DNA Repair and Its Pathogenetic Implications

Defective Repair Replication of DNA in Xeroderma Pigmentosum

1968 • 1,739 citations

Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli

1984 • 1,608 citations

A mechanism for gene conversion in fungi

1964 • 1,459 citations

Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene

1987 • 1,235 citations

DNA repair in an active gene: Removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall

1985 • 1,233 citations

Handbook of the Biology of Aging

1990 • 1,219 citations

A mechanism for gene conversion in fungi

2007 • 1,149 citations

Discontinuities in the DNA synthesized in an Excision-defective strain of Escherichia coli following ultraviolet irradiation

1968 • 1,089 citations

Xeroderma pigmentosum. Cutaneous, ocular, and neurologic abnormalities in 830 published cases

1987 • 1,070 citations

DNA Repair in Bacteria and Mammalian Cells

1979 • 854 citations

DNA REPAIR ENZYMES

1988 • 822 citations

Radiosensitivity in ataxia-telangiectasia: a new explanation.

1980 • 784 citations

Xeroderma Pigmentosum

1987 • 774 citations

DNA damage-inducible transcripts in mammalian cells.

1988 • 613 citations

Overexpression of Metallothionein Confers Resistance to Anticancer Drugs

1988 • 600 citations

Handbook of the Biology of Aging

1986 • 572 citations

Differential induction of heat shock, SOS, and oxidation stress regulons and accumulation of nucleotides in Escherichia coli

1987 • 492 citations

Modern Biological Theories of Aging

1989 • 469 citations

Preferential DNA repair of an active gene in human cells.

1986 • 455 citations

Bloom’s Syndrome

1995 • 422 citations

Failure of RNA synthesis to recover after UV irradiation; An early defect in cells from individuals with Cockayne syndrome and xeroderma pigmentosum

1982 • 418 citations

Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains

1980 • 371 citations

Transcriptionally active chromatin

1984 • 361 citations

Deoxyribonucleic acid repair in the yeast Saccharomyces cerevisiae

1988 • 361 citations

Acquired Precursors of Cutaneous Malignant Melanoma

1985 • 345 citations

Molecular characterization of the human excision repair gene : cDNA cloning and amino acid homology with the yeast DNA repair gene

1986 • 330 citations

Enhanced DNA repair as a mechanism of resistance to cis-diamminedichloroplatinum(II)

1988 • 314 citations

Mortality and Cancer Incidence in 263 Patients With Ataxia-Telangiectasia<xref ref-type="fn" rid="FN1">2</xref>

1986 • 309 citations

Cross-link repair in human cells and its possible defect in Fanconi's anemia cells

1977 • 294 citations

Characterization of a human squamous carcinoma cell line resistant to cis-diamminedichloroplatinum(II).

1987 • 288 citations

Modern Biological Theories of Aging

1987 • 274 citations

Heterogeneous DNA damage and repair in the mammalian genome.

1987 • 274 citations

Chemical Carcinogenesis: From Animal Models To Molecular Models In One Decade

1988 • 270 citations

The role of O6-methylguanine-DNA methyltransferase in cell survival, mutagenesis and carcinogenesis

1985 • 224 citations

A structural analysis of the role of the nuclear matrix and DNA loops in the organization of the nucleus and chromosome

1984 • 220 citations

Induction of metallothionein and other mRNA species by carcinogens and tumor promoters in primary human skin fibroblasts.

1986 • 215 citations

Persistence of pyrimidine dimers during post-replication repair in ultraviolet light-irradiated Escherichia coli K12

1974 • 210 citations

Topoisomerase I interacts with transcribed regions in Drosophila cells

1986 • 210 citations

RAD1, an excision repair gene of Saccharomyces cerevisiae, is also involved in recombination.

1988 • 209 citations

Repair of ultraviolet light damage in a variety of human fibroblast cell strains.

1977 • 209 citations

Nucleosome rearrangement in human chromatin during UV-induced DNA- reapir synthesis.

