IL-4– and IL-5–positive T lymphocytes, eosinophils, and mast cells in allergen-induced late-phase cutaneous reactions in atopic subjects☆☆☆★★★

Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines.

1994 • 850 citations

Messenger RNA expression of the cytokine gene cluster, interleukin 3 (IL-3), IL-4, IL-5, and granulocyte/macrophage colony-stimulating factor, in allergen-induced late-phase cutaneous reactions in atopic subjects.

1991 • 676 citations

An improved immunomagnetic procedure for the isolation of highly purified human blood eosinophils

1991 • 628 citations

Immunolocalization of cytokines in the nasal mucosa of normal and perennial rhinitic subjects. The mast cell as a source of IL-4, IL-5, and IL-6 in human allergic mucosal inflammation.

1993 • 561 citations

The late phase of the immediate wheal and flare skin reaction. Its dependence upon IgE antibodies.

1976 • 545 citations

High-affinity IgE receptor on eosinophils is involved in defence against parasites

1994 • 524 citations

Late cutaneous allergic responses in isolated IgE-dependent reactions

1973 • 454 citations

Expression of IL-4 and IL-5 mRNA and protein product by CD4+ and CD8+ T cells, eosinophils, and mast cells in bronchial biopsies obtained from atopic and nonatopic (intrinsic) asthmatics.

1997 • 416 citations

IL-4 and IL-5 mRNA and protein in bronchial biopsies from patients with atopic and nonatopic asthma: evidence against "intrinsic" asthma being a distinct immunopathologic entity.

1996 • 413 citations

IgA-induced eosinophil degranulation.

1989 • 397 citations

Skin-derived aeroallergen-specific T-cell clones of Th2 phenotype in patients with atopic dermatitis

1992 • 388 citations

The skin immune system: progress in cutaneous biology

1993 • 387 citations

Phenotype of cells expressing mRNA for TH2-type (interleukin 4 and interleukin 5) and TH1-type (interleukin 2 and interferon gamma) cytokines in bronchoalveolar lavage and bronchial biopsies from atopic asthmatic and normal control subjects.

1995 • 342 citations

Heterogeneity of human mast cells based on cytokine content.

1995 • 308 citations

The relationship between infiltrating CD4+ lymphocytes, activated eosinophils, and the magnitude of the allergen-induced late phase cutaneous reaction in man.

1988 • 301 citations

Interleukin 5 synthesis by eosinophils: association with granules and immunoglobulin-dependent secretion.

1994 • 295 citations

Deficiency of the tryptase-positive, chymase-negative mast cell type in gastrointestinal mucosa of patients with defective T lymphocyte function.

1987 • 223 citations

Identification of messenger RNA for IL-4 in human eosinophils with granule localization and release of the translated product.

1995 • 223 citations

Predominance of ?memory? T cells (CD4+, CDw29+) over ?naive? T cells (CD4+, CD45R+) in both normal and diseased human skin

1989 • 218 citations

Distinct immunohistochemical localization of IL-4 in human inflamed airway tissues. IL-4 is localized to eosinophils in vivo and is released by peripheral blood eosinophils.

1995 • 158 citations

T Cells Are the Principal Source of Interleukin-5 mRNA in Allergen-induced Rhinitis

1993 • 142 citations

Release of granule proteins from eosinophils cultured with IL-5.

1992 • 127 citations

Lymphokine and Cytokine Production by FcεRI+ Cells

1993 • 122 citations

Eosinophil activation and T lymphocyte infiltration in allergen-induced late phase skin reactions and classical delayed-type hypersensitivity.

1991 • 122 citations

Secretion of the eosinophil‐active cytokines interleukin‐5, granulocyte/macrophage colonystimulating factor and interleukin‐3 by bronchoalveolar lavage CD4⁺ and CD8⁺ T cell lines in atopics asthmatics, and atopic and nonatopic controls

1995 • 116 citations

T lymphocytes and mast cells express messenger RNA for interleukin-4 in the nasal mucosa in allergen-induced rhinitis.

1994 • 94 citations

Kinetics of cell infiltration and cytokine messenger RNA expression after intradermal challenge with allergen and tuberculin in the same atopic individuals

1994 • 93 citations

Mechanisms for eosinophil degranulation; release of the eosinophil cationic protein.

1984 • 91 citations

Ultrastructural analysis of maturing human T and TC mast cells in situ.

1989 • 86 citations

Human eosinophils express messenger RNA encoding RANTES and store and release biologically active RANTES protein

1996 • 81 citations

Polymerase chain reaction quantification of cytokine messenger RNA expression in peripheral blood mononuclear cells of patients with acute exacerbations of asthma: effect of glucocorticoid therapy

1994 • 48 citations

Allergen‐induced recruitment of FcσRI⁺ eosinophils in human atopic skin

1997 • 26 citations

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