Drug Targeting into the Central Nervous System by Stereotactic Implantation of Biodegradable Microspheres

Polymers for the sustained release of proteins and other macromolecules

1976 • 1,127 citations

Aliphatic polyesters II. The degradation of poly (DL-lactide), poly (ε-caprolactone), and their copolymers in vivo

1981 • 833 citations

Tumor Growth and Neovascularization: An Experimental Model Using the Rabbit Cornea 2

1974 • 762 citations

Present and future applications of biomaterials in controlled drug delivery systems

1981 • 642 citations

Fluorescent latex microspheres as a retrograde neuronal marker for in vivo and in vitro studies of visual cortex

1984 • 605 citations

A new absorbable suture

1971 • 564 citations

Bioerodible polyanhydrides as drug‐carrier matrices. I: Characterization, degradation, and release characteristics

1985 • 532 citations

Interstitial chemotherapy with drug polymer implants for the treatment of recurrent gliomas

1991 • 485 citations

Drug delivery to the central nervous system: A review

1992 • 371 citations

The use of silicone rubber as a carrier for prolonged drug therapy

1964 • 343 citations

Immunological aspects of grafting in the mammalian central nervous system. A review and speculative synthesis

1988 • 296 citations

Perivascular Meningeal Projections from Cat Trigeminal Ganglia: Possible Pathway for Vascular Headaches in Man

1981 • 274 citations

In vitro and In vivo degradation of poly(D,L lactide/glycolide) type microspheres made by solvent evaporation method

1989 • 265 citations

Bioerodible polyanhydrides as drug‐carrier matrices. II. Biocompatibility and chemical reactivity

1986 • 258 citations

Angiogenesis inhibition by minocycline.

1991 • 254 citations

Interstitial chemotherapy of the 9L gliosarcoma: controlled release polymers for drug delivery in the brain.

1993 • 225 citations

Biodegradation of and tissue reaction to 50:50 poly(DL‐lactide‐co‐glycolide) microcapsules

1985 • 221 citations

Bioerodible polyanhydrides for controlled drug delivery

1983 • 217 citations

The intracerebral distribution of BCNU delivered by surgically implanted biodegradable polymers

1992 • 215 citations

Microcapsules and Nanoparticles in Medicine and Pharmacy

2020 • 210 citations

Biodegradation and brain tissue reaction to poly(D,L-lactide-co-glycolide) microspheres

1993 • 181 citations

Long-term cross-species brain transplantation of a polymer-encapsulated dopamine-secreting cell line

1991 • 175 citations

Behavioral recovery following intrastriatal implantation of microencapsulated PC12 cells

1991 • 168 citations

Transplantation of neural tissue in polymer capsules

1988 • 164 citations

Brain biocompatibility of a biodegradable, controlled‐release polymer in rats

1989 • 156 citations

Preparation and evaluation in vitro of polylactic acid microspheres containing local anesthetics.

1981 • 138 citations

Formation and Characterization of Cisplatin Loaded Poly(d,l-Lactide) Microspheres for Chemoembolization

1986 • 136 citations

Biocompatibility of a Biodegradable, Controlled-Release Polymer in the Rabbit Brain

1989 • 127 citations

Sustained Release of Nerve Growth Factor from Biodegradable Polymer Microspheres

1992 • 120 citations

Macroencapsulation of dopamine-secreting cells by coextrusion with an organic polymer solution

1991 • 118 citations

An encapsulated dopamine-releasing polymer alleviates experimental parkinsonism in rats

1989 • 117 citations

Diffusion in Polymer Gel Implants

1974 • 110 citations

Controlled release of dopamine from a polymeric brain implant: In vivo characterization

1989 • 104 citations

NGF released from a polymer matrix prevents loss of ChAT expression in basal forebrain neurons following a fimbria-fornix lesion

1990 • 101 citations

Controlled release of nerve growth factor from a polymeric implant

1990 • 96 citations

Controlled delivery of 1,3-bis(2-chloroethyl)-1-nitrosourea from ethylene-vinyl acetate copolymer.

