Hybrid tyrosine kinase/cytokine receptors transmit mitogenic signals in response to ligand.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

PCR protocols — A guide to methods and applications

1990 • 10,078 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex

1992 • 2,236 citations

Structural design and molecular evolution of a cytokine receptor superfamily.

1990 • 2,104 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

Growth factor signaling by receptor tyrosine kinases

1992 • 1,450 citations

Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130

1989 • 1,411 citations

Cloning and expression of the human erythropoietin gene.

1985 • 1,144 citations

Cloning of the γ Chain of the Human IL-2 Receptor

1992 • 835 citations

Expression cloning of the murine erythropoietin receptor

1989 • 776 citations

Demonstration of permanent factor-dependent multipotential (erythroid/neutrophil/basophil) hematopoietic progenitor cell lines.

1983 • 559 citations

A new cytokine receptor superfamily

1990 • 506 citations

Expression Cloning of Human EGF Receptor Complementary DNA: Gene Amplification and Three Related Messenger RNA Products in A431 Cells

1984 • 406 citations

Homodimerization and constitutive activation of the erythropoietin receptor.

1992 • 326 citations

Subunit promiscuity among hemopoietic growth factor receptors

1991 • 273 citations

Expression of human class II major histocompatibility complex antigens using retrovirus vectors.

1987 • 257 citations

Regulation of T cell differentiation: in vitro induction of 20 alpha-hydroxysteroid dehydrogenase in splenic lymphocytes from athymic mice by a unique lymphokine.

1981 • 252 citations

Signal Transduction Through the EGF Receptor Transfected in IL-3-Dependent Hematopoietic Cells

1988 • 238 citations

Reconstitution of functional receptors for human granulocyte/macrophage colony-stimulating factor (GM-CSF): evidence that the protein encoded by the AIC2B cDNA is a subunit of the murine GM-CSF receptor.

1991 • 221 citations

An activating mutation in the murine erythropoietin receptor induces erythroleukemia in mice: A cytokine receptor superfamily oncogene

1991 • 154 citations

Rotational diffusion of epidermal growth factor complexed to cell surface receptors reflects rapid microaggregation and endocytosis of occupied receptors.

1981 • 146 citations

EGF Receptor anderbB-2 Tyrosine Kinase Domains Confer Cell Specificity for Mitogenic Signaling

1990 • 142 citations

Chimeric NGF-EGF Receptors Define Domains Responsible for Neuronal Differentiation

1991 • 116 citations

EGF induces increased ligand binding affinity and dimerization of soluble epidermal growth factor (EGF) receptor extracellular domain.

1991 • 100 citations

A functional soluble extracellular region of the platelet-derived growth factor (PDGF) beta-receptor antagonizes PDGF-stimulated responses.

1991 • 89 citations

Structure of the murine erythropoietin receptor complex. Characterization of the erythropoietin cross-linked proteins.

1991 • 77 citations

Intermediates in degradation of the erythropoietin receptor accumulate and are degraded in lysosomes

1993 • 75 citations

Tyrosine kinase activation through the extracellular domains of cytokine receptors

1993 • 66 citations

SH2 domains: elements that control protein interactions during signal transduction

1991 • 43 citations

The Two Proteins of the Erythropoietin Receptor Are Structurally Similar

1989 • 43 citations

Structural basis for epidermal growth factor receptor function

1989 • 40 citations

Analysis of platelet-derived growth factor receptor domain function using a novel chimeric receptor approach

1991 • 35 citations

Receptor functions and ligand-dependent transforming potential of a chimeric kit proto-oncogene.

1990 • 33 citations

Pharmacokinetic study of recombinant human epidermal growth factor in the anterior eye.

1991 • 18 citations

Insulin-EGF receptor chimerae mediate tyrosine transphosphorylation and serine/threonine phosphorylation of kinase-deficient EGF receptors

1991 • 18 citations

High-affinity interleukin 2 binding by an oncogenic hybrid interleukin 2-epidermal growth factor receptor molecule.

1987 • 18 citations

Construction and expression of chimeric cell surface receptors

1991 • 4 citations