Targeting of adenovirus E1A and E4-ORF3 proteins to nuclear matrix-associated PML bodies.

Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia

1988 • 2,380 citations

Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML

1991 • 1,463 citations

A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes

1983 • 1,449 citations

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

1988 • 1,440 citations

The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

1991 • 1,371 citations

All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results [see comments]

1990 • 1,224 citations

Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor.

1994 • 1,046 citations

A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei

1992 • 1,027 citations

Existence of two populations of cyclin/proliferating cell nuclear antigen during the cell cycle: association with DNA replication sites.

1987 • 945 citations

A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein

1994 • 798 citations

Cellular targets for transformation by the adenovirus E1A proteins

1989 • 747 citations

Monoclonal antibodies to nucleic acid-containing cellular constituents: probes for molecular biology and autoimmune disease.

1981 • 725 citations

Retinoic acid regulates aberrant nuclear localization of PML-RARα in acute promyelocytic leukemia cells

1994 • 668 citations

The t(15;17) translocation alters a nuclear body in a retinoic acid-reversible fashion.

1994 • 492 citations

Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein

1991 • 464 citations

Characterization of a Zinc Finger Gene Disrupted by the t(15;17) in Acute Promyelocytic Leukemia

1991 • 464 citations

Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins.

1992 • 441 citations

The nonchromatin substructures of the nucleus: the ribonucleoprotein (RNP)-containing and RNP-depleted matrices analyzed by sequential fractionation and resinless section electron microscopy.

1986 • 420 citations

Monoclonal antibodies specific for adenovirus early region 1A proteins: extensive heterogeneity in early region 1A products

1985 • 417 citations

Structure of two spliced mRNAs from the transforming region of human subgroup C adenoviruses

1979 • 395 citations

Adenovirus early region 4 encodes functions required for efficient DNA replication, late gene expression, and host cell shutoff

1985 • 383 citations

Association of adenovirus early-region 1A proteins with cellular polypeptides.

1986 • 368 citations

Multiple functional domains in the adenovirus E1A gene

1987 • 361 citations

G1/S phosphorylation of the retinoblastoma protein is associated with an altered affinity for the nuclear compartment

1991 • 319 citations

Modification of discrete nuclear domains induced by herpes simplex virus type 1 immediate early gene 1 product (ICP0)

1993 • 316 citations

Structure and origin of the acute promyelocytic leukemia myl/RAR alpha cDNA and characterization of its retinoid-binding and transactivation properties.

1991 • 291 citations

Identification of a novel nuclear domain.

1991 • 285 citations

Functional domains of adenovirus type 5 E1a proteins

1987 • 283 citations

In vivo evidence that transcription and splicing are coordinated by a recruiting mechanism

1993 • 272 citations

Isolation and characterization of cDNA encoding a human nuclear antigen predominantly recognized by autoantibodies from patients with primary biliary cirrhosis.

1990 • 266 citations

Redundant control of adenovirus late gene expression by early region 4

1989 • 261 citations

A novel zinc finger coiled-coil domain in a family of nuclear proteins

1992 • 260 citations

A monoclonal antibody recognizing nuclear matrix-associated nuclear bodies

1992 • 258 citations

Identification of specific adenovirus E1A N-terminal residues critical to the binding of cellular proteins and to the control of cell growth

1993 • 254 citations

Detection of cellular proteins associated with human adenovirus type 5 early region 1A polypeptides

1985 • 227 citations

Adenovirus early region 4 encodes two gene products with redundant effects in lytic infection

1989 • 225 citations

E1a regions of the human adenoviruses and of the highly oncogenic simian adenovirus 7 are closely related

1985 • 213 citations

Mutational analysis of the adenovirus E1a gene: the role of transcriptional regulation in transformation.

1987 • 201 citations

Adenovirus E4orf4 protein binds to protein phosphatase 2A, and the complex down regulates E1A-enhanced junB transcription

1993 • 168 citations

Association of Adenovirus Early-Region 1A Proteins with Cellular Polypeptides

1986 • 166 citations

Adenovirus replication and transcription sites are spatially separated in the nucleus of infected cells.

1994 • 162 citations

The nucleolus

1994 • 156 citations

Adenoviral early region 4 is required for efficient viral DNA replication and for late gene expression

1986 • 145 citations

Interaction of adenoviral E4 and E1b products in late gene expression

1990 • 143 citations

The adenovirus E4-6/7 protein transactivates the E2 promoter by inducing dimerization of a heteromeric E2F complex.

1994 • 136 citations

Interaction of adenoviral proteins with pRB and p53

1993 • 134 citations

Antibodies specific for the human retinoblastoma protein identify a family of related polypeptides.

1991 • 131 citations

Analysis of adenovirus early region 4-encoded polypeptides synthesized in productively infected cells

1987 • 120 citations

Identification and characterization of an immunologically conserved adenovirus early region 11,000 Mr protein and its association with the nuclear matrix

1982 • 102 citations

mRNAs from human adenovirus 2 early region 4

1984 • 95 citations

DP-1: a cell cycle-regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein.

1994 • 90 citations

Expression and interactions of human adenovirus oncoproteins

1991 • 88 citations

Nuclear Dot Antigens may Specify Transcriptional Domains in the Nucleus

1993 • 84 citations

Human adenovirus encodes two proteins which have opposite effects on accumulation of alternatively spliced mRNAs.

1994 • 81 citations

Characterization of the major mRNAs from adenovirus 2 early region 4 by cDNA cloning and sequencing

1984 • 69 citations

An N-terminal region of adenovirus E1a essential for cell transformation and induction of an epithelial cell growth factor.

1988 • 68 citations

Localisation of splicing snRNPs in mammalian cells

1993 • 67 citations

The Adenovirus E4-6/7 Protein Transactivates the E2 Promoter by Inducing Dimerization of a Heteromeric E2F Complex

1994 • 67 citations

Differential distribution of the adenovirus E1A proteins and colocalization of E1A with the 70-kilodalton cellular heat shock protein in infected cells

1988 • 66 citations

Rearrangements of intranuclear structures involved in RNA processing in response to adenovirus infection

1994 • 61 citations

Two Adenovirus Proteins with Redundant Activities in Virus Growth Facilitates Tripartite Leader mRNA Accumulation

1993 • 61 citations

Heterodimerization of the transcription factors E2F-1 and DP-1 is required for binding to the adenovirus E4 (ORF6/7) protein

1994 • 59 citations

Human adenovirus encodes two proteins which have opposite effects on accumulation of alternatively spliced mRNAs

1994 • 46 citations

Antibodies Specific for the Human Retinoblastoma Protein Identify a Family of Related Polypeptides

1991 • 41 citations

Proteins with transcription regulatory properties encoded by human adenoviruses

1993 • 39 citations

An adenovirus E1A transcriptional repressor domain functions as an activator when tethered to a promoter

1994 • 37 citations

Enhanced invasive properties of rat embryo fibroblasts transformed by adenovirus E1A mutants with deletions in the carboxy-terminal exon.

1992 • 35 citations

Gene product of region E4 of adenovirus type 5 modulates accumulation of certain viral polypeptides

1988 • 35 citations

Immunobiochemical characterization with monoclonal antibodies of Epstein-Barr virus-associated early antigens in chemically induced cells

1984 • 33 citations