Synergistic trans-activation of the human C-reactive protein promoter by transcription factor HNF-1 binding at two distinct sites.

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins

1989 • 3,219 citations

Firefly luciferase gene: structure and expression in mammalian cells.

1987 • 3,088 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

DNA cloning : a practical approach

1985 • 2,302 citations

Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism

1986 • 2,043 citations

How eukaryotic transcriptional activators work

1988 • 1,924 citations

Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene

1987 • 1,364 citations

Five intermediate complexes in transcription initiation by RNA polymerase II

1989 • 1,033 citations

Isolation of a recombinant copy of the gene encoding C/EBP.

1988 • 1,003 citations

Firefly Luciferase Gene: Structure and Expression in Mammalian Cells

1987 • 924 citations

Trans-acting protein factors and the regulation of eukaryotic transcription: lessons from studies on DNA tumor viruses.

1988 • 736 citations

Synergistic activation by the glutamine-rich domains of human transcription factor Sp1

1989 • 539 citations

The liver-specific transcription factor LF-B1 contains a highly diverged homeobox DNA binding domain

1989 • 490 citations

A small-scale procedure for preparation of nuclear extracts that support efficient transcription and pre-mRNA splicing

1988 • 485 citations

Transcriptional repression of eukaryotic promoters

1989 • 481 citations

DBP, a liver-enriched transcriptional activator, is expressed late in ontogeny and its tissue specificity is determined posttranscriptionally

1990 • 410 citations

Synergistic action of the glucocorticoid receptor with transcription factors.

1988 • 407 citations

A mechanism for synergistic activation of a mammalian gene by GAL4 derivatives

1990 • 386 citations

Induction of sequence-specific binding of Drosophila heat shock activator protein without protein synthesis

1987 • 382 citations

Cooperativity of the glucocorticoid receptor and the CACCC-box binding factor

1988 • 370 citations

Modularity in promoters and enhancers

1989 • 366 citations

GAL4 activates gene expression in mammalian cells

1988 • 355 citations

The Role of Cis-Acting Promoter Elements in Tissue-Specific Albumin Gene Expression

1989 • 329 citations

Purified hepatocyte nuclear factor 1 interacts with a family of hepatocyte-specific promoters.

1988 • 323 citations

Double-stranded RNA activates binding of NF-kappa B to an inducible element in the human beta-interferon promoter.

1989 • 317 citations

A liver-specific factor essential for albumin transcription differs between differentiated and dedifferentiated rat hepatoma cells.

1988 • 307 citations

GAL4 derivatives function alone and synergistically with mammalian activators in vitro

1988 • 274 citations

Dual control of C-reactive protein gene expression by interleukin-1 and interleukin-6.

1989 • 270 citations

HNF-1 shares three sequence motifs with the POU domain proteins and is identical to LF-B1 and APF.

1990 • 264 citations

How different eukaryotic transcriptional activators can cooperate promiscuously

1990 • 261 citations

A glycosylated liver-specific transcription factor stimulates transcription of the albumin gene

1989 • 244 citations

Two different liver-specific factors stimulate in vitro transcription from the human alpha 1-antitrypsin promoter.

1988 • 236 citations

Cooperative DNA binding of the yeast transcriptional activator GAL4.

1988 • 227 citations

Two distinct factors interact with the promoter regions of several liver-specific genes.

1988 • 226 citations

Promoter specificity and modulation of RNA polymerase II transcription

1989 • 221 citations

Cis- and trans-acting elements responsible for the cell-specific expression of the human alpha 1-antitrypsin gene.

1987 • 178 citations

Constitutive and IL-6-induced nuclear factors that interact with the human C-reactive protein promoter.

1990 • 176 citations

Interleukin 6 induces a liver-specific nuclear protein that binds to the promoter of acute-phase genes.

1989 • 172 citations

Two different virus-inducible elements are required for human beta-interferon gene regulation.

1989 • 168 citations

Determinants of Rat Albumin Promoter Tissue Specificity Analyzed by an Improved Transient Expression System

1987 • 166 citations

A myosin-like dimerization helix and an extra-large homeodomain are essential elements of the tripartite DNA binding structure of LFB1

1990 • 157 citations

Tissue-specific transcription of the mouse alpha-fetoprotein gene promoter is dependent on HNF-1.

1989 • 130 citations

Inducible and tissue-specific expression of human C-reactive protein in transgenic mice.

1987 • 127 citations

The rat albumin promoter: cooperation with upstream elements is required when binding of APF/HNF1 to the proximal element is partially impaired by mutation or bacterial methylation.

1989 • 88 citations

Transcription Elements and Factors of Rna Polymerase B Promoters of Higher Eukaryote

1988 • 82 citations

A cell-specific enhancer of the mouse alpha 1-antitrypsin gene has multiple functional regions and corresponding protein-binding sites.

1988 • 77 citations

Regulation of the human C-reactive protein gene, a major marker of inflammation and cancer.

1990 • 71 citations

[9] pEMBL: A new family of single-stranded plasmids for sequencing DNA

1987 • 64 citations

Tissue-specificity of liver gene expression: a common liver-specific promoter element

1988 • 63 citations

Liver cell specific gene transcriptionin vitro: the promoter elements HP1 and TATA box are necessary and sufficient to generate a liver-specific promoter

1989 • 57 citations

Tissue-Specific Transcription of the Mouse α-Fetoprotein Gene Promoter Is Dependent on HNF-1

1989 • 36 citations

The Rat Albumin Promoter: Cooperation with Upstream Elements Is Required when Binding of APF/HNF1 to the Proximal Element Is Partially Impaired by Mutation or Bacterial Methylation

1989 • 35 citations

A Cell-Specific Enhancer of the Mouse α1-Antitrypsin Gene Has Multiple Functional Regions and Corresponding Protein-Binding Sites

1988 • 28 citations