Serotonergic Dysfunction, Negative Mood States, and Response to Alcohol

Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region

1996 • 5,154 citations

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

1988 • 4,617 citations

A Systematic Method for Clinical Description and Classification of Personality Variants

1987 • 3,661 citations

Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter

1996 • 2,452 citations

Neurogenetic Adaptive Mechanisms in Alcoholism

1987 • 2,300 citations

Inheritance of Alcohol Abuse

1981 • 1,873 citations

Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from nonimpulsive violent behavior

1983 • 1,290 citations

Caudate Glucose Metabolic Rate Changes With Both Drug and Behavior Therapy for Obsessive-Compulsive Disorder

1992 • 1,283 citations

Serotonergic Studies in Patients With Affective and Personality Disorders

1989 • 1,093 citations

Serotonin Function and the Mechanism of Antidepressant Action

1990 • 911 citations

Enhanced Aggressive Behavior in Mice Lacking 5-HT _1B Receptor

1994 • 823 citations

Low doses of ethanol activate dopaminergic neurons in the ventral tegmental area

1985 • 788 citations

An 8-Year Follow-up of 450 Sons of Alcoholic and Control Subjects

1996 • 645 citations

Reflectivity and learning from aversive events: Toward a psychological mechanism for the syndromes of disinhibition.

1993 • 633 citations

Animal Models of Alcoholism: Neurobiology of High Alcohol-Drinking Behavior in Rodents

1998 • 619 citations

Passive avoidance learning in psychopathic and nonpsychopathic offenders.

1986 • 611 citations

The neurobiology of craving: Implications for the understanding and treatment of addiction.

1988 • 555 citations

Reduced brain serotonin transporter availability in major depression as measured by [123I]-2β-carbomethoxy-3β-(4-iodophenyl)tropane and single photon emission computed tomography

1998 • 507 citations

Selective Alteration of Personality and Social Behavior by Serotonergic Intervention

1998 • 504 citations

Alcohol challenge with sons of alcoholics: A critical review and analysis.

1990 • 493 citations

A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity

2000 • 468 citations

Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African- and European-American and Japanese populations and in alcohol-dependent subjects

1997 • 441 citations

Cerebrospinal Fluid Monoamine Metabolites, Aggression, and Impulsivity in Disruptive Behavior Disorders of Children and Adolescents

1990 • 418 citations

Serotonin and alcohol intake, abuse, and dependence: Findings of animal studies

1994 • 380 citations

Elevated alcohol consumption in null mutant mice lacking 5–HT1B serotonin receptors

1996 • 356 citations

Serotonin and alcohol intake, abuse, and dependence: Clinical evidence

1994 • 343 citations

Dopaminergic and serotonergic function following isolation rearing in rats: Study of behavioural responses and postmortem and in vivo neurochemistry

1992 • 340 citations

Linkage of Antisocial Alcoholism to the Serotonin 5-HT1B Receptor Gene in 2 Populations

1998 • 322 citations

Reduced Central Serotonin Transporters in Alcoholism

1998 • 316 citations

A Tryptophan Hydroxylase Gene Marker for Suicidality and Alcoholism

1998 • 305 citations

Differential inhibitory effects of a 5-HT3 antagonist on drug-induced stimulation of dopamine release

1989 • 277 citations

Personality Profiles and State Aggressiveness in Finnish Alcoholic, Violent Offenders, Fire Setters, and Healthy Volunteers

1994 • 270 citations

Passive avoidance in psychopaths: The effects of reward

1990 • 270 citations

Selective genotyping for the role of 5-HT2A, 5-HT2C, and GABAα6 receptors and the serotonin transporter in the level of response to alcohol: a pilot study

1999 • 258 citations

Paternal and Maternal Genetic and Environmental Contributions to Cerebrospinal Fluid MonoamineMetabolites in Rhesus Monkeys (Macaca mulatta)

1993 • 254 citations

Role of the Serotonin Transporter Promoter Polymorphism in Anxiety-Related Traits

1998 • 248 citations

CSF monoamine metabolite concentrations vary according to age, rearing, and sex, and are influenced by the stressor of social separation in rhesus monkeys

1991 • 225 citations

A Nonhuman Primate Model of Type II Excessive Alcohol Consumption? Part 1. Low Cerebrospinal Fluid 5‐Hydroxyindoleacetic Acid Concentrations and Diminished Social Competence Correlate with Excessive Alcohol Consumption

1996 • 198 citations

Clinical Importance of Age at Onset in Type 1 and Type 2 Primary Alcoholics

1990 • 194 citations

Early-Onset Alcoholics Have Lower Cerebrospinal Fluid 5-Hydroxyindoleacetic Acid Levels Than Late-Onset Alcoholics

1996 • 192 citations

Role of serotonin transporter promoter repeat length polymorphism (5-HTTLPR) in seasonality and seasonal affective disorder

1998 • 190 citations

A meta‐analysis of depressive symptomatology and alcohol consumption over time^*

1991 • 189 citations

How Common Is Resistance to Treatment in Recurrent, Nonpsychotic Geriatric Depression?

