Second-Generation Antihistamines

H1-Receptor Antagonists

1994 • 757 citations

Mechanism of the Cardiotoxic Actions of Terfenadine

1993 • 627 citations

Torsades de pointes occurring in association with terfenadine use

1990 • 550 citations

Intranasal corticosteroids versus oral H1 receptor antagonists in allergic rhinitis: systematic review of randomised controlled trials

1998 • 529 citations

Soluble markers of allergic inflammation

1994 • 388 citations

Changes in the pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine with concomitant administration of erythromycin

1992 • 373 citations

Clinical Pharmacokinetics of H1-Receptor Antagonists (The Antihistamines)

1985 • 330 citations

The Pharmacology and Use of H₁-Receptor-Antagonist Drugs

1994 • 326 citations

The role of histamine in allergic diseases

1990 • 321 citations

International consensus report on the diagnosis and management of rhinitis

1994 • 313 citations

Systemic Antifungal Agents

1998 • 284 citations

Recent Advances: the Cytochrome P450 Enzymes

1995 • 271 citations

Cardiac Actions of Antihistamines

1996 • 261 citations

Astemizole

1984 • 258 citations

Ketotifen

1990 • 228 citations

Cetirizine in patients with seasonal rhinitis and concomitant asthma: prospective, randomized, placebo-controlled trial

1995 • 188 citations

Terfenadine A Review of its Pharmacodynamic Properties and Therapeutic Efficacy

1985 • 175 citations

Loratadine

1994 • 173 citations

Cardiotoxic effect with convulsions in terfenadine overdose.

1989 • 168 citations

The antipruritic effect of a sedative and a non-sedative antihistamine in atopic dermatitis

1990 • 162 citations

A double-blind, single-dose, crossover comparison of cetirizine, terfenadine, loratadine, astemizole, and chlorpheniramine versus placebo: Suppressive effects on histamine-induced wheals and flares during 24 hours in normal subjects

1990 • 160 citations

Pharmacokinetics and pharmacodynamics of terfenadine and chlorpheniramine in the elderly

1990 • 159 citations

Torsade de pointes after astemizole overdose.

1986 • 157 citations

Cetirizine

1990 • 142 citations

The prevalence and medical and economic impact of allergic rhinitis in the United States.

1997 • 140 citations

Loratadine

1989 • 134 citations

Azelastine

1989 • 124 citations

Prospective Controlled Study of Hydroxyzine and Cetirizine in Pregnancy

1997 • 122 citations

Efficacy and Safety of Fexofenadine Hydrochloride for Treatment of Seasonal Allergic Rhinitis

1997 • 116 citations

Torsades de Pointes after treatment with terfenadine and ketoconazole

1992 • 114 citations

Comparative trial of two non-sedative H1 antihistamines, terfenadine and astemizole, for hay fever.

1984 • 114 citations

International Consensus Report on the diagnosis and management of rhinitis. International Rhinitis Management Working Group.

1994 • 113 citations

Comparative outdoor study of the efficacy, onset and duration of action, and safety of cetirizine, loratadine, and placebo for seasonal allergic rhinitis

1996 • 111 citations

Cetirizine, loratadine, or placebo in subjects with seasonal allergic rhinitis: Effects after controlled ragweed pollen challenge in an environmental exposure unit☆☆☆★★★

1998 • 110 citations

Terfenadine in exercise induced asthma.

1984 • 109 citations

Disease Management of Atopic Dermatitis: a Practice Parameter

1997 • 109 citations

Fexofenadine

1998 • 107 citations

Terfenadine

1990 • 104 citations

Urticaria: Clinical efficacy of cetirizine in comparison with hydroxyzine and placebo

1990 • 100 citations

Failure of terfenadine in relieving the pruritus of atopic dermatitis

1989 • 96 citations

Effects of terfenadine and diphenhydramine alone or in combination with diazepam or alcohol on psychomotor performance and subjective feelings

1978 • 94 citations

IL-4– and IL-5–positive T lymphocytes, eosinophils, and mast cells in allergen-induced late-phase cutaneous reactions in atopic subjects☆☆☆★★★

1998 • 92 citations

Drug-Induced Torsade de Pointes

1994 • 92 citations

Cisapride

1996 • 90 citations

Dose ranging study: cetirizine in the treatment of atopic dermatitis in adults.

