Prolactin, Growth Hormone, and Insulin-like Growth Factor-I in the Immune System

Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions*

1995 • 4,419 citations

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

1993 • 2,880 citations

The Hypothalamic–Pituitary–Adrenal Axis and Immune-Mediated Inflammation

1995 • 2,525 citations

Structural design and molecular evolution of a cytokine receptor superfamily.

1990 • 2,104 citations

Insulin-like growth factors and their binding proteins: biological actions

1995 • 1,976 citations

A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting

1990 • 1,650 citations

Lymphokine Production by Human T Cells in Disease States

1994 • 1,351 citations

Cytokine receptor signalling

1995 • 1,242 citations

Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1

1990 • 1,211 citations

A role for CD95 ligand in preventing graft rejection

1995 • 1,184 citations

GLYCOBIOLOGY

1988 • 1,107 citations

Wound Macrophages Express TGF-α and Other Growth Factors in Vivo: Analysis by mRNA Phenotyping

1988 • 1,107 citations

MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia

1993 • 995 citations

Insulin-like growth factors and their binding proteins

1990 • 929 citations

Dual control of cell growth by somatomedins and platelet-derived growth factor.

1979 • 926 citations

Insulin-Like Growth Factors

1997 • 897 citations

Role of IRS-2 in insulin and cytokine signalling

1995 • 843 citations

Sex hormones, immune responses, and autoimmune diseases. Mechanisms of sex hormone action.

1985 • 816 citations

Soluble receptors for cytokines and growth factors: generation and biological function

1994 • 766 citations

Release of Multiple Hormones by a Direct Action of Interleukin-1 on Pituitary Cells

1987 • 670 citations

Cellular Localization of Somatomedin (Insulin-Like Growth Factor) Messenger RNA in the Human Fetus

1987 • 663 citations

The Nature and Regulation of the Receptors for Insulin-Like Growth Factors

1985 • 639 citations

Signaling Through the Hematopoietic Cytokine Receptors

1995 • 617 citations

Constitutively Activated Jak-STAT Pathway in T Cells Transformed with HTLV-I

1995 • 571 citations

Regulation of insulin-like growth factor I gene expression by growth hormone.

1986 • 558 citations

Neuroendocrine-Immune System Interactions and Autoimmunity

1995 • 460 citations

Cytokine cytotoxicity against oligodendrocytes. Apoptosis induced by lymphotoxin.

1991 • 455 citations

Growth Hormone Heterogeneity: Genes, Isohormones, Variants, and Binding Proteins

1991 • 448 citations

Structural Variants of Prolactin: Occurrence and Physiological Significance

1995 • 420 citations

Frequency of lupus flare in pregnancy: The hopkins lupus pregnancy center experience

1991 • 396 citations

Suppression of Macrophage Activation and T-Lymphocyte Function in Hypoprolactinemic Mice

1988 • 387 citations

Prolactin receptors on human T and B lymphocytes: antagonism of prolactin binding by cyclosporine.

1985 • 356 citations

Jak-STAT Signaling Induced by the v- abl oncogene

1995 • 341 citations

Hyaluronate activation of CD44 induces insulin-like growth factor-1 expression by a tumor necrosis factor-alpha-dependent mechanism in murine macrophages.

1993 • 330 citations

INTERLEUKIN-6 STIMULATES ANTERIOR PITUITARY HORMONE RELEASEIN VITRO.

1989 • 323 citations

Developmental regulation of insulin-like growth factor II mRNA in different rat tissues.

1986 • 322 citations

Prolactin and Growth Hormone in the Regulation of the Immune System

1991 • 321 citations

Lymphoid and myeloid differentiation of single human CD34+, HLA-DR+, CD38- hematopoietic stem cells

1994 • 314 citations

Expression of prolactin and its receptor in human lymphoid cells.

1992 • 291 citations

Prolactin-stimulated growth of cell cultures established from malignant Nb rat lymphomas.

1980 • 279 citations

Production of Interleukin-6 by Folliculo-Stellate Cells of the Anterior Pituitary Gland in a Histiotypic Cell Aggregate Culture System

1989 • 272 citations

Receptor-specific induction of insulin-like growth factor I in human monocytes by advanced glycosylation end product-modified proteins.

1992 • 261 citations

Alveolar macrophages release an insulin-like growth factor I-type molecule.

1988 • 255 citations

Regulation of immunity in rats by lactogenic and growth hormones

1983 • 255 citations

Expression of prolactin and prolactin receptor in human breast carcinoma. Evidence for an autocrine/paracrine loop.

1995 • 255 citations

Prolactin as a modulator of lymphocyte responsiveness provides a possible mechanism of action for cyclosporine.

1986 • 247 citations

Nonpituitary human prolactin gene transcription is independent of Pit-1 and differentially controlled in lymphocytes and in endometrial stroma.

1994 • 239 citations

Binding of 125I-Human Growth Hormone to Specific Receptors in Human Cultured Lymphocytes

1974 • 229 citations

The Growth Hormone/Prolactin Receptor Family

1993 • 227 citations

Insulin-like growth factor-I inhibits apoptosis in IL-3-dependent hemopoietic cells.

1992 • 225 citations

Prolactin influences autoimmune disease activity in the female B/W mouse.

1991 • 225 citations

Gut Peptides: Biochemistry and Physiology

1995 • 223 citations

Transcriptional Regulation by the Helix Bundle Peptide Hormones: Growth Hormone, Prolactin, and Hematopoietic Cytokines

1994 • 221 citations

Prolactin synthesized and secreted by human peripheral blood mononuclear cells: an autocrine growth factor for lymphoproliferation.

1992 • 219 citations

Growth hormone, lymphocytes and macrophages

1989 • 218 citations

Insulin-like Growth Factors: Molecular and Cellular Aspects

1992 • 214 citations

A Newly Defined Property of Somatotropin: Priming of Macrophages for Production of Superoxide Anion

1988 • 208 citations

Insulin-like growth factor I treatment reduces demyelination and up-regulates gene expression of myelin-related proteins in experimental autoimmune encephalomyelitis.

1995 • 207 citations

Circulating erythroid progenitors in polycythemia vera are hypersensitive to insulin-like growth factor-1 in vitro: studies in an improved serum-free medium [see comments]

1994 • 199 citations

Inhibition of lymphocyte proliferation by antibodies to prolactin ¹

1989 • 197 citations

Regulation of interleukin 2-driven T-lymphocyte proliferation by prolactin.