1989 • 93 citations

Intralesional Infusion of Lymphokine-activated Killer (LAK) Cells and Recombinant Interleukin-2 (rIL-2) for the Treatment of Patients with Malignant Brain Tumor

1988 • 93 citations

Polymers to treat brain tumours

1990 • 92 citations

A physicochemical study of the morphology of progesterone-loaded poly (d,l-lactide) microspheres

1986 • 89 citations

Visualization of migration of transplanted astrocytes using polystyrene microspheres

1988 • 88 citations

Preparation of Poly(D,L-Lactide/Glycolide) Nanoparticles of Controlled Particle Size Distribution: Application of Experimental Designs

1992 • 87 citations

Microencapsulation and Dissolution Properties of a Neuroleptic in a Biodegradable Polymer, Poly(d,l-lactide)

1985 • 84 citations

Modification in Growth of Transplantable Rat Tumors Exposed to Friend Virus

1969 • 77 citations

Estimation of growth fraction with bromodeoxyuridine in human central nervous system tumors

1986 • 76 citations

Cytokines in neural regeneration

1992 • 74 citations

Growth inhibition of the 9L glioma using polymers to release heparin and cortisone acetate

1990 • 73 citations

Effect of particle size on the in vitro and in vivo degradation rates of poly(DL‐lactide‐co‐glycolide) microcapsules

1988 • 72 citations

Protective effect of NGF atelocollagen mini-pellet on the hippocampal delayed neuronal death in gerbils

1992 • 71 citations

Intracerebral drug delivery in rats with lesion-induced memory deficits

1989 • 71 citations

Polymeric controlled release of dexamethasone in normal rat brain

1991 • 66 citations

In vivo peptide release from poly(dl-lactic acid-co-glycolic acid) copolymer 5050 microspheres

1991 • 64 citations

The formation and characterization of hydrocortisone-loaded poly((±)-lactide) microspheres

1986 • 63 citations

Use of Implantable Pumps for Central Nervous System Drug Infusions to Treat Neurological Disease

1988 • 61 citations

Controlled release of dopamine from a polymeric brain implant: In vitro characterization

1989 • 58 citations

Polymer implants for drug delivery in the brain

1991 • 56 citations

Sustained behavioral recovery from unilateral nigrostriatal damage produced by the controlled release of dopamine from a silicone polymer pellet placed into the denervated striatum

1990 • 56 citations

Interstitial delivery of dexamethasone in the brain for the reduction of peritumoral edema

1991 • 56 citations

[30] Controlled release and magnetically modulated release systems for macromolecules

1985 • 52 citations

Implantable microencapsulated dopamine (DA): A new approach for slow-release DA delivery into brain tissue

1988 • 50 citations

Transplantation strategies in the treatment of Parkinson's disease: experimental basis and clinical trials

1989 • 43 citations

Neurosurgery Quarterly

1994 • 42 citations

[Treatment of malignant brain tumors with slowly releasing anticancer drug-polymer composites].

1986 • 33 citations

Controlled release of 4‐hydroperoxycyclophosphamide from the fatty acid dimer‐sebacic acid copolymer

1992 • 29 citations

In vivo Fate of Repeat-Unit-Radiolabelled Poly(β-malic acid), a Potential Drug Carrier

1992 • 29 citations

The intraneoplastic chemotherapy in a rat brain tumour model utilizing methotrexate-polymethylmethacrylate-pellets

1987 • 26 citations

Polymers as controlled drug delivery devices for the treatment of malignant brain tumors

1993 • 21 citations

[Treatment of brain tumors with anticancer pellet--experimental and clinical study (author's transl)].

1982 • 20 citations

Microencapsulation of isolated pituitary cells by polyacrylamide microlatex coagulation on agarose beads

1991 • 20 citations

Microencapsulated monosialoganglioside GM1: Physical properties andin vivoeffects

1989 • 17 citations

Growth of tumour cell lines in polymer capsules: ultrastructure of encapsulated PC12 cells

1992 • 15 citations

Site-specific drug delivery to CNS: Old and new

1989 • 14 citations

Neurotrophic Factors and Neurodegenerative Diseases

1991 • 6 citations

Deleted Work

1955 • 0 citations