Interstitial chemotherapy for brain tumors: review

Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporation.

1978 • 2,254 citations

Controlled Release of Biologically Active Agents

1987 • 542 citations

Bioerodible polyanhydrides as drug‐carrier matrices. I: Characterization, degradation, and release characteristics

1985 • 532 citations

Topographic anatomy and CT correlations in the untreated glioblastoma multiforme

1988 • 450 citations

The use of silicone rubber as a carrier for prolonged drug therapy

1964 • 343 citations

Chemotherapy for malignant gliomas

1988 • 343 citations

The release of gentamicin from polymethylmethacrylate beads. An experimental and pharmacokinetic study

1978 • 328 citations

Intrathecal chemotherapy: brain tissue profiles after ventriculocisternal perfusion.

1975 • 321 citations

Passage of Steroids Through Silicone Rubber

1966 • 309 citations

Bioerodible polyanhydrides as drug‐carrier matrices. II. Biocompatibility and chemical reactivity

1986 • 258 citations

Controlled drug delivery: Fundamentals and applications

1988 • 235 citations

Neurotoxicity of antineoplastic drugs.

1982 • 231 citations

Bioerodible polyanhydrides for controlled drug delivery

1983 • 217 citations

Chemotherapy of Brain Tumors

1977 • 196 citations

Permeability Characteristics of Brain Adjacent to Tumors in Rats

1975 • 165 citations

Controlled release of biologically active agents

1988 • 163 citations

Cell kinetics of human gliomas

1972 • 158 citations

Mechanisms of Drug Absorption and Excretion Passage of Drugs in and out of the Central Nervous System

1962 • 147 citations

Wiener Klinische Wochenschrift

1966 • 140 citations

Sustained release hormonal preparations. I. Diffusion of various steroids through polymer membranes

1968 • 140 citations

Neurotoxicity of chemotherapeutic agents after blood‐brain barrier modification: Neuropathological studies

1983 • 129 citations

Evaluation of postoperative intratumoral injection of bleomycin for craniopharyngioma in children

1985 • 126 citations

Arterial Chemoembolization With Microencapsulated Anticancer Drug

1981 • 121 citations

Heuristic modeling of drug delivery to malignant brain tumors

1980 • 112 citations

Chemotherapy of Solid Tumors with Triethylene Thiophosphoramide

1955 • 106 citations

Cerebrospinal fluid perfusion for central nervous system neoplasms

1966 • 103 citations

Chemotherapy of brain tumors: physiological and pharmacokinetic considerations.

1986 • 97 citations

Evaluation, Control, and Prediction of Drug Diffusion Through Polymeric Membranes II

1968 • 91 citations

Intracerebral Chemotherapy

1982 • 78 citations

Principles of brain tumor chemotherapy.

1986 • 72 citations

Spatial distribution of dopamine, methotrexate and antipyrine during continuous intracerebral microperfusion

1985 • 72 citations

Mechanisms of Drug Absorption and Excretion

1964 • 71 citations

Sustained release hormonal preparations

1968 • 69 citations

Brain-tumor chemotherapy

1977 • 60 citations

Methotrexate, cytosine arabinoside, and BCNU concentration in brain after ventriculocisternal perfusion.

1977 • 53 citations

Postoperative intracavitary chemotherapy of malignant gliomas

1973 • 53 citations

In vitro drug sensitivity testing in human gliomas

1987 • 51 citations

Chemosensitivity of malignant human brain tumors

1983 • 49 citations

Direct Delivery of Medication into a Brain Tumor through Multiple Chronically Implanted Catheters

1987 • 49 citations

Evaluation, Control, and Prediction of Drug Diffusion Through Polymeric Membranes III

1968 • 48 citations

THE EXTRACELLULAR SPACE IN BRAIN TUMOURS

1970 • 43 citations

Sustained release hormonal preparations

1968 • 39 citations

Bleomycin and brain tumors

1983 • 39 citations

Intraneoplastic injection of methotrexate for experimental brain-tumor chemotherapy

1977 • 37 citations

Use of Polymers in Controlled Release of Active Agents

1987 • 34 citations

THE EXTRACELLULAR SPACE IN BRAIN TUMOURS

1970 • 34 citations

Postoperative intracavitary chemotherapy of malignant supratentorial astrocytomas using BCNU.

1975 • 33 citations

Chronic Intratumoral Chemotherapy of a Rat Tumor with Cisplatin and Fluorouracil

1983 • 33 citations

[Treatment of malignant brain tumors with slowly releasing anticancer drug-polymer composites].