1993 • 89 citations

Cetirizine and astemizole therapy for chronic idiopathic urticaria: A double-blind, placebo-controlled, comparative trial

1995 • 88 citations

Onset of Action, Efficacy, and Safety of a Single Dose of Fexofenadine Hydrochloride for Ragweed Allergy Using an Environmental Exposure Unit

1997 • 87 citations

Comparison of the bronchodilatory effects of cetirizine, albuterol, and both together versus placebo in patients with mild-to-moderate asthma

1995 • 86 citations

The pharmacology and mechanisms of action of histamine H₁‐antagonists

1990 • 85 citations

Clinical comparison of histamine H1–receptor antagonist drugs

1996 • 85 citations

Antidepressant Drug Interactions and the Cytochrome P450 System: A Critical Appraisal

1995 • 81 citations

Excretion of Loratadine in Human Breast Milk

1988 • 79 citations

Cetirizine versus Hydroxyzine and Placebo in Chronic Idiopathic Urticaria

1996 • 79 citations

Sedative effects of antihistamines: safety, performance, learning, and quality of life

1997 • 76 citations

Sedation in allergic rhinitis is caused by the condition and not by antihistamine treatment

1996 • 75 citations

Comparative analysis of the cardiotoxicity proclivities of second generation antihistamines in an experimental model predictive of adverse clinical ECG effects.

1996 • 75 citations

Double-blind study of cetirizine in atopic eczema in children.

1994 • 75 citations

Onset of Action and Efficacy of Terfenadine, Astemizole, Cetirizine, and Loratadine for the Relief of Symptoms of Allergic Rhinitis

1997 • 74 citations

The clinical safety of H₁‐receptor antagonists: An EAACI position paper*

1996 • 74 citations

Pharmacokinetics of cetirizine in the elderly and patients with renal insufficiency.

1987 • 71 citations

Effect of the nonsedative H-receptor antagonist astemizole in perennial allergic and nonallergic rhinitis

1985 • 67 citations

Relative efficacy and safety of loratadine, hydroxyzine, and placebo in chronic idiopathic urticaria and atopic dermatitis.

1992 • 67 citations

Regulation of Potassium Channels by Nonsedating Antihistamines

1995 • 67 citations

Cetirizine effects on objective measures of daytime sleepiness and performance.

1987 • 66 citations

Evaluation of Cetirizine in Patients with Allergic Rhinitis and Perennial Asthma

1996 • 65 citations

Therapeutic effect of loratadine on pruritus in patients with atopic dermatitis

1994 • 63 citations

Pharmacokinetic Optimisation of Histamine H1-Receptor Antagonist Therapy

1991 • 60 citations

Comparison of the central nervous system effects produce by six H₁‐receptor antagonists

1996 • 60 citations

Efficacy and safety of loratadine (10 mg once daily), terfenadine (60 mg twice daily), and placebo in the treatment of seasonal allergic rhinitis

1989 • 57 citations

Eosinophil Migration in Atopic Dermatitis I: Increased Migratory Responses to N-Formyl-Methionyl-Leucyl-Phenylalanine, Neutrophil-Activating Factor, Platelet-Activating Factor, and Platelet Factor 4

1993 • 55 citations

Acrivastine

1991 • 54 citations

Once-Daily Cetirizine Effective in the Treatment of Seasonal Allergic Rhinitis in Children Aged 6 to 1 Years: A Randomized, Double-Blind, Placebo-Controlled Study

1997 • 53 citations

Histamine and asthma: an appraisal based on specific H₁‐receptor antagonism

1990 • 50 citations

Comparative Study of Cetirizine and Terfenadine Versus Placebo in the Symptomatic Management of Seasonal Allergic Rhinitis

1996 • 49 citations

Cardiotoxic and drug interaction profile of the second generation antihistamines ebastine and terfenadine in an experimental animal model of torsade de pointes.

1996 • 46 citations

Pharmacokinetics of the H1-receptor antagonist ebastine and its active metabolite carebastine in healthy subjects.

1994 • 45 citations

Beneficial effects of propylene and polyethylene glycol and saline in the treatment of perennial rhinitis

1982 • 44 citations

The effect of astemizole on exercise-induced asthma.

