The Pharmacology and Use of H₁-Receptor-Antagonist Drugs

H1-Receptor Antagonists

1994 • 757 citations

Distribution, properties, and functional characteristics of three classes of histamine receptor.

1990 • 579 citations

Changes in the pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine with concomitant administration of erythromycin

1992 • 373 citations

Clinical Pharmacokinetics of H1-Receptor Antagonists (The Antihistamines)

1985 • 330 citations

The role of histamine in allergic diseases

1990 • 321 citations

Ketotifen

1990 • 228 citations

Cetirizine

1993 • 214 citations

Effect of cetirizine on mast cell-mediator release and cellular traffic during the cutaneous late-phase reaction

1989 • 209 citations

Over-the-counter cold medications. A critical review of clinical trials between 1950 and 1991

1993 • 207 citations

Lack of Efficacy of a Decongestant-Antihistamine Combination for Otitis Media with Effusion (Secretory Otitis Media) in Children

1983 • 182 citations

Pharmacokinetics and pharmacodynamics of terfenadine and chlorpheniramine in the elderly

1990 • 159 citations

Inhibitory effect of oral cetirizine on in vivo antigen-induced histamine and PAF-acether release and eosinophil recruitment in human skin

1988 • 147 citations

Effects of terfenadine and its metabolites on a delayed rectifier K+ channel cloned from human heart.

1993 • 136 citations

Loratadine

1989 • 134 citations

Genomic Cloning, Heterologous Expression and Pharmacological Characterization of a Human Histamine H1 Receptor

1993 • 131 citations

Cimetidine and chlorpheniramine in the treatment of chronic idiopathic urticaria: a multi-centre randomized double-blind study

1987 • 124 citations

Azelastine

1989 • 124 citations

Sedation and histamine H₁‐receptor antagonism: studies in man with the enantiomers of chlorpheniramine and dimethindene

1991 • 118 citations

Risk of developing life-threatening ventricular arrhythmia associated with terfenadine in comparison with over-the-counter antihistamines, ibuprofen and clemastine

1994 • 116 citations

Incidence and Toxicological Aspects of Drugs Detected in 484 Fatally Injured Drivers and Pedestrians in Ontario

1982 • 111 citations

Levocabastine

1991 • 111 citations

Antiallergic activity of H-receptor antagonists assessed by nasal challenge

1988 • 106 citations

The relative antihistaminic and psychomotor effects of hydroxyzine and cetirizine

1987 • 104 citations

Terfenadine

1990 • 104 citations

Terfenadine-ketoconazole interaction. Pharmacokinetic and electrocardiographic consequences

1993 • 102 citations

Terfenadine, an H₁Antihistamine, Inhibits Histamine ReleaseIn Vivoin the Human

1990 • 96 citations

Failure of terfenadine in relieving the pruritus of atopic dermatitis

1989 • 96 citations

Mechanism of the cardiotoxic actions of terfenadine

1993 • 93 citations

Double-blind comparison of cetirizine and placebo in the treatment of seasonal rhinitis.

1991 • 91 citations

Astemizole, a potent histamine H1‐receptor antagonist: effect in allergic rhinoconjunctivitis, on antigen and histamine induced skin weal responses and relationship to serum levels.

1984 • 87 citations

The pharmacology and mechanisms of action of histamine H₁‐antagonists

1990 • 85 citations

Comparison of beclomethasone dipropionate aqueous nasal spray, astemizole, and the combination in the prophylactic treatment of ragweed pollen-induced rhinoconjunctivitis

1989 • 84 citations

Cetirizine: A pharmacokinetic and pharmacodynamic evaluation in children with seasonal allergic rhinitis

1989 • 81 citations

Studies on the central effects of the H1-antagonist, loratadine

1987 • 79 citations

Treatment of chronic urticaria with cetirizine dihydrochloride a non-sedating antihistamine

1988 • 73 citations

Effect of cetirizine, a new histamine H1 antagonist, on airway dynamics and responsiveness to inhaled histamine in mild asthma

1987 • 72 citations

Ineffectiveness of oral terfenadine in natural colds

1988 • 71 citations

Pharmacokinetics of cetirizine in the elderly and patients with renal insufficiency.

1987 • 71 citations

The effect of cetirizine on early allergic response

1989 • 70 citations

Allergen-induced increase in nonspecific nasal reactivity is blocked by antihistamines without a clear-cut relationship to eosinophil influx

1990 • 69 citations

Treatment of chronic urticaria with terfenadine and ranitidine

1986 • 68 citations

Comparative safety of H1 antihistamines.

1991 • 67 citations

Terfenadine, a potent histamine H1‐receptor antagonist in the treatment of grass pollen sensitive asthma.

1990 • 66 citations

Comparative effects of loratadine and terfenadine in the treatment of chronic idiopathic urticaria.

