p53 Is Covalently Linked to 5.8S rRNA

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Identification of p53 as a Sequence-Specific DNA-Binding Protein

1991 • 1,109 citations

Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form.

1990 • 978 citations

Presence of a Potent Transcription Activating Sequence in the p53 Protein

1990 • 811 citations

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

1990 • 801 citations

Wild-type p53 can inhibit oncogene-mediated focus formation.

1989 • 738 citations

Transcriptional Activation by Wild-Type but Not Transforming Mutants of the p53 Anti-Oncogene

1990 • 644 citations

Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation

1991 • 617 citations

TGF-β1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains

1990 • 612 citations

Wild-type p53 activates transcription in vitro

1992 • 609 citations

Transcriptional Repression Mediated by the WT1 Wilms Tumor Gene Product

1991 • 492 citations

Wild-type p53 can down-modulate the activity of various promoters.

1991 • 461 citations

A protein covalently linked to poliovirus genome RNA.

1977 • 424 citations

Major deletions in the gene encoding the p53 tumor antigen cause lack of p53 expression in HL-60 cells.

1985 • 414 citations

Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication

1991 • 382 citations

Covalent linkage of a protein to a defined nucleotide sequence at the 5'-terminus of virion and replicative intermediate RNAs of poliovirus.

1977 • 344 citations

Rearrangements of the cellular p53 gene in erythroleukaemic cells transformed by Friend virus

1985 • 334 citations

Characterization of a new low molecular weight RNA in HeLa cell ribosomes

1968 • 299 citations

Negative regulation of human c-fos expression by thes retinoblastoma gene product

1990 • 298 citations

Monoclonal antibody analysis of p53 expression in normal and transformed cells

1986 • 285 citations

In vivo disruption of Xenopus U3 snRNA affects ribosomal RNA processing.

1990 • 214 citations

Nuclear accumulation of p53 protein is mediated by several nuclear localization signals and plays a role in tumorigenesis.

1990 • 207 citations

Protein-mediated nuclear export of RNA: 5S rRNA containing small RNPs in xenopus oocytes

1990 • 205 citations

Adenovirus DNA replication in vitro: characterization of a protein covalently linked to nascent DNA strands.

1980 • 190 citations

DNA is linked to the rat liver DNA nicking-closing enzyme by a phosphodiester bond to tyrosine.

1981 • 188 citations

Identification of the p53 protein domain involved in formation of the simian virus 40 large T-antigen-p53 protein complex

1986 • 175 citations

Oligomerization of oncoprotein p53

1988 • 158 citations

Precise epitope mapping of the murine transformation-associated protein, p53.

1985 • 139 citations

Characterization of the in Vitro interaction between SV40 T antigen and p53: Mapping the p53 binding site

1988 • 86 citations

Mapping of phosphomonoester and apparent phosphodiester bonds of the oncogene product p53 from simian virus 40-transformed 3T3 cells.

1986 • 76 citations

Analysis of bacteriophage phi X174 gene A protein-mediated termination and reinitiation of phi X DNA synthesis. II. Structural characterization of the covalent phi X A protein-DNA complex.

1984 • 53 citations

Identification by affinity chromatography of the eukaryotic ribosomal proteins that bind to 5.8 S ribosomal ribonucleic acid.

1979 • 50 citations

Evolutionary conservation of the biochemical properties of p53: specific interaction of Xenopus laevis p53 with simian virus 40 large T antigen and mammalian heat shock proteins 70

1989 • 41 citations

A simple method for cloning blunt ended DNA fragments

1991 • 30 citations

Inhibition of protein synthesis by anti-5.8 S rRNA oligodeoxyribonucleotides.

1990 • 29 citations

The Tumor Suppressor p53 Is Bound to RNA by a Stable Covalent Linkage

1991 • 24 citations

Mutation of the serine 312 phosphorylation site does not alter the ability of mouse p53 to inhibit simian virus 40 DNA replication in vivo

1990 • 23 citations