1986 • 33 citations

TREATMENT OF INTRACRANIAL GLIOMAS AND METASTATIC CARCINOMAS BY LOCAL APPLICATION OF CYTOSTATIC AGENTS

1968 • 31 citations

Neurotoxicity of adriamycin (Doxorubicin) perfused through the cerebrospinal fluid spaces of the rhesus monkey

1978 • 30 citations

Report of vascilitis and blindness after intracarotid injection of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU; NSC-409962) in dogs.

1973 • 30 citations

Studies on the intracerebral injection of bleomycin free and entrapped within liposomes in the rat.

1984 • 28 citations

Uptake of bleomycin by human brain tumours

1976 • 28 citations

Treatment of malignant brain tumors by local methotrexate. A preliminary report.

1969 • 26 citations

The intraneoplastic chemotherapy in a rat brain tumour model utilizing methotrexate-polymethylmethacrylate-pellets

1987 • 26 citations

A potential application for the intracerebral injection of drugs entrapped within liposomes in the treatment of human cerebral gliomas.

1985 • 26 citations

Intraneoplastic Administration of Bleomycin in Intracerebral Gliomas: A Pilot Study

1980 • 24 citations

Study of effectiveness of bleomycin in rat brain tumor model intravenously and intracerebrally

1979 • 23 citations

Lokale Chemotherapie der Hirntumoren

1963 • 21 citations

Intraneoplastic injection of CCNU for experimental brain tumor chemotherapy.

1977 • 20 citations

Controlled release rate of a lipophilic drug (BCNU) from a refillable silicone rubber device

1982 • 20 citations

[Treatment of brain tumors with anticancer pellet--experimental and clinical study (author's transl)].

1982 • 20 citations

Studies on the intracerebral injection of vincristine free and entrapped within liposomes in the rat

1985 • 17 citations

Therapy of an experimental glioma with systemic or intraneoplastic methotrexate or radiation

1977 • 15 citations

Intrathecal Chemotherapy

1970 • 15 citations

[A new treatment of malignant brain tumor -1: local injection of bleomycin (author's transl)].

1981 • 15 citations

Diffusion in vitro and in vivo of 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea from silicone rubber capsules, a potentially new mode of chemotherapy administration.

1973 • 15 citations

Treatment of malignant brain tumors with alkylating agents

1960 • 15 citations

CONTINUOUS CANCER THEMOTHERAPY

1972 • 14 citations

Studies on the use of antimitotic drugs entrapped within liposomes and of their action on a human glioma cell line

1984 • 14 citations

[Intracystic therapy of bleomycin for craniopharyngioma--effect of bleomycin for cultured craniopharyngioma cells and intracystic concentration of bleomycin (author's transl)].

1974 • 14 citations

[New management of brain neoplasms. 2. Local injection of adriamycin].

1983 • 12 citations

In vitro versus in vivo correlations of chemosensitivity of human medulloblastoma.

1984 • 11 citations

Trial of anticancer pellet in malignant brain tumours; 5 FU and urokinase embedded in silastic.

1979 • 10 citations

Sustained release of BCNU for the treatment of intraocular malignancies in animal models.

1979 • 10 citations

Release of a nitrosourea derivative from refillable silicone rubber implants for the treatment of intraocular malignancies.

1978 • 8 citations

[Clinical application of a sustained release anticancer pellet].

1985 • 7 citations

Focal chemotherapy of brain tumours using semipermeable membranes.

1977 • 6 citations

[Local use of cytostatic drugs following removal of glioblastomas].

1987 • 5 citations

[A device for prolonged releasing of anticancer drug--bleomycin (author's transl)].

1980 • 4 citations

[A device for prolonged releasing of anticancer drug--bleomycin: Second report].

1982 • 4 citations

[Intraneoplastic local injection of adriamycin for malignant brain tumor chemotherapy--a clinicopathological study (author's transl)].

1980 • 3 citations

[Necrotomy of brain stem glioma and local administration of anticancer agents].

1985 • 3 citations

[Evaluation of the sustained release of anticancer agents from silicone pellets].

1985 • 2 citations

Local Chemotherapy of Malignant Glioma

1986 • 2 citations

[Constant release of fluorouracil embedded in silastic (author's transl)].

1978 • 1 citations

[Experimental studies of brain edema by infusion edema model-- biophysical changes of edema fluid in white matter of the brain].

1983 • 1 citations

[Intraneoplastic local injection of adriamycin for the treatment of experimental brain tumor--an autoradiographic study (author's transl)].

1981 • 1 citations

Intraneoplastic local injection of adriamycin for the treatment of experimental brain tumor. An autoradiographic study.

1982 • 1 citations

Deleted Work

1955 • 0 citations