1990 • 60 citations

Pharmacokinetic Optimisation of Histamine H1-Receptor Antagonist Therapy

1991 • 60 citations

Efficacy and safety of loratadine (10 mg once daily), terfenadine (60 mg twice daily), and placebo in the treatment of seasonal allergic rhinitis

1989 • 57 citations

Comparison of the effect of loratadine on the airway and skin responses to histamine, methacholine, and allergen in subjects with asthma

1990 • 57 citations

Acrivastine

1991 • 54 citations

Biological effects of histamine: An overview

1991 • 54 citations

Prophylactic treatment of grass pollen‐induced asthma with cetirizine

1990 • 54 citations

Histamine and its antagonists in asthma

1989 • 53 citations

Histamine in Cardiovascular Function and Dysfunction: Recent Developments

1991 • 49 citations

Objective antihistamine side effects are mitigated by evening dosing of hydroxyzine.

1991 • 47 citations

Double-blind comparison of terfenadine, chlorpheniramine, and placebo in the treatment of chronic idiopathic urticaria

1988 • 47 citations

Prolongation of simple and choice reaction times in a double-blind comparison of twice-daily hydroxyzine versus terfenadine

1989 • 45 citations

Pharmacokinetic and pharmacodynamic studies of the H1-receptor antagonist hydroxyzine in the elderly

1989 • 45 citations

Is there a difference in the affinity of histamine H1 receptor antagonists for CNS and peripheral receptors? An in vitro study

1993 • 44 citations

Perioperative uses of histamine antagonists

1990 • 43 citations

The effects of terfenadine with and without alcohol on an aspect of car driving performance

1989 • 43 citations

Acute effects of hydroxyzine on nocturnal sleep and sleep tendency the following day: A C‐EEG study

1992 • 43 citations

Peripheral antihistamine and central sedative effects of single and continuous oral doses of cetirizine and hydroxyzine

1991 • 42 citations

SCH 434: A new antihistamine/decongestant for seasonal allergic rhinitis

1989 • 40 citations

Lack of subsensitivity to terfenadine during long-term terfenadine treatment

1988 • 39 citations

Differential cognitive effects of terfenadine and chlorpheniramine

1989 • 38 citations

Direct measurement of daytime sleepiness after administration of cetirizine and hydroxyzine with a standardized electroencephalographic assessment

1990 • 37 citations

Lack of subsensitivity to loratadine during long-term dosing during 12 weeks

1990 • 36 citations

A comparison of topical levocabastine and sodium cromoglycate in the treatment of pollen‐provoked allergic conjunctivitis

1993 • 34 citations

Comparison of intranasal cromolyn sodium, 4%, and oral terfenadine for allergic rhinitis: symptoms, nasal cytology, nasal ciliary clearance, and rhinomanometry.

1991 • 31 citations

Histamine H₁‐Receptor in Heart: Unique Electrophoretic Mobility and Autoradiographic Localization

1990 • 29 citations

The Pharmacokinetics and Pharmacodynamics of Hydroxyzine in Patients with Primary Biliary Cirrhosis

1989 • 28 citations

Rational Use of Antihistamines in Allergic Dermatological Conditions

1989 • 28 citations

Astemizole

1993 • 26 citations

Double-blind comparison of astemizole and terfenadine in the treatment of chronic urticaria.

1986 • 26 citations

Structure-activity relationships within a series of analogues of the histamine H1-antagonist terfenadine

1993 • 26 citations

Profile of ragweed hay fever symptom control with terfenadine started before or after symptoms are established

1990 • 25 citations

Effects of topical administration of levocabastine on psychomotor and cognitive function.

1991 • 24 citations

Efficacy of continuous treatment with astemizole (Hismanal) and terfenadine (Seldane) in ragweed pollen-induced rhinoconjunctivitis

1988 • 22 citations

Duration of the effect of astemizole on histamine-inhalation tests

1990 • 21 citations

Chronic chlorpheniramine therapy: subsensitivity, drug metabolism, and compliance.

1987 • 19 citations

Hypertension during reduction of long-term steroid therapy in young subjects with asthma

1992 • 19 citations

Diphenhydramine Poisoning Treated by Exchange Transfusion

1963 • 18 citations

Effects of H1-antihistamine drug regimen on histamine release by nonlesional skin mast cells of patients with chronic urticaria

1990 • 15 citations

Duration of Effect of Loratadine and Terfenadine Administered Once a Day for One Week on Cutaneous and Inhaled Reactivity to Histamine

1993 • 13 citations

Acrivastine in two doses compared with placebo in a multicentre, parallel group study for the treatment of seasonal allergic rhinitis

1989 • 12 citations

Antagonists of H1 Receptors of Histamine: Recent Developments

1991 • 7 citations

A comparative study of terfenadine at two dose levels in the management of hayfever

1990 • 5 citations

337 Double-blind multicentre study of ketotifen (zaditen) in chronic idiopathic urticaria

1991 • 4 citations

319 A safety and efficacy evaluation of azelastine (AZ) nasal spray (NS) in seasonal allergic rhinitis (SAR)

1991 • 4 citations

Fibroblast-induced cytokine (fic) and monocyte chemoattractant peptide-2 (mcp-2), 2 new beta-chemokines, cause basophil histamine-release

1994 • 4 citations

Deleted Work

1955 • 0 citations