New Strategies in Oral Immunotherapy for Diabetes Prevention

The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus

1993 • 23,535 citations

The Transforming Growth Factor-beta Family

1990 • 3,028 citations

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase

1990 • 1,955 citations

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy

1995 • 1,695 citations

Lymphokine Production by Human T Cells in Disease States

1994 • 1,351 citations

Breeding of a Non-Obese, Diabetic Strain of Mice

1980 • 1,255 citations

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

1993 • 1,087 citations

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice

1993 • 962 citations

The mucosal immune system: from fundamental concepts to vaccine development

1992 • 912 citations

Oral Tolerance: Immunologic Mechanisms and Treatment of Animal and Human Organ-Specific Autoimmune Diseases by Oral Administration of Autoantigens

1994 • 895 citations

Salmonella typhimurium initiates murine infection by penetrating and destroying the specialized epithelial M cells of the Peyer's patches.

1994 • 859 citations

Negative selection of lymphocytes

1994 • 810 citations

Peripheral deletion of antigen-reactive T cells in oral tolerance

1995 • 775 citations

Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering.

1992 • 734 citations

Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain.

1992 • 726 citations

Induction of anergy or active suppression following oral tolerance is determined by antigen dosage.

1994 • 643 citations

Effects of Oral Administration of Type II Collagen on Rheumatoid Arthritis

1993 • 634 citations

Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease.

1994 • 599 citations

Double-Blind Pilot Trial of Oral Tolerization with Myelin Antigens in Multiple Sclerosis

1993 • 592 citations

Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin.

1991 • 562 citations

Evidence for function of Ia molecules on gut epithelial cells in man.

1987 • 521 citations

Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice.

1993 • 510 citations

The regulation of immune responses to dietary protein antigens

1987 • 489 citations

Immunobiology: The immune system in health and disease

1995 • 475 citations

Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues.

1993 • 457 citations

Oral tolerance.

1994 • 456 citations

Recombinant Human IL-10 Prevents the Onset of Diabetes in the Nonobese Diabetic Mouse

1994 • 429 citations

Health care expenditures for people with diabetes mellitus, 1992.

1994 • 398 citations

Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein.

1991 • 384 citations

Epitope specificity, cytokine production profile and diabetogenic activity of insulin‐specific T cell clones isolated from NOD mice

1995 • 359 citations

Oral tolerance in humans. T cell but not B cell tolerance after antigen feeding.

1994 • 318 citations

Cholera toxin B subunit: an efficient transmucosal carrier-delivery system for induction of peripheral immunological tolerance.

1994 • 317 citations

Immunosuppression with Azathioprine and Prednisone in Recent-Onset Insulin-Dependent Diabetes Mellitus

1988 • 304 citations

Insulin prophylaxis in individuals at high risk of type 1 diabetes

1993 • 303 citations

Production of interleukin 10 by islet cells accelerates immune-mediated destruction of beta cells in nonobese diabetic mice.

1994 • 300 citations

Inflammatory leukocytes and cytokines in the peptide-induced disease of experimental allergic encephalomyelitis in SJL and B10.PL mice.

1992 • 299 citations

Suppression of experimental autoimmune encephalomyelitis by the oral administration of myelin basic protein

1988 • 291 citations

Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein. II. Suppression of disease and in vitro immune responses is mediated by antigen-specific CD8+ T lymphocytes.

1989 • 284 citations

Antigen acquisition by dendritic cells: intestinal dendritic cells acquire antigen administered orally and can prime naive T cells in vivo.

1993 • 284 citations

Insulin‐specific T cells are a predominant component of islet infiltrates in pre‐diabetic NOD mice

1994 • 279 citations

Animal models

1994 • 276 citations

Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-gamma transcription.

1995 • 248 citations

The ups and downs of T cell costimulation

1994 • 240 citations

Impaired mucosal immune responses in interleukin 4-targeted mice.

1995 • 227 citations

Induction of oral tolerance to myelin basic protein in CD8-depleted mice: both CD4+ and CD8+ cells mediate active suppression.

