Interleukin-1

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

1987 • 2,492 citations

Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin

1985 • 2,380 citations

Interleukin-1 and interleukin-1 antagonism

1991 • 2,276 citations

Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils.

1989 • 1,993 citations

Detection of Circulating Tumor Necrosis Factor after Endotoxin Administration

1988 • 1,711 citations

Correlations and interactions in the production of interleukin-6 (IL- 6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF

1990 • 991 citations

Interleukin 1 induces a shock-like state in rabbits. Synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition.

1988 • 990 citations

The Role of Interleukin-1 in Disease

1993 • 967 citations

Interleukin-1 receptor antagonist reduces mortality from endotoxin shock

1990 • 865 citations

Circulating Interleukin-1 and Tumor Necrosis Factor in Septic Shock and Experimental Endotoxin Fever

1990 • 765 citations

Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro

1991 • 729 citations

Antibodies to cachectin/tumor necrosis factor reduce interleukin 1 beta and interleukin 6 appearance during lethal bacteremia.

1989 • 651 citations

Interleukin 1 receptor antagonist. A new member of the interleukin 1 family.

1991 • 589 citations

Interleukin 1 induces interleukin 1. I. Induction of circulating interleukin 1 in rabbits in vivo and in human mononuclear cells in vitro.

1987 • 545 citations

Identification of a monocyte specific pre-interleukin 1 beta convertase activity.

1989 • 501 citations

Interleukin 1 stimulates fibroblasts to produce granulocyte-macrophage colony-stimulating activity and prostaglandin E2.

1986 • 458 citations

Interleukin-1 (IL-1) receptor antagonist binds to the 80-kDa IL-1 receptor but does not initiate IL-1 signal transduction

1991 • 457 citations

Soluble cytokine receptors are present in normal human urine.

1989 • 441 citations

A specific receptor antagonist for interleukin 1 prevents Escherichia coli ‐induced shock in rabbits

1991 • 435 citations

Pretranslational modulation of acute phase hepatic protein synthesis by murine recombinant interleukin 1 (IL-1) and purified human IL-1.

1985 • 423 citations

Interleukin 1 induces prolonged L-arginine-dependent cyclic guanosine monophosphate and nitrite production in rat vascular smooth muscle cells.

1991 • 403 citations

Extension of the Life-Span of Human Endothelial Cells by an Interleukin-1αAntisense Oligomer

1990 • 399 citations

Synergy of interleukin 1 and granulocyte colony-stimulating factor: in vivo stimulation of stem-cell recovery and hematopoietic regeneration following 5-fluorouracil treatment of mice.

1987 • 380 citations

Infusion of tumor necrosis factor/cachectin promotes muscle catabolism in the rat. A synergistic effect with interleukin 1.

1989 • 378 citations

Generation of biologically active interleukin-1 beta by proteolytic cleavage of the inactive precursor.

1988 • 377 citations

Prostacyclin Synthesis Induced in Vascular Cells by Interleukin-1

1985 • 364 citations

A urine inhibitor of interleukin 1 activity that blocks ligand binding.

1987 • 351 citations

Anti-IL-6 monoclonal antibodies protect against lethal Escherichia coli infection and lethal tumor necrosis factor-alpha challenge in mice.

1990 • 343 citations

Interleukin-1 receptor blockade improves survival and hemodynamic performance in Escherichia coli septic shock, but fails to alter host responses to sublethal endotoxemia.

1992 • 338 citations

Interleukin-1-induced anorexia in the rat. Influence of prostaglandins.

1989 • 333 citations

Interleukin 1 (IL-1) gene expression, synthesis, and effect of specific IL-1 receptor blockade in rabbit immune complex colitis.

1990 • 333 citations

cDNA cloning of an intracellular form of the human interleukin 1 receptor antagonist associated with epithelium.

1991 • 326 citations

Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase.

1991 • 326 citations

Effects of immune complexes on production by human monocytes of interleukin 1 or an interleukin 1 inhibitor.

1985 • 325 citations

Production of interleukin-1-receptor antagonist during experimental endotoxaemia

1991 • 311 citations

Human tumor necrosis factor potentiates human interleukin 1-mediated rat pancreatic beta-cell cytotoxicity.

