Ras controls growth, survival and differentiation in the Drosophila eye by different thresholds of MAP kinase activity

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

Genetic Transformation of Drosophila with Transposable Element Vectors

1982 • 2,995 citations

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

Analysis of genetic mosaics in developing and adult Drosophila tissues

1993 • 2,029 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

Increasing complexity of Ras signaling

1998 • 1,069 citations

Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras

1997 • 1,064 citations

Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells

1985 • 913 citations

Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase

1991 • 869 citations

Organizing activity of wingless protein in Drosophila

1993 • 852 citations

Autonomous Control of Cell and Organ Size by CHICO, a Drosophila Homolog of Vertebrate IRS1–4

1999 • 838 citations

Coordination of Growth and Cell Division in the Drosophila Wing

1998 • 760 citations

Drosophila S6 Kinase: A Regulator of Cell Size

1999 • 710 citations

Requirement for c-ras proteins during viral oncogene transformation

1986 • 680 citations

Multiple ras functions can contribute to mammalian cell transformation

1995 • 658 citations

Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaics

2000 • 632 citations

Catalytic Activation of the Phosphatase MKP-3 by ERK2 Mitogen-Activated Protein Kinase

1998 • 496 citations

The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth.

1996 • 492 citations

The Drosophila Gene hid Is a Direct Molecular Target of Ras-Dependent Survival Signaling

1998 • 477 citations

Sprouty, an Intracellular Inhibitor of Ras Signaling

1999 • 462 citations

A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways

1994 • 417 citations

Multiple Ras Effector Pathways Contribute to G1Cell Cycle Progression

1999 • 414 citations

The beginning of pattern formation in theDrosophilacompound eye: the morphogenetic furrow and the second mitotic wave

1991 • 397 citations

Ras Promotes Cell Survival in Drosophila by Downregulating hid Expression

1998 • 378 citations

Stimulation of Membrane Ruffling and MAP Kinase Activation by Distinct Effectors of RAS

1996 • 377 citations

In Situ Activation Pattern of Drosophila EGF Receptor Pathway During Development

1997 • 372 citations

Signalling by the sevenless protein tyrosine kinase is mimicked by Rasl activation

1992 • 315 citations

Regulation of imaginal disc cell size, cell number and organ size by Drosophila class IA phosphoinositide 3-kinase and its adaptor

1999 • 299 citations

Ectopic expression of activated Ras1 induces hyperplastic growth and increased cell death in Drosophila imaginal tissues

1998 • 295 citations

Ras1 Promotes Cellular Growth in the Drosophila Wing

2000 • 276 citations

decapentaplegic and wingless are regulated by eyes absent and eyegone and interact to direct the pattern of retinal differentiation in the eye disc

1998 • 243 citations

argos transcription is induced by the Drosophila EGF receptor pathway to form an inhibitory feedback loop

1996 • 235 citations

The Ras signaling pathway in Drosophila

1995 • 226 citations

Multiple functions of the EGF receptor in Drosophila eye development

1998 • 210 citations

Genetics of RAS signaling in C. elegans

1998 • 200 citations

Sevenless : A Cell-Specific Homeotic Mutation of the Drosophila Eye

1986 • 197 citations

The sevenless signalling cassette mediates Drosophila EGF receptor function during epidermal development

1994 • 195 citations

Control of photoreceptor cell fate by the sevenless protein requires a functional tyrosine kinase domain

1988 • 177 citations

The Hox gene lin-39 is required during C. elegans vulval induction to select the outcome of Ras signaling

1998 • 168 citations

PDGF induces an early and a late wave of PI 3-kinase activity, and only the late wave is required for progression through G1

1999 • 146 citations

Developmental and molecular characterization of mutations in the Drosophila-raf serine/threonine protein kinase

1993 • 105 citations

Ras - a versatile cellular switch

1998 • 100 citations

Complexity of EGF receptor signalling revealed in Drosophila

1998 • 68 citations

Functional analysis of CNK in RAS signaling

1999 • 64 citations

Misexpression of the Drosophila argos gene, a secreted regulator of cell determination

1994 • 61 citations

Different levels of Ras activity can specify distinct transcriptional and morphological consequences in early Drosophila embryos

1997 • 56 citations

Nuclear factors in sevenless signalling

1995 • 50 citations

Quantitative Variations in the Level of MAPK Activity Control Patterning of the Embryonic Termini inDrosophila

1999 • 43 citations

The torso pathway in Drosophila: a model system to study receptor tyrosine kinase signal transduction

1993 • 42 citations

Differential Activity of Ras1 during Patterning of the Drosophila Dorsoventral Axis

1996 • 41 citations

Biochemical Characterization of RolledSem, an Activated Form of Drosophila Mitogen-activated Protein Kinase

1996 • 27 citations