A low dose of recombinant interleukin 1 protects granulocytopenic mice from lethal gram-negative infection.

Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples

1977 • 8,468 citations

Quantitative Relationships Between Circulating Leukocytes and Infection in Patients with Acute Leukemia

1966 • 2,470 citations

Interleukin-1

1984 • 1,625 citations

THE ORIGIN AND KINETICS OF MONONUCLEAR PHAGOCYTES

1968 • 1,492 citations

Interleukin 1 is a radioprotector.

1986 • 386 citations

Multiple biological activities of human recombinant interleukin 1.

1986 • 372 citations

Increased production of superoxide anion by macrophages exposed in vitro to muramyl dipeptide or lipopolysaccharide.

1980 • 356 citations

Interleukin 1 regulates hematopoietic activity, a role previously ascribed to hemopoietin 1.

1987 • 309 citations

Enhancement of nonspecific immunity to Klebsiella pneumoniae infection by a synthetic immunoadjuvant (N-acetylmuramyl-L-alanyl-D-isoglutamine) and several analogs.

1977 • 237 citations

Kinetics of Endotoxin Release During Antibiotic Therapy For Experimental Gram-Negative Bacterial Sepsis

1984 • 235 citations

Impact of Dosing Intervals on Activity of Gentamicin and Ticarcillin Against Pseudomonas aeruginosa in Granulocytopenic Mice

1983 • 150 citations

Enhanced resistance of mice to bacterial infection induced by recombinant human interleukin-1a

1987 • 146 citations

Recombinant tumor necrosis factor/cachectin and interleukin 1 pretreatment decreases lung oxidized glutathione accumulation, lung injury, and mortality in rats exposed to hyperoxia.

1987 • 122 citations

Activation of macrophages for enhanced release of superoxide anion and greater killing of Candida albicans by injection of muramyl dipeptide.

1980 • 116 citations

Development and use of a radioimmunoassay for human interleukin-1 beta.

1987 • 106 citations

The Role of Iron in Nonspecific Resistance to Infection Induced by Endotoxin

1974 • 81 citations

Effect of Indomethacin on Increased Resistance to Bacterial Infection and on Febrile Responses Induced by Muramyl Dipeptide

1980 • 73 citations

Effects of Endotoxins on Susceptibility to Infections

1970 • 61 citations

Prophylactic administration of interleukin-2 protects mice from lethal challenge with gram-negative bacteria

1987 • 59 citations

Stimulation of antimicrobial activity in the rat with leukocytic endogenous mediator.

1975 • 35 citations

Administration in vivo of recombinant interleukin 2 protects mice against septic death.

1987 • 33 citations

Role of interleukin-1 in augmenting serum neutralization of bacterial lipopolysaccharide

1987 • 31 citations

Effect of Bacterial Endotoxin on Experimental Fungal Infections

1968 • 26 citations

Infectious episodes in severely granulocytopenic patients

1979 • 22 citations

Antibacterial efficacy of cefazolin and cephradine in neutropenic mice

1979 • 14 citations

Alterations in Host Responses to Experimental Candida Albicans Infections by Bacterial Endotoxin

1969 • 14 citations