1987 • 305 citations

A recombinant human receptor antagonist to interleukin 1 improves survival after lethal endotoxemia in mice.

1991 • 298 citations

Adrenalectomy sensitizes mice to the lethal effects of interleukin 1 and tumor necrosis factor.

1988 • 295 citations

Inhibition of interleukin 1 (IL-1) binding and bioactivity in vitro and modulation of acute inflammation in vivo by IL-1 receptor antagonist and anti-IL-1 receptor monoclonal antibody.

1991 • 295 citations

Interleukin 1 stimulates granulocyte macrophage colony-stimulating activity release by vascular endothelial cells.

1986 • 283 citations

Vascular endothelial cells and granulopoiesis: interleukin-1 stimulates release of G-CSF and GM-CSF

1988 • 277 citations

Two high-affinity interleukin 1 receptors represent separate gene products.

1989 • 268 citations

Interdependence of the radioprotective effects of human recombinant interleukin 1 alpha, tumor necrosis factor alpha, granulocyte colony-stimulating factor, and murine recombinant granulocyte-macrophage colony-stimulating factor.

1988 • 265 citations

Staphylococcus epidermidis induces complement activation, tumor necrosis factor and interleukin-1, a shock-like state and tissue injury in rabbits without endotoxemia. Comparison to Escherichia coli.

1991 • 248 citations

A low dose of recombinant interleukin 1 protects granulocytopenic mice from lethal gram-negative infection.

1988 • 241 citations

Homogeneous interferon-inducing 22K factor is related to endogenous pyrogen and interleukin-1

1985 • 236 citations

Regulation of Alloreactivity in Vivo by a Soluble Form of the Interleukin-1 Receptor

1990 • 235 citations

Kinetics and mechanisms of recombinant human interleukin 1 and tumor necrosis factor-alpha-induced changes in circulating numbers of neutrophils and lymphocytes.

1987 • 229 citations

Interleukin 1 receptor blockade attenuates the host inflammatory response.

1990 • 216 citations

Pharmacokinetics, safety and immunomodulatory effects of human recombinant interleukin-1 receptor antagonist in healthy humans

1992 • 214 citations

Acute inflammation and a Shwartzman-like reaction induced by interleukin-1 and tumor necrosis factor. Synergistic action of the cytokines in the induction of inflammation and microvascular injury.

1987 • 214 citations

Prostaglandin E2 and collagenase production by fibroblasts and synovial cells is regulated by urine-derived human interleukin 1 and inhibitor(s).

1986 • 211 citations

Interleukin-1 receptor antagonist circulates in experimental inflammation and in human disease

1992 • 209 citations

An IL-1 inhibitor from human monocytes. Production and characterization of biologic properties.

1989 • 208 citations

Production of interleukin-1 receptor antagonist and interleukin-1 beta by peripheral blood mononuclear cells is differentially regulated

1991 • 201 citations

Studies on the molecular nature of human interleukin 1.

1987 • 186 citations

Experimental autoimmune encephalomyelitis is exacerbated by IL-1 alpha and suppressed by soluble IL-1 receptor.

1991 • 183 citations

Down regulation of the receptors for tumor necrosis factor by interleukin 1 and 4 beta-phorbol-12-myristate-13-acetate.

1987 • 181 citations

Inhibition of interleukin-1 by an interleukin-1 receptor antagonist prevents graft-versus-host disease

1991 • 180 citations

Sensitization and desensitization to lethal effects of tumor necrosis factor and IL-1.

1988 • 179 citations

Occurrence of interleukin-1 in cerebrospinal fluid of the conscious cat

1988 • 178 citations

Regulation of food intake and hepatic protein synthesis by recombinant-derived cytokines

1988 • 178 citations

Purification and characterization of a novel soluble receptor for interleukin 1.

1991 • 173 citations

In vitro production of IL 1β, IL 1α, TNF and IL 2 in healthy subjects: distribution, effect of cyclooxygenase inhibition and evidence of independent gene regulation

1989 • 172 citations

Inhibition of Cyclo-oxygenase Attenuates the Metabolic Response to Endotoxin in Humans

1988 • 171 citations

Native interleukin 1 inhibitors

1989 • 169 citations

Preliminary report: effects of interleukin-1 on platelet counts

1990 • 164 citations

Interleukin-6 as an endogenous pyrogen: induction of prostaglandin E2 in brain but not in peripheral blood mononuclear cells

1991 • 164 citations

Differences in the synthesis and kinetics of release of interleukin 1α, interleukin 1β and tumor necrosis factor from human mononuclear cells

1989 • 163 citations

The intratracheal administration of endotoxin and cytokines. III. The interleukin-1 (IL-1) receptor antagonist inhibits endotoxin- and IL-1-induced acute inflammation.

