Intratumoral Chemotherapy

Biodegradable Long-Circulating Polymeric Nanospheres

1994 • 2,832 citations

New Methods of Drug Delivery

1990 • 1,730 citations

Randomized Comparisons of Radiotherapy and Nitrosoureas for the Treatment of Malignant Glioma after Surgery

1980 • 1,625 citations

Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas

1995 • 1,359 citations

Assumptions in the radiotherapy of glioblastoma

1980 • 987 citations

Bioerodible polyanhydrides as drug‐carrier matrices. I: Characterization, degradation, and release characteristics

1985 • 532 citations

Interstitial chemotherapy with drug polymer implants for the treatment of recurrent gliomas

1991 • 485 citations

Chemotherapy of Neoplastic Diseases

1962 • 430 citations

Antiangiogenic agents potentiate cytotoxic cancer therapies against primary and metastatic disease.

1992 • 259 citations

Bioerodible polyanhydrides as drug‐carrier matrices. II. Biocompatibility and chemical reactivity

1986 • 258 citations

Angiogenesis inhibition by minocycline.

1991 • 254 citations

Preliminary trial of specific targeting therapy against malignant glioma

1990 • 241 citations

Drug Spotlight Program

1974 • 225 citations

Interstitial chemotherapy of the 9L gliosarcoma: controlled release polymers for drug delivery in the brain.

1993 • 225 citations

The intracerebral distribution of BCNU delivered by surgically implanted biodegradable polymers

1992 • 215 citations

Interstitial taxol delivered from a biodegradable polymer implant against experimental malignant glioma.

1994 • 208 citations

Phase I and pharmacodynamic study of taxol in refractory acute leukemias.

1989 • 196 citations

Chemotherapy of Brain Tumors

1977 • 196 citations

Therapeutic Efficacy of Multiagent Chemotherapy with Drug Delivery Enhancement by Blood-Brain Barrier Modification in Glioblastoma

1986 • 166 citations

Permeability Characteristics of Brain Adjacent to Tumors in Rats

1975 • 165 citations

Intracarotid infusion of RMP-7, a bradykinin analog: a method for selective drug delivery to brain tumors

1994 • 158 citations

Brain biocompatibility of a biodegradable, controlled‐release polymer in rats

1989 • 156 citations

Biodegradable polymers for controlled delivery of chemotherapy with and without radiation therapy in the monkey brain

1994 • 140 citations

The value of reoperation for recurrent glioblastoma.

1993 • 136 citations

Do anticancer agents reach the tumor target in the human brain?

1992 • 133 citations

Immunotoxins and central nervous system neoplasia

1992 • 132 citations

Biocompatibility of a Biodegradable, Controlled-Release Polymer in the Rabbit Brain

1989 • 127 citations

Evaluation of postoperative intratumoral injection of bleomycin for craniopharyngioma in children

1985 • 126 citations

Osmotic blood-brain barrier disruption and chemotherapy in the treatment of high grade malignant glioma: patient series and literature review

1992 • 123 citations

Optimizing drug delivery to brain tumors

1987 • 118 citations

Cytotoxicity of taxol in vitro against human and rat malignant brain tumors

1994 • 112 citations

Distribution of methotrexate in the cerebrospinal fluid and brain after intraventricular administration.

1977 • 108 citations

The Antitumor Agent, 1,3-bis(2-chloroethyl)-1-nitrosourea

1966 • 106 citations

Microvascular abnormalities in virally-induced canine brain tumors

1972 • 103 citations

Cerebrospinal fluid perfusion for central nervous system neoplasms

1966 • 103 citations

Chemotherapy of brain tumors: physiological and pharmacokinetic considerations.

1986 • 97 citations

In vivo versus in vitro degradation of controlled release polymers for intracranial surgical therapy

1994 • 96 citations

Pharmacology of cyclophosphamide and metabolites.

1981 • 94 citations

Controlled delivery of 1,3-bis(2-chloroethyl)-1-nitrosourea from ethylene-vinyl acetate copolymer.

