Ethanol as a neurochemical surrogate of conventional reinforcers: The dopamine-opioid link

Drugs of abuse: anatomy, pharmacology and function of reward pathways

1992 • 2,091 citations

Naltrexone in the Treatment of Alcohol Dependence

1992 • 1,875 citations

Opioids excite dopamine neurons by hyperpolarization of local interneurons

1992 • 1,585 citations

Naltrexone and Coping Skills Therapy for Alcohol Dependence

1992 • 1,510 citations

Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway.

1992 • 1,001 citations

Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol.

1986 • 852 citations

The role of dopamine in locomotor activity and learning

1983 • 849 citations

Low doses of ethanol activate dopaminergic neurons in the ventral tegmental area

1985 • 788 citations

Oral alcohol self-administration stimulates dopamine release in the rat nucleus accumbens: genetic and motivational determinants.

1993 • 741 citations

The role of dopamine in drug abuse viewed from the perspective of its role in motivation

1995 • 632 citations

The Mesolimbic Dopamine System: From Motivation to Action

1992 • 591 citations

The mesolimbic dopamine system : from motivation to action

1991 • 555 citations

Neurobiology of opiate abuse

1992 • 546 citations

Alcohol stimulates the release of dopamine and serotonin in the nucleus accumbens

1992 • 510 citations

Ethanol increases the firing rate of dopamine neurons of the rat ventral tegmental area in vitro

1990 • 507 citations

Mechanism of action of ethanol: initial central nervous system actions.

1989 • 445 citations

Alcohol tolerance and dependence

1980 • 419 citations

Alteration of ethanol self-administration by naltrexone

1980 • 402 citations

Naloxone attenuates voluntary ethanol intake in rats selectively bred for high ethanol preference

1990 • 303 citations

Diencephalon, Autonomic and Extrapyramidal Functions

1955 • 293 citations

Ethanol preferentially stimulates dopamine release in the nucleus accumbens of freely moving rats

1985 • 279 citations

Genetic differences in the rewarding and activating effects of morphine and ethanol

1992 • 271 citations

Oral ethanol self-administration in rats is reduced by the administration of dopamine and glutamate receptor antagonists into the nucleus accumbens

1992 • 257 citations

The effects of 6-hydroxydopamine lesions of the nucleus accumbens and the mesolimbic dopamine system on oral self-administration of ethanol in the rat

1993 • 211 citations

Naltrexone in the treatment of alcoholism: A clinical review

1996 • 200 citations

Ethanol potentiates GABA- and glycine-induced chloride currents in chick spinal cord neurons

1988 • 192 citations

In-vivo brain dialysis of neurotransmitters

1990 • 180 citations

Ethanol Enhances the Release of Dopamine and Serotonin in the Nucleus Accumbens of HAD and LAD Lines of Rats

1992 • 177 citations

Oral ethanol self-administration in the rat: Effect of naloxone

1985 • 168 citations

Antagonism by naltrexone of voluntary alcohol selection in the chronically drinking macaque monkey

1986 • 167 citations

Haloperidol and apomorphine effects on ethanol reinforcement in free feeding rats

1988 • 156 citations

Low doses of ethanol inhibit the firing of neurons in the substantia nigra, pars reticulata: a GABAergic effect?

1985 • 155 citations

The Genetic Basis of Alcohol and Drug Actions

1991 • 154 citations

Focal application of alcohols elevates extracellular dopamine in rat brain: a microdialysis study

1991 • 153 citations

Effects of D1 and D2 dopamine receptor agents on ethanol consumption in the high-alcohol-drinking (HAD) line of rats

1993 • 151 citations

Alcohol and biological membranes

1985 • 141 citations

The alcohol-preferring C57BL/6 mice present an enhanced sensitivity of the hypothalamic beta-endorphin system to ethanol than the alcohol-avoiding DBA/2 mice.

1992 • 130 citations

Blockade of δ-opioid receptors in the nucleus accumbens prevents ethanol-induced stimulation of dopamine release

1993 • 128 citations

The effects of selective blockade of delta and mu opiate receptors on ethanol consumption by C57BL/6 mice in a restricted access paradigm

1993 • 111 citations

Implication of the endogenous opioid system in excessive ethanol consumption

1996 • 97 citations

Naltrexone and the Treatment of Alcohol-Dependence: Initial Observations

1990 • 96 citations

Enkephalinase inhibition: Regulation of ethanol intake in genetically predisposed mice

1987 • 90 citations

Opioids, Bulimia, and Alcohol Abuse & Alcoholism

1990 • 87 citations

Drugs of abuse: biochemical surrogates of specific aspects of natural reward?

1993 • 86 citations

Modulation of gamma-aminobutyric acid receptor-channel complex by alcohols.

1991 • 85 citations

Decrease in ethanol consumption by naloxone in naive and dependent rats

1983 • 81 citations

Dopamine receptor agonist reduces ethanol self-administration in the ethanol-preferring C57BL/6J inbred mouse

1994 • 79 citations

Effects of dopaminergic agents on alcohol consumption by rats in a limited access paradigm

1990 • 76 citations

Endogenous Opioids Are Involved in the Genetically Determined High Preference for Ethanol Consumption

1991 • 73 citations

Effect of pimozide on home cage ethanol drinking in the rat: Dependence on drinking session length

1986 • 73 citations

SDZ-205,152, a novel dopamine receptor agonist, reduces oral ethanol self-administration in rats

1993 • 70 citations

Endogenous opioids and alcohol dependence: opioid alkaloids and the propensity to drink alcoholic beverages

1996 • 60 citations

Oral ethanol reinforcement: interactive effects of amphetamine, pimozide and food-restriction.

1985 • 49 citations

Suppression of ethanol consumption by MET-enkephalin in rats

1982 • 48 citations

Ethanol as a reinforcer: a review of laboratory studies of non-human primates.

1994 • 47 citations

Mesolimbic dopamine: An analysis of its role in motivated behavior

1993 • 39 citations

Neurochemical Studies of Genetic Differences in Alcohol Action

1991 • 36 citations

Constant infusions of morphine and intakes of sweetened ethanol solution among rats

1988 • 36 citations

Endorphins and experimental addiction

1996 • 35 citations

Endorphins in Individuals with High and Low Risk for Development of Alcoholism

1990 • 34 citations