1984 • 43 citations

Urticaria

1994 • 43 citations

Double-Blind Multicentre Comparative Study of Ebastine, Terfenadine and Placebo in the Treatment of Chronic Idiopathic Urticaria in Adults

1996 • 43 citations

Pharmacologic management of allergic rhinitis

1998 • 42 citations

Psychometric aspects of antihistamines

1995 • 41 citations

Pharmacokinetic-Pharmacodynamic Relationships of H1-Antihistamines

1995 • 41 citations

Antihistamines in the treatment of asthma

1997 • 41 citations

Comparison of the efficacy and safety of loratadine, terfenadine, and placebo in the treatment of seasonal allergic rhinitis

1988 • 41 citations

Efficacy and Safety of Mizolastine in Seasonal Allergic Rhinitis

1996 • 41 citations

Effect of loratadine on human eosinophil function in vitro.

1993 • 40 citations

Quantitation of H1-receptor antagonists in skin and serum☆☆☆★★★

1995 • 40 citations

Effect of cetirizine, a new H antihistamine, on the early and late allergic reactions in a bronchial provocation test with allergen

1993 • 40 citations

Lack of subsensitivity to terfenadine during long-term terfenadine treatment

1988 • 39 citations

First-line treatment of seasonal (ragweed) rhinoconjunctivitis. A randomized management trial comparing a nasal steroid spray and a nonsedating antihistamine.

1997 • 39 citations

Lack of correlation between titers of serum allergen-specific IgE and symptoms in untreated patients with seasonal allergic rhinitis

1986 • 38 citations

Individual differences in central nervous system response to antihistamines (H1-receptor antagonists).

1995 • 37 citations

Comparative wheal and flare study of mizolastine vs terfenadine, cetirizine, loratadine and placebo in healthy volunteers.

1995 • 37 citations

A review of the current guidelines for allergic rhinitis and asthma

1998 • 36 citations

Lack of subsensitivity to loratadine during long-term dosing during 12 weeks

1990 • 36 citations

Terfenadine pharmacokinetics in breast milk in lactating women

1995 • 36 citations

The interaction of azelastine with human lung histamine H1, beta, and muscarinic receptor-binding sites

1989 • 36 citations

Double-blind comparison of loratadine (SCH 29851), astemizole, and placebo in hay fever with special regard to onset of action.

1988 • 35 citations

A comparison of the effects of oral cetirizine and inhaled beclomethasone on early and late asthmatic responses to allergen and the associated increase in airways hyperresponsiveness

1996 • 34 citations

Effect of Cetirizine on Human Eosinophil Superoxide Generation, Eosinophil Chemotaxis and Eosinophil Peroxidase in vitro

1994 • 33 citations

In vivo and in vitro interaction of the novel selective histamine H1 receptor antagonist mizolastine with H1 receptors in the rodent.

1995 • 33 citations

Pharmacology of antihistamines

1990 • 33 citations

The Effect of Antihistamines on the Immediate Allergic Response: A Comparative Review

1993 • 30 citations

Consistency of the Efficacy of Cetirizine and Ebastine on Skin Reactivity

1998 • 30 citations

Assessment of the efficacy and safety of three dose levels of cetirizine given once daily in children with perennial allergic rhinitis

1994 • 30 citations

A Preclinical Overview of Ebastine

1996 • 28 citations

Once daily loratadine versus astemizole once daily.

1994 • 27 citations

Loratadine (SCH29851) 40 mg Once Daily versus Terfenadine 60 mg Twice Daily in the Treatment of Seasonal Allergic Rhinitis

1987 • 27 citations

Arabinogalactan- and dextran-induced ear inflammation in mice: Differential inhibition by H1-antihistamines, 5-HT-serotonin antagonists and lipoxygenase blockers

1989 • 27 citations

Effects of loratadine on anti‐IgE‐induced inflammation, histamine release, and leukocyte recruitment in skin of atopics

1995 • 27 citations

Effects of ketotifen on symptoms and on bronchial mucosa in patients with atopic asthma

1997 • 26 citations

Controlled clinical assessment of astemizole in the treatment of chronic idiopathic urticaria and angioedema

1987 • 26 citations

Double-Blind Comparison of Astemizole, Terfenadine and Placebo in Hay Fever with Special Regard to Onset of Action

1985 • 24 citations

Does ketotifen have a steroid-sparing effect in childhood asthma?