1995 • 222 citations

The Membranous Epithelial (M) Cell and the Mucosal Immune System

1984 • 211 citations

Optimizing oral vaccines: induction of systemic and mucosal B-cell and antibody responses to tetanus toxoid by use of cholera toxin as an adjuvant

1993 • 208 citations

Thymus Independent T Cell Development and Selection in the Intestinal Epithelium

1994 • 197 citations

Immunoregulatory functions for murine intraepithelial lymphocytes: gamma/delta T cell receptor-positive (TCR+) T cells abrogate oral tolerance, while alpha/beta TCR+ T cells provide B cell help.

1992 • 186 citations

Oral tolerance in experimental autoimmune uveoretinitis. Distinct mechanisms of resistance are induced by low dose vs high dose feeding protocols.

1993 • 184 citations

Leukocyte extravasation into the pancreatic tissue in transgenic mice expressing interleukin 10 in the islets of Langerhans.

1993 • 183 citations

Immune regulation: a new role for the CD8+ T cell

1994 • 179 citations

Prevention or delay of Type 1 (insulin-dependent) diabetes mellitus in children using nicotinamide

1991 • 176 citations

Regulation of intestinal epithelial barrier function by TGF-beta 1. Evidence for its role in abrogating the effect of a T cell cytokine.

1994 • 172 citations

Studies on the mechanisms by which transforming growth factor-beta (TGF-beta) protects against allergic encephalomyelitis. Antagonism between TGF-beta and tumor necrosis factor.

1993 • 170 citations

Flow cytometric analysis for cytokine production identifies T helper 1, T helper 2, and T helper 0 cells within the human CD4+CD27- lymphocyte subpopulation.

1995 • 168 citations

Patterns of cytokine secretion by autoreactive proteolipid protein-specific T cell clones during the course of multiple sclerosis.

1995 • 166 citations

Epitopes of myelin basic protein that trigger TGF-beta release after oral tolerization are distinct from encephalitogenic epitopes and mediate epitope-driven bystander suppression.

1993 • 158 citations

Effect of adjuvant therapy on development of diabetes in mouse and man

1994 • 157 citations

Cyclosporin-Induced Remission of IDDM After Early Intervention: Association of 1 yr of Cyclosporin Treatment With Enhanced Insulin Secretion

1988 • 155 citations

New perspectives in vaccine development: mucosal immunity to infections.

1993 • 153 citations

Immunology of the intestinal tract

1993 • 142 citations

Oral Administration of Human Insulin to NOD Mice Generates CD4+ T Cells that Suppress Adoptive Transfer of Diabetes

1994 • 137 citations

Macrophage-inactivating IL-13 suppresses experimental autoimmune encephalomyelitis in rats.

1994 • 135 citations

Islet cell antibodies predict insulin-dependent diabetes in United States school age children as powerfully as in unaffected relatives.

1994 • 134 citations

Oral Immunization with Influenza Virus in Biodegradable Microspheres

1993 • 132 citations

Immunization With the Larger Isoform of Mouse Glutamic Acid Decarboxylase (GAD67) Prevents Autoimmune Diabetes in NOD Mice

1994 • 128 citations

Extrathymic differentiation of intraepithelial lymphocytes: generation of a separate and unequal T-cell repertoire?

1991 • 114 citations

Interleukin-2 treatment potentiates induction of oral tolerance in a murine model of autoimmunity.

1994 • 112 citations

Prevention of diabetes in the NOD mouse: implications for therapeutic intervention in human disease

1994 • 108 citations

Vaccine technologies: view to the future

1994 • 99 citations

Peripheral engraftment of fetal intestine into athymic mice sponsors T cell development: direct evidence for thymopoietic function of murine small intestine.

