[3] Mechanism-based irreversible enzyme inhibitors

Chemistry and Enzymology of k _cat Inhibitors

1974 • 283 citations

The Inactivation of Pepsin by Diazoacetylnorleucine Methyl Ester

1966 • 214 citations

Studies on the Mechanism of Action of d-Amino Acid Oxidase

1971 • 208 citations

Active-site-directed irreversible inhibition of rat brain 4-aminobutyrate aminotransferase by ethanolamine O-sulphate in vitro and in vivo

1972 • 178 citations

Azaserine-reactive Sulfhydryl Group of 2-Formamido-N-ribosylacetamide 5'-Phosphate:l-Glutamine Amido-ligase (Adenosine Diphosphate)

1963 • 102 citations

Irreversible inhibition of aspartate aminotransferase by 2-amino-3-butenoic acid

1974 • 98 citations

A new method for labelling the active center of chymotrypsin

1962 • 95 citations

Products from the Photolysis of Diazoacetyl Chymotrypsin

1966 • 85 citations

Inactivation of a Flavoprotein, Lactate Oxidase, by an Acetylenic Substrate

1972 • 79 citations

Reaction of L-serine O-sulfate with aspartate aminotransferase

1969 • 71 citations

Mechanism of inhibition of spinach β-cystathionase by rhizobitoxine

1971 • 71 citations

Monoamine Oxidase Inhibitors

1972 • 70 citations

A new pyrrolizidine aminoalcohol in alkaloids from crotalaria species

1966 • 67 citations

Azaserine-reactive Sulfhydryl Group of 2-Formamido-N-ribosylacetamide 5'-Phosphate:l-Glutamine Amido-ligase (Adenosine Diphosphate)

1963 • 62 citations

Allyl alcohol-induced irreversible inhibition of yeast alcohol dehydrogenase

1974 • 61 citations

Rearrangement accompanying the photolysis of diazoacyl esters

1968 • 58 citations

A chemical investigation of the active center of pepsin

1966 • 56 citations

Mechanism of the irreversible inhibition of aspartate aminotransferase by the bacterial toxin L-2-amino-4-methoxy-trans-3-butenoic acid.

1976 • 53 citations

β,γ Unsaturated amino acids as irreversible enzyme inhibitors

1974 • 51 citations

Labeling of the active site of cytoplasmic aspartate aminotransferase by β-chloro-L-alanine

1973 • 49 citations

Highly specific enzyme inhibitors. Inhibition of plasma amine oxidase

1973 • 42 citations

A new type of pyridoxal-p enzyme catalyzed reaction: The conversion of β, γ-unsaturated amino acids to saturated α-keto acids by tryptophan synthase

1975 • 30 citations

The Mechanism of the Reaction of β-hydroxyaspartate with L-Aspartate β-Decarboxylase. A New Type of Pyridoxal 5'-Phosphate-Enzyme Inhibition^*

1967 • 25 citations

2,6–Anhydro–1–diazo–1–deoxy–D–glycero–L–manno–heptitol: A specific blocking agent for the active site of β–galactosidase

1976 • 24 citations

Active site directed inhibition of enzymes utilizing deaminatively produced carbonium ions. Application to chymotrypsin

1975 • 22 citations

ChemInform Abstract: 3‐BROMOALLYLAMINE INDUCED IRREVERSIBLE INHIBITION OF MONOAMINE OXIDASE

1973 • 20 citations