Differential Hormone-Dependent Transcriptional Activation and -Repression by Naturally Occurring Human Glucocorticoid Receptor Variants

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation

1991 • 3,396 citations

The Hypothalamic–Pituitary–Adrenal Axis and Immune-Mediated Inflammation

1995 • 2,525 citations

Steroid hormone receptors: Many Actors in search of a plot

1995 • 1,854 citations

Primary structure and expression of a functional human glucocorticoid receptor cDNA

1985 • 1,851 citations

A transcriptional co-repressor that interacts with nuclear hormone receptors

1995 • 1,744 citations

Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor

1990 • 1,272 citations

Functional domains of the human glucocorticoid receptor

1986 • 933 citations

The role of heat shock proteins in regulating the function, folding, and trafficking of the glucocorticoid receptor.

1993 • 652 citations

A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1.

1994 • 527 citations

Hormone-mediated repression: a negative glucocorticoid response element from the bovine prolactin gene.

1988 • 485 citations

Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familial glucocorticoid resistance.

1991 • 373 citations

Interference between pathway-specific transcription factors: glucocorticoids antagonize phorbol ester-induced AP-1 activity without altering AP-1 site occupation in vivo.

1992 • 282 citations

Syndromes of Glucocorticoid Resistance

1993 • 237 citations

Lack of association between five polymorphisms in the human glucocorticoid receptor gene and glucocorticoid resistance

1997 • 235 citations

Transcriptional control by nuclear receptors

1991 • 234 citations

Steroid receptors and their associated proteins

1993 • 231 citations

A mutation of the glucocorticoid receptor in primary cortisol resistance.

1993 • 217 citations

Requirement of hormone for thermal conversion of the glucocorticoid receptor to a DNA-binding state

1988 • 186 citations

Cushing's disease preceded by generalized glucocorticoid resistance: clinical consequences of a novel, dominant-negative glucocorticoid receptor mutation.

1996 • 169 citations

Glucocorticoid receptor binding to a specific DNA sequence is required for hormone-dependent repression of pro-opiomelanocortin gene transcription.

1989 • 156 citations

Familial glucocorticoid resistance caused by a splice site deletion in the human glucocorticoid receptor gene

1993 • 132 citations

Ligand-induced Conformational Alterations of the Androgen Receptor Analyzed by Limited Trypsinization

1995 • 132 citations

Transcriptional activation by the estrogen receptor requires a conformational change in the ligand binding domain

1993 • 105 citations

Clinical aspects of glucocorticoid sensitivity

1996 • 102 citations

Characterization of the protein-protein interactions determining the heat shock protein (hsp90.hsp70.hsp56) heterocomplex

1994 • 78 citations

Interaction of the Ubc9 human homologue with c-Jun and with the glucocorticoid receptor

1996 • 75 citations

Human small cell lung cancer cell lines expressing the proopiomelanocortin gene have aberrant glucocorticoid receptor function.

1994 • 65 citations

Familial Cortisol Resistance: Differential Diagnostic and Therapeutic Aspects

1986 • 64 citations

The Glucocorticoid Receptor Synergizes with Jun Homodimers to Activate AP-1-regulated Promoters Lacking GR Binding Sites

1995 • 63 citations

Hormone-Independent Repression of AP-1-Inducible Collagenase Promoter Activity by Glucocorticoid Receptors

1995 • 59 citations

Cortisol receptor resistance: the variability of its clinical presentation and response to treatment

1992 • 58 citations

Glucocorticoid receptor structure and function in an adrenocorticotropin-secreting small cell lung cancer

1995 • 44 citations

Potentiation of glucocorticoid receptor-mediated gene expression by heat and chemical shock

1994 • 34 citations

Primary glucocorticoid receptor defect with likely familial involvement.

1989 • 23 citations

Glucocorticoid receptor abnormalities in fibroblasts from patients with idiopathic resistance to dexamethasone diagnosed when evaluated for adrenocortical disorders

1992 • 23 citations