Gluco-incretins control insulin secretion at multiple levels as revealed in mice lacking GLP-1 and GIP receptors

Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and β-cell function in type 2 diabetes: a parallel-group study

2002 • 1,295 citations

Reduced incretin effect in Type 2 (non-insulin-dependent) diabetes

1986 • 1,275 citations

Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats.

1999 • 1,207 citations

Inhibition of gastric inhibitory polypeptide signaling prevents obesity

2002 • 887 citations

Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1.

1992 • 880 citations

Antidiabetogenic Effect of Glucagon-like Peptide-1 (7–36)amide in Normal Subjects and Patients with Diabetes Mellitus

1992 • 858 citations

Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line.

1987 • 830 citations

Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas.

1987 • 814 citations

Glucose intolerance but normal satiety in mice with a null mutation in the glucagon–like peptide 1 receptor gene

1996 • 771 citations

Disruption of the p70s6k/p85s6k gene reveals a small mouse phenotype and a new functional S6 kinase

1998 • 636 citations

Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas.

2000 • 590 citations

Glucagon-like Peptide-1 Receptor Signaling Modulates β Cell Apoptosis

2002 • 583 citations

cAMP promotes pancreatic β-cell survival via CREB-mediated induction of IRS2

2003 • 541 citations

cAMP-GEFII is a direct target of cAMP in regulated exocytosis

2000 • 480 citations

Glucose intolerance caused by a defect in the entero-insular axis: A study in gastric inhibitory polypeptide receptor knockout mice

1999 • 446 citations

Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2

1997 • 419 citations

Critical Role of cAMP-GEFII·Rim2 Complex in Incretin-potentiated Insulin Secretion

2001 • 372 citations

Persistent Improvement of Type 2 Diabetes in the Goto-Kakizaki Rat Model by Expansion of the β-Cell Mass During the Prediabetic Period With Glucagon-Like Peptide-1 or Exendin-4

2002 • 288 citations

Voltage-dependent K + channels in pancreatic beta cells: Role, regulation and potential as therapeutic targets

2003 • 261 citations

Glucose Competence of the Hepatoportal Vein Sensor Requires the Presence of an Activated Glucagon-Like Peptide-1 Receptor

2001 • 247 citations

REPRODUCIBLE HIGH YIELD OF RAT ISLETS BY STATIONARY IN VITRO DIGESTION FOLLOWING PANCREATIC DUCTAL OR PORTAL VENOUS COLLAGENASE INJECTION1

1987 • 220 citations

Glucose sensing by the hepatoportal sensor is GLUT2-dependent: in vivo analysis in GLUT2-null mice.

2000 • 200 citations

Transgenic Reexpression of GLUT1 or GLUT2 in Pancreatic β Cells Rescues GLUT2-null Mice from Early Death and Restores Normal Glucose-stimulated Insulin Secretion

2000 • 184 citations

Gut hormones and diabetes mellitus

1992 • 182 citations

PKA-mediated phosphorylation of the human KATP channel: separate roles of Kir6.2 and SUR1 subunit phosphorylation

1999 • 179 citations

Therapy of type 2 diabetes mellitus based on the actions of glucagon‐like peptide‐1

2002 • 161 citations

Enhanced glucose-dependent insulinotropic polypeptide secretion and insulinotropic action in glucagon-like peptide 1 receptor -/- mice.

1998 • 161 citations

cAMP-dependent Protein Kinase and Ca2+Influx through L-type Voltage-gated Calcium Channels Mediate Raf-independent Activation of Extracellular Regulated Kinase in Response to Glucagon-like Peptide-1 in Pancreatic β-Cells

2002 • 157 citations

Identification and Characterization of Glucoresponsive Neurons in the Enteric Nervous System

1999 • 148 citations

Portal glucose infusion in the mouse induces hypoglycemia: evidence that the hepatoportal glucose sensor stimulates glucose utilization.

2000 • 140 citations

The pathogenesis of NIDDM involves a defective expression of the GIP receptor

1997 • 117 citations

Glucose-dependent insulinotropic polypeptide receptor null mice exhibit compensatory changes in the enteroinsular axis

2003 • 117 citations

Gastric inhibitory polypeptide receptor, a member of the secretin- vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain

1993 • 104 citations

The hepatic vagal nerve is receptive to incretin hormone glucagon-like peptide-l, but not to glucose-dependent insulinotropic polypeptide, in the portal vein

1996 • 93 citations

Gastrointestinal peptides and insulin secretion

1987 • 92 citations

Expression and Characterization of Mutant Forms of the Type I Regulatory Subunit of cAMP-dependent Protein Kinase

1989 • 78 citations

Mouse pancreatic beta-cells exhibit preserved glucose competence after disruption of the glucagon-like peptide-1 receptor gene.

1998 • 72 citations

Glucagonlike peptide I (7-37) actions on endocrine pancreas

1989 • 69 citations

Protein Kinase A-dependent Phosphorylation of GLUT2 in Pancreatic β Cells

1996 • 68 citations

Implication of Glutamate in the Kinetics of Insulin Secretion in Rat and Mouse Perfused Pancreas

2002 • 63 citations

GLUT4, AMP kinase, but not the insulin receptor, are required for hepatoportal glucose sensor–stimulated muscle glucose utilization

2003 • 55 citations

Cloning, functional expression, and chromosomal localization of the human pancreatic islet glucose-dependent insulinotropic polypeptide receptor

1995 • 41 citations

Glucagon-like peptide-1 affects gene transcription and messenger ribonucleic acid stability of components of the insulin secretory system in RIN 1046-38 cells

1995 • 20 citations

Modulation of voltage-gated K+ channels Kv1.1 and Kv1.4 by forskolin

2002 • 16 citations

cAMP-dependent phosphorylation of the cardiac-type alpha 1 subunit of the voltage-dependent Ca2+ channel in a murine pancreatic beta-cell line

1996 • 10 citations