Recent Advances: the Cytochrome P450 Enzymes

The P450 Superfamily: Update on New Sequences, Gene Mapping, Accession Numbers, Early Trivial Names of Enzymes, and Nomenclature

1993 • 1,663 citations

The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans.

1994 • 958 citations

The Human Hepatic Cytochromes P450 Involved in Drug Metabolism

1992 • 932 citations

The P450 Gene Superfamily: Recommended Nomenclature

1987 • 812 citations

Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions

1992 • 605 citations

Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man.

1987 • 475 citations

Extrahepatic Metabolism of Drugs in Humans

1994 • 426 citations

Determination of CYP1A2 and NAT2 phenotypes in human populations by analysis of caffeine urinary metabolites

1992 • 417 citations

Noninvasive tests of CYP3A enzymes

1994 • 414 citations

Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease

1992 • 414 citations

Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin

1992 • 406 citations

CYP3A gene expression in human gut epithelium

1994 • 367 citations

Evidence That CYP2C19 is the Major (S)-Mephenytoin 4'-Hydroxylase in Humans

1994 • 366 citations

Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction

1992 • 337 citations

Racial and gender differences in N-acetyltransferase, xanthine oxidase, and CYP1A2* activities

1992 • 304 citations

Isolation and Characterization of Human Liver Cytochrome P450 2C19: Correlation between 2C19 and S-Mephenytoin 4′-Hydroxylation

1993 • 286 citations

Mephenytoin hydroxylation deficiency in Caucasians: Frequency of a new oxidative drug metabolism polymorphism

1984 • 271 citations

Use of caffeine metabolite ratios to explore CYP1A2 and xanthine oxidase activities

1991 • 258 citations

Characterization of human cytochrome P450 enzymes

1992 • 227 citations

Identification of human liver cytochrome P450 isoforms mediating omeprazole metabolism

1993 • 225 citations

Selective Inhibitors of Cytochromes P450

1994 • 215 citations

Caffeine as a metabolic probe: Exploration of the enzyme-inducing effect of cigarette smoking

1991 • 214 citations

Analysis of the CYP2D6 gene in relation to debrisoquin and desipramine hydroxylation in a Swedish population

1992 • 190 citations

P450 Enzymes

1992 • 181 citations

Simple and reliable CYP1A2 phenotyping by the paraxanthine/caffeine ratio in plasma and in saliva

1994 • 179 citations

Catalytic selectivity of human cytochrome P450 enzymes: relevance to drug metabolism and toxicity

1994 • 160 citations

A predictive model for substrates of cytochrome P450-debrisoquine (2D6)

1992 • 152 citations

Increase of cytochrome P450IA2 activity by omeprazole: Evidence by the 13C-[N-3-methyl]-caffeine breath test in poor and extensive metabolizers of S-mephenytoin

1992 • 138 citations

Comparison of urinary 6-β-cortisol and the erythromycin breath test as measures of hepatic P450IIIA (CYP3A) activity

1992 • 138 citations

Absence of correlations among three putative in vivo probes of human cytochrome P4503A activity in young healthy men

1993 • 137 citations

Genetically variable metabolism of antidepressants and neuroleptic drugs in man

1993 • 136 citations

Inhibitory potency of quinolone antibacterial agents against cytochrome P450IA2 activity in vivo and in vitro

1992 • 135 citations

Molecular genetics of the debrisoquin-sparteine polymorphism

1991 • 132 citations

Incidence of S-mephenytoin hydroxylation deficiency in a Korean population and the interphenotypic differences in diazepam pharmacokinetics

1992 • 121 citations

Predicting the cytochrome P450 mediated metabolism of xenobiotics

1993 • 119 citations

Characterization of dextromethorphan N-demethylation by human liver microsomes

1994 • 116 citations

Genetic basis for a lower prevalence of deficient CYP2D6 oxidative drug metabolism phenotypes in black Americans.

1993 • 108 citations

Accelerated caffeine metabolism after omeprazole treatment is indicated by urinary metabolite ratios: Coincidence with plasma clearance and breath test

1994 • 107 citations

Identification of a new variant CYP2D6 allele with a single base deletion in exon 3 and its association with the poor metabolizer phenotype

1994 • 102 citations

Terfenadine-ketoconazole interaction. Pharmacokinetic and electrocardiographic consequences

1993 • 102 citations

Lower prevalence of the debrisoquin oxidative poor metabolizer phenotype in American black versus white subjects

1991 • 102 citations

In vitro approaches can predict human drug metabolism

1993 • 90 citations

Frequency distribution of dapsone N-hydroxylase, a putative probe for P4503A4 activity, in a white population

1994 • 90 citations

Biochemical Individuality and Its Implications for Drug and Carcinogen Metabolism: Recent Insights from Acetyltransferase and Cytochrome P4501a2 Phenotyping and Genotyping in Humans

1994 • 81 citations

Genetic Differences in Drug Disposition

1994 • 58 citations

Contrasting effects of fluconazole and ketoconazole on phenytoin and testosterone disposition in man.

1992 • 57 citations

Genetic basis for differences in debrisoquin polymorphism between a spanish and other white populations

1994 • 45 citations

Effect of quinidine on the interconversion kinetics between haloperidol and reduced haloperidol in humans: implications for the involvement of cytochrome P450IID6

1993 • 42 citations

Low activity of dapsone N-hydroxylation as a susceptibility risk factor in aggressive bladder cancer

1994 • 20 citations