REVIEW

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain.

1980 • 1,099 citations

RECEPTORS AND PHOSPHOINOSITIDE-GENERATED SECOND MESSENGERS

1985 • 722 citations

myo-Inositol 1,4,5-trisphosphate. A second messenger for the hormonal mobilization of intracellular Ca2+ in liver.

1984 • 567 citations

5-Hydroxytryptamine stimulates inositol phosphate production in a cell-free system from blowfly salivary glands. Evidence for a role of GTP in coupling receptor activation to phosphoinositide breakdown.

1985 • 429 citations

Inositol trisphosphate-induced calcium release and contraction in vascular smooth muscle.

1985 • 417 citations

Growth factors immediately raise cytoplasmic free Ca2+ in human fibroblasts.

1984 • 394 citations

Inositol 1,4,5-trisphosphate releases Ca2+ from intracellular store sites in skinned single cells of porcine coronary artery

1984 • 389 citations

Relationship between inositol polyphosphate production and the increase of cytosolic free Ca2+ induced by vasopressin in isolated hepatocytes.

1984 • 358 citations

Phosphatidyldmositol hydrolysis: A multifunctional transducing mechanism

1981 • 341 citations

The temporal integration of the aldosterone secretory response to angiotensin occurs via two intracellular pathways.

1984 • 332 citations

Inositol 1,4,5-trisphosphate: a possible chemical link in excitation-contraction coupling in muscle.

1985 • 330 citations

Mass changes in myoinositol trisphosphate in human platelets stimulated by thrombin. Inhibitory effects of phorbol ester.

1985 • 292 citations

Thyrotropin-releasing hormone rapidly activates the phosphodiester hydrolysis of polyphosphoinositides in GH3 pituitary cells. Evidence for the role of a polyphosphoinositide-specific phospholipase C in hormone action.

1983 • 292 citations

Role of a guanine nucleotide-binding regulatory protein in the hydrolysis of hepatocyte phosphatidylinositol 4,5-bisphosphate by calcium-mobilizing hormones and the control of cell calcium. Studies utilizing aluminum fluoride.

1985 • 290 citations

Phorbol ester inhibits phosphoinositide hydrolysis and calcium mobilization in cultured astrocytoma cells.

1985 • 274 citations

Ca2+ homeostasis in permeabilized human neutrophils. Characterization of Ca2+-sequestering pools and the action of inositol 1,4,5-triphosphate.

1984 • 266 citations

A role for inositol triphosphate in intracellular Ca2+ mobilization and granule secretion in platelets.

1985 • 263 citations

Activation of frog (Xenopus laevis) eggs by inositol trisphosphate. I. Characterization of Ca2+ release from intracellular stores.

1985 • 255 citations

Phorbol ester and 1-oleoyl-2-acetylglycerol inhibit angiotensin activation of phospholipase C in cultured vascular smooth muscle cells.

1985 • 240 citations

Protein kinase C and calcium ion in mitogenic response of macrophage-depleted human peripheral lymphocytes.

1985 • 220 citations

Regulation of cortical vesicle exocytosis in sea urchin eggs by inositol 1,4,5-trisphosphate and GTP-binding protein.

1986 • 209 citations

Phosphoinositide interconversion in thrombin-stimulated human platelets.

1985 • 205 citations

Short Communication Inositol Tetrakis- And Pentakisphosphates In Gh4 Cells

1985 • 201 citations

Inositol(1,4,5)trisphosphate-promoted Ca2+ release from microsomal fractions of rat liver

1984 • 193 citations

Inositol trisphosphate induces calcium release from nonmitochondrial stores i sea urchin egg homogenates.

1985 • 190 citations

Ca2+-dependent and -independent release of neurotransmitters from PC12 cells: a role for protein kinase C activation?

1984 • 180 citations

Inositol trisphosphate mediates thyrotropin-releasing hormone mobilization of nonmitochondrial calcium in rat mammotropic pituitary cells.

1984 • 168 citations

Release of Ca2+ from plant hypocotyl microsomes by inositol-1,4,5-trisphosphate

1985 • 164 citations

Pharmacomechanical coupling in smooth muscle may involve phosphatidylinositol metabolism.

1984 • 157 citations

Inositol trisphosphate modification of ion transport in rough endoplasmic reticulum.

1985 • 154 citations

Temperature and nucleotide dependence of calcium release by myo-inositol 1,4,5-trisphosphate in cultured vascular smooth muscle cells.

1985 • 148 citations

A transient rise in cytosolic calcium follows stimulation of quiescent cells with growth factors and is inhibitable with phorbol myristate acetate.

1985 • 121 citations

Calcium‐dependent activation of lymphocytes by ionophore, A23187, and a phorbol ester tumor promoter

1983 • 120 citations

Protein kinase C translocates from cytosol to membrane upon hormone activation: Effects of thyrotropin-releasing hormone in GH3 cells

1985 • 119 citations

A direct demonstration that inositol-trisphosphate induces an increase in intracellular calcium in limulus photoreceptors

1984 • 114 citations

Inositol-1,4,5-trisphosphate releases calcium from skinned cultured smooth muscle cells

1985 • 106 citations

The effect of inositol trisphosphate on Ca2+ fluxes in insulin-secreting tumor cells.

1984 • 104 citations

Platelet-derived growth factor mimics phorbol diester action on epidermal growth factor receptor phosphorylation at threonine-654.

1985 • 101 citations

Direct stimulation by thyrotropin-releasing hormone (TRH) of polyphosphoinositide hydrolysis in GH3 cell membranes by a guanine nucleotide-modulated mechanism

1985 • 99 citations

Mitogens and melittin stimulate an increase in intracellular free calcium concentration in human fibroblasts

1984 • 99 citations

Prostaglandin F_2α stimulates phosphatidylinositol turnover and increases the cellular content of 1,2‐diacylglycerol in confluent resting swiss 3T3 cells

1984 • 97 citations

Inositol 1,4,5-trisphosphate and the endoplasmic reticulum Ca2+ cycle of a rat insulinoma cell line.

1985 • 89 citations

Ca2+ Release by inositol trisphosphate from Ca2+-transporting microsomes derived from uterine sarcoplasmic reticulum

1985 • 81 citations

Inositol triphosphate-induced Ca2+ release from human platelet membranes

1985 • 71 citations

Platelet‐derived growth factor stimulates rapid polyphosphoinositide breakdown in fetal human fibroblasts

1985 • 48 citations

Acetylcholine promotes progesterone‐induced maturation of Xenopus oocytes

1984 • 48 citations

Inositol 1,4,5-trisphosphate is not effective in releasing calcium from skeletal sarcoplasmic reticulum microsomes

1985 • 48 citations

Effects of inositol-1,4,5-trisphosphate injections into salamander rods

1985 • 44 citations

Synergism between diacylglycerols and calcium ionophore in the induction of human B cell proliferation mimics the inositol lipid polyphosphate breakdown signals induced by crosslinking surface immunoglobulin

1985 • 43 citations

Increase in Ca2+ Permeability of Intracellular Ca2+ Store Membrane of Saponin-Treated Guinea Pig Peritoneal Macrophages by Inositol 1,4,5-Trisphosphate1

1985 • 28 citations

Effects of platelet-derived growth factor on Ca2+ in 3T3 cells

1985 • 27 citations

Rapid calcium mobilization by vasopressin and prostaglandin F2α is independent of sodium influx in quiescent 3T3 cells

1984 • 14 citations

Inositol 1,4,5-trisphosphate-induced Ca2+ release from permeabilized mastocytoma cells

1986 • 9 citations