The sevenless signalling cassette mediates Drosophila EGF receptor function during epidermal development

Analysis of genetic mosaics in developing and adult Drosophila tissues

1993 • 2,029 citations

The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus

1988 • 1,390 citations

The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene

1988 • 1,336 citations

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

1993 • 1,313 citations

ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

1992 • 948 citations

Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells

1985 • 913 citations

Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor

1992 • 885 citations

Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase

1991 • 869 citations

Activation of the MAP kinase pathway by the protein kinase raf

1992 • 816 citations

Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases

1992 • 714 citations

C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

1992 • 603 citations

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos

1993 • 555 citations

An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro

1993 • 451 citations

Extracellular signals and reversible protein phosphorylation: What to Mek of it all

1993 • 426 citations

Sevenless , a Cell-Specific Homeotic Gene of Drosophila , Encodes a Putative Transmembrane Receptor with a Tyrosine Kinase Domain

1987 • 421 citations

The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily

1990 • 420 citations

A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways

1994 • 417 citations

Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction

1990 • 412 citations

let-60, a gene that specifies cell fates during C. elegans vulval induction, encodes a ras protein

1990 • 397 citations

Germ line and soma cooperate during oogenesis to establish the dorsoventral pattern of egg shell and embryo in Drosophila melanogaster

1987 • 373 citations

Growth factor signaling: Where is the specificity?

1992 • 341 citations

The Drosophila gene torso encodes a putative receptor tyrosine kinase

1989 • 327 citations

Raf functions downstream of Rasl in the Sevenless signal transduction pathway

1992 • 323 citations

The Drosophila rhomboid gene mediates the localized formation of wing veins and interacts genetically with components of the EGF-R signaling pathway.

1993 • 320 citations

Signalling by the sevenless protein tyrosine kinase is mimicked by Rasl activation

1992 • 315 citations

seven in absentia, a gene required for specification of R7 cell fate in the Drosophila eye

1990 • 313 citations

A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinase

1992 • 288 citations

C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation

1993 • 276 citations

The maternal ventralizing locus torpedo is allelic to faint little ball, an embryonic lethal, and encodes the Drosophila EGF receptor homolog

1989 • 268 citations

Signal transduction by nerve growth factor and fibroblast growth factor in PC12 cells requires a sequence of src and ras actions.

1991 • 255 citations

The Drosophila EGF receptor homolog (DER) gene is allelic to faint little ball, a locus essential for embryonic development

1989 • 235 citations

wingless expression mediates determination of peripheral nervous system elements in late stages of Drosophila wing disc development

1993 • 234 citations

Function of torso in determining the terminal anlagen of the Drosophila embryo

1988 • 228 citations

Effect on eye development of dominant mutations in Drosophila homologue of the EGF receptor

1989 • 219 citations

The genetics of Drosophila

1988 • 218 citations

Localized surface activity of torso, a receptor tyrosine kinase, specifies terminal body pattern in Drosophila.

1989 • 213 citations

Genetic dissection of a neurodevelopmental pathway: Son of sevenless functions downstream of the sevenless and EGF receptor tyrosine kinases

1991 • 209 citations

Requirement of the Drosophila raf homologue for torso function

1989 • 181 citations

Control of photoreceptor cell fate by the sevenless protein requires a functional tyrosine kinase domain

1988 • 177 citations

Wing formation in Drosophila melanogaster requires decapentaplegic gene function along the anterior-posterior compartment boundary

1990 • 170 citations

Coordinately and differentially mutable activities of torpedo, the Drosophila melanogaster homolog of the vertebrate EGF receptor gene.

1989 • 163 citations

Molecular characterization and expression of sevenless, a gene involved in neuronal pattern formation in the Drosophila eye

1987 • 161 citations

DEVELOPMENTAL GENETICS OF THE VENATION PATTERN OF DROSOPHILA

1992 • 144 citations

Ellipse mutations in the Drosophila homologue of the EGF receptor affect pattern formation, cell division, and cell death in eye imaginal discs

1992 • 131 citations

Establishment of ventral cell fates in the Drosophila embryonic ectoderm requires DER, the EGF receptor homolog.

1993 • 117 citations

GENETIC ANALYSIS OF THE CENTROMERIC HETEROCHROMATIN OF CHROMOSOME 2 OF DROSOPHILA MELANOGASTER: DEFICIENCY MAPPING OF EMS-INDUCED LETHAL COMPLEMENTATION GROUPS

1976 • 114 citations

SHORTVEIN, A NEW COMPONENT OF THE DECAPENTAPLEGIC GENE COMPLEX IN DROSOPHILA MELANOGASTER

1985 • 114 citations

Control of cell fate determination by p21ras/Ras1, an essential component of torso signaling in Drosophila.

1993 • 110 citations

Behaviour of cells mutant for an EGFreceptorhomologue ofDrosophilain genetic mosaics

1990 • 110 citations

Developmental and molecular characterization of mutations in the Drosophila-raf serine/threonine protein kinase

1993 • 105 citations

Torso, a receptor tyrosine kinase required for embryonic pattern formation, shares substrates with the sevenless and EGF-R pathways in Drosophila.

1993 • 99 citations

Nucleotide sequence and structure of the sevenless gene of Drosophila melanogaster.

1988 • 93 citations

Ultrasonic relaxation in the study of rotational isomers

1957 • 92 citations

Genetic analysis of the wing vein pattern of Drosophila

1990 • 88 citations

The torpedo (DER) receptor tyrosine kinase is required at multiple times during Drosophila embryogenesis

1992 • 73 citations

Inductive mechanisms in the process of wing vein formation inDrosophila

1977 • 62 citations

PARAMETERS OF MITOTIC RECOMBINATION IN MINUTE MUTANTS OF DROSOPHILA MELANOGASTER

1975 • 60 citations

Expression of an activated ras gene causes developmental abnormalities in transgenic Drosophila melanogaster.

1988 • 60 citations

Morphogenetic mutants detected in mitotic recombination clones

1976 • 37 citations

Deleted Work

1955 • 0 citations