1989 • 93 citations

Intralesional Infusion of Lymphokine-activated Killer (LAK) Cells and Recombinant Interleukin-2 (rIL-2) for the Treatment of Patients with Malignant Brain Tumor

1988 • 93 citations

Effectiveness of controlled release of a cyclophosphamide derivative with polymers against rat gliomas

1995 • 89 citations

Covalent coupling of methotrexate to dextran enhances the penetration of cytotoxicity into a tissue-like matrix.

1994 • 85 citations

The role of minocycline in the treatment of intracranial 9L glioma

1995 • 83 citations

Intracerebral Chemotherapy

1982 • 78 citations

The MTT assay for chemosensitivity testing of human tumors of the central nervous system

1992 • 77 citations

Drug Targeting into the Central Nervous System by Stereotactic Implantation of Biodegradable Microspheres

1994 • 75 citations

Treatment of recurrent malignant glioma by repeated intracerebral injections of human recombinant interleukin-2 alone or in combination with systemic interferon-?. Results of a phase I clinical trial

1992 • 75 citations

Growth inhibition of the 9L glioma using polymers to release heparin and cortisone acetate

1990 • 73 citations

Randomised, controlled study of intratumoral recombinant γ-interferon treatment in newly diagnosed glioblastoma

1994 • 73 citations

Interstitial chemotherapy for brain tumors: review

1991 • 72 citations

Spatial distribution of dopamine, methotrexate and antipyrine during continuous intracerebral microperfusion

1985 • 72 citations

Local delivery of the topoisomerase I inhibitor camptothecin sodium prolongs survival in the rat intracranial 9L gliosarcoma model

1995 • 68 citations

Polymeric controlled release of dexamethasone in normal rat brain

1991 • 66 citations

Use of Implantable Pumps for Central Nervous System Drug Infusions to Treat Neurological Disease

1988 • 61 citations

Brain-tumor chemotherapy

1977 • 60 citations

Interstitial delivery of dexamethasone in the brain for the reduction of peritumoral edema

1991 • 56 citations

The Clinical Effects of a Synthetic Gluco-Corticoid used for Brain Edema in the Practice of Neurosurgery

1972 • 54 citations

Methotrexate, cytosine arabinoside, and BCNU concentration in brain after ventriculocisternal perfusion.

1977 • 53 citations

Postoperative intracavitary chemotherapy of malignant gliomas

1973 • 53 citations

Chemosensitivity of malignant human brain tumors

1983 • 49 citations

Direct Delivery of Medication into a Brain Tumor through Multiple Chronically Implanted Catheters

1987 • 49 citations

Pharmacologic Principles of Cancer Treatment

1983 • 47 citations

Treatment of malignant glioma by a new therapeutic principle

1992 • 41 citations

Therapy of recurrent high grade gliomas with surgery, and autologous mitogen activated IL-2 stimulated killer (MAK) Lymphocytes: I. Enhancement of MAK lytic activity and cytokine production by PHA and clinical use of PHA

1993 • 40 citations

Direct delivery of platinum-based antineoplastics to the central nervous system: a toxicity and ultrastructural study

1993 • 40 citations

Bleomycin and brain tumors

1983 • 39 citations

Intraneoplastic injection of methotrexate for experimental brain-tumor chemotherapy

1977 • 37 citations

Postoperative intracavitary chemotherapy of malignant supratentorial astrocytomas using BCNU.

1975 • 33 citations

Chronic Intratumoral Chemotherapy of a Rat Tumor with Cisplatin and Fluorouracil

1983 • 33 citations

TREATMENT OF INTRACRANIAL GLIOMAS AND METASTATIC CARCINOMAS BY LOCAL APPLICATION OF CYTOSTATIC AGENTS

1968 • 31 citations

Medtronic SynchroMed Drug Administration System

1988 • 31 citations

Controlled release of 4‐hydroperoxycyclophosphamide from the fatty acid dimer‐sebacic acid copolymer

1992 • 29 citations

Studies on the intracerebral injection of bleomycin free and entrapped within liposomes in the rat.