1991 • 157 citations

Natural and recombinant human IL-1 receptor antagonists block the effects of IL-1 on bone resorption and prostaglandin production.

1990 • 154 citations

Pro- and anti-inflammatory roles of interleukin-1 in recurrence of bacterial cell wall-induced arthritis in rats

1991 • 151 citations

The in vivo effects of interleukin 1. I. Bone marrow cells are induced to cycle after administration of interleukin 1.

1987 • 150 citations

Expression of colony-stimulating factor genes by normal human mesothelial cells and human malignant mesothelioma cells lines in vitro

1989 • 147 citations

Both Inflammatory and Endocrine Mediators Stimulate Host Responses to Sepsis

1986 • 146 citations

Circulating interleukin-1β and tumor necrosis factor-α concentrations after burn injury in humans

1992 • 141 citations

Regulation of Granulocyte- and Monocyte-colony Stimulating Factor mRNA Levels in Human Blood Monocytes Is Mediated Primarily at a Post-transcriptional Level

1989 • 139 citations

Modulation of endothelial cell functions by different molecular species of interleukin 1

1987 • 137 citations

Demonstration of a circulating suppressor factor of thymocyte proliferation during endotoxin fever in humans.

1981 • 132 citations

Modulation of cell proliferation and cytokine production in acute myeloblastic leukemia by interleukin-1 receptor antagonist and lack of its expression by leukemic cells

1991 • 128 citations

Interleukin 1 inhibits contraction of vascular smooth muscle.

1989 • 126 citations

SPECIFIC INTERLEUKIN-1 INHIBITOR IN SERUM AND URINE OF CHILDREN WITH SYSTEMIC JUVENILE CHRONIC ARTHRITIS

1987 • 125 citations

Interleukin-1 beta in human plasma: optimization of blood collection, plasma extraction, and radioimmunoassay methods.

1988 • 122 citations

Anorexic effects of interleukin 1 in the rat

1989 • 116 citations

Identification of soluble interleukin-1 binding protein in cell-free supernatants. Evidence for soluble interleukin-1 receptor.

1990 • 115 citations

Interleukin-1 enhances pain reflexes. Mediation through increased prostaglandin E2 levels

1988 • 114 citations

Decreased serum interleukin 1 activity and monocyte interleukin 1 production in patients with fatal sepsis

1986 • 112 citations

Interleukin-1 and hematopoiesis

1989 • 112 citations

IL-2 stimulates the production of IL-1 alpha and IL-1 beta by human peripheral blood mononuclear cells.

1988 • 107 citations

Role of interleukin 1 and tumor necrosis factor on energy metabolism in rabbits

1988 • 105 citations

Evidence for Two Classes of Cytokines That Stimulate Hepatic Lipogenesis: Relationships among Tumor Necrosis Factor, Interleukin-1 and Interferon-Alpha*

1990 • 105 citations

Induction by Toxic-Shock-Syndrome Toxin-1 of a Circulating Tumor Necrosis Factor-Like Substance in Rabbits and of Immunoreactive Tumor Necrosis Factor and Interleukin-1 from Human Mononuclear Cells

1988 • 99 citations

An interleukin-1 receptor antagonist blocks lipopolysaccharide-induced colony-stimulating factor production and early endotoxin tolerance

1991 • 98 citations

The biology of GM-CSF: Regulation of production and interaction with its receptor

1990 • 96 citations

Suppression of chronic myelogenous leukemia colony growth by interleukin-1 (IL-1) receptor antagonist and soluble IL-1 receptors: a novel application for inhibitors of IL-1 activity

1991 • 95 citations

Interleukin 1 stimulates hexose transport in fibroblasts by increasing the expression of glucose transporters.

