Phosphatidylinositol 4-Kinase: Gene Structure and Requirement for Yeast Cell Viability

Basic local alignment search tool

1990 • 87,358 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.

1989 • 8,705 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

[12] One-step gene disruption in yeast

1983 • 3,302 citations

INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL: TWO INTERACTING SECOND MESSENGERS

1987 • 3,302 citations

Oncogenes and signal transduction

1991 • 2,816 citations

[2] Protein kinase catalytic domain sequence database: Identification of conserved features of primary structure and classification of family members

1991 • 1,225 citations

Phosphatidylinositol 3-Kinase Encoded by Yeast VPS 34 Gene Essential for Protein Sorting

1993 • 909 citations

Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

1993 • 832 citations

An ATPase domain common to prokaryotic cell cycle proteins, sugar kinases, actin, and hsp70 heat shock proteins.

1992 • 805 citations

Phosphatidylinositol 3-kinase: Structure and expression of the 110 kd catalytic subunit

1992 • 692 citations

Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

1993 • 658 citations

Regulation of Phospholipase C-γ1 by Profilin and Tyrosine Phosphorylation

1991 • 532 citations

Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae.

1990 • 443 citations

Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis

1992 • 438 citations

A candidate protein kinase C gene, PKC1, is required for the S. cerevisiae cell cycle

1990 • 422 citations

Point mutation of an FGF receptor abolishes phosphatidylinositol turnover and Ca2+ flux but not mitogenesis

1992 • 414 citations

Yeast α factor is processed from a larger precursor polypeptide: The essential role of a membrane-bound dipeptidyl aminopeptidase

1983 • 403 citations

INOSITOL PHOSPHATE BIOCHEMISTRY

1992 • 402 citations

Isolation of the yeast calmodulin gene: Calmodulin is an essential protein

1986 • 400 citations

Phosphoinositide kinases

1990 • 331 citations

The carboxy-terminal segment of the yeast α-factor receptor is a regulatory domain

1988 • 317 citations

Yeast has homologs (CNA1 and CNA2 gene products) of mammalian calcineurin, a calmodulin-regulated phosphoprotein phosphatase.

1991 • 297 citations

Targeted selection of recombinant clones through gene dosage effects.

1983 • 262 citations

Recent insights in phosphatidylinositol signaling

1990 • 245 citations

Regulatory subunit (CNB1 gene product) of yeast Ca2+/calmodulin-dependent phosphoprotein phosphatases is required for adaptation to pheromone.

1992 • 244 citations

INOSITOL-REQUIRING MUTANTS OF SACCHAROMYCES CEREVISIAE

1975 • 230 citations

myo-Inositol-1-phosphate synthase. Characteristics of the enzyme and identification of its structural gene in yeast.

1981 • 228 citations

Signal transduction and the actin cytoskeleton: the roles of MARCKS and profilin

1992 • 203 citations

Genetic and biochemical characterization of a phosphatidylinositol-specific phospholipase C in Saccharomyces cerevisiae.

1993 • 195 citations

Triggering signaling cascades by receptor tyrosine kinases

1992 • 168 citations

Primary structure and disruption of the phosphatidylinositol synthase gene of Saccharomyces cerevisiae.

1987 • 151 citations

Bovine brain contains two types of phosphatidylinositol kinase

1987 • 125 citations

Multiple Ca2+/calmodulin-dependent protein kinase genes in a unicellular eukaryote.

1991 • 123 citations

The isolation and characterization of a mutant strain of Saccharomyces cerevisiae that requires a long chain base for growth and for synthesis of phosphosphingolipids.

1983 • 118 citations

Phosphatidylinositol 3-Kinase and Its Novel Product, Phosphatidylinositol 3-phosphate, Are Present in Saccharomyces cerevisiae

1989 • 118 citations

Possible involvement of RAS-encoded proteins in glucose-induced inositolphospholipid turnover in Saccharomyces cerevisiae.

1986 • 118 citations

The Intron-Containing Gene for Yeast Profilin (PFY) Encodes a Vital Function

1988 • 105 citations

[16] Gene overexpression in studies of Saccharomyces cerevisiae

1991 • 102 citations

Profilin, a weak CAP for actin and RAS

1991 • 89 citations

Multiple forms of phospholipase C isozymes and their activation mechanisms.

1992 • 88 citations

Purification and characterization of a soluble phosphatidylinositol 4-kinase from the yeast Saccharomyces cerevisiae.

1992 • 73 citations

Purification and characterization of a phosphatidylinositol kinase from A431 cells

1988 • 72 citations

THE GENETIC REGULATION AND COORDINATION OF BIOSYNTHETIC PATHWAYS IN YEAST: AMINO ACID AND PHOSPHOLIPID SYNTHESIS

1984 • 66 citations

Purification and characterization of a phosphatidylinositol 4-kinase from bovine uteri.

1988 • 62 citations

GENETIC ANALYSIS OF YEAST PHOSPHOLIPID BIOSYNTHESIS

1991 • 62 citations

Structural changes in profilin accompany its binding to phosphatidylinositol 4,5‐bisphosphate

1992 • 57 citations

Inositol Metabolism in Yeasts

1991 • 56 citations

Purification and characterization of phosphatidylinositol kinase from Saccharomyces cerevisiae.

1988 • 54 citations

Phosphatidylinositol 4-kinase from Saccharomyces cerevisiae. Kinetic analysis using Triton X-100/phosphatidylinositol-mixed micelles

1991 • 50 citations

Purification and characterization of phosphatidylinositol kinase from porcine liver microsomes

1988 • 37 citations

Purification, characterization, and kinetic analysis of a 55-kDa form of phosphatidylinositol 4-kinase from Saccharomyces cerevisiae.

1992 • 36 citations

Synthesis of diphosphoinositide by a soluble fraction of Saccharomyces cerevisiae

1974 • 21 citations

Separation and identification of two phosphatidylinositol 4-kinase activities in bovine uterus

1989 • 20 citations

Isolation of the phosphatidylinositol 4-monophosphate dissociable high-affinity profilin-actin complex

1992 • 18 citations

Molecular cloning and sequencing of cDNA encoding the phosphatidylinositol kinase from rat brain.

1991 • 15 citations

The hexose phosphate synthetase of Methylococcus capsulatus

1972 • 10 citations

Retraction: Molecular cloning and sequencing of cDNA encoding the phosphatidylinositol kinase from rat brain.

1992 • 1 citations

Deleted Work

1955 • 0 citations