1978 • 204 citations

Angiotoxicity of Oxygenated Sterols and Possible Precursors

1980 • 202 citations

Differential DNA repair in transcriptionally active and inactive proto-oncogenes: c-abl and c-mos

1986 • 202 citations

Ataxia-telangiectasia: an inherited disorder of ionizing-radiation sensitivity in man

1987 • 200 citations

Survival of UV-irradiated mammalian cells correlates with efficient DNA repair in an essential gene.

1986 • 196 citations

Repair of interstrand cross-links in DNA of Saccharomyces cerevisiae requires two systems for DNA repair: The RAD3 system and the RAD51 system

1981 • 195 citations

Ataxia Telangiectasia: Genetics, Neuropathology, and Immunology of a Degenerative Disease of Childhood

1987 • 187 citations

Dyskeratosis congenita: clinical features and genetic aspects. Report of a family and review of the literature.

1975 • 180 citations

DNA repair and its inhibition

1984 • 174 citations

DNA ligase I deficiency in Bloom's syndrome

1987 • 169 citations

Mechanism of ultraviolet-induced mutagenesis: Extent and fidelity of in vitro DNA synthesis on irradiated templates

1978 • 160 citations

Induction of beta-polymerase mRNA by DNA-damaging agents in Chinese hamster ovary cells.

1989 • 158 citations

Specific Saccharomyces cerevisiae genes are expressed in response to DNA-damaging agents.

1985 • 157 citations

Altered DNA ligase I activity in Bloom's syndrome cells

1987 • 152 citations

Preferential DNA Repair in Human Cells

1974 • 144 citations

Cancer-prone hereditary diseases with DNA processing abnormalities

1986 • 143 citations

Ataxia-telangiectasia: Genetics, neuropathology, and immunology of a degenerative disease of childhood.

1987 • 141 citations

Deoxyribonucleic acid repair in the yeast Saccharomyces cerevisiae.

1988 • 139 citations

Xeroderma pigmentosum (complementation group D) mutation is present in patients affected by trichothiodystrophy with photosensitivity

1986 • 135 citations

The yeast DNA polymerase I transcript is regulated in both the mitotic cell cycle and in meiosis and is also induced after DNA damage

1987 • 129 citations

Effect of carcinogens on chicken atherosclerosis.

1977 • 129 citations

A yeast excision-repair gene is inducible by DNA damaging agents.

1986 • 125 citations

Sensitive determination of pyrimidine dimers in DNA of UV-irradiated mammalian cells Introduction of T4 endonuclease V into frozen and thawed cells

1981 • 124 citations

Suppression of human DNA alkylation-repair defects by Escherichia coli DNA-repair genes.

1986 • 115 citations

Effects of DNA damaging agents on cultured fibroblasts derived from patients with Cockayne syndrome

1979 • 113 citations

Cholesterol epoxide is a direct-acting mutagen.

1984 • 112 citations

Carcinogens can induce homologous recombination between duplicated chromosomal sequences in mouse L cells.

1988 • 111 citations

Repair of N-methylpurines in specific DNA sequences in Chinese hamster ovary cells: absence of strand specificity in the dihydrofolate reductase gene.

1989 • 105 citations

Characterization of a DNA repair domain containing the dihydrofolate reductase gene in Chinese hamster ovary cells.

1986 • 105 citations

Trichothiodystrophy, a human DNA repair disorder with heterogeneity in the cellular response to ultraviolet light.

1988 • 104 citations

Formation of hybrid DNA by rotary diffusion during genetic recombination

1972 • 103 citations

Cross-linking and repair of DNA in sensitive and resistant strains of E. coli treated with nitrogen mustard.

1965 • 100 citations

recA protein promotes homologous-pairing and strand-exchange reactions between duplex DNA molecules.

1981 • 99 citations

Nuclear matrix associated DNA is preferentially repaired in normal human fibroblasts, exposed to a low dose of ultraviolet light but not in Cockayne's syndrome fibroblasts

1988 • 94 citations

Skin fibroblasts from a D-deletion type retinoblastoma patient are abnormally X-ray sensitive

1977 • 93 citations

DNA damage and heat shock dually regulate genes in Saccharomyces cerevisiae.

1986 • 86 citations

The use of antibodies to 5-bromo-2'-deoxyuridine for the isolation of DNA sequences containing excision-repair sites.

