Ligand-induced Conformational Alterations of the Androgen Receptor Analyzed by Limited Trypsinization

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

MOLECULAR MECHANISMS OF ACTION OF STEROID/THYROID RECEPTOR SUPERFAMILY MEMBERS

1994 • 2,875 citations

A mutation in the ligand binding domain of the androgen receptor of human INCaP cells affects steroid binding characteristics and response to anti-androgens

1990 • 948 citations

Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors.

1992 • 829 citations

Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen.

1990 • 772 citations

The role of heat shock proteins in regulating the function, folding, and trafficking of the glucocorticoid receptor.

1993 • 652 citations

Domains of the Human Androgen Receptor Involved in Steroid Binding, Transcriptional Activation, and Subcellular Localization

1991 • 513 citations

Contragestion and Other Clinical Applications of RU 486, an Antiprogesterone at the Receptor

1989 • 495 citations

Inhibition of estrogen receptor-DNA binding by the "pure" antiestrogen ICI 164,384 appears to be mediated by impaired receptor dimerization.

1990 • 400 citations

The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor

1992 • 381 citations

TRANSCRIPTION ACTIVATION BY ESTROGEN AND PROGESTERONE RECEPTORS

1991 • 372 citations

Hormone and antihormone induce distinct conformational changes which are central to steroid receptor activation.

1992 • 363 citations

The human androgen receptor: Domain structure, genomic organization and regulation of expression

1989 • 334 citations

Agonistic and antagonistic activities of RU486 on the functions of the human progesterone receptor.

1990 • 333 citations

Anti-androgens and the mutated androgen receptor of LNCaP cells: differential effects on binding affinity, heat-shock protein interaction, and transcription activation

1992 • 284 citations

The progesterone receptor stimulates cell-free transcription by enhancing the formation of a stable preinitiation complex

1990 • 223 citations

The Mechanism of ICI 164,384 Antiestrogenieity Involves Rapid Loss of Estrogen Receptor in Uterine Tissue

1991 • 201 citations

Immunological evidence that the nonhormone binding component of avian steroid receptors exists in a wide range of tissues and species

1985 • 188 citations

Reconstitution of Progesterone Receptor with Heat Shock Proteins

1990 • 149 citations

Human Progesterone Receptor Complexed with the Antagonist RU 486 Binds to Hormone Response Elements in a Structurally Altered Form

1989 • 138 citations

Hormone-induced dissociation of the androgen receptor-heat-shock protein complex: use of a new monoclonal antibody to distinguish transformed from nontransformed receptors

1992 • 136 citations

Differential DNA-binding abilites of estrogen receptor occupied with two classes of antiestrogens: studies using human estrogen receptor overexpressed in mammalian cells

1991 • 128 citations

Different agonist- and antagonist-induced conformational changes in retinoic acid receptors analyzed by protease mapping.

1994 • 125 citations

Hormone-induced progesterone receptor phosphorylation consists of sequential DNA-independent and DNA-dependent stages: analysis with zinc finger mutants and the progesterone antagonist ZK98299.

1992 • 119 citations

Ligand-dependent conformational changes in the progesterone receptor are necessary for events that follow DNA binding.

1992 • 108 citations

Mechanisms of antihormone action

1992 • 104 citations

Epitope prediction and confirmation for the human androgen receptor: Generation of monoclonal antibodies for multi-assay performance following the synthetic peptide strategy

1991 • 104 citations

Antiestrogen can establish nonproductive receptor complexes and alter chromatin structure at target enhancers.

1991 • 99 citations

A 22-amino-acid peptide restores DNA-binding activity to dimerization-defective mutants of the estrogen receptor.

1990 • 89 citations

The steroid antagonist RU486 exerts different effects on the glucocorticoid and progesterone receptors.

1993 • 88 citations

Structural differences between the hormone and antihormone estrogen receptor complexes bound to the hormone response element.

1991 • 84 citations

Localization and hormonal stimulation of phosphorylation sites in the LNCaP-cell androgen receptor

1993 • 67 citations

Agonists, but not antagonists, alter the conformation of the hormone-binding domain of androgen receptor.

1994 • 59 citations

Mechanism of antiandrogen action: Conformational changes of the receptor

1994 • 58 citations

In vivo evidence against the existence of antiprogestins disrupting receptor binding to DNA.

1993 • 55 citations

Interaction of the 90-kDa heat shock protein with native and in vitro translated androgen receptor and receptor fragments

1992 • 55 citations

Transformation of calf uterine progesterone receptor: analysis of the process when receptor is bound to progesterone and RU38486

1987 • 51 citations

Mechanisms of transcriptional activation by steroid hormone receptors

1993 • 51 citations

Mechanism of action of a steroidal antiglucocorticoid in lymphoid cells.

1990 • 49 citations

The nonactivated progesterone receptor is a nuclear heterooligomer.

1990 • 47 citations

Type II antagonists impair the DNA binding of steroid hormone receptors without affecting dimerization

1993 • 45 citations

Association of the 90-kDa heat shock protein does not affect the ligand-binding ability of androgen receptor

1992 • 41 citations

Modulation of oestrogen receptor activity by oestrogens and anti-oestrogens

1990 • 39 citations

From RU 38486 towards Dissociated Antiglucocorticoid and Antiprogesterone

2015 • 38 citations

Detection of potential ligands for nuclear receptors in cellular extracts.

1994 • 17 citations

Loss of biological activity of human chorionic gonadotropin (hCG) by the amino acid substitution on the “CMGCC” region of the α-subunit

1994 • 13 citations

Analysis of steroid receptor domains with the aid of antihormones

1994 • 6 citations