Synthesis of LIAZALTM, a retinoic acid metabolism blocking agent (ramba) with potential clinical applications in oncology and dermatology

Continuous treatment with all-trans retinoic acid causes a progressive reduction in plasma drug concentrations: implications for relapse and retinoid "resistance" in patients with acute promyelocytic leukemia [published erratum appears in Blood 1992 Aug 1;80(3):855]

1992 • 421 citations

Retinoic acid biosynthesis and metabolism

1996 • 384 citations

Identification of the Retinoic Acid-inducible All-trans-retinoic Acid 4-Hydroxylase

1996 • 376 citations

Continuous treatment with all-trans retinoic acid causes a progressive reduction in plasma drug concentrations: implications for relapse and retinoid "resistance" in patients with acute promyelocytic leukemia [published erratum appears in Blood 1992 Aug 1;80(3):855]

1992 • 307 citations

Liarozole, an inhibitor of retinoic acid metabolism, exerts retinoid-mimetic effects in vivo.

1992 • 99 citations

Inhibitors of P450-dependent steroid biosynthesis: From research to medical treatment

1992 • 89 citations

Ketoconazole inhibits the in vitro and in vivo metabolism of all-trans-retinoic acid.

1988 • 86 citations

Effects of liarozole, a new antitumoral compound, on retinoic acid-induced inhibition of cell growth and on retinoic acid metabolism in MCF-7 human breast cancer cells.

1992 • 82 citations

Retinoids: 10 Years On

1991 • 66 citations

Antitumoral Effects of Liarozole in Androgen-Dependent and Independent R3327-Dunning Prostate Adenocarcinomas

1994 • 39 citations

Liarozole fumarate inhibits the metabolism of 4-keto-all-trans-retinoic acid

1994 • 36 citations

Liarozole, an antitumor drug, modulates cytokeratin expression in the dunning AT‐6sq prostatic carcinoma through in situ accumulation of all‐trans‐retinoic acid

1995 • 21 citations

Induction of the oxidative catabolism of retinoic acid in MCF-7 cells

1997 • 17 citations

Standardized assessment to enhance the diagnostic value of prostate volume; Part I: Morphometry in patients with lower urinary tract symptoms

1996 • 16 citations

Liarozole potentiates the all-trans-retinoic acid-induced structural remodelling in human breast carcinoma MCF-7 cells in vitro.

1996 • 15 citations

Diphenylcarbinyl derivatives. III. Solvolysis of polysubstituted benzhydryl chlorides. Examination of the Hammett relationship in a multiply-substituted system

1967 • 13 citations

Mechanisms of action of retinoic acid in skin repair

1992 • 10 citations

Retinoids in dermatology

1986 • 7 citations

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