Control Of Globin Gene Transcription

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements

1987 • 2,107 citations

Interaction of a gene-specific transcription factor with the adenovirus major late promoter upstream of the TATA box region

1985 • 1,244 citations

A cellular DNA-binding protein that activates eukaryotic transcription and DNA replication

1987 • 1,050 citations

Hemoglobin: Molecular, Genetic and Clinical Aspects.

1986 • 1,005 citations

A family of human CCAAT-box-binding proteins active in transcription and DNA replication: cloning and expression of multiple cDNAs

1988 • 747 citations

A multiplicity of CCAAT box-binding proteins

1987 • 745 citations

Human CCAAT-binding proteins have heterologous subunits

1988 • 712 citations

The "beta-like-globin" gene domain in human erythroid cells.

1985 • 634 citations

Homologous recognition of a promoter domain common to the MSV LTR and the HSV tk gene

1986 • 562 citations

An erythrocyte-specific DNA-binding factor recognizes a regulatory sequence common to all chicken globin genes.

1988 • 518 citations

Expression of an erythroid transcription factor in megakaryocytic and mast cell lineages

1990 • 481 citations

Megakaryocytic and erythrocytic lineages share specific transcription factors

1990 • 446 citations

Evidence for a locus activation region: the formation of developmentally stable hypersensitive sites in globin-expressing hybrids

1987 • 440 citations

The Molecular Genetics of Human Hemoglobin

1984 • 420 citations

Mutually exclusive interaction of the CCAAT-binding factor and of a displacement protein with overlapping sequences of a histone gene promoter

1987 • 407 citations

A developmentally stable chromatin structure in the human beta-globin gene cluster.

1986 • 391 citations

Cooperativity of the glucocorticoid receptor and the CACCC-box binding factor

1988 • 370 citations

Function of a yeast TATA element-binding protein in a mammalian transcription system

1988 • 364 citations

Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice

1990 • 364 citations

The human beta-globin gene 3' enhancer contains multiple binding sites for an erythroid-specific protein.

1988 • 362 citations

Two tissue-specific factors bind the erythroid promoter of the human porphobilinogen deaminase gene

1989 • 326 citations

Definition of the minimal requirements within the human beta-globin gene and the dominant control region for high level expression.

1990 • 322 citations

Human gamma- to beta-globin gene switching in transgenic mice.

1990 • 291 citations

DNA "fingerprints" and segregation analysis of multiple markers in human pedigrees.

1986 • 286 citations

Cis- and trans-acting elements involved in the regulation of the erythroid promoter of the human porphobilinogen deaminase gene.

1989 • 272 citations

A single erythroid-specific DNase I super-hypersensitive site activates high levels of human beta-globin gene expression in transgenic mice.

1989 • 269 citations

A yeast activity can substitute for the HeLa cell TATA box factor

1988 • 253 citations

Rapid reprogramming of globin gene expression in transient heterokaryons

1986 • 246 citations

Gamma delta beta-thalassemia due to a de novo mutation deleting the 5' beta-globin gene activation-region hypersensitive sites.

1989 • 240 citations

Nuclear scaffold attachment sites in the human globin gene complexes.

1988 • 225 citations

Molecular analysis of the human beta-globin locus activation region.

1989 • 218 citations

DNA binding specificity of steroid receptors

1989 • 212 citations

The human beta-globin promoter; nuclear protein factors and erythroid specific induction of transcription.

1988 • 211 citations

An embryonic pattern of expression of a human fetal globin gene in transgenic mice

1986 • 204 citations

Two 3' sequences direct adult erythroid-specific expression of human beta-globin genes in transgenic mice.

1987 • 202 citations

The human beta-globin gene contains multiple regulatory regions: identification of one promoter and two downstream enhancers.

1988 • 175 citations

Structure and evolution of a human erythroid transcription factor

1990 • 160 citations

Identification of a transcriptional silencer in the 5'-flanking region of the human epsilon-globin gene.

1989 • 158 citations

Regulated gene expression in transfected primary chicken erythrocytes.

1986 • 144 citations

The −117 mutation in Greek HPFH affects the binding of three nuclear factors to the CCAAT region of the gamma-globin gene.

1988 • 143 citations

Mouse globin gene expression in erythroid and non-erythroid tissues

1976 • 136 citations

Globins: A Case Study in Molecular Phylogeny

1987 • 133 citations

Human Sickle Hemoglobin in Transgenic Mice

1990 • 131 citations

A 3' enhancer contributes to the stage-specific expression of the human beta-globin gene.

1987 • 128 citations

In vitro binding of several cell-specific and ubiquitous nuclear proteins to the GT-I motif of the SV40 enhancer.

1987 • 127 citations

The beta-globin stage selector element factor is erythroid-specific promoter/enhancer binding protein NF-E4.

1989 • 126 citations

Synthesis of Functional Human Hemoglobin in Transgenic Mice

1989 • 125 citations

Human beta-globin gene expression in transgenic mice is enhanced by a distant DNase I hypersensitive site.

1989 • 122 citations

Mutational analysis of the chicken beta-globin enhancer reveals two positive-acting domains.

