVENTS DURING MUSCULAR CONTRACTION

1986 • 241 citations

Amino acid sequence of retinal transducin at the site ADP-ribosylated by cholera toxin.

1984 • 235 citations

Nucleotide and deduced amino acid sequences of a GTP-binding protein family with molecular weights of 25,000 from bovine brain.

1988 • 234 citations

Functional homology between signal-coupling proteins. Cholera toxin inactivates the GTPase activity of transducin.

1982 • 221 citations

Amino acid sequence of the alpha subunit of transducin deduced from the cDNA sequence.

1985 • 202 citations

Chapter 5 Interactions between photoexcited rhodopsin and light-activated enzymes in rods

1984 • 174 citations

Carboxyl Rerminal Domain of G _sα Specifies Coupling of Receptors to Stimulation of Adenylyl Cyclase

1988 • 174 citations

Magnitude of increase in retinal cGMP metabolic flux determined by 18O incorporation into nucleotide alpha-phosphoryls corresponds with intensity of photic stimulation.

1983 • 171 citations

GTPase of bovine rod outer segments: the amino acid sequence of the alpha subunit as derived from the cDNA sequence.

1985 • 169 citations

Phosphorylation of rhodopsin and quenching of cyclic GMP phosphodiesterase activation by ATP at weak bleaches.

1983 • 165 citations

Organizing centres for three-dimensional chemical waves

1984 • 160 citations

GTP-binding proteins: One molecular machine can transduce diverse signals

1986 • 157 citations

Reciprocal control of retinal rod cyclic GMP phosphodiesterase by its γ subunit and transducin

1986 • 151 citations

Mechanism of ATP quench of phosphodiesterase activation in rod disc membranes.

1983 • 144 citations

Molecular Properties of the cGMP Cascade of Vertebrate Photoreceptors

1987 • 137 citations

Light-induced binding of guanosinetriphosphatase to bovine photoreceptor membranes: effect of limited proteolysis of the membranes

1981 • 136 citations

Characterization of transducin from bovine retinal rod outer segments. Participation of the amino-terminal region of T alpha in subunit interaction.

1987 • 131 citations

The G-protein of retinal rod outer segments (transducin). Mechanism of interaction with rhodopsin and nucleotides.

1985 • 122 citations

Homologies in the primary structure of GTP-binding proteins: the nucleotide-binding site of EF-Tu and p21.

1984 • 109 citations

G protein-effector coupling: binding of rod phosphodiesterase inhibitory subunit to transducin

1989 • 104 citations

Activation of retinal rod cyclic GMP‐phosphodiesterase by transducin: Characterization of the complex formed by phosphodiesterase inhibitor and transducin α‐subunit

1986 • 102 citations

Stereochemistry of the guanyl nucleotide binding site of transducin probed by phosphorothioate analogs of GTP and GDP

1985 • 102 citations

Radioimmune precipitation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from Chinese hamster fibroblasts. Effect of 25-hydroxycholesterol.

1981 • 93 citations

Kinetic studies suggest that light-activated cyclic GMP phosphodiesterase is a complex with G-protein subunits

1986 • 93 citations

Sequence analysis of bovine retinal S‐antigen

1986 • 92 citations

Receptor activation of G proteins

1988 • 86 citations

Characterization of transducin from bovine retinal rod outer segments. Mechanism and effects of cholera toxin-catalyzed ADP-ribosylation.

1984 • 79 citations

Characterization of transducin from bovine retinal rod outer segments. The role of sulfhydryl groups.

1984 • 78 citations

Chemical cross-linking of bovine retinal transducin and cGMP phosphodiesterase.

1988 • 71 citations

Interaction between photoexcited rhodopsin and peripheral enzymes in frog retinal rods

1983 • 65 citations

The energy utilized in protein breakdown by the ATP-dependent protease (La) from Escherichia coli.

1987 • 64 citations

Characterization of transducin from bovine retinal rod outer segments. Use of monoclonal antibodies to probe the structure and function of the subunit.

1988 • 51 citations

Interaction of retinal transducin with guanosine triphosphate analog: specificity of the .gamma.-phosphate binding region

1986 • 50 citations

Ca2+-dependent changes in cyclic GMP levels are not correlated with opening and closing of the light-dependent permeability of toad photoreceptors.

1982 • 50 citations

Mechanistic aspects of the DNA strand exchange activity of E. coli recA protein

1987 • 47 citations

Surfaces of rod photoreceptor disk membranes: light-activated enzymes.

1982 • 41 citations

A structural model for the α‐subunit of transducin Implications of its role as a molecular switch in the visual signal transduction mechanism

1987 • 36 citations

Chemical probing of the light-induced interaction between rhodopsin and G-protein. Near-infrared light-scattering and sulfhydryl modifications.

1985 • 33 citations

Chemical modification of bovine transducin: effect of fluorescein 5'-isothiocyanate labeling on the activities of the transducin .alpha. subunit

1987 • 28 citations

Fluorescent labeling of signal-transducing G-proteins. Pertussis toxin-catalyzed etheno-ADP ribosylation of transducin.

1988 • 26 citations

GTPase from rod outer segments: Characterization by photoaffinity labeling and tryptic peptide mapping

1981 • 26 citations

Ability of guanine nucleotide derivatives to bind and activate bovine transducin.

1986 • 24 citations

Sulfhydryl group modification of photoreceptor G‐protein prevents its light‐induced binding to rhodopsin

1984 • 24 citations

Immological determination of transducin content in retinas exhibiting inherited degeneration

1987 • 22 citations

Use of [.gamma.-32P]-8-azidoguanosine 5'-triphosphate as a probe of the guanosine 5'-triphosphate binding protein subunits in bovine rod outer segments

1985 • 11 citations

Chromium(III) .beta.,.gamma.-bidentate guanine nucleotide complexes as probes of the GTP-activated cGMP cascade of retinal rod outer segments

1988 • 10 citations