1992 • 97 citations

Listeria monocytogenes-induced gamma interferon secretion by intestinal intraepithelial gamma/delta T lymphocytes

1993 • 91 citations

CELLS AND CYTOKINES IN MUCOSAL IMMUNITY AND INFLAMMATION

1992 • 89 citations

Morphologic and functional alterations of mucosal T cells by cholera toxin and its B subunit.

1995 • 88 citations

Thymus influences the development of extrathymically derived intestinal intraepithelial lymphocytes

1993 • 86 citations

Dynamic response of murine gut intraepithelial T cells after infection by the coccidian parasite Eimeria

1993 • 79 citations

Comparative effectiveness of the cholera toxin B subunit and alkaline phosphatase as carriers for oral vaccines

1993 • 79 citations

Hepatitis B virus nucleocapsid/pre-S2 fusion proteins expressed in attenuated Salmonella for oral vaccination.

1990 • 76 citations

Peptide determinants of myelin proteolipid protein (PLP) in autoimmune demyelinating disease: A review

1994 • 73 citations

Developmental relationship between cytotoxic α/β T cell receptor‐positive intraepithelial lymphocytes and Peyer's patch lymphocytes

1993 • 72 citations

Suppression of Collagen Induced Arthritis by Oral Administration of Type II Collagen: Changes in Immune and Arthritic Responses Mediated by Active Peripheral Suppression

1993 • 71 citations

Retroviral infection of neonatal Peyer's patch lymphocytes: the mouse mammary tumor virus model.

1994 • 68 citations

Evidence that active protection following oral immunization of mice with live rotavirus is not dependent on neutralizing antibody

1992 • 64 citations

Immunomorphological Characteristics of Human Peyer’s Patches

1990 • 63 citations

Cytokine synthesis by intestinal intraepithelial lymphocytes. Both gamma/delta T cell receptor-positive and alpha/beta T cell receptor-positive T cells in the G1 phase of cell cycle produce IFN-gamma and IL-5.

1993 • 62 citations

Minireview: Autoimmune responses to myelin proteolipid protein

1994 • 59 citations

Oral Tolerance: A Biologically Relevant Pathway to Generate Peripheral Tolerance against External and Self Antigens

2015 • 55 citations

Inhibition of Experimental Autoimmune Uveoretinitis by Oral Administration of S-Antigen and Synthetic Peptides

1992 • 46 citations

Systemic and mucosal immune responses in mice orally immunized with avirulent Salmonella typhimurium expressing a cloned Porphyromonas gingivalis hemagglutinin

1994 • 44 citations

Conversion of orally induced suppression of the mucosal immune response to ovalbumin into stimulation by conjugating ovalbumin to cholera toxin or its B subunit

1994 • 39 citations

Primate responses to a vaccinia-rabies glycoprotein recombinant virus vaccine

1992 • 33 citations

Antigen‐specific immunotherapy: Oral tolerance and subcutaneous immunization in the treatment of insulin‐dependent diabetes

1993 • 30 citations

Rapid recovery in mice after combined nasal/oral immunization with killed respiratory syncytial virus

1990 • 29 citations

T Cell Reactivity to Acetylcholine Receptor in Rats Orally Tolerized against Experimental Autoimmune Myasthenia Gravis

1993 • 29 citations

Insulin and islet cell autoantibodies as time-dependent covariates in the development of insulin-dependent diabetes: a prospective study in relatives

1993 • 29 citations

THE FUNCTION OF γδ T CELLS

1992 • 19 citations

Vaccination by cholera toxin conjugated to a herpes simplex virus type 2 glycoprotein D peptide

1992 • 18 citations

Protection against ocular and cutaneous infection with herpes simplex virus type 1 by intragastric immunization with live virus

1993 • 15 citations

Analysis of Responsive Cells in Tolerance by the Oral Administration of Ovalbumin

1993 • 8 citations

Oral Immunization with Polyvalent Bacterial Lysate and Infection with <i>Streptococcus</i> <i>pneumoniae</i>: Influence on Interferon-Gamma and PMN Elastase Concentrations in Murine Bronchoalveolar Lavage Fluid

1992 • 8 citations