1990 • 194 citations

Production of immunoreactive growth hormone by mononuclear leukocytes

1988 • 191 citations

Insulin-like growth factor-I regulates pro-B cell differentiation

1992 • 190 citations

The regulation of protein transport to the nucleus by phosphorylation

1995 • 181 citations

Prolactin Induction of Interleukin-2 Receptors on Rat Splenic Lymphocytes*

1990 • 178 citations

X-Linked Hypogammaglobulinemia and Isolated Growth Hormone Deficiency

1980 • 177 citations

Immunohistochemical localization of insulin-like growth factor I in the adult rat

1988 • 177 citations

Requirement for phosphatidylinositol 3'-kinase to protect hemopoietic progenitors against apoptosis depends upon the extracellular survival factor.

1996 • 171 citations

Insulin-like growth factor-1 stimulation of lymphopoiesis.

1993 • 166 citations

Enhancement of human granulopoiesis in vitro by biosynthetic insulin-like growth factor I/somatomedin C and human growth hormone.

1988 • 166 citations

The Clinical Course of Multiple Sclerosis During Pregnancy and the Puerperium

1990 • 163 citations

Interleukin involvement in anterior pituitary cell growth regulation: effects of IL-2 and IL-6.

1993 • 163 citations

Somatostatin and the immune and haematopoetic system; a review

1994 • 162 citations

Interferon-regulatory factor 1 is an immediate-early gene under transcriptional regulation by prolactin in Nb2 T cells.

1990 • 159 citations

The protein tyrosine kinase P59fyn is associated with prolactin (PRL) receptor and is activated by PRL stimulation of T-lymphocytes.

1994 • 158 citations

A single amino acid substitution in the exoplasmic domain of the human growth hormone (GH) receptor confers familial GH resistance (Laron syndrome) with positive GH-binding activity by abolishing receptor homodimerization.

1994 • 155 citations

Structural symmetry of the extracellular domain of the Cytokine/Growth hormone/Prolactin receptor family and Interferon receptors revealed by Hydrophobic Cluster Analysis

1991 • 152 citations

Neuropeptide Regulation of Interleukin-6 Production from the Pituitary: Stimulation by Pituitary Adenylate Cyclase Activating Polypeptide and Calcitonin Gene-Related Peptide*

1991 • 151 citations

Expression of prolactin receptors in murine lymphoid cells in normal and autoimmune situations.

1993 • 149 citations

Rapid activation of protein kinase C in isolated rat liver nuclei by prolactin, a known hepatic mitogen.

1988 • 148 citations

Insulin-like Growth Factors: Molecular and Cellular Aspects

1991 • 143 citations

A specific, high affinity, saturable binding site for the 16-kilodalton fragment of prolactin on capillary endothelial cells.

1992 • 143 citations

Growth hormone and insulin-like growth factor-I stimulate hormonal function and proliferation of thymic epithelial cells.

1992 • 142 citations

Prenatal expression of the growth hormone (GH) receptor/binding protein in the rat: a role for GH in embryonic and fetal development?

1992 • 141 citations

Expression of prolactin and its receptor in human lymphoid cells

1992 • 140 citations

Specific binding of growth hormone to thymocytes

1974 • 136 citations

Differential effects of growth hormone and prolactin on murine T cell development and function.

1993 • 136 citations

A novel role of growth hormone and insulin-like growth factor-I. Priming neutrophils for superoxide anion secretion.

1991 • 135 citations

Prolactin receptor expression in human hematopoietic tissues analyzed by flow cytofluorometry.

1994 • 135 citations

A Human B-Lymphoblastoid Cell Line Produces Prolactin*

1988 • 134 citations

Anterior pituitary hormone control by interleukin 2.

1991 • 134 citations

The rat prolactin gene is expressed in brain tissue: detection of normal and alternatively spliced prolactin messenger RNA.

1992 • 133 citations

Specific Growth Hormone Receptors on Human Peripheral Mononuclear Cells: Reexpression, Identification, and Characterization

1985 • 133 citations

Signal transduction in T lymphocytes using a conditional allele of Sos.

1995 • 131 citations

The pituitary gland is required for protection against lethal effects of Salmonella typhimurium.

1991 • 130 citations

Growth hormone augments superoxide anion secretion of human neutrophils by binding to the prolactin receptor.

1992 • 128 citations

Central action of interleukin‐1 in altering the release of tsh, growth hormone, and prolactin in the male rat

1987 • 126 citations

Characterization of an up-stream promoter directing extrapituitary expression of the human prolactin gene.

1994 • 126 citations

Role of neuroendocrine hormones in murine T cell development. Growth hormone exerts thymopoietic effects in vivo.

1992 • 126 citations

Immunologic and hematologic effects of neuroendocrine hormones. Studies on DW/J dwarf mice.

1992 • 125 citations

Insulin-Like Growth Factor-I Binds Selectively to Human Peripheral Blood Monocytes and B-Lymphocytes*

1991 • 124 citations

The prolactin receptor in the fetal rat: cellular localization of messenger ribonucleic acid, immunoreactive protein, and ligand-binding activity and induction of expression in late gestation.

1995 • 122 citations

Pituitary follicular cells secrete an inhibitor of aortic endothelial cell growth: identification as leukemia inhibitory factor.

1992 • 122 citations

Expression of type I insulin-like growth factor receptors on human peripheral blood mononuclear cells.

1992 • 122 citations

Hypophysectomized Rats Depend on Residual Prolactin for Survival*

1991 • 121 citations

Growth hormone stimulates tyrosine phosphorylation of insulin receptor substrate-1.

1994 • 121 citations

The influence of pituitary hormones on adjuvant arthritis

1984 • 120 citations

Nonpituitary human prolactin gene transcription is independent of Pit-1 and differentially controlled in lymphocytes and in endometrial stroma

1994 • 120 citations

Structural and functional characterization of the human T lymphocyte receptor for insulin-like growth factor I in vitro.

1988 • 118 citations

Prolactin induces rapid phosphorylation and activation of prolactin receptor-associated RAF-1 kinase in a T-cell line.

