Molecular Biology of Cytochrome P-450: Evolution, Structure and Regulation

The neighbor-joining method: a new method for reconstructing phylogenetic trees.

1987 • 59,130 citations

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

1991 • 2,371 citations

The P450 Superfamily: Update on New Sequences, Gene Mapping, Accession Numbers, Early Trivial Names of Enzymes, and Nomenclature

1993 • 1,663 citations

High-resolution crystal structure of cytochrome P450cam

1987 • 1,396 citations

Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences.

1992 • 1,168 citations

Cloning of a Factor Required for Activity of the Ah (Dioxin) Receptor

1991 • 963 citations

Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor.

1992 • 830 citations

The P450 Gene Superfamily: Recommended Nomenclature

1987 • 812 citations

Identification of the Ah Receptor Nuclear Translocator Protein (Arnt) as a Component of the DNA Binding Form of the Ah Receptor

1992 • 769 citations

Crystal structure of substrate-free Pseudomonas putida cytochrome P-450

1986 • 545 citations

PAS is a dimerization domain common to Drosophila Period and several transcription factors

1993 • 515 citations

Association of the Ah receptor with the 90-kDa heat shock protein.

1988 • 511 citations

Molecular genetics of the P-450 superfamily

1990 • 496 citations

The DNA recognition site for the dioxin-Ah receptor complex. Nucleotide sequence and functional analysis.

1988 • 455 citations

Cloning and Sequence of the Human Gene for P450cl7 (Steroid 17α-Hydroxylase/17,20 Lyase): Similarity with the Gene for P450c21

1987 • 415 citations

Glutathione S-transferases, structure, regulation, and therapeutic implications

1993 • 409 citations

cDNA cloning and structure of mouse putative Ah receptor

1992 • 406 citations

On the antiquity of introns

1986 • 324 citations

Coding Nucleotide, 5′ Regulatory, and Deduced Amino Acid Sequences of P-450BM-3, a Single Peptide Cytochrome P-450:NADPH-P-450 Reductase from Bacillus megaterium

1989 • 242 citations

Association of the dioxin receptor with the Mr 90,000 heat shock protein: A structural kinship with the glucocorticoid receptor

1988 • 234 citations

Genes for Cytochrome P-450 and Their Regulatio

1986 • 227 citations

The specific DNA binding activity of the dioxin receptor is modulated by the 90 kd heat shock protein.

1990 • 204 citations

A DNA-binding factor specific for xenobiotic responsive elements of P-450c gene exists as a cryptic form in cytoplasm: its possible translocation to nucleus.

1988 • 198 citations

Ligand-dependent recruitment of the Arnt coregulator determines DNA recognition by the dioxin receptor.

1993 • 192 citations

Tissue-specific expression of human P-450AROM. The promoter responsible for expression in adipose tissue is different from that utilized in placenta

1991 • 178 citations

Regulatory gene product of the Ah locus. Characterization of receptor mutants among mouse hepatoma clones.

1982 • 160 citations

A factor binding to the xenobiotic responsive element (XRE) of P-4501A1 gene consists of at least two helix-loop-helix proteins, Ah receptor and Arnt.

1993 • 150 citations

Identification by site-directed mutagenesis of two lysine residues in cholesterol side chain cleavage cytochrome P450 that are essential for adrenodoxin binding

1992 • 142 citations

Location of regulatory elements responsible for drug induction in the rat cytochrome P-450c gene.

1986 • 140 citations

Probing the role of lysines and arginines in the catalytic function of cytochrome P450d by site-directed mutagenesis. Interaction with NADPH-cytochrome P450 reductase

1991 • 137 citations

Regulation of Mouse CYP1A1 Gene Expression by Dioxin: Requirement of Two cis-Acting Elements during Induction

1989 • 126 citations

Dominant and recessive aryl hydrocarbon hydroxylase-deficient mutants of mouse hepatoma line, Hepa-1, and assignment of recessive mutants to three complementation groups

1983 • 124 citations

Nucleotide sequence of the unique nitrate/nitrite-inducible cytochrome P-450 cDNA from Fusarium oxysporum

1991 • 123 citations

Protein-DNA interactions at a dioxin-responsive enhancer. Evidence that the transformed Ah receptor is heteromeric

1990 • 115 citations

A unique aromatase (P-450arom) mRNA formed by alternative use of tissue-specific exons 1 in human skin fibroblasts

1992 • 101 citations

A novel cis-acting DNA element required for a high level of inducible expression of the rat P-450c gene.

1990 • 96 citations

The Potential Role of DNA Methylation in the Response to 2,3,7,8-Tetrachlorodibenzo-p-dioxin

1989 • 89 citations

Structural characterization of the gene encoding rat 25-hydroxyvitamin D3 24-hydroxylase

1993 • 86 citations

Fluorescein Isothiocyanate Specifically Modifies Lysine 338 of Cytochrome P-450scc and Inhibits Adrenodoxin Binding

1989 • 73 citations

Regulation of mouse CYP1A1 gene expression by dioxin: requirement of two cis-acting elements during induction.

1989 • 72 citations

Role of the ligand in intracellular receptor function: receptor affinity determines activation in vitro of the latent dioxin receptor to a DNA-binding form.

1991 • 51 citations

Inhibition of electron transfer from adrenodoxin to cytochrome P-450scc by chemical modification with pyridoxal 5'-phosphate: identification of adrenodoxin-binding site of cytochrome P-450scc

1989 • 50 citations

Aryl hydrocarbon (Ah) receptor DNA-binding activity. Sequence specificity and Zn2+ requirement.

1990 • 49 citations