1990 • 86 citations

Interleukin‐1 (IL‐1) receptor blockade reduces endotoxin and Borrelia burgdorferi ‐stimulated IL‐8 synthesis in human mononuclear cells

1992 • 85 citations

Interleukin 1 suppresses inflammation in rabbit colitis. Mediation by endogenous prostaglandins.

1990 • 84 citations

The interleukin-1 receptor antagonist can either reduce or enhance the lethality of Klebsiella pneumoniae sepsis in newborn rats

1993 • 80 citations

Detection of interleukin 1 alpha and 1 beta in rabbit tissues during endotoxemia using sensitive radioimmunoassays

1991 • 78 citations

Purification and characterization of a 26‐kDa competitive inhibitor of interleukin 1

1990 • 76 citations

Peripheral nerve regeneration is impeded by interleukin‐1 receptor antagonist released from a polymeric guidance channel

1991 • 70 citations

Purification of soluble cytokine receptors from normal human urine by ligand-affinity and immunoaffinity chromatography

1990 • 70 citations

Rabbit IL-1. Cloning, expression, biologic properties, and transcription during endotoxemia.

1989 • 64 citations

In vivo modulation with anti-interleukin-1 (IL-1) receptor (p80) antibody 35F5 of the response to IL-1. The relationship of radioprotection, colony-stimulating factor, and IL-6

1990 • 58 citations

A natural interleukin 1 (IL-1) inhibitor counteracts the inhibitory effect of IL-1 on insulin production in cultured rat pancreatic islets

1989 • 56 citations

Interleukin-1 downregulates gene and surface expression of interleukin-1 receptor type I by destabilizing its mRNA whereas interleukin-2 increases its expression

1991 • 53 citations

A single low dose of human recombinant interleukin 1 accelerates the recovery of neutrophils in mice with cyclophosphamide-induced neutropenia.

1989 • 53 citations

The precursor of interleukin-1 alpha is phosphorylated at residue serine 90.

1988 • 50 citations

Interleukin-1 enhances survival of lethally irradiated mice treated with allogeneic bone marrow cells

1989 • 50 citations

Interleukin 1 inhibitory activity secreted by a human myelomonocytic cell line (M20)

1986 • 50 citations

Interleukin-1 inhibitors

1987 • 49 citations

Protection against pulmonary oxygen toxicity by interleukin-1 and tumor necrosis factor: Role of antioxidant enzymes and effect of cyclooxygenase inhibitors

1989 • 43 citations

Purification and characterization of a unique human interleukin 1 from the tumor cell line U937.

1986 • 42 citations

Enhanced Hematopoietic Recovery in Irradiated Mice Pretreated with Interleukin-1 (IL-1)

1987 • 37 citations

Failure of IL-1 receptor antagonist and monoclonal anti-IL-1 receptor antibody to inhibit antigen-specific immune responses in vivo.

1992 • 36 citations

Interleukin-1-inducible tumor growth arrest is characterized by activation of cell type-specific “early” gene expression programs.

1992 • 33 citations

Interleukin-1 potentiates glucose stimulated insulin release in the isolated perfused pancreas

1988 • 26 citations

Pro-interleukin-1β production by a subpopulation of human T cells, but not NK cells, in response to interleukin-2

1990 • 23 citations

In vivo effects of interleukin-1 alpha on regenerating mouse bone marrow myeloid colony-forming cells after treatment with 5-fluorouracil.

1989 • 21 citations

The induction of interleukin-1 in humans and its metabolic effects

1986 • 20 citations

Monoclonal antibodies reacting with the interleukin 1 receptor define a multi‐molecular complex

1990 • 17 citations

Expression of c-fos proto-oncogene in tumor-associated macrophages.

1990 • 16 citations

Biological role of the IL-1 receptor type II (IL-1RII) as defined by a monoclonal antibody

1991 • 11 citations

Mechanisms which take part in regulation of the response to tumor necrosis factor.

1989 • 11 citations

Interleukin-1 receptor antagonist blocks hypotension in a rabbit model of gram positive septic shock

1991 • 7 citations

Interleukin-1β can be secreted from mammalian cells by the human MDR1 P-glycoprotein

1991 • 3 citations

Molecular cloning of the IL-1β processing enzyme

1991 • 3 citations

The effect of IL-1 receptor antagonist (IL-1ra) in murine cerebral malaria

1991 • 2 citations