1998 • 187 citations

Attempted Suicide Characteristics and Cerebrospinal Fluid Amine Metabolites in Depressed Inpatients

1996 • 177 citations

Predisposition to Petty Criminality in Swedish Adoptees

1982 • 175 citations

Concentrations of monoamine metabolites in the cerebrospinal fluid of twins and unrelated individuals—A genetic study

1986 • 174 citations

In Vivo Association Between Alcohol Intoxication, Aggression, and Serotonin Transporter Availability in Nonhuman Primates

1998 • 173 citations

Meta-analysis of subjective sensitivity to alcohol in sons of alcoholics

1992 • 167 citations

Neurotransmitter Actions in the Thalamus and Cerebral Cortex

1992 • 158 citations

Serotonin transporter gene variants in alcohol-dependent subjects with dissocial personality disorder

1998 • 149 citations

Reduced brain 5-HT and elevated NE turnover and metabolites in bipolar affective disorder

1994 • 148 citations

Interactions of pharmacological agents which alter biogenic amine metabolism and depression

1979 • 147 citations

Causes and consequences of the loss of serotonergic presynapses elicited by the consumption of 3,4-methylenedioxymethamphetamine (MDMA, ?ecstasy?) and its congeners

1997 • 138 citations

Tryptophan Depletion in Patients With Obsessive-Compulsive Disorder Who Respond to Serotonin Reuptake Inhibitors

1994 • 133 citations

Involvement of the dorsal raphe but not median raphe nucleus in morphine-induced increases in serotonin release in the rat forebrain

1995 • 133 citations

Psychopathological and Behavioral Correlates of Dopaminergic Sensitivity in Alcohol-Dependent Patients

1996 • 125 citations

The Electroencephalogram After Alcohol Administration in High-Risk Men and the Development of Alcohol Use Disorders 10 Years Later

1996 • 124 citations

Ethanol as a neurochemical surrogate of conventional reinforcers: The dopamine-opioid link

1996 • 123 citations

A Family‐Based Analysis of Whether the Functional Promoter Alleles of the Serotonin Transporter Gene HTT Affect the Risk for Alcohol Dependence

1998 • 106 citations

Cerebral glucose metabolism, CSF 5-HIAA levels, and aggressive behavior in rhesus monkeys

1995 • 103 citations

Psychopharmacology of Central Serotonergic Systems

1995 • 97 citations

Alcohol Sensitivity and Smoking History in Men and Women

1995 • 96 citations

Tourette's syndrome

1998 • 93 citations

Prediction of Resumption of Drinking in Posttreatment Alcoholics

1991 • 93 citations

High ethanol tolerance in young adults is associated with the low-activity variant of the promoter of the human serotonin transporter gene

1998 • 89 citations

CSF monoamine metabolites of depressed patients during illness and after recovery

1984 • 86 citations

Rearing experience and biogenic amine activity in infant rhesus monkeys

1996 • 83 citations

Influence of Fluoxetine on Regional Serotonin Synthesis in the Rat Brain

1996 • 77 citations

An evaluation of Type A and B alcoholics

1995 • 76 citations

Does Psychomotor Sensitivity to Alcohol Predict Subsequent Alcohol Use?

1993 • 73 citations

Neuroendocrine Evidence for Reduced Dopamine Receptor Sensitivity in Alcoholism

1992 • 67 citations

Adaptive changes of dopamine-D2 receptors in rat brain following ethanol withdrawal: A quantitative autoradiographic investigation

1992 • 66 citations

The neuroanatomy of 5-HT dysregulation and panic disorder

1997 • 66 citations

Striatal dopamine receptors and transporters in monkeys with neonatal temporal limbic damage

1999 • 56 citations

Subtypes of Alcohol‐Dependent Men: A Typology Based on Relative Genetic and Environmental Loading

1996 • 55 citations

Altered dopamine transporter densities in alcohol-preferring vervet monkeys

1996 • 54 citations

Genetic perspectives on crime

1993 • 50 citations

Role of serotonin in ethanol abuse

1993 • 36 citations

Effects of fluoxetine on play dominance in juvenile rats

1996 • 31 citations

5‐Hydroxytryptophol in Human Cerebrospinal Fluid: Conjugation, Concentration Gradient, Relationship to 5‐Hydroxyindoleacetic Acid, and Influence of Hereditary Factors

1984 • 30 citations

Neurobiological and Anthropological Aspects of Compulsions and Rituals

1999 • 29 citations

Serotonin uptake blockers influence serotonin autoreceptors by increasing the biophase concentration of serotonin and not through a ?molecular link?

1990 • 21 citations

Serotonerge Dysfunktion als Folge sozialer Isolation

1999 • 15 citations