1997 • 23 citations

Nonsedating H1 antihistamines in chronic urticaria.

1993 • 23 citations

Effect of terfenadine on human eosinophil and neutrophil chemotactic response and generation of superoxide.

1994 • 23 citations

A pharmacologic continuum in the treatment of rhinorrhea: The clinician as economist

1995 • 22 citations

A comparison of the pharmacodynamics of H₁‐receptor antagonists as assessed by the induced wheal‐and‐flare model

1995 • 22 citations

Anti-anaphylactic activity of the novel selective histamine H1 receptor antagonist mizolastine in the rodent.

1995 • 21 citations

Multicenter, crossover study of the efficacy and tolerability of terfenadine, 120 mg, versus cetirizine, 10 mg, in perennial allergic rhinitis.

1991 • 21 citations

Skin eosinophilia in patients with allergic and nonallergic asthma and atopic dermatitis†

1992 • 20 citations

Affinity profiles of pizotifen, ketotifen and other tricyclic antimuscarinics at muscarinic receptor subtypes M1, M2 and M3

1992 • 19 citations

Dose-ranging comparative evaluation of cetirizine in patients with seasonal allergic rhinitis.

1995 • 18 citations

Disease management of atopic dermatitis: a practice parameter These parameters were developed by the Joint Task Force on Practice Parameters, representing the American Academy of Allergy, Asthma and Immunology, the American College of Allergy, Asthma and Immunology, and the Joint Council of Allergy, Asthma and Immunology*

1997 • 18 citations

Lack of subsensitivitvy to mizolastine over 8‐week treatment

1996 • 17 citations

A comparison of acrivastine versus hydroxyzine and placebo in the treatment of chronic idiopathic urticaria.

1989 • 16 citations

Acrivastine versus hydroxyzine in the treatment of cholinergic urticaria. A placebo-controlled study.

1988 • 15 citations

The placebo effect is nothing to sneeze at

1992 • 14 citations

Double-blind, placebo-controlled study of terfenadine and hydroxyzine in patients with chronic idiopathic urticaria.

1989 • 14 citations

Multi-Centre Double-Blind Comparison of Terfenadine Once Daily versus Twice Daily in Patients with Hay Fever

1987 • 14 citations

Inhibition of Histamine‐Induced Skin Wheal and Flare after 5 days of Mizolastine

1996 • 14 citations

An evaluation of the efficacy and safety of azelastine in patients with chronic asthma

1996 • 13 citations

Clinical evaluation of ketotifen syrup on atopic dermatitis: a comparative multicenter double-blind study of ketotifen and clemastine.

1989 • 13 citations

Side effects of rhinitis medications

1998 • 12 citations

Milestones in the biology and pharmacology of histamine H₁-receptor antagonists

1997 • 12 citations

Ketotifen in the treatment of atopic dermatitis. Results of a double blind study.

1993 • 10 citations

Long-term multicentric study with azelastine in patients with intrinsic asthma.

1990 • 9 citations

Mechanism of inhibitory effects of azelastine on smooth muscle contraction.

1992 • 9 citations

Interactions between Histamine and Leukotrienes in the Microcirculation: Aspects of Relevance to Acute Allergic Inflammation^a

1994 • 9 citations

Acrivastine: a review of its dermatopharmacology and clinical activity.

1989 • 8 citations

H1-receptor antagonists: does a dose-response relationship exist?

1993 • 7 citations

A comparative study of terfenadine at two dose levels in the management of hayfever

1990 • 5 citations

Drug interactions associated with terfenadine and related nonsedating antihistamines.

1996 • 4 citations

Comparison of Terfenadine Once Daily with Terfenadine Twice Daily for the Treatment of Perennial Allergic Rhinitis

1991 • 4 citations

Nonclassical clinical indications for H₁‐receptor antagonists in dermatology

1995 • 3 citations

Does nasal provocation play a role in the diagnosis and management of ragweed-induced allergic rhinitis?

1992 • 3 citations

Histamine(H1) antagonists and airway hyperreactivity in the guinea-pig.

1991 • 2 citations