Uncoupling of the order of the S and M phases: effects of staurosporine on human cell cycle kinases

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

Checkpoints: Controls That Ensure the Order of Cell Cycle Events

1989 • 3,036 citations

Universal control mechanism regulating onset of M-phase

1990 • 2,882 citations

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

1994 • 2,154 citations

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

1994 • 2,071 citations

Effects of an Rb mutation in the mouse

1992 • 1,779 citations

The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit.

1993 • 1,459 citations

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

1992 • 1,285 citations

Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

1993 • 1,258 citations

Feedback control of mitosis in budding yeast

1991 • 1,167 citations

S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function

1991 • 1,125 citations

Distinct Roles for Cyclin-Dependent Kinases in Cell Cycle Control

1993 • 1,096 citations

Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

1993 • 1,047 citations

The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

1989 • 1,031 citations

p53 mutations in colorectal cancer.

1990 • 1,030 citations

Requirement for a functional Rb-1 gene in murine development

1992 • 1,015 citations

Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation

1989 • 990 citations

A family of human cdc2-related protein kinases.

1992 • 928 citations

Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins

1992 • 906 citations

Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases

1989 • 905 citations

Physical interaction of the retinoblastoma protein with human D cyclins

1993 • 780 citations

p53 functions as a cell cycle control protein in osteosarcomas.

1990 • 774 citations

The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle

1991 • 708 citations

Creative blocks: cell-cycle checkpoints and feedback controls

1992 • 686 citations

Regulation of p34cdc2 protein kinase during mitosis

1989 • 544 citations

TGFβ inhibition of Cdk4 synthesis is linked to cell cycle arrest

1993 • 544 citations

Regulatory phosphorylation of the p34cdc2 protein kinase in vertebrates.

1991 • 502 citations

Evidence that the G1-S and G2-M transitions are controlled by different cdc2 proteins in higher eukaryotes

1991 • 493 citations

Cell Polyploidy: Its Relation to Tissue Growth and Function

1977 • 394 citations

Temporal order of S phase and mitosis in fission yeast is determined by the state of the p34cdc2-mitotic B cyclin complex

1994 • 393 citations

Activation of cyclin A-dependent protein kinases during apoptosis.

1994 • 352 citations

p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein.

1994 • 347 citations

Involvement of p34cdc2 in establishing the dependency of S phase on mitosis

1991 • 340 citations

DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1.

1994 • 279 citations

Growth arrest induced by wild-type p53 protein blocks cells prior to or near the restriction point in late G1 phase.

1992 • 274 citations

Specific enzymatic dephosphorylation of the retinoblastoma protein.

1993 • 258 citations

Parallel activation of the NIMA and p34cdc2 cell cycle-regulated protein kinases is required to initiate mitosis in A. nidulans

1991 • 243 citations

Coupling of mitosis to the completion of S phase in Xenopus occurs via modulation of the tyrosine kinase that phosphorylates p34cdc2

1992 • 231 citations

Protein phosphatase type 1 in mammalian cell mitosis: chromosomal localization and involvement in mitotic exit.

1992 • 198 citations

Loss of RCC1, a nuclear DNA-binding protein, uncouples the completion of DNA replication from the activation of cdc2 protein kinase and mitosis.

1991 • 195 citations

Regulation of cell cycle progression and nuclear affinity of the retinoblastoma protein by protein phosphatases.

1993 • 158 citations

Dephosphorylation of cdc2 on threonine 161 is required for cdc2 kinase inactivation and normal anaphase.

1992 • 145 citations

Staurosporine is a potent inhibitor of p34cdc2 and p34cdc2-like kinases

1992 • 134 citations

Highly synchronous culture of fibroblasts from G2 block caused by staurosporine, a potent inhibitor of protein kinases

1991 • 129 citations

Transformed mammalian cells are deficient in kinase-mediated control of progression through the G1 phase of the cell cycle.

1991 • 119 citations

Inhibition of cAMP-dependent protein kinase plays a key role in the induction of mitosis and nuclear envelope breakdown in mammalian cells.

1991 • 113 citations

Expression of a constitutive form of calcium/calmodulin dependent protein kinase II leads to arrest of the cell cycle in G2.

1992 • 108 citations

Flow cytometric discrimination of mitotic cells: Resolution of M, as well as G₁, S, and G₂ phase nuclei with mithramycin, propidium iodide, and ethidium bromide after fixation with formaldehyde

1986 • 89 citations

Requirement for p34cdc2 kinase is restricted to mitosis in the mammalian cdc2 mutant FT210

1992 • 65 citations

Molecular Genetic Studies of Tumor suppressor Gene Regions on chromosomes 13 and 17 in Colorectal Tumors

1992 • 53 citations

The Retinoblastoma Gene Product Is Bound in the Nucleus in Early G1 Phase

1993 • 45 citations

Requirement of mosXe protein kinase for meiotic maturation of Xenopus oocytes induced by a cdc2 mutant lacking regulatory phosphorylation sites.

1992 • 37 citations

Staurosporine- and Radiation-Induced G 2 -Phase Cell Cycle Blocks Are Equally Released by Caffeine

1993 • 29 citations

Effect of staurosporine on MOLT‐4 cell progression through G₂ and on cytokinesis

1994 • 21 citations

Cell cycle-specific expression and nuclear binding of DNA polymerase alpha.

1991 • 20 citations

Reversible G1 arrest of a human lung epithelial cell line by staurosporine

1992 • 18 citations

Establishment in monolayer culture and characterization of four human melanoma cell lines

1991 • 14 citations

Staurosporine suppresses replicon initiation in mammalian cells

1993 • 10 citations

The fraction of cells in G₁ with bound retinoblastoma protein increases with the duration of the cell cycle

1994 • 5 citations