Characterizaton of Short Isoforms of the Leptin Receptor in Rat Cerebral Microvessels and of Brain Uptake of Leptin in Mouse Models of Obesity

Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans

1996 • 6,254 citations

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

1995 • 3,302 citations

Role of leptin in the neuroendocrine response to fasting

1996 • 3,106 citations

Abnormal splicing of the leptin receptor in diabetic mice

1996 • 2,361 citations

Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice

1996 • 2,185 citations

Adipose Tissue as an Endocrine Organ

2000 • 1,568 citations

Leptin enters the brain by a saturable system independent of insulin

1996 • 1,210 citations

Positional cloning of the mouse obese gene and its human homologue

1995 • 1,164 citations

Leptin activation of Stat3 in the hypothalamus of wild–type and ob/ob mice but not db/db mice

1996 • 1,097 citations

Physiological response to long-term peripheral and central leptin infusion in lean and obese mice

1997 • 1,043 citations

Divergent Signaling Capacities of the Long and Short Isoforms of the Leptin Receptor

1997 • 907 citations

Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity

2000 • 873 citations

Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues

1997 • 771 citations

Leptin Regulation of Neuroendocrine Systems

2000 • 769 citations

Diet-induced obese mice develop peripheral, but not central, resistance to leptin.

1997 • 750 citations

Unraveling the central nervous system pathways underlying responses to leptin

1998 • 520 citations

Expression of Leptin Receptor Isoforms in Rat Brain Microvessels

1998 • 342 citations

Impaired transport of leptin across the blood-brain barrier in obesity☆

1999 • 328 citations

Orexin A but not orexin B rapidly enters brain from blood by simple diffusion.

1999 • 312 citations

Peptides and the blood-brain barrier: Lipophilicity as a predictor of permeability

1985 • 297 citations

Functional properties of leptin receptor isoforms: internalization and degradation of leptin and ligand-induced receptor downregulation.

1999 • 249 citations

Interleukin 1 receptors in the brain and endocrine tissues

1993 • 228 citations

Decreased transport of leptin across the blood–brain barrier in rats lacking the short form of the leptin receptor☆

1999 • 191 citations

Partial saturation and regional variation in the blood-to-brain transport of leptin in normal weight mice

2000 • 157 citations

Evidence for a Leptin-Neuropeptide Y Axis for the Regulation of Growth Hormone Secretion in the Rat

1998 • 131 citations

Unidirectional Specific and Modulated Brain to Blood Transport of Corticotropin-Releasing Hormone

1996 • 119 citations

Entry of EGF into brain is rapid and saturable

1999 • 99 citations

Glucose utilization and glucose transporter proteins GLUT-1 and GLUT-3 in brains of diabetic (db/db) mice

1997 • 88 citations

Fasting, but not adrenalectomy, reduces transport of leptin into the brain☆

2000 • 68 citations

Inhibition of food response to intracerebroventricular injection of leptin is attenuated in rats with diet-induced obesity

1997 • 60 citations

Persistence of blood-to-brain transport of leptin in obese leptin-deficient and leptin receptor-deficient mice

2000 • 57 citations

Entry of CART into brain is rapid but not inhibited by excess CART or leptin

1999 • 53 citations

Agouti-related protein(83-132) aggregates and crosses the blood-brain barrier slowly

2000 • 51 citations

Differential Regulation of Leptin Transport by the Choroid Plexus and Blood-Brain Barrier and High Affinity Transport Systems for Entry into Hypothalamus and Across the Blood-Cerebrospinal Fluid Barrier

2000 • 44 citations

Transcellular Transport of Leptin by the Short Leptin Receptor Isoform ObRa in Madin-Darby Canine Kidney Cells

2000 • 36 citations

Brain deviations in adult obese-hyperglycemic mice (ob/ob)

1979 • 32 citations

Peptide transport system-1 (PTS-1) for Tyr-MIF-1 and Met-enkephalin differs from the receptors for either

1999 • 24 citations

Partial Leptin Receptor Gene Deletion in Transgenic Mice Prevents Expression of the Membrane-Bound Isoforms Except for Ob-Rc

2000 • 4 citations