1984 • 28 citations

Uptake of bleomycin by human brain tumours

1976 • 28 citations

The MTT assay for chemosensitivity testing of human tumors of the central nervous system

1992 • 28 citations

Treatment of malignant brain tumors by local methotrexate. A preliminary report.

1969 • 26 citations

A potential application for the intracerebral injection of drugs entrapped within liposomes in the treatment of human cerebral gliomas.

1985 • 26 citations

Shiley Infusaid Pump Technology

1988 • 26 citations

The intraneoplastic chemotherapy in a rat brain tumour model utilizing methotrexate-polymethylmethacrylate-pellets

1987 • 26 citations

Intraneoplastic Administration of Bleomycin in Intracerebral Gliomas: A Pilot Study

1980 • 24 citations

Complete remission of recurrent glioblastoma multiforme following local infusions of lymphokine activated killer cells

1989 • 23 citations

Combination of radiation therapy and intracranial bleomycin in the 9L rat brain tumor model

1990 • 23 citations

Study of effectiveness of bleomycin in rat brain tumor model intravenously and intracerebrally

1979 • 23 citations

Continuous Intratumoral Infusion of Methotrexate for Recurrent Glioblastoma: A Pilot Study

1991 • 22 citations

Interstitial chemotherapy of experimental gliomas

1990 • 21 citations

Lokale Chemotherapie der Hirntumoren

1963 • 21 citations

Intraneoplastic injection of CCNU for experimental brain tumor chemotherapy.

1977 • 20 citations

Controlled release rate of a lipophilic drug (BCNU) from a refillable silicone rubber device

1982 • 20 citations

In vitro chemosensitivity test of malignant gliomas: clinical relevance of test results independent of adjuvant chemotherapy.

1994 • 18 citations

Tumoricidal Effect of Controlled-release Polymeric Needle Devices Containing Adriamycin Hc1 in Tumor-bearing Mice

1989 • 17 citations

Studies on the intracerebral injection of vincristine free and entrapped within liposomes in the rat

1985 • 17 citations

MiniMed Technologies Programmable Implantable Infusion System

1988 • 16 citations

Use of Implantable Pump Systems for Intraarterial, Intraventricular and Intratumoral Treatment of Malignant Brain Tumors

1988 • 15 citations

Diffusion in vitro and in vivo of 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea from silicone rubber capsules, a potentially new mode of chemotherapy administration.

1973 • 15 citations

Intrathecal Chemotherapy

1970 • 15 citations

Neurotoxicity of Local Administration of Two Nitrosoureas in Malignant Gliomas

1990 • 14 citations

Flexibility and efficacy of automatic continuous fluorodeoxyuridine infusion in metastases from a renal cell carcinoma

1991 • 14 citations

In vitro versus in vivo correlations of chemosensitivity of human medulloblastoma.

1984 • 11 citations

Trial of anticancer pellet in malignant brain tumours; 5 FU and urokinase embedded in silastic.

1979 • 10 citations

Intratumoural and intraventricular human lymphoblastoid alpha interferon (HLBI) for treatment of glioblastoma multiforme

1989 • 10 citations

Cerebral Revascularization

2006 • 10 citations

Sustained release of BCNU for the treatment of intraocular malignancies in animal models.

1979 • 10 citations

Critical Appraisal of Experimental Radiation Modalities for Malignant Astrocytomas

1990 • 8 citations

Release of a nitrosourea derivative from refillable silicone rubber implants for the treatment of intraocular malignancies.

1978 • 8 citations

Focal chemotherapy of brain tumours using semipermeable membranes.

1977 • 6 citations

Reduction in peritumoral brain edema by an intracranial polymer implant

1990 • 5 citations

Untitled

1980 • 5 citations

Brain Tumor Angiogenesis: Drug Delivery and New Inhibitors

1992 • 5 citations

Cerebrovascular Effects and Tumor Kinetics after a Single Intratumoral Injection of Human Recombinant Interleukin-2 Alone or in Combination with Intravenous Chemotherapy in a Rat Model of Glioma

1992 • 3 citations