1984 • 85 citations

DNA repair and replication in aging organisms and cells

1985 • 85 citations

Effect of double-strand breaks on homologous recombination in mammalian cells and extracts.

1985 • 84 citations

Expression of the yeast UB14 gene increases in response to DNA-damaging agents and in meiosis.

1988 • 84 citations

Immunological lesions in human uracil DNA glycosylase: association with Bloom syndrome.

1988 • 81 citations

Bloom's Syndrome. VII. Progress report for 1978

1979 • 76 citations

Reduced Capacity for DNA Repair Synthesis in Patients With or Genetically Predisposed to Colorectal Cancer<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1983 • 71 citations

Differential repair of DNA damage in the human metallothionein gene family.

1988 • 70 citations

Sites of topoisomerase I action on X. laevis ribosomal chromatin: Transcriptionally active rDNA has an ∼200 bp repeating structure

1988 • 69 citations

Induction of urokinase-type plasminogen activator by UV light in human fetal fibroblasts is mediated through a UV-induced secreted protein.

1987 • 69 citations

Hereditary dysplastic nevus syndrome: lymphoid cell ultraviolet hypermutability in association with increased melanoma susceptibility.

1986 • 69 citations

Alzheimer's disease cells exhibit defective repair of alkylating agent—induced DNA damage

1987 • 67 citations

DNA repair in the metallothionein gene increases with transcriptional activation

1987 • 65 citations

General method for quantifying base adducts in specific mammalian genes.

1988 • 63 citations

Coordinate induction of metallothioneins I and II in rodent cells by UV irradiation.

1988 • 61 citations

Enhancement of DNA repair capacity of mammalian cells by carcinogen treatment

1988 • 61 citations

Impaired DNA-repair synthesis in lymphocytes of breast cancer patients

1986 • 55 citations

Decreased UV-induced DNA Repair Synthesis in Peripheral Leukocytes from Patients with the Nevoid Basal Cell Carcinoma Syndrome

1981 • 54 citations

Resistance to antineoplastic drugs

1989 • 53 citations

Familial melanoma associated with dominant ultraviolet radiation sensitivity.

1982 • 53 citations

Pyrimidine dimers block simian virus 40 replication forks.

1986 • 53 citations

Reduced DNA repair synthesis in healthy women having first degree relatives with breast cancer

1987 • 51 citations

Cultured diploid fibroblasts from patients with the nevoid basal cell carcinoma syndrome are hypersensitive to killing by ionizing radiation.

1983 • 51 citations

Evidence that lack of deoxyribonucleic acid repair causes death of neurons in xeroderma pigmentosum

1983 • 51 citations

Update: Dermatology in General Medicine.

1983 • 50 citations

Alzheimer disease fibroblasts are hypersensitive to the lethal effects of a DNA-damaging chemical

1986 • 49 citations

Rearrangement of mammalian chromatin structure following excision repair

1982 • 49 citations

Elevated DNA polymerase beta activity in a cis-diamminedichloroplatinum(II) resistant P388 murine leukemia cell line

1988 • 47 citations

Demethylation enhances removal of pyrimidine dimers from the overall genome and from specific DNA sequences in Chinese hamster ovary cells.

1989 • 47 citations

Sister chromatid exchange in dyskeratosis congenita lymphocytes.

1977 • 45 citations

Abnormal sensitivity of diploid skin fibroblasts from a family with Gardner's syndrome to the lethal effects of X-irradiation, ultraviolet light and mitomycin-C

1980 • 45 citations

Origins of human atherosclerotic plaques. The role of altered gene expression.

1988 • 44 citations

A nonuniform distribution of excision repair synthesis in nucleosome core DNA

1985 • 44 citations

Review: Diseases with DNA Damage-Processing Defects

1988 • 43 citations

Psoralen-DNA Cross-linking Photoadducts in Dyskeratosis Congenita: Delay in Excision and Promotion of Sister Chromatid Exchange

1979 • 43 citations

PIBI(D)S syndrome—trichothiodystrophy with xeroderma pigmento sum (group D) mutation

1987 • 43 citations

DNA repair at the level of the gene

1988 • 40 citations

Transient expression of a plasmid gene, a tool to study DNA repair in human cells: defect of DNA repair in Cockayne syndrome; one thymine cyclobutane dimer is sufficient to block transcription.

