5-HT Receptors Coupled to Phosphoinositide Hydrolysis

Inositol phospholipids and cell surface receptor function

1975 • 2,458 citations

Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands

1982 • 2,148 citations

Multiple serotonin receptors: differential binding of [3H]5-hydroxytryptamine, [3H]lysergic acid diethylamide and [3H]spiroperidol.

1979 • 1,321 citations

Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol

1983 • 1,104 citations

Calcium-mobilizing receptors, polyphosphoinositides, and the generation of second messengers.

1986 • 831 citations

The binding of serotonergic ligands to the porcine choroid plexus: Characterization of a new type of serotonin recognition site

1984 • 598 citations

Inositol Phospholipid Hydrolysis in Rat Cerebral Cortical Slices: I. Receptor Characterisation

1984 • 517 citations

5-Hydroxytryptamine stimulates inositol phosphate production in a cell-free system from blowfly salivary glands. Evidence for a role of GTP in coupling receptor activation to phosphoinositide breakdown.

1985 • 429 citations

Inositol trisphosphate-induced calcium release and contraction in vascular smooth muscle.

1985 • 417 citations

A unique serotonin receptor in choroid plexus is linked to phosphatidylinositol turnover.

1986 • 265 citations

Relative efficacies of piperazines at the phosphoinositide hydrolysis-linked serotonergic (5-HT-2 and 5-HT-1c) receptors.

1987 • 217 citations

Evidence that phospholipid turnover is the signal transducing system coupled to serotonin-S2 receptor sites.

1985 • 206 citations

5-Hydroxytryptamine-stimulated inositol phospholipid hydrolysis in rat cerebral cortex slices: pharmacological characterization and effects of antidepressants.

1985 • 198 citations

Serotonin-stimulated phosphoinositide turnover: mediation by the S2 binding site in rat cerebral cortex but not in subcortical regions.

1985 • 197 citations

Relationship between hormonal activation of phosphatidylinositol hydrolysis, fluid secretion and calcium flux in the blowfly salivary gland

1979 • 193 citations

Regulation of serotonin-stimulated phosphoinositide hydrolysis: relation to the serotonin 5-HT-2 binding site

1986 • 190 citations

Muscarinic agonist binding and phospholipid turnover in brain.

1983 • 185 citations

Inhibition of phosphatidylinositol synthesis and the inactivation of calcium entry after prolonged exposure of the blowfly salivary gland to 5-hydroxytryptamine

1979 • 181 citations

Selective 5ht-2 antagonists inhibit serotonin stimulated phosphatidylinositol metabolism in cerebral cortex

1984 • 179 citations

Similar effects of substance P and related peptides on salivation and on phosphatidylinositol turnover in rat salivary glands.

1980 • 168 citations

125I-lysergic acid diethylamide binds to a novel serotonergic site on rat choroid plexus epithelial cells

1985 • 159 citations

Aortic recognition sites for serotonin (5HT) are coupled to phospholipase C and modulate phosphatidylinositol turnover

1984 • 146 citations

Inhibitors of Na+/H+ exchange block stimulus-provoked arachidonic acid release in human platelets. Selective effects on platelet activation by epinephrine, ADP, and lower concentrations of thrombin.

1985 • 144 citations

5-Hydroxytryptamine2 receptors coupled to phospholipase C in rat aorta: modulation of phosphoinositide turnover by phorbol ester.

1986 • 141 citations

A role for inositol 1,4,5‐trisphosphate in the initiation of agonist‐induced contractions of dog tracheal smooth muscle

1985 • 140 citations

Receptor coupling to polyphosphoinositide turnover: a parallel with the adenylate cyclase system

1986 • 128 citations

Phasic and tonic components in 5-HT2 receptor-mediated rat aorta contraction: participation of Ca++ channels and phospholipase C.

