Induction of the Mouse Serum Amyloid A3 Gene by Cytokines Requires both C/EBP Family Proteins and a Novel Constitutive Nuclear Factor

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Interleukin-6 and the acute phase response

1990 • 2,740 citations

IκB: a Specific Inhibitor of the NF-κB Transcription Factor

1988 • 2,203 citations

Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells.

1991 • 1,684 citations

Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone

1990 • 1,605 citations

Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction

1990 • 1,583 citations

A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family.

1990 • 1,517 citations

Transcription Factor Interactions: Selectors of Positive or Negative Regulation from a Single DNA Element

1990 • 1,326 citations

EUKARYOTIC TRANSCRIPTIONAL REGULATORY PROTEINS

1989 • 1,299 citations

Differential transcriptional activation by Oct-1 and Oct-2: Interdependent activation domains induce Oct-2 phosphorylation

1990 • 696 citations

IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to CEBP

1990 • 637 citations

LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein.

1990 • 599 citations

Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level.

1993 • 543 citations

The interplay of DNA-binding proteins on the promoter of the mouse albumin gene

1987 • 532 citations

Functional antagonism between c-Jun and MyoD proteins: A direct physical association

1992 • 424 citations

The hormone regulatory element of mouse mammary tumour virus mediates progesterone induction.

1986 • 406 citations

Monocyte-conditioned medium, interleukin-1, and tumor necrosis factor stimulate the acute phase response in human hepatoma cells in vitro.

1986 • 398 citations

cAMP stimulates the C/EBP-related transcription factor rNFIL-6 to trans-locate to the nucleus and induce c-fos transcription.

1991 • 388 citations

Interaction among hepatocyte-stimulating factors, interleukin 1, and glucocorticoids for regulation of acute phase plasma proteins in human hepatoma (HepG2) cells.

1987 • 358 citations

A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6.

1992 • 327 citations

Differential expression of three C/EBP isoforms in multiple tissues during the acute phase response.

1992 • 313 citations

HNF1, a homeoprotein member of the hepatic transcription regulatory network

1992 • 210 citations

The human haptoglobin gene promoter: interleukin-6-responsive elements interact with a DNA-binding protein induced by interleukin-6.

1989 • 196 citations

The different tissue transcription patterns of genes for HNF-1, C/EBP, HNF-3, and HNF-4, protein factors that govern liver-specific transcription.

1991 • 188 citations

Transcriptional regulation of serum amyloid A gene expression.

1986 • 188 citations

Structure of the murine serum amyloid A gene family. Gene conversion.

1986 • 187 citations

Acute-phase reaction induces a specific complex between hepatic nuclear proteins and the interleukin 6 response element of the rat alpha 2-macroglobulin gene.

1990 • 177 citations

The two C/EBP isoforms, IL6DBP/NFIL6 and CEBP6δ/NFIL63, are induced by IL6β to promote acute phase gene transcription via different mechanisms

1993 • 176 citations

Constitutive and IL-6-induced nuclear factors that interact with the human C-reactive protein promoter.

1990 • 176 citations

Interleukin 6 induces a liver-specific nuclear protein that binds to the promoter of acute-phase genes.

1989 • 172 citations

Synergistic trans-activation of the human C-reactive protein promoter by transcription factor HNF-1 binding at two distinct sites.

1990 • 146 citations

A ubiquitous factor is required for C/EBP-related proteins to form stable transcription complexes on an albumin promoter segment in vitro.

1992 • 138 citations

Participation of the transcription factor C/EBP delta in the acute-phase regulation of the human gene for complement component C3.

1993 • 136 citations

Role of CAAT-enhancer binding protein isoforms in the cytokine regulation of acute-phase plasma protein genes.

1992 • 132 citations

Expression of rat serum amyloid A1 gene involves both C/EBP-like and NF kappa B-like transcription factors

1991 • 88 citations

Temporal expression of the human alcohol dehydrogenase gene family during liver development correlates with differential promoter activation by hepatocyte nuclear factor 1, CCAAT/enhancer-binding protein alpha, liver activator protein, and D-element-binding protein.

1992 • 83 citations

Cooperative effects of C/EBP-like and NFxB-like binding sites on rat serum amyloid A1 gene expression in liver cells

1992 • 73 citations

The sequence and structure of a new serum amyloid A gene

1986 • 53 citations

Nuclear signaling by interleukin-6

1993 • 48 citations

Identification of a novel serum amyloid A protein in BALB/c mice

1991 • 42 citations

Interaction of acute-phase-inducible and liver-enriched nuclear factors with the promoter region of the mouse .alpha.1-acid glycoprotein gene-1

1992 • 33 citations

Differential acute-phase response of rat kininogen genes involves type I and type II interleukin-6 response elements.

1993 • 31 citations

Interleukin-6 responsiveness and cell-specific expression of the rat kininogen gene.

1991 • 24 citations

Advances in amyloidosis

1993 • 22 citations

Identification of a Transcriptional Enhancer in a Mouse Amyloid Gene

1989 • 15 citations