Fas-Independent and Nonapoptotic Cytotoxicity Mediated by a Human CD4+ T-Cell Clone Directed Against an Acute Myelogenous Leukemia–Associated DEK-CAN Fusion Peptide

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1994 • 1,772 citations

Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

1994 • 1,558 citations

Dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

1995 • 1,477 citations

Mutations in Fas Associated with Human Lymphoproliferative Syndrome and Autoimmunity

1995 • 1,306 citations

A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: Ramifications for the complex physiology of TNF

1988 • 1,105 citations

Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways

1994 • 1,073 citations

Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity.

1993 • 801 citations

Molecular Mechanisms of Lymphocyte-Mediated Cytotoxicity and Their Role in Immunological Protection and Pathogenesis In Vivo

1996 • 614 citations

Differential Effects of Cytolytic T Cell Subsets on Intracellular Infection

1997 • 526 citations

Immune function in mice lacking the perforin gene.

1994 • 474 citations

Lymphocyte-mediated cytotoxicity: Two pathways and multiple effector molecules

1994 • 414 citations

Concanamycin A, a powerful tool for characterization and estimation of contribution of perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity.

1996 • 401 citations

Fas antigen is the major target molecule for CD4+ T cell-mediated cytotoxicity.

1994 • 386 citations

The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA.

1992 • 377 citations

Cytotoxic T cells deficient in both functional fas ligand and perforin show residual cytolytic activity yet lose their capacity to induce lethal acute graft-versus-host disease.

1996 • 310 citations

Participation of target Fas protein in apoptosis pathway induced by CD4+ Th1 and CD8+ cytotoxic T cells.

1994 • 309 citations

Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes

1994 • 307 citations

Fas and its ligand in a general mechanism of T-cell-mediated cytotoxicity.

1994 • 294 citations

Perforin, Fas/Fas ligand, and TNF-alpha pathways as specific and bystander killing mechanisms of hepatitis C virus-specific human CTL.

1997 • 256 citations

Long-term human cytolytic T-cell lines allospecific for HLA-DR6 antigen are OKT4+.

1982 • 237 citations

Clonal transformation of adult human leukocytes by Epstein-Barr virus

1977 • 213 citations

Measles virus-specific T4+ human cytotoxic T cell clones are restricted by class II HLA antigens.

1984 • 209 citations

Recognition of BCR-ABL positive leukemic blasts by human CD4+ T cells elicited by primary in vitro immunization with a BCR-ABL breakpoint peptide

1996 • 200 citations

In Vitro– and Ex Vivo–derived Cytolytic Leukocytes from Granzyme A × B Double Knockout Mice Are Defective in Granule-mediated Apoptosis but not Lysis of Target Cells

1997 • 192 citations

Perforin, Fas ligand, and tumor necrosis factor are the major cytotoxic molecules used by lymphokine-activated killer cells.

1996 • 187 citations

Human cytotoxic T cell clones directed against herpes simplex virus-infected cells. I. Lysis restricted by HLA class II MB and DR antigens.

1984 • 174 citations

Cytotoxic CD4+ and CD8+ T lymphocytes, generated by mutant p21-ras (12VAL) peptide vaccination of a patient, recognize 12VAL-dependent nested epitopes present within the vaccine peptide and kill autologous tumour cells carrying this mutation

1997 • 163 citations

Purified perforin induces target cell lysis but not DNA fragmentation.

1989 • 162 citations

Cloned helper T cells can kill B lymphoma cells in the presence of specific antigen: Ia restriction and cognate vs. noncognate interactions in cytolysis

1984 • 152 citations

Identification of a population of CD4+ CTL that utilizes a perforin- rather than a Fas ligand-dependent cytotoxic mechanism.

1996 • 130 citations

The translocation (6;9) (p23;q34) shows consistent rearrangement of two genes and defines a myeloproliferative disorder with specific clinical features

1992 • 109 citations

Human autoreactive CD4+ T cell clones use perforin- or Fas/Fas ligand-mediated pathways for target cell lysis.

1997 • 100 citations

Novel Fas (CD95/APO-1) mutations in infants with a lymphoproliferative disorder.

1998 • 99 citations

Expression and function of CD95 (FAS/APO‐1) in leukaemia‐lymphoma tumour lines

1997 • 73 citations

Functional heterogeneity among herpes simplex virus-specific human CD4+ T cells.

1991 • 71 citations

A polymerase chain reaction assay for the detection and quantitation of cytokine gene expression in small numbers of cells

1992 • 68 citations

Lymphotoxin and an associated 33-kDa glycoprotein are expressed on the surface of an activated human T cell hybridoma.

1991 • 68 citations

Comparison of Fas(Apo-1/CD95)- and perforin-mediated cytotoxicity in primary T lymphocytes

1996 • 63 citations

Acute Myeloid Leukemia With t(6;9) (p23;q34):Association With Myelodysplasia, Basophilia, and Initial CD34 Negative Immunophenotype

1997 • 55 citations

Cytolytic activity of antigen-specific T cells with helper phenotype.

1986 • 50 citations

Sr++-induced inhibition of human natural killer (NK) cell-mediated cytotoxicity.

1982 • 50 citations

Helper activity in antigen-specific antibody production mediated by CD4+ human cytotoxic T cell clones directed against herpes simplex virus.

1988 • 48 citations

Cloned protein antigen-specific, Ia-restricted T cells with both helper and cytolytic activities: Mechanisms of activation and killing

1987 • 46 citations

Studies of the mechanism of cytolysis by HIV-1-specific CD4+ human CTL clones induced by candidate AIDS vaccines.

1994 • 43 citations

Peptide‐specific activation of cytolytic CD4⁺ T lymphocytes against tumor cells bearing mutated epitopes of K‐ras p21

1995 • 42 citations

Expression of perforin and membrane-bound lymphotoxin (tumor necrosis factor-beta) in virus-specific CD4+ human cytotoxic T-cell clones

1993 • 39 citations

Antigen-specific directional target cell lysis by perforin-negative T lymphocyte clones

1991 • 36 citations

Production of transmembrane and secreted forms of tumor necrosis factor (TNF)-alpha by HIV-1-specific CD4+ cytolytic T lymphocyte clones. Evidence for a TNF-alpha-independent cytolytic mechanism.

1992 • 35 citations

Establishment and functional characterization of human herpesvirus 6-specific CD4+ human T-cell clones

1992 • 31 citations

Mechanisms Responsible for Granzyme B–Independent Cytotoxicity

1997 • 25 citations

Analysis of anchor residues in a naturally processed HLA-DR53 ligand

1996 • 22 citations

Expression of Membrane‐associated Lymphotoxin/Tumor Necrosis Factor‐β on Human Lymphokine‐activated Killer Cells

1991 • 22 citations

Two Distinct Mechanisms of Cytotoxity Mediated by Herpes Simplex Virus-Specific CD4+Human Cytotoxic T Cell Clones

1996 • 19 citations

Correlation between killing activity towards the murine L929 cell line and expression of membrane‐associated lymphotoxin‐related molecule of human lymphokine‐activated killer cells

1992 • 16 citations