1994 • 118 citations

Expression and regulation of insulin-like growth factor-I (IGF-I) and IGF-binding protein messenger ribonucleic acid levels in tissues of hypophysectomized rats infused with IGF-I and growth hormone.

1994 • 115 citations

Stimulation of in vivo antibody production and concanavalin-A-induced mouse spleen cell mitogenesis by prolactin

1987 • 115 citations

The Molecular Basis for Growth Hormone–Receptor Interactions

1993 • 114 citations

Differential gene expression of growth hormone (GH)-releasing hormone (GRH) and GRH receptor in various rat tissues.

1995 • 114 citations

The role of glucocorticoids in the regulation of growth hormone secretion Mechanisms and clinical significance

1992 • 113 citations

The role of prolactin in autoimmune demyelination: Suppression of experimental allergic encephalomyelitis by bromocriptine

1991 • 113 citations

Transcriptional mechanisms in anterior pituitary cell differentiation

1994 • 113 citations

Risk of Leukemia After Treatment With Pituitary Growth Hormone

1993 • 113 citations

Growth-promoting effects of insulin-like growth factor-1 (IGF-1) on hematopoietic cells: overexpression of introduced IGF-1 receptor abrogates interleukin-3 dependency of murine factor-dependent cells by a ligand-dependent mechanism

1991 • 112 citations

Ubiquitin and the Enigma of Intracellular Protein Degradation

1995 • 111 citations

Prolactin Release After Mating and Genitosensory Stimulation in Females*

1995 • 110 citations

Modulatory effect of prolactin on the resting and mitogen-induced activity of T, B, and NK lymphocytes

1992 • 109 citations

Insulin-like growth factor-1 potentiates expansion of interleukin-7- dependent pro-B cells

1993 • 109 citations

Secretion of insulinlike growth factor I and insulinlike growth factor-binding proteins by murine bone marrow stromal cells.

1991 • 108 citations

Stimulation of monocyte chemotaxis by human growth hormone and its deactivation by somatostatin

1993 • 108 citations

Consequences of postnatally elevated insulin-like growth factor-II in transgenic mice: endocrine changes and effects on body and organ growth.

1994 • 108 citations

The Anterior Pituitary-Grafted Rat: A Valid Model of Chronic Hyperprolactinemia*

1986 • 106 citations

The prolactin gene is expressed in the hypothalamic-neurohypophyseal system and the protein is processed into a 14-kDa fragment with activity like 16-kDa prolactin.

1994 • 106 citations

Prolactin activates Ras via signaling proteins SHC, growth factor receptor bound 2, and son of sevenless.

1995 • 105 citations

Murine macrophages express abundant insulin-like growth factor-I class I Ea and Eb transcripts.

1993 • 105 citations

In vivo administration of recombinant growth hormone or gamma interferon activities macrophages: enhanced resistance to experimental Salmonella typhimurium infection is correlated with generation of reactive oxygen intermediates

1992 • 105 citations

Growth Hormone Mediates the Growth of TLymphoblast Cell Lines via Locally Generated Insulin-Like Growth Factor-I*

1990 • 104 citations

Repopulation of the atrophied thymus in diabetic rats by insulin-like growth factor I.

1990 • 104 citations

Hormones: from molecules to disease

1991 • 104 citations

Some forms of big big prolactin behave as a complex of monomeric prolactin with an immunoglobulin G in patients with macroprolactinemia or prolactinoma.

1995 • 103 citations

Growth hormone is a human macrophage activating factor. Priming of human monocytes for enhanced release of H2O2.

1995 • 103 citations

The effect of growth hormone and insulin upon MLC responses and the generation of cytotoxic lymphocytes.

1981 • 103 citations

Immunoreactive growth hormone (GH) secretion by human lymphocytes: Augmented release by exogenous GH

1990 • 101 citations

Differential signal transduction of the short, Nb2, and long prolactin receptors. Activation of interferon regulatory factor-1 and cell proliferation

1994 • 100 citations

Longstanding hyperprolactinemia associated with systemic lupus erythematosus: possible hormonal stimulation of an autoimmune disease.

1994 • 100 citations

Growth hormone promotes human T cell adhesion and migration to both human and murine matrix proteins in vitro and directly promotes xenogeneic engraftment.

1994 • 99 citations

In vivo administration of insulin-like growth factor-I stimulates primary B lymphopoiesis and enhances lymphocyte recovery after bone marrow transplantation.

1994 • 99 citations

Characterization of Immunoreactive Insulin-Like Growth Factor-I from Leukocytes and Its Regulation by Growth Hormone*

1991 • 99 citations

Growth hormone and insulin-like growth factor-I stimulate hormonal function and proliferation of thymic epithelial cells

1992 • 98 citations

Visualization of gene expression of short and long forms of prolactin receptor in the rat.

1993 • 98 citations

Hypophysectomy Inhibits the Synthesis of Tumor Necrosis Factor α by Rat Macrophages: Partial Restoration by Exogenous Growth Hormone or Interferon γ*

1991 • 94 citations

Human thymocytes express a prolactin-like messenger ribonucleic acid and synthesize bioactive prolactin-like proteins.

1992 • 94 citations

From Basic to Clinical Immunology

2019 • 93 citations

Expression and function of insulin-like growth factor receptors on anti-CD3-activated human T lymphocytes.

1992 • 92 citations

Exogenous growth hormone treatment alters body composition and increases natural killer cell activity in women with impaired endogenous growth hormone secretion

1987 • 91 citations

Human growth hormone promotes engraftment of murine or human T cells in severe combined immunodeficient mice.

1992 • 91 citations

Ubiquitin and the Enigma of Intracellular Protein Degradation

1995 • 89 citations

The insulin-like growth factor system in regulation of normal and malignant hematopoiesis

1995 • 88 citations

Regulation of insulin-like growth factor I gene expression in the human macrophage-like cell line U937.

1990 • 86 citations

Requirement for prolactin during cell cycle regulated gene expression in cloned T-lymphocytes.

