Erythropoietin Receptor and STAT5-Specific Pathways Promote SKT6 Cell Hemoglobinization

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

STATs and Gene Regulation

1997 • 3,927 citations

Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor

1990 • 1,448 citations

Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1

1991 • 1,321 citations

Cytokine receptor signalling

1995 • 1,242 citations

Stat5a is mandatory for adult mammary gland development and lactogenesis.

1997 • 1,106 citations

Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor

1995 • 1,027 citations

Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression

1997 • 989 citations

Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals

1995 • 956 citations

Erythropoietin

1991 • 852 citations

Erythropoietin Retards DNA Breakdown and Prevents Programmed Death in Erythroid Progenitor Cells

1990 • 837 citations

FOG, a Multitype Zinc Finger Protein, Acts as a Cofactor for Transcription Factor GATA-1 in Erythroid and Megakaryocytic Differentiation

1997 • 723 citations

Lethal β-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF

1995 • 620 citations

Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue.

1995 • 556 citations

CIS, a Cytokine Inducible SH2 Protein, Is a Target of the JAK-STAT5 Pathway and Modulates STAT5 Activation

1997 • 538 citations

Recombinant human stem cell factor synergises with GM-CSF, G-CSF, IL-3 and epo to stimulate human progenitor cells of the myeloid and erythroid lineages.

1991 • 454 citations

Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis.

1996 • 439 citations

GATA-1 reprograms avian myelomonocytic cell lines into eosinophils, thromboblasts, and erythroblasts.

1995 • 430 citations

Jaks, STATs, Cytokine Signal Transduction, and Immunoregulation: Are We There Yet?

1997 • 381 citations

Interaction of the erythropoietin and stem-cell-factor receptors

1995 • 309 citations

The cytoplasmic region of the erythropoietin receptor contains nonoverlapping positive and negative growth-regulatory domains.

1991 • 297 citations

Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation.

1995 • 291 citations

Erythropoietin Induces Activation of Stat5 through Association with Specific Tyrosines on the Receptor That Are Not Required for a Mitogenic Response

1996 • 272 citations

Erythropoietin sensitivity as a differentiation marker in the hemopoietic system: Studies of three erythropoietic colony responses in culture

1976 • 254 citations

Interleukin 2 and erythropoietin activate STAT5/MGF via distinct pathways.

1995 • 224 citations

Thrombopoietin Signal Transduction in Purified Murine Megakaryocytes

1997 • 199 citations

Distinct roles of erythropoietin, insulin-like growth factor I, and stem cell factor in the development of erythroid progenitor cells.

1994 • 181 citations

Thrombopoietin rescues in vitro erythroid colony formation from mouse embryos lacking the erythropoietin receptor.

1996 • 181 citations

STAT5A-Deficient Mice Demonstrate a Defect in Granulocyte-Macrophage Colony-Stimulating Factor–Induced Proliferation and Gene Expression

1997 • 180 citations

Functional interaction of erythropoietin and stem cell factor receptors is essential for erythroid colony formation

1997 • 174 citations

Stem cell factor retards differentiation of normal human erythroid progenitor cells while stimulating proliferation

1995 • 149 citations

Human burst-forming units-erythroid need direct interaction with stem cell factor for further development

1991 • 138 citations

Anemia and mast cell depletion in mutant rats that are homozygous at "white spotting (Ws)" locus

1991 • 138 citations

Erythropoietin Induces the Tyrosine Phosphorylation, Nuclear Translocation, and DNA Binding of STAT1 and STAT5 in Erythroid Cells

1995 • 122 citations

JAK2 is associated with the c-kit proto-oncogene product and is phosphorylated in response to stem cell factor

1996 • 118 citations

Human P40 T-cell growth factor (interleukin-9) supports erythroid colony formation

1990 • 114 citations

Apoptosis and hematopoiesis in murine fetal liver

1993 • 106 citations

Specific binding of erythropoietin to its receptor on responsive mouse erythroleukemia cells.

1987 • 104 citations

The Prolactin Receptor and Severely Truncated Erythropoietin Receptors Support Differentiation of Erythroid Progenitors

1997 • 101 citations

Tec Kinase Associates with c-kit and Is Tyrosine Phosphorylated and Activated following Stem Cell Factor Binding

1994 • 100 citations

Differential signal transduction of the short, Nb2, and long prolactin receptors. Activation of interferon regulatory factor-1 and cell proliferation

1994 • 100 citations

Localized cytosolic domains of the erythropoietin receptor regulate growth signaling and down-modulate responsiveness to granulocyte-macrophage colony-stimulating factor.

1991 • 97 citations

Erythropoietin-independent erythrocyte production: signals through gp130 and c-kit dramatically promote erythropoiesis from human CD34+ cells.

1996 • 93 citations

STAT5 Activation Correlates with Erythropoietin Receptor-mediated Erythroid Differentiation of an Erythroleukemia Cell Line

1997 • 90 citations

The gene for erythropoietin receptor is expressed in multipotential hematopoietic and embryonal stem cells: evidence for differentiation stage-specific regulation.

1992 • 87 citations

Erythropoietin-induced erythroid differentiation of the human erythroleukemia cell line TF-1 correlates with impaired STAT5 activation.

1996 • 83 citations

Erythropoietin receptor signals both proliferation and erythroid-specific differentiation.

1993 • 83 citations

Induction of sequence-specific DNA-binding factors by erythropoietin and the spleen focus-forming virus

1995 • 81 citations

The last proline of Box 1 is essential for association with JAK2 and functional activation of the prolactin receptor

1997 • 75 citations

Stem cell factor activates STAT-5 DNA binding in IL-3-derived bone marrow mast cells.

1997 • 66 citations

Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding.

1994 • 64 citations

Bcl-2 Targeted Overexpression Into the Erythroid Lineage of Transgenic Mice Delays But Does Not Prevent the Apoptosis of Erythropoietin-Deprived Erythroid Progenitors

1997 • 44 citations

Mechanisms of Stem Cell Factor and Erythropoietin Proliferative Co-signaling in FDC2-ER Cells

1997 • 44 citations

Erythropoietin and interleukin-3 induce distinct events in erythropoietin receptor-expressing BA/F3 cells

1995 • 43 citations

Hematopoietic Cell Phosphatase Negatively Regulates Erythropoietin-Induced Hemoglobinization in Erythroleukemic SKT6 Cells

1997 • 41 citations

A Possible Involvement of Stat5 in Erythropoietin-Induced Hemoglobin Synthesis

1997 • 35 citations

Signal Transduction by a CD16/CD7/Jak2 Fusion Protein

1995 • 35 citations

Hybrid tyrosine kinase/cytokine receptors transmit mitogenic signals in response to ligand.

1994 • 30 citations

Thrombopoietin Enhances Proliferation and Differentiation of Murine Yolk Sac Erythroid Progenitors

1997 • 28 citations

Improved Dicistronic mRNA Expression Vectors for Efficient Selection of Transfectants Highly Expressing Foreign Genes

1996 • 25 citations

Epo-Induced Hemoglobinhation of SKT6 Cells is Mediated by Minimal Cytoplasmic Domains of the Epo or Prolactin Receptors without Modulation of GATA-1 or EKLF

1997 • 23 citations

Granulocyte-Macrophage colony stimulating factor and interleukin 3: Target cells and kinetics of response in vivo

1996 • 21 citations