1986 • 39 citations

Induction of yeast DNA ligase genes in exponential and stationary phase cultures in response to DNA damaging agents

1986 • 39 citations

DNA Repair in Specific Sequences in Mammalian Cells

1987 • 39 citations

DNA Repair in Relation to the Aging Process

1987 • 39 citations

Cytogenetic studies on cultured fibroblast‐like cells derived from basal cell carcinoma tissue

1973 • 38 citations

Inducible repair of ionizing radiation damage in higher eukaryotic cells

1986 • 36 citations

Mitomycin-induced chromatid breaks in HeLa cells: a consequence of incomplete DNA replication.

1986 • 36 citations

Recombination of parent and daughter strand DNA after UV-irradiation in mammalian cells

1983 • 34 citations

Immune responses in four patients with Bloom syndrome

1979 • 32 citations

Differential repair of DNA damage in specific nucleotide sequences in monkey cells

1986 • 31 citations

Update: Dermatology in General Medicine

1984 • 30 citations

Monoclonal antibodies detect conformationl abnormality of uracil DNA glycosylase in Bloom's syndrome cells

1987 • 29 citations

Human repair gene restores normal pattern of preferential DNA repair in repair defective CHO cells

1988 • 28 citations

Enhanced repair of pyrimidine dimers in coding and non-coding genomic sequences in CHO cells expressing a prokaryotic DNA repair gene

1987 • 28 citations

Mechanisms of cross-resistance between radiation and antineoplastic drugs.

1988 • 28 citations

Hypersensitivity to DNA-Damaging Agents in Abiotrophies: A New Explanation for Degeneration of Neurons, Photoreceptors, and Muscle in Alzheimer, Parkinson and Huntington Diseases, Retinitis Pigmentosa, and Duchenne Muscular Dystrophy

1985 • 27 citations

Investigations of chromosomal stability in the Gorlin-Goltz syndrome

1985 • 26 citations

Chromatid damage induced by fluorescent light during G2 phase in normal and Gardner syndrome fibroblasts

1985 • 25 citations

A Childhood Neurodegeneration Due to Defective DNA Repair: A Novel Concept of Disease Based on Studies of Xeroderma Pigmentosum

1989 • 24 citations

Human DNA repair defects

1986 • 23 citations

DNA repair in lymphocytes from patients with secondary leukemia as measured by strand rejoining and unscheduled DNA synthesis

1985 • 20 citations

Heterogeneous Response to X-Ray and Ultraviolet Light Irradiations of Cultured Skin Fibroblasts in Two Families With Gardner's Syndrome<xref ref-type="fn" rid="fn2">2</xref>

1982 • 19 citations

Induction of proteins and mRNAs after uv irradiation of human epidermal keratinocytes

1988 • 17 citations

Alzheimer's disease fibroblasts have normal repair of N-methyl-N′-nitro-N-nitrosoguanidine-induced DNA damage determined by the alkaline elution technique

1987 • 17 citations

Yeast gene RAD52 can substitute for phage T4 gene 46 or 47 in carrying out recombination and DNA repair.

1988 • 16 citations

Dna repair and transcriptional activity in genes

1988 • 14 citations

Heritable Disorders of DNA Repair: Xeroderma pigmentosum and Fanconi�s Anemia1

2015 • 13 citations

A sensitive assay for detecting hypersensitivity to ionizing radiation in lymphoblastoid lines from patients with duchenne muscular dystrophy and primary neuronal degenerations

1984 • 12 citations

Splicing of Viral mRNAs

1981 • 12 citations

Search for DNA interchange corresponding to sister chromatid exchanges in Chinese hamster ovary cells

1978 • 12 citations

Novobiocin does not inhibit DNA repair in an activve gene

1986 • 11 citations

Historical perspectives

1985 • 10 citations

Inducibility of gene conversion in Saccharomyces cerevisiae treated with MMS

1986 • 8 citations

DNA repair synthesis as a marker of predisposition to colorectal cancer.

1988 • 7 citations

Radiation-induced recovery processes in cultured marsupial cells

1988 • 4 citations

Deleted Work

1955 • 0 citations