1992 • 86 citations

Induction by Cytokines of the Pattern of Pituitary Hormone Secretion in Infection

1994 • 85 citations

Identification of Phenylalanine 346 in the Rat Growth Hormone Receptor as Being Critical for Ligand-mediated Internalization and Down-regulation

1995 • 84 citations

An Antisense Oligodeoxynucleotide to Growth Hormone Messenger Ribonucleic Acid Inhibits Lymphocyte Proliferation*

1991 • 83 citations

The production of growth hormone by subpopulations of rat mononuclear leukocytes

1991 • 83 citations

Growth hormone secretion: The role of glucocorticoids

1994 • 83 citations

The insulin-like growth factor 1 receptor is required for the proliferation of hemopoietic cells.

1992 • 82 citations

Immunosuppressive activity of bromocriptine on human T lymphocyte functionin vitro

1994 • 82 citations

The transcription factor Pit‐l/GHF‐1 is expressed in hemopoietic and lymphoid tissues

1993 • 82 citations

Somatostatin receptors on human lymphocytes and leukaemia cells.

1990 • 82 citations

Hyperprolactinemia in multiple sclerosis

1991 • 80 citations

Prolactin-Induced Mitogenesis of Lymphocytes from Ovariectomized Rats*

1991 • 80 citations

Characterization of an up-stream promoter directing extrapituitary expression of the human prolactin gene

1994 • 80 citations

Prolactin receptors on large granular lymphocytes: Dual regulation by cyclosporin A

1988 • 79 citations

IDENTIFICATION OF PROLACTIN-LIKE PROTEINS SYNTHESIZED BY NORMAL MURINE LYMPHOCYTES

1990 • 79 citations

Growth hormone releasing hormone receptors on thymocytes and splenocytes from rats

1991 • 78 citations

Soluble hormone receptors [editorial; comment]

1993 • 78 citations

Hormones: From Molecules to Disease

1991 • 77 citations

Prolactin gene expression in human thymocytes

1992 • 77 citations

Identification and functional activity of prolactin receptors in thymic epithelial cells.

1991 • 76 citations

Overexpression of human insulin-like growth factor-II in transgenic mice causes increased growth of the thymus

1995 • 76 citations

Evidence that insulin-like growth factor 2 (IGF2) is the dominant thymic peptide of the insulin superfamily.

1993 • 76 citations

Differential expression of surface membrane growth hormone receptor on human peripheral blood lymphocytes detected by dual fluorochrome flow cytometry.

1994 • 75 citations

Bromocriptine and low dose cyclosporine in the treatment of experimental autoimmune uveitis in the rat.

1987 • 73 citations

Interleukin-2 Driven Nuclear Translocation of Prolactin in Cloned T-Lymphocytes*

1990 • 73 citations

Differential effects of proclatic upon activation and differentiation of human B lymphocytes

1993 • 73 citations

Insulin-like growth factor and growth hormone secretion in juvenile chronic arthritis.

1991 • 72 citations

Reduction in superoxide anion secretion and bactericidal activity of neutrophils from aged rats: reversal by the combination of gamma interferon and growth hormone

1994 • 72 citations

Interferon-gamma inhibits macrophage insulin-like growth factor-I synthesis at the transcriptional level.

1995 • 71 citations

Reduced number of natural killer cells in patients with pathological hyperprolactinemia.

1986 • 69 citations

Prolactin-stimulated mitogenesis of cultured astrocytes.

1992 • 69 citations

Specific binding sites for growth hormone in cultured mouse thymic epithelial cells

1991 • 68 citations

Type I and II insulin-like growth factor receptors on human phytohemagglutinin-activated T lymphocytes

1987 • 68 citations

Growth hormone secretion by human peripheral blood mononuclear cells detected by an enzyme-linked immunoplaque assay.

1993 • 68 citations

The expression of insulin-like growth factors and their binding proteins in normal human lymphocytes

1993 • 67 citations

Lymphocyte subset distribution and natural killer activity in growth hormone deficiency before and during short-term treatment with growth hormone releasing hormone

1988 • 67 citations

Rapid induction of pim-1 expression by prolactin and interleukin-2 in rat Nb2 lymphoma cells.

1995 • 67 citations

Prolactin-dependent mitogenesis in Nb 2 node lymphoma cells: effects of immunosuppressive cyclopeptides.

1987 • 66 citations

A specific, high affinity, saturable binding site for the 16-kilodalton fragment of prolactin on capillary endothelial cells

1992 • 66 citations

Enhanced Yields of Gamma Interferon in Prolactin Treated Human Peripheral Blood Mononuclear Cells

1994 • 65 citations

The Role of the Growth and Lactogenic Hormone Family in Immune Function (Part 1 of 2)

1994 • 65 citations

Type I insulin-like growth factor receptor expression in different developmental stages of human thymocytes

1995 • 65 citations

Regulatory action of prolactin on the in vitro growth of CD34+ve human hemopoietic progenitor cells

1995 • 65 citations

T-cell dysregulation in patients with hyperprolactinemia: Effect of bromocriptine treatment

1986 • 64 citations

Constitutive in vivo cytokine and hematopoietic growth factor gene expression in the bone marrow and peripheral blood of healthy individuals

1995 • 64 citations

Insulin receptor substrate 1 and 2 (IRS1 and IRS2): what a tangled web we weave

1996 • 64 citations

Leukemia in Growth-Hormone Treated Patients: An Update, 1992

1992 • 64 citations

ENHANCEMENT OF THYMIC RECOVERY AFTER CYCLOSPORINE BY RECOMBINANT HUMAN GROWTH HORMONE AND INSULIN-LIKE GROWTH FACTOR I

1991 • 64 citations

Endogenous Iridocyclitis Relieved During Treatment With Bromocriptine

1985 • 62 citations

Transforming growth factor beta 1-like immunoreactivity in the pituitary gland of the rat: effect of estrogen.

1993 • 62 citations

Growth hormone and insulin-like growth factor-I increase macrophage uptake and degradation of low density lipoprotein.

1992 • 62 citations

Divergence in macrophage insulin-like growth factor-I (IGF-I) synthesis induced by TNF-alpha and prostaglandin E2.

1995 • 62 citations

Growth hormone and insulin-like growth factor I induce immunoglobulin (Ig)E and IgG4 production by human B cells.

