Endogenous IL-1α from systemic sclerosis fibroblasts induces IL-6 and PDGF-A

Preliminary criteria for the classification of systemic sclerosis (scleroderma)

1980 • 4,703 citations

Quantitation of mRNA by the polymerase chain reaction.

1989 • 1,648 citations

ARTHRITIS AND ALLIED CONDITIONS

1949 • 1,599 citations

Interleukin-1 Mitogenic Activity for Fibroblasts and Smooth Muscle Cells Is Due to PDGF-AA

1989 • 648 citations

Physicochemical properties of phospborothioate oligodeoxynucleotides

1988 • 567 citations

Increased Collagen Synthesis by Scleroderma Skin Fibroblasts In Vitro A POSSIBLE DEFECT IN THE REGULATION OR ACTIVATION OF THE SCLERODERMA FIBROBLAST

1974 • 545 citations

Interleukin 1 stimulates fibroblasts to produce granulocyte-macrophage colony-stimulating activity and prostaglandin E2.

1986 • 458 citations

Role of RNase H in hybrid-arrested translation by antisense oligonucleotides.

1988 • 445 citations

Epidermal cell (keratinocyte)-derived thymocyte-activating factor (ETAF).

1981 • 420 citations

Extension of the Life-Span of Human Endothelial Cells by an Interleukin-1αAntisense Oligomer

1990 • 399 citations

The interleukin-1 receptor binds the human interleukin-1 alpha precursor but not the interleukin-1 beta precursor.

1987 • 342 citations

Skin thickness and collagen content in progressive systemic sclerosis and localized scleroderma

1979 • 331 citations

Stimulation of Collagen and Glycosaminoglycan Production in Cultured Human Adult Dermal Fibroblasts by Recombinant Human Interleukin 6

1991 • 315 citations

Interleukin‐1, Interleukin‐2, Interleukin‐4, Interleukin‐6, Tumor Necrosis Factor α, and Interferon‐γ Levels in Sera from Patients With Scleroderma

1992 • 303 citations

IL-1 and tumor necrosis factor synergistically stimulate fibroblast IL-6 production and stabilize IL-6 messenger RNA.

1990 • 242 citations

Modulation of eukaryotic gene expression by complementary RNA or DNA sequences.

1988 • 227 citations

Co-localization of transforming growth factor beta 2 with alpha 1(I) procollagen mRNA in tissue sections of patients with systemic sclerosis.

1990 • 219 citations

Studies on the molecular nature of human interleukin 1.

1987 • 186 citations

Selective upregulation of platelet-derived growth factor alpha receptors by transforming growth factor beta in scleroderma fibroblasts.

1992 • 181 citations

IL-1 alpha or tumor necrosis factor-alpha stimulate release of three NAP-1/IL-8-related neutrophil chemotactic proteins in human dermal fibroblasts.

1990 • 179 citations

Increased collagen accumulation in dermal fibroblast cultures from patients with progressive systemic sclerosis (scleroderma).

1978 • 154 citations

Inhibition of translation initiation by antisense oligonucleotides via an RNase-H independent mechanism

1991 • 144 citations

Serum levels of interleukin 6 (IL-6), oncostatin M, soluble IL-6 receptor, and soluble gp130 in patients with systemic sclerosis.

1998 • 136 citations

Techniques for using antisense oligodeoxyribonucleotides to study gene expression

1988 • 130 citations

Interleukin-1 increases collagen production and mRNA levels in cultured skin fibroblasts

1987 • 117 citations

Synergistic and overlapping activities of tumor necrosis factor-alpha and IL-1.

1988 • 102 citations

Increased endothelin-1 production in fibroblasts derived from patients with systemic sclerosis.

1994 • 100 citations

Increased production of interleukin 6 and interleukin 8 in scleroderma fibroblasts.

1998 • 88 citations

Oligonucleotides antisense to the interleukin 1 receptor mRNA block the effects of interleukin 1 in cultured murine and human fibroblasts and in mice.

1991 • 71 citations

IL-1α gene expression and protein production by fibroblasts from patients with systemic sclerosis

1994 • 61 citations

Control of Il-6 Expression and Response in Fibroblasts from Patients with Systemic Sclerosis

1994 • 52 citations

Elevated expression of c-myc proto-oncogene in scleroderma fibroblasts.

1988 • 51 citations

Regulation of levels of IL‐1 mRNA in human fibroblasts

1989 • 50 citations

Heterogeneous synthetic phenotype of cloned scleroderma fibroblasts may be due to aberrant regulation in the synthesis of connective tissues

1988 • 33 citations

Interleukin 1 Receptor on Fibroblasts from Systemic Sclerosis Patients Induces Excessive Functional Responses to Interleukin 1β

1993 • 30 citations

Phenotypic and functional activation of alveolar macrophages, T lymphocytes and NK cells in patients with systemic sclerosis and primary Sjogren's syndrome.

1994 • 30 citations

Interleukin-1 α and β induce interleukin-1 β gene expression in human dermal fibroblasts

1988 • 27 citations

Effect of prolyl 4-hydroxylase inhibitor on fibroblast collagen production in vitro: an approach to the treatment of systemic sclerosis.

1992 • 12 citations

Deleted Work

1955 • 0 citations