1988 • 120 citations

Linker scanning mutagenesis of the 5'-flanking region of the mouse beta-major-globin gene: sequence requirements for transcription in erythroid and nonerythroid cells.

1985 • 118 citations

The human beta-globin locus activation region alters the developmental fate of a human fetal globin gene in transgenic mice.

1989 • 112 citations

Analysis of the tissue-specific enhancer at the 3' end of the chicken adult beta-globin gene.

1987 • 104 citations

An erythrocyte-specific protein that binds to the poly(dG) region of the chicken beta-globin gene promoter.

1988 • 99 citations

High-level erythroid expression of human alpha-globin genes in transgenic mice.

1989 • 96 citations

Activation of cellular genes by avian RNA tumor viruses.

1980 • 91 citations

A promoter of the rat insulin-like growth factor II gene consists of minimal control elements

1988 • 88 citations

Cell-specific activity of the constituent elements of the simian virus 40 enhancer.

1987 • 86 citations

High-level, erythroid-specific expression of the human alpha-globin gene in transgenic mice and the production of human hemoglobin in murine erythrocytes.

1989 • 83 citations

Developmental modulation of protein binding to beta-globin gene regulatory sites within chicken erythrocyte nuclei.

1989 • 79 citations

A gene controlling fetal hemoglobin expression in adults is not linked to the non-alpha globin cluster.

1983 • 75 citations

Nuclease Hypersensitive Sites In Chromatin

1988 • 69 citations

Bidirectional control of the chicken beta- and epsilon-globin genes by a shared enhancer.

1988 • 67 citations

Developmental regulation of topoisomerase II sites and DNase I-hypersensitive sites in the chicken beta-globin locus.

1990 • 66 citations

Identification and characterization of a chicken alpha-globin enhancer.

1989 • 58 citations

Nuclear proteins that bind the human gamma-globin gene promoter: alterations in binding produced by point mutations associated with hereditary persistence of fetal hemoglobin.

1988 • 58 citations

Digestion of the chicken beta-globin gene chromatin with micrococcal nuclease reveals the presence of an altered nucleosomal array characterized by an atypical ladder of DNA fragments.

1986 • 54 citations

A directly repeated sequence in the beta-globin promoter regulates transcription in murine erythroleukemia cells.

1990 • 53 citations

The purification of an erythroid protein which binds to enhancer and promoter elements of haemoglobin genes

1989 • 49 citations

Perturbation of chromatin structure in the region of the adult beta-globin gene in chicken erythrocyte chromatin

1987 • 49 citations

Comparison of the folding of .beta.-globin and ovalbumin gene containing chromatin isolated from chicken oviduct and erythrocytes

1986 • 40 citations

Transcriptional promiscuity of the human alpha-globin gene.

1989 • 36 citations

Nuclear extracts from globin-synthesizing cells enhance globin transcription in vitro

1985 • 28 citations

Activation of Developmentally Mutated Human Globin Genes by Cell Fusion

1988 • 28 citations

Protein-Binding sites within the 5′ DNase I-Hypersensitive Region of the Chicken Alpha D-globin Gene

1987 • 26 citations

Expression of human gamma-globin genes in human erythroleukemia (K562) cells.

1987 • 25 citations

Beta-globin enhancers target expression of a heterologous gene to erythroid tissues of transgenic mice.

1989 • 24 citations

Detection of two tissue-specific DNA-binding proteins with affinity for sites in the mouse beta-globin intervening sequence 2.

1988 • 24 citations

Identification and characterization of multiple erythroid cell proteins that interact with the promoter of the murine alpha-globin gene.

1988 • 23 citations

Active beta-globin gene transcription occurs in methylated, DNase I-resistant chromatin of nonerythroid chicken cells.

1990 • 18 citations

Purification and characterization of an erythroid cell-specific factor that binds the murine alpha- and beta-globin genes.

1989 • 17 citations

A transcriptional enhancer located between adult beta-globin and embryonic epsilon-globin genes in chicken and duck

1987 • 15 citations

HumAn Globin Gene Promoter Sequences are Sufficient for Specific Expression of a Hybrid Gene Transfected into Tissue Culture Cells

1987 • 15 citations

A novel in vivo transcription assay demonstrates the presence of globin-inducing trans-acting factors in uninduced murine erythroleukemia cells.

1988 • 14 citations

Expression of the affected A gamma globin gene associated with Greek nondeletion hereditary persistence of fetal hemoglobin.

1987 • 14 citations

Line-restricted hemoglobin synthesis in chick embryonic erythrocytes

1985 • 12 citations

Identification of regulatory elements of human beta-like globin genes.

1987 • 10 citations

HbF production in adult life.

1989 • 7 citations

Function of normal and mutated gamma-globin gene promoters in electroporated K562 erythroleukemia cells

1990 • 6 citations

Chicken liver TGGCA protein purified by preparative mobility shift electrophoresis (PMSE) shows a 36.8 to 29.8 kd microheterogeneity

1988 • 5 citations

X-linked dominant control of F-cells in normal adult life: characterization of the Swiss type as hereditary persistence of fetal hemoglobin regulated dominantly by gene(s) on X chromosome

1988 • 5 citations

Nuclear matrix attachment regions of the chicken beta-type globin gene cluster.

1989 • 2 citations