1985 • 115 citations

SEPARATE 5‐HYDROXYTRYPTAMINE RECEPTORS ON THE SALIVARY GLAND OF THE BLOWFLY ARE LINKED TO THE GENERATION OF EITHER CYCLIC ADENOSINE 3‘,5’‐MONOPHOSPHATE OR CALCIUM SIGNALS

1981 • 111 citations

Serotonin receptor-mediated stimulation of bovine smooth muscle cell prostacyclin synthesis and its modulation by platelet-derived growth factor.

1981 • 106 citations

Receptors and phosphoinositide metabolism in the central nervous system

1986 • 104 citations

Rat brain 5-HT1C receptors are encoded by a 5-6 kbase mRNA size class and are functionally expressed in injected Xenopus oocytes

1987 • 91 citations

Membrane permeability changes during stimulation of isolated salivary glands of Calliphora by 5‐hydroxytryptamine.

1975 • 90 citations

Characterization of neurotransmitter receptor-mediated phosphatidylinositol hydrolysis in the rat hippocampus

1984 • 86 citations

5-Methyltryptamine stimulates phospholipase C-mediated breakdown of exogenous phosphoinositides by blowfly salivary gland membranes.

1985 • 81 citations

Phospholipids as intermediates in hormone action

1984 • 73 citations

Serotonin increases the production of inositol phosphates and mobilises calcium via the 5-HT2 receptor in A7r5 smooth muscle cells

1986 • 71 citations

Agonist‐Induced Phosphoinositide Hydrolysis in Choroid Plexus

1986 • 69 citations

Ca2+ as messenger of 5HT2-receptor stimulation in human blood platelets

1984 • 60 citations

Stimulation of Phosphoinositide Hydrolysis by Serotonin in C6 Glioma Cells

1987 • 57 citations

Denervation supersensitivity of 5-HT-1c receptors in rat choroid plexus

1987 • 49 citations

Identification of a serotonin type 2 receptor linked to prostacyclin synthesis in vascular smooth muscle cells

1984 • 49 citations

Serotonin Receptor Activation of Phosphoinositide Turnover in Uterine, Fundal, Vascular, and Tracheal Smooth Muscle

1987 • 46 citations

Stimulation of phosphatidylinositol turnover by histamine, 5-hydroxytryptamine and adrenaline in the longitudinal smooth muscle of guinea pig ileum

1976 • 45 citations

EFFECTS OF DOPAMINE, GAMMA‐AMINOBUTYRIC ACID AND 5‐HYDROXYTRYPTAMINE ON INCORPORATION OF ³²P INTO PHOSPHATIDES IN SLICES FROM THE GUINEA PIG BRAIN¹

1970 • 40 citations

Stimulation by serotonin of 40 kDa and 20 kDa protein phosphorylation in human platelets

1984 • 40 citations

Relationship of polyphosphoinositide metabolism to the hormonal activation of the inset salivary gland by 5-hydroxytryptamine

1984 • 39 citations

Biochemical characterization of serotonin stimulated phosphoinositide turnover

1986 • 37 citations

REVIEW

1986 • 34 citations

Mechanisms involved in calcium-mobilizing agonist responses.

1986 • 33 citations

Ernst Klenk Lecture, November 1985. Intracellular signalling through inositol trisphosphate and diacylglycerol.

1986 • 30 citations

Electrophysiological evidence for the existence of separate receptor mechanisms mediating the action of 5-hydroxytryptamine

1981 • 30 citations

5-HT2 receptor-stimulated inositol phosphate formation in rat aortic myocytes

1986 • 28 citations

Serotonergic agonists stimulate inositol lipid metabolism in rabbit platelets

1985 • 26 citations

Serotonin-1C sites in the choroid plexus are not linked in a stimulatory or inhibitory way to adenylate cyclase

1986 • 20 citations

5-HT-stimulated arachidonic acid release from labeled phosphatidylinositol in blowfly salivary glands

1982 • 15 citations

Phosphoinositide synthesis and Ca2+ gating in blowfly salivary glands exposed to 5-hydroxytryptamine

1984 • 15 citations