1994 • 62 citations

The protein tyrosine kinase P59fyn is associated with prolactin (PRL) receptor and is activated by PRL stimulation of T-lymphocytes

1994 • 62 citations

Prolactin receptor gene expression in lymphoid cells

1991 • 61 citations

Identification of macroprolactin in a patient with asymptomatic hyperprolactinemia as a stable PRL-IgG complex

2009 • 61 citations

Recombinant human growth hormone stimulates B cell immunoglobulin synthesis and proliferation in serum-free medium

1992 • 61 citations

New frontiers in insulin receptor substrate signaling

1995 • 60 citations

Interleukin involvement in anterior pituitary cell growth regulation: effects of IL-2 and IL-6

1993 • 60 citations

Functional insulin and insulin-like growth factor-1 receptors are preferentially expressed in multiple myeloma cell lines as compared to B-lymphoblastoid cell lines.

1994 • 60 citations

Endotoxin-induced suppression of the somatotropic axis is mediated by interleukin-1 beta and corticotropin-releasing factor in the juvenile rat.

1995 • 60 citations

Hematopoietin sub-family classification based on size, gene organization and sequence homology

1993 • 60 citations

Thyroid autoimmunity in hyperprolactinaemic disorders

1983 • 60 citations

Priming of normal human neutrophils by recombinant human growth hormone

1991 • 58 citations

Insulin-Like Growth Factor Secretion by Human B-Lymphocytes: A Comparison of Cells from Normal and Pygmy Subjects*

1989 • 58 citations

Hyperprolactinemia in acute myeloid leukemia and indication of ectopic expression of human prolactin in blast cells of a patient of subtype M4

1990 • 57 citations

The rat prolactin gene is expressed in brain tissue: detection of normal and alternatively spliced prolactin messenger RNA

1992 • 57 citations

Priming of human polymorphonuclear neutrophilic leukocytes by insulin-like growth factor I: increased phagocytic capacity, complement receptor expression, degranulation, and oxidative burst.

1995 • 57 citations

T cell development in insulin-like growth factor-II transgenic mice.

1995 • 57 citations

Immunological effects of insulin-like growth factor-I—enhancement of immunoglobulin synthesis

1994 • 57 citations

Stimulation and Inhibition of Growth Hormone Secretion by Interleukin-1β; The Involvement of Growth Hormone-Releasing Hormone

1992 • 56 citations

Differential effect of growth hormone and insulin-like growth factor-I, insulin-like growth factor-II, and insulin on Ig production and growth in human plasma cells

1994 • 56 citations

Casein expression in cytotoxic T lymphocytes.

1990 • 56 citations

Basic & clinical immunology

1980 • 56 citations

Consequences of postnatally elevated insulin-like growth factor-II in transgenic mice: endocrine changes and effects on body and organ growth

1994 • 55 citations

Immunological Findings in Growth Hormone-Treated Patients

1993 • 55 citations

Somatostatin may participate in the antiinflammatory actions of glucocorticoids.

1995 • 55 citations

Identification by analytical flow cytometry of prolactin receptors on immunocompetent cell populations in the mouse.

1993 • 55 citations

Prolactin receptor expression in human hematopoietic tissues analyzed by flow cytofluorometry

1994 • 55 citations

Insulin-like growth factor-I supports proliferation of autocrine thymic lymphoma cells with a pre-T cell phenotype.

1990 • 54 citations

Rapid changes in gene expression after in vivo growth hormone treatment.

1995 • 53 citations

Neurointermediate pituitary lobe cells synthesize and release interleukin-6 in vitro: effects of lipopolysaccharide and interleukin-1 beta.

1994 • 53 citations

Studies on the microheterogeneity and in vitro activity of glycosylated and nonglycosylated recombinant human prolactin separated using a novel purification process.

1995 • 52 citations

Functional receptors for insulin-like growth factors I and II in rat thymocytes and mouse thymoma cells

1989 • 52 citations

A possible role of prolactin in adjuvant arthritis

1982 • 52 citations

Immunologic disparity in the hypopituitary dwarf mouse.

1992 • 52 citations

Receptor binding and mitogenic effects of insulin and insulinlike growth factors I and II for human myeloid leukemic cells

1987 • 52 citations

Growth hormone therapy and leukaemia

1989 • 51 citations

The cytokine wall chart

1993 • 51 citations

The prolactin receptor in the fetal rat: cellular localization of messenger ribonucleic acid, immunoreactive protein, and ligand-binding activity and induction of expression in late gestation

1995 • 51 citations

Dexamethasone induces advanced growth hormone expression in the fetal rat pituitary gland in vivo.

1993 • 51 citations

Multiple Stat complexes interact at the interferon regulatory factor-1 interferon-γ activation sequence in prolactin-stimulated Nb2 T cells

1996 • 51 citations

Some forms of big big prolactin behave as a complex of monomeric prolactin with an immunoglobulin G in patients with macroprolactinemia or prolactinoma

1995 • 51 citations

Prolactin deficiency in rheumatoid arthritis.

1991 • 50 citations

Effects of parturition, suckling and pseudopregnancy on variables of disease activity in the B/W mouse model of systemic lupus erythematosus.

1993 • 50 citations

Structural and Immunological Characterization of Insulin-Like Growth Factor II Binding to IM-9 Cells*

1986 • 49 citations

Effects of insulin-like growth factors and growth hormone on the in vitro proliferation of T lymphocytes

1992 • 49 citations

Regulation of Prolactin Secretion in the Human BLymphoblastoid Cell Line IM-9-P3 by Dexamethasone but not Other Regulators of Pituitary Prolactin Secretion*

1989 • 48 citations

Independent and synergistic effect of interleukin-2 and prolactin on development of T- and NK-derived LAK effectors

1994 • 48 citations

Elevated serum prolactin levels in children with juvenile rheumatoid arthritis and antinuclear antibody seropositivity.

1995 • 48 citations

Effect of growth hormone and insulin-like growth factor-I on immunoglobulin production by and growth of human B cells.

1994 • 48 citations

Differential expression of type I insulin‐like growth factor receptors in different stages of human T cells

1995 • 47 citations

Human thymocytes express a prolactin-like messenger ribonucleic acid and synthesize bioactive prolactin-like proteins

1992 • 46 citations

The Effect of Growth Hormone and IGF-I on Clonogenic Growth of Hematopoietic Cells in Leukemic Patients During Active Disease and During Remission - A Preliminary Report

1993 • 46 citations

Murine macrophages express abundant insulin-like growth factor-I class I Ea and Eb transcripts

1993 • 46 citations

Prolactin induced expression of interleukin‐1 alpha, tumor necrosis factor‐alpha, and transforming growth factor‐alpha in cultured astrocytes

1995 • 46 citations

The colony-stimulating factors induce expression of insulin-like growth factor-I messenger ribonucleic acid during hematopoiesis.

