The antitumor effects of IFN-α are abrogated in a STAT1-deficient mouse

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Production of high-titer helper-free retroviruses by transient transfection.

1993 • 2,280 citations

A severe combined immunodeficiency mutation in the mouse

1983 • 2,193 citations

JAKS AND STATS: Biological Implications

1998 • 1,788 citations

Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease

1996 • 1,560 citations

Demonstration of an interferon γ-dependent tumor surveillance system in immunocompetent mice

1998 • 1,400 citations

Interferon Alfa-2a Therapy for Life-Threatening Hemangiomas of Infancy

1992 • 1,076 citations

High- and Low-Dose Interferon Alfa-2b in High-Risk Melanoma: First Analysis of Intergroup Trial E1690/S9111/C9190

2000 • 923 citations

Interferons α and β as Immune Regulators—A New Look

2001 • 671 citations

The complete nucleotide sequence of mouse 28S rRNA gene. Implications for the process of size increase of the large subunit rRNA In higher eukaryotes

1984 • 619 citations

Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional control.

1988 • 583 citations

Biologic consequences of Stat1-independent IFN signaling

2001 • 345 citations

Interferon-alpha in tumor immunity and immunotherapy

2002 • 332 citations

Retroviral Expression in Embryonic Stem Cells and Hematopoietic Stem Cells

2000 • 277 citations

Stat1-independent regulation of gene expression in response to IFN-γ

2001 • 243 citations

Activation of the p38 Mitogen-activated Protein Kinase by Type I Interferons

1999 • 226 citations

Distinct Requirements for IFNs and STAT1 in NK Cell Function

2000 • 214 citations

Activation of target-tissue immune-recognition molecules by double-stranded polynucleotides

1999 • 193 citations

Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways

1997 • 174 citations

Stat1 negatively regulates angiogenesis, tumorigenicity and metastasis of tumor cells

2002 • 166 citations

IFNα/β promotes cell survival by activating NF-κB

2000 • 155 citations

Detection of Intracellular Phosphorylated STAT-1 by Flow Cytometry

1999 • 127 citations

RNA-Dependent Protein Kinase PKR Is Required for Activation of NF-κB by IFN-γ in a STAT1-Independent Pathway

2001 • 118 citations

Defective Jak-STAT signal transduction pathway in melanoma cells resistant to growth inhibition by interferon-?

2000 • 106 citations

Targeted Inhibition of Interferon-γ-dependent Intercellular Adhesion Molecule-1 (ICAM-1) Expression Using Dominant-Negative Stat1

1997 • 100 citations

Antitumor Functions of Natural Killer Cells and Control of Metastases

1996 • 65 citations

Structure, Chromosome Localization, and Regulation of Expression of the Interferon-Regulated Mouse Ifi54/Ifi56 Gene Family

1994 • 60 citations

Two γ‐interferon‐activation sites (GAS) on the promoter of the human intercellular adhesion molecule (ICAM‐1) gene are required for induction of transcription by IFN‐γ

1998 • 42 citations

Serum imbalance of cytokines in melanoma patients

2001 • 39 citations

Immunological effects of recombinant interferon alfa-2a in patients with disseminated melanoma

1986 • 31 citations

Effects of systemic interferon-α (IFN-α) on the antigenic phenotype of melanoma metastases. EORTC melanoma group cooperative study No. 18852

1993 • 30 citations

EnhancedIn VivoSensitivity ofIn VitroInterferon-Treated B16 Melanoma Cells to CD8 Cells and Activated Macrophages

1996 • 25 citations

Potential uses of interferon α2 as adjuvant therapy in cancer

1995 • 19 citations

Time-dependent suppression of melanoma metastases and natural killer cell activation by interferon

1986 • 8 citations