The 21- and 23-kD forms of TCRζ are generated by specific ITAM phosphorylations

Signal transduction by lymphocyte antigen receptors

1994 • 2,145 citations

pEF-BOS, a powerful mammalian expression vector

1990 • 1,641 citations

LAT

1998 • 1,251 citations

Sequential Interactions of the TCR with Two Distinct Cytoplasmic Tyrosine Kinases

1994 • 711 citations

Altered Peptide Ligand–Induced Partial T Cell Activation: Molecular Mechanisms and Role in T Cell Biology

1996 • 698 citations

Partial T cell signaling: Altered phospho-? and lack of zap70 recruitment in APL-induced T cell anergy

1994 • 608 citations

Complex Complexes: Signaling at the TCR

1996 • 512 citations

ζ Phosphorylation Without ZAP-70 Activation Induced by TCR Antagonists or Partial Agonists

1995 • 510 citations

The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules

1992 • 438 citations

Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor

1995 • 349 citations

Fidelity of T Cell Activation Through Multistep T Cell Receptor ζ Phosphorylation

1998 • 338 citations

Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes.

1996 • 324 citations

Genetic and Mutational Analysis of the T-Cell Antigen Receptor

1990 • 275 citations

Improved version of a human CD2 minigene based vector for T cell-specific expression in transgenic mice

1995 • 273 citations

ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR ζ in murine thymocytes and lymph node T cells

1994 • 254 citations

Adaptors and Molecular Scaffolds in Immune Cell Signaling

1999 • 222 citations

T Cell Development in Mice that Lack the ζ Chain of the T Cell Antigen Receptor Complex

1993 • 217 citations

ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity.

1995 • 196 citations

The T cell antigen receptor zeta chain is tyrosine phosphorylated upon activation.

1988 • 167 citations

Tyrosine Phosphorylation of Pyk2 Is Selectively Regulated by Fyn During TCR Signaling

1997 • 165 citations

Analysis of the interaction of ZAP-70 and syk protein-tyrosine kinases with the T-cell antigen receptor by plasmon resonance.

1995 • 151 citations

Differential Requirements for ZAP-70 in TCR Signaling and T Cell Development

1998 • 122 citations

Role of the Multiple T Cell Receptor (TCR)-ζ Chain Signaling Motifs in Selection of the T Cell Repertoire

1997 • 116 citations

Crippling of CD3-ζ ITAMs Does Not Impair T Cell Receptor Signaling

1999 • 100 citations

Dominant-negative zeta-associated protein 70 inhibits T cell antigen receptor signaling.

1996 • 100 citations

TCR Activation of ZAP70 Is Impaired in CD4+CD8+ Thymocytes as a Consequence of Intrathymic Interactions that Diminish Available p56lck

1996 • 83 citations

ITAM Multiplicity and Thymocyte Selection

2000 • 81 citations

Altered peptide ligands induce quantitatively but not qualitatively different intracellular signals in primary thymocytes

1998 • 71 citations

Regulation of TCR signal transduction in murine thymocytes by multiple TCR zeta-chain signaling motifs.

1998 • 70 citations

Regulation of TCR Signal Transduction in Murine Thymocytes by Multiple TCR ζ-Chain Signaling Motifs

1998 • 60 citations

Phosphorylation of multiple CD3 zeta tyrosine residues leads to formation of pp21 in vitro and in vivo. Structural changes upon T cell receptor stimulation.

1992 • 50 citations

Qualitatively distinct signaling through T cell antigen receptor subunits

1997 • 41 citations

Mutagenesis of T cell antigen receptor zeta chain tyrosine residues. Effects on tyrosine phosphorylation and lymphokine production.

1992 • 31 citations

Differential CD3 zeta phosphorylation is not required for the induction of T cell antagonism by altered peptide ligands.

1999 • 29 citations

Differential CD3ζ Phosphorylation Is Not Required for the Induction of T Cell Antagonism by Altered Peptide Ligands

1999 • 24 citations