1995 • 45 citations

The Effect of Neonatal Sex Hormone Manipulation on the Incidence of Diabetes in Nonobese Diabetic Mice

1993 • 45 citations

Expression and localization of prolactin messenger ribonucleic acid in the human immune system.

1996 • 45 citations

Insulin-like growth factor-1 (IGF-1) protects NOD mice from insulitis and diabetes

1995 • 44 citations

The importance of estrogens in systemic lupus erythematosus

1992 • 44 citations

Bromocriptine Microcapsules Inhibit Ornithine Decarboxylase Activity Induced by Freund's Complete Adjuvant in Lymphoid Tissues of Male Rats

1989 • 44 citations

Expression of short and long forms of prolactin receptor in murine lymphoid tissues

1994 • 44 citations

Expression of IL-6 mRNA in normal rat and human pituitaries and in human pituitary adenomas.

1994 • 44 citations

Effect of purified somatomedins on thymidine incorporation into lectin-activated human lymphocytes

1983 • 44 citations

In vitro and in vivo effect of growth hormone on cytotoxic activity

1990 • 43 citations

Spontaneous growth hormone (GH) secretion by unstimulated human lymphocytes and the effects of GH-releasing hormone and somatostatin.

1994 • 43 citations

Differential gene expression of growth hormone (GH)-releasing hormone (GRH) and GRH receptor in various rat tissues

1995 • 43 citations

The production of growth hormone and insulin-like growth factor-I by the same subpopulation of rat mononuclear leukocytes

1992 • 43 citations

Growth hormone (GH) receptor and GH-binding protein messenger ribonucleic acids with alternative 5'-untranslated regions are differentially expressed in mouse liver and placenta.

1995 • 42 citations

Prolactin induced expression of glial fibrillary acidic protein and tumor necrosis factor-alpha at a wound site in the rat brain

1995 • 42 citations

Modulation of human basophil histamine release by insulin-like growth factors.

1993 • 42 citations

Interferon regulatory factor-1 is inducible by prolactin, interleukin-2 and concanavalin A in T cells

1992 • 41 citations

The human growth hormone receptor of cultured human lymphocytes. Structural characteristics and glycosylation properties

1986 • 41 citations

Differential expression of surface membrane growth hormone receptor on human peripheral blood lymphocytes detected by dual fluorochrome flow cytometry

1994 • 41 citations

Stimulation of macrophage growth and multinucleated cell formation in rat bone marrow cultures by insulin-like growth factor I

1991 • 41 citations

An alternatively spliced form of Pit-1 represses prolactin gene expression.

1994 • 40 citations

Interleukin 2 and a lactogen regulate proliferation and protein phosphorylation in Nb2 cells

1988 • 40 citations

Influence of Prolactin and Growth Hormone on the Activation of Dwarf Mouse Lymphocytes In Vivo

1993 • 40 citations

Visualization of gene expression of short and long forms of prolactin receptor in the rat

1993 • 40 citations

Rapid activation of mitogen-activated protein kinase and p21ras by prolactin and interleukin 2 in rat Nb2 node lymphoma cells.

1995 • 40 citations

Growth Hormone (GH) and the Immune System: Impaired Phagocytic Function in Children with Idiopathic GH Deficiency is Corrected by Treatment with Biosynthetic GH

1994 • 40 citations

Insulin-like growth factor I increases myelination and inhibits demyelination in cultured organotypic nerve tissue

1995 • 39 citations

Influence of antibodies against IGF-I, insulin or their receptors on proliferation of human acute lymphoblastic leukemia cell lines

1992 • 39 citations

The Leukemia Inhibitory Factor Receptor (LIFR) Gene Is Located within a Cluster of Cytokine Receptor Loci on Mouse Chromosome 15 and Human Chromosome 5p12-p13

1993 • 39 citations

Pituitary-type transcription of the human prolactin gene in the absence of Pit-1.

1995 • 38 citations

Expression of type I insulin-like growth factor receptors on human peripheral blood mononuclear cells

1992 • 38 citations

Confirmation of X-linked hypogammaglobulinemia with isolated growth hormone deficiency as a disease entity

1990 • 38 citations

Does Growth Hormone Increase the Risk of Malignancies?

1993 • 38 citations

Growth hormone secretion by human peripheral blood mononuclear cells detected by an enzyme-linked immunoplaque assay

1993 • 37 citations

Insulin-like growth factor-1 increases the mitogenic response of human peripheral blood lymphocytes to phytohemagglutinin

1989 • 37 citations

Macrophages synthesize and secrete a 25-kilodalton protein that binds insulin-like growth factor-I.

1996 • 37 citations

Phosphorylated and nonphosphorylated prolactin isoforms

1994 • 37 citations

Prolactin protection against lethal effects of Salmonella typhimurium

1993 • 36 citations

Cloning and Nucleotide Sequencing of Rat Lymphocyte Growth Hormone cDNA

1995 • 36 citations

Insulin-like growth factor induces phosphorylation of immunoreactive insulin receptor substrate and its association with phosphatidylinositol-3 kinase in human thymocytes.

1995 • 36 citations

The Insulin-Like Growth Factor-II/Mannose 6-Phosphate Receptor

1989 • 35 citations

Supplemental growth hormone increases the tumor cytotoxic activity of natural killer cells in healthy adults with normal growth hormone secretion

1990 • 35 citations

Freund's complete adjuvant induces ornithine decarboxylase activity in the central nervous system of male rats and triggers the release of pituitary hormones

1990 • 35 citations

Interferon-gamma inhibits macrophage insulin-like growth factor-I synthesis at the transcriptional level

1995 • 34 citations

Immunologic studies in Turner syndrome before and during treatment with growth hormone

1991 • 34 citations

Expression and regulation of insulin-like growth factor-I (IGF-I) and IGF-binding protein messenger ribonucleic acid levels in tissues of hypophysectomized rats infused with IGF-I and growth hormone

1994 • 34 citations

IGF-I potentiates interleukin-2 production in human peripheral T cells

1996 • 34 citations

Measurement of Peptide Secretion and Gene Expression in the Same Cell

1991 • 34 citations

Down-regulation of autoantibody levels of cyclosporine and bromocriptine treatment in patients with uveitis

1990 • 34 citations

Simultaneous calcium‐dependent delivery of neutrophil lactoferrin and reactive oxygen metabolites to erythrocyte targets: Evidence supporting granule‐dependent triggering of superoxide deposition

1993 • 33 citations

Comparative studies of the granulopoietic enhancing effects of biosynthetic human insulin-like growth factors I and II

1993 • 33 citations

Requirement for prolactin during cell cycle regulated gene expression in cloned T-lymphocytes

1992 • 33 citations

Functional interactions between colony-stimulating factors and the insulin family hormones for human myeloid leukemic cells.

1990 • 32 citations

Prolactin activates Ras via signaling proteins SHC, growth factor receptor bound 2, and son of sevenless

1995 • 32 citations

Development and Heterogeneity of Prolactin Cells

1995 • 32 citations

Growth Hormone and Prolactin Variants in Normal Subjects

1993 • 31 citations

Growth hormone expression in human Burkitt lymphoma serum-free Ramos cell line.

1993 • 31 citations

Transgenic mice expressing either bovine growth hormone (bGH) or human GH releasing hormone (hGRH) have increased splenic progenitor cell colony formation and DNA synthesis in vitro and in vivo.

1995 • 30 citations

Prolactin Modulates the Incidence of Diabetes in Male and Female Nod Mice

1994 • 30 citations

Immunoreactive growth hormone production by human lymphocyte cell lines

1992 • 30 citations

Hormones in self Tolerance and Autoimmunity: A role in the Pathogenesis of Rheumatoid Arthritis?

1993 • 30 citations

Studies on the microheterogeneity and in vitro activity of glycosylated and nonglycosylated recombinant human prolactin separated using a novel purification process

1995 • 29 citations

Effect of growth hormone and insulin-like growth factor-I on immunoglobulin production by and growth of human B cells

1994 • 29 citations

Identification by analytical flow cytometry of prolactin receptors on immunocompetent cell populations in the mouse

1993 • 29 citations

Effect of the Administration of Growth-Hormone-Producing Lymphocytes on Weight Gain and Immune Function in Dwarf Mice

1994 • 29 citations

Endothelin inhibits basal and stimulated release of prolactin by human decidual cells.

1993 • 28 citations

In vivo growth hormone gene expression in neonatal rat thymus and bone marrow

1994 • 28 citations

Spontaneous growth hormone (GH) secretion by unstimulated human lymphocytes and the effects of GH-releasing hormone and somatostatin

1994 • 28 citations

Evolving understanding of the cellular defect in polycythemia vera: implications for its clinical diagnosis and molecular pathophysiology [editorial; comment]

1994 • 28 citations

Somatostatin may participate in the antiinflammatory actions of glucocorticoids

1995 • 27 citations

Evidence for the Release of a Prolactin-like Substance by Mouse Lymphocytes and Macrophages

1994 • 27 citations

Increased chromosome fragility in lymphocytes of short normal children treated with recombinant human growth hormone

1993 • 27 citations

Phenotypic and functional abnormalities of T lymphocytes in pathological hyperprolactinemia

1987 • 27 citations

Placental lactogen is a haemopoietic hormone

1991 • 25 citations

Is brain tumor recurrence increased following growth hormone treatment?

1995 • 25 citations

Evidence for Protein Kinase C Involvement in the Short‐Term Activation by Prolactin of Tyrosine Hydroxylase in Tuberoinfundibular Dopaminergic Neurons

1994 • 25 citations

GROWTH HORMONE POLYPEPTIDES STIMULATE PROLIFERATION OF K562 HUMAN ERYTHROLEUKEMIA CELLS

1980 • 25 citations

Activation of the prolactin receptor gene by promoter insertion in a Moloney murine leukemia virus-induced rat thymoma

1992 • 25 citations

Rapid induction of pim-1 expression by prolactin and interleukin-2 in rat Nb2 lymphoma cells

1995 • 25 citations

Rapid changes in gene expression after in vivo growth hormone treatment

1995 • 24 citations

Transforming growth factor beta 1-like immunoreactivity in the pituitary gland of the rat: effect of estrogen

1993 • 24 citations

Expression of functional insulin-like growth factor-1 receptor on lymphoid cell subsets of rats.

1995 • 24 citations

Regulation of prolactin receptor mRNA expression in peripheral lymphocytes in rats in response to changes in serum concentrations of prolactin.

1995 • 23 citations

Human leukemic T and B lymphoblasts produce insulin-like growth factor binding proteins 2 and 4

1991 • 23 citations

Effect of Biosynthetic Methionyl Growth Hormone (GH) Therapy on the Immune Function in GH-Deficient Children

1989 • 23 citations

Stimulation of growth of Nb2 lymphoma cells by interleukin-2 in serum-free and serum-containing media

1988 • 23 citations

Hyperprolactinemia in Reiter's syndrome.

1994 • 23 citations

The colony-stimulating factors induce expression of insulin-like growth factor-I messenger ribonucleic acid during hematopoiesis

1995 • 23 citations

Prolactin receptor expression in lymphocytes from patients with hyperprolactinemia or acromegaly

1995 • 23 citations

Pituitary-type transcription of the human prolactin gene in the absence of Pit-1

1995 • 23 citations

Growth hormone induces tyrosine phosphorylation but does not alter insulin-like growth factor-I gene expression in human IM9 lymphocytes

1994 • 22 citations

Neurointermediate pituitary lobe cells synthesize and release interleukin-6 in vitro: effects of lipopolysaccharide and interleukin-1 beta

1994 • 22 citations

Human leukemic cells: Receptor binding and biological effects of insulin and insulin-like growth factors

1986 • 22 citations

In vivo activation of circulating monocytes by exogenous growth hormone in man

1992 • 22 citations

Serum prolactin levels in active multiple sclerosis and during cyclosporin treatment

1993 • 22 citations

Prolactin-stimulated mitogenesis of cultured astrocytes

1992 • 21 citations

Priming of human polymorphonuclear neutrophilic leukocytes by insulin- like growth factor I: increased phagocytic capacity, complement receptor expression, degranulation, and oxidative burst

1995 • 21 citations

Growth hormone (GH) receptor and GH-binding protein messenger ribonucleic acids with alternative 5'-untranslated regions are differentially expressed in mouse liver and placenta

1995 • 20 citations

Effect of Elevated Growth Hormone Concentrations on the Phenotype and Functions of Human Lymphocytes and Natural Killer Cells

1994 • 20 citations

Prolactin receptor expression by lymphoid tissues in normal and immunized rats

1993 • 20 citations

Quantitation of insulin-like growth factor-I binding to highly purified human erythroid colony-forming units.

1991 • 20 citations

INCREASED LEVELS OF PROLACTIN DURING, BUT NOT AFTER, THE IMMUNISATION WITH RAT COLLAGEN II ENHANCES THE COURSE OF ARTHRITIS IN DBA/1 MICE

1992 • 20 citations

Modulation of prolactin secretion in human myometrium by cytokines

1994 • 19 citations

Endotoxin-induced suppression of the somatotropic axis is mediated by interleukin-1 beta and corticotropin-releasing factor in the juvenile rat

1995 • 19 citations

Growth Hormone, Prolactin and Igf-I As Lymphohemopoietic Cytokines

1995 • 18 citations

Case 25-1995

1995 • 18 citations

Insulin-like growth factor-1 induces rapid tyrosine phosphorylation of the vav proto-oncogene product.

1996 • 18 citations

Lack of mitogenic effects of growth hormone on human leukemic lymphoblasts

1987 • 18 citations

Growth hormone and insulin-like growth factor-I increase macrophage uptake and degradation of low density lipoprotein

1992 • 18 citations

An alternatively spliced form of Pit-1 represses prolactin gene expression

1994 • 17 citations

Influence of Thyroxine and Thyroxine with Growth Hormone and Prolactin on Splenocyte Subsets and on the Expression of Interleukin-2 and Prolactin Receptors on Splenocyte Subsets of Snell Dwarf Mice

1995 • 17 citations

Hematopoietic growth factor receptors: structure variations and alternatives of receptor complex formation in normal hematopoiesis and in hematopoietic disorders.

1995 • 17 citations

Interleukin-1, Interleukin-6: Messengers in the Neuroendocrine Immune System?

1991 • 17 citations

Growth hormone inhibits normal B-cell differentiation and neutrophils' chemotaxis in vitro

1994 • 16 citations

Production of Interleukin-1α and Interleukin-2 by Mononuclear Cells from Children with Growth Delay in Relation to the Degree of Growth Hormone Deficiency: Effects of Substitutive Treatment

1990 • 16 citations

Growth hormone expression in human Burkitt lymphoma serum-free Ramos cell line

1993 • 16 citations

Expression and localization of prolactin messenger ribonucleic acid in the human immune system

1996 • 16 citations

Analysis of growth hormone release from rat anterior pituitary cells by reverse hemolytic plaque assay: influence of interleukin-1

1994 • 16 citations

Pituitary-specific transcription factor Pit-1 in the rdw rat with growth hormone- and prolactin-deficient dwarfism

1994 • 15 citations

Functional characterization of the insulin-like growth factor I receptor on Jurkat T cells

1995 • 15 citations

Up-regulation of prolactin gene expression and feedback modulation of lymphocyte proliferation during acute allograft rejection.

1992 • 14 citations

Effects of Prolactin on Galactosyl Transferase and -Lactalbumin mRNA Accumulation in Mouse Mammary Gland Explants

1995 • 13 citations

Phorbol ester stimulates prolactin release but reduces prolactin mRNA in the human B-lymphoblastoid cell line IM-9-P3

1989 • 13 citations

Comparison of hGH Binding to Isolated Rat Liver Macrophages and Hepatocytes

1984 • 13 citations

A monoclonal antibody to the T‐cell receptor increases IGF‐I receptor content in normal T‐lymphocytes: Comparison with phytohemagglutinin

1992 • 13 citations

Further Characterization of Rat 26,000 Prolactin as a Glycoprotein with Essentially O‐Linked Carbohydrate Chains

1991 • 12 citations

Dexamethasone induces advanced growth hormone expression in the fetal rat pituitary gland in vivo

1993 • 12 citations

Primary Antiphospholipid Antibody Syndrome and Microscopic Polyarteritis in the Puerperium: A Case Report

1994 • 10 citations

Endothelin inhibits basal and stimulated release of prolactin by human decidual cells

1993 • 10 citations

Cellular and Humoral Immune Parameters in Women With Pathological Hyperprolactinemia Before and During Treatment With Bromocriptine

1994 • 10 citations

Human promyelocytic cell line HL60 has the specific binding sites for prolactin and its ornithine decarboxylase, DNA synthesis and cellular proliferation are induced by prolactin

1993 • 10 citations

Transgenic targeting of neuroendocrine peptide genes in the hypothalamic-pituitary axis

1995 • 10 citations

Late Leukemic Relapse 10 Years from Diagnosis in a Child on Recombinant Human Growth Hormone

1993 • 10 citations

The influence of thyroxine, growth hormone and prolactin alone and in combination on the production of prolactin-like activity by splenocytes from snell dwarf mice

1995 • 8 citations

Effects of insulin-like growth factor-I and its analogues on bovine hydrogen peroxide release by neutrophils and blastogenesis by mononuclear cells

1993 • 8 citations

Human Mononuclear Phagocytes Express the Insulin-like Growth Factor-II/Mannose-6-Phosphate Receptor

1991 • 8 citations

Evaluation of prolactin-like activity produced by concanavalin-A stimulated mouse splenocytes

1995 • 8 citations

Inhibition of Nb2 T-lymphoma cell growth by transforming growth factor-β

1988 • 6 citations

Clastogenic effects of biosynthetic human growth hormone in Snell dwarf mice and CHO cells in vitro

1984 • 6 citations

Normal development of Lymphokine Activated Killing (LAK) in peripheral blood lymphocytes from hyperprolactinemic patients

1992 • 5 citations

Regulation of prolactin receptor mRNA expression in peripheral lymphocytes in rats in response to changes in serum concentrations of prolactin

1995 • 4 citations

Endocrine-Immune Interactions in Pituitary Pathology

1994 • 1 citations