Neurotrophic molecules

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

The Cholinergic Hypothesis of Geriatric Memory Dysfunction

1982 • 5,422 citations

The Nerve Growth Factor 35 Years Later

1987 • 3,107 citations

Isolation of a Mouse Submaxillary Gland Protein Accelerating Incisor Eruption and Eyelid Opening in the New-born Animal

1962 • 2,192 citations

Nerve growth factor.

1968 • 2,025 citations

Purification of a new neurotrophic factor from mammalian brain.

1982 • 1,762 citations

Physiology of nerve growth factor.

1980 • 1,602 citations

Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections

1986 • 1,458 citations

A Nerve Growth Factor-Induced Gene Encodes a Possible Transcriptional Regulatory Factor

1987 • 1,217 citations

Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection.

1986 • 1,063 citations

Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor

1987 • 1,031 citations

Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection.

1987 • 1,012 citations

Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve

1987 • 1,000 citations

Proliferation, differentiation and degeneration in the spinal ganglia of the chick embryo under normal and experimental conditions

1949 • 974 citations

Effect of Granulocyte Colony-Stimulating Factor on Neutropenia and Associated Morbidity Due to Chemotherapy for Transitional-Cell Carcinoma of the Urothelium

1988 • 961 citations

Expression and structure of the human NGF receptor

1986 • 956 citations

Selective growth stimulating effects of mouse sarcoma on the sensory and sympathetic nervous system of the chick embryo

1951 • 947 citations

Gene transfer and molecular cloning of the rat nerve growth factor receptor

1987 • 946 citations

Nerve Growth Factor Treatment After Brain Injury Prevents Neuronal Death

1987 • 942 citations

Levels of nerve growth factor and its mRNA in the central nervous system of the rat correlate with cholinergic innervation.

1985 • 941 citations

THE NERVE GROWTH FACTOR: PURIFICATION AS A 30,000-MOLECULAR-WEIGHT PROTEIN

1969 • 920 citations

Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation.

1988 • 909 citations

Growth factors: Mechanism of action and relation to oncogenes

1984 • 885 citations

Interleukin-1 Stimulation of Astroglial Proliferation After Brain Injury

1985 • 855 citations

Effect of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor on Hematopoietic Reconstitution after High-Dose Chemotherapy and Autologous Bone Marrow Transplantation

1988 • 779 citations

Platelet-derived growth factor from astrocytes drives the clock that times oligodendrocyte development in culture

1988 • 760 citations

Fibroblast growth factor promotes survival of dissociated hippocampal neurons and enhances neurite extension.

1986 • 741 citations

NGF-Mediated increase of choline acetyltransferase (ChAT) in the neonatal rat forebrain: Evidence for a physiological role of NGF in the brain?

1983 • 725 citations

Differential regulation of mRNA encoding nerve growth factor and its receptor in rat sciatic nerve during development, degeneration, and regeneration: role of macrophages.

1987 • 711 citations

Basic fibroblast growth factor supports the survival of cerebral cortical neurons in primary culture.

1986 • 696 citations

PURIFICATION OF A NERVE-GROWTH PROMOTING PROTEIN FROM THE MOUSE SALIVARY GLAND AND ITS NEURO-CYTOTOXIC ANTISERUM

1960 • 692 citations

Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene

1988 • 661 citations

Nerve growth factors (NGF, BDNF) enhance axonal regeneration but are not required for survival of adult sensory neurons

1988 • 657 citations

Destruction of the sympathetic ganglia in mammals by an antiserum to a nerve-growth protein

1960 • 651 citations

Effect of Recombinant Human Granulocyte–Macrophage Colony-Stimulating Factor on Myelopoiesis in the Acquired Immunodeficiency Syndrome

1987 • 633 citations

Nerve growth factor receptors. Characterization of two distinct classes of binding sites on chick embryo sensory ganglia cells.

1979 • 627 citations

Induction of nerve growth factor receptor in Schwann cells after axotomy.

1986 • 614 citations

An immunohistochemical study of the nerve growth factor receptor in developing rats

1988 • 610 citations

Viral oncogenes

1985 • 605 citations

Basic fibroblast growth factor prevents death of lesioned cholinergic neurons in vivo

1988 • 599 citations

Specific retrograde transport of nerve growth factor (NGF) from neocortex to nucleus basalis in the rat

1984 • 598 citations

Axonal regeneration and synapse formation in the superior colliculus by retinal ganglion cells in the adult rat

1987 • 587 citations

Mouse prepro-epidermal growth factor synthesis by the kidney and other tissues

1985 • 568 citations

Nerve growth factor in sympathetic ganglia and corresponding target organs of the rat: correlation with density of sympathetic innervation.

1983 • 564 citations

Microtubule-Associated Proteins

1986 • 559 citations

Timing and site of nerve growth factor synthesis in developing skin in relation to innervation and expression of the receptor

1987 • 555 citations

Expression of nerve growth factor receptors by Schwann cells of axotomized peripheral nerves: ultrastructural location, suppression by axonal contact, and binding properties

1988 • 539 citations

Basic and acidic fibroblast growth factors have trophic effects on neurons from multiple CNS regions

1988 • 529 citations

Studies on the expression of the beta nerve growth factor (NGF) gene in the central nervous system: level and regional distribution of NGF mRNA suggest that NGF functions as a trophic factor for several distinct populations of neurons.

1986 • 528 citations

Development and regional expression of beta nerve growth factor messenger RNA and protein in the rat central nervous system.

1986 • 525 citations

Neuronal Chemotaxis: Chick Dorsal-Root Axons Turn Toward High Concentrations of Nerve Growth Factor

1979 • 522 citations

Purification of the Chick Eye Ciliary Neuronotrophic Factor

1984 • 519 citations

Expression of the beta-nerve growth factor gene correlates with the density of sympathetic innervation in effector organs.

1984 • 519 citations

Brain-derived neurotrophic factor supports the survival of cultured rat retinal ganglion cells

1986 • 519 citations

A NERVE GROWTH-STIMULATING FACTOR ISOLATED FROM SARCOM AS 37 AND 180

1954 • 513 citations

Grafting Genetically Modified Cells to the Damaged Brain: Restorative Effects of NGF Expression

1988 • 508 citations

Nerve growth factor-induced neurite outgrowth in PC12 cells involves the coordinate induction of microtubule assembly and assembly-promoting factors.

1985 • 506 citations

A monoclonal antibody modulates the interaction of nerve growth factor with PC12 cells.

1984 • 503 citations

Dorsal Root Ganglion Neurons Are Destroyed by Exposure in Utero to Maternal Antibody to Nerve Growth Factor

1980 • 500 citations

The expression, localization and functional significance of β-nerve growth factor in the central nervous system

1987 • 496 citations

Astroglial and fibroblast growth factors have neurotrophic functions for cultured peripheral and central nervous system neurons.

1987 • 495 citations

Nerve growth factor increases choline acetyl-transferase but not survival or fiber outgrowth of cultured fetal septal cholinergic neurons

1985 • 491 citations

Brain-derived neurotrophic factor prevents neuronal death in vivo

1988 • 490 citations

Choline Acetyltransferase Activity in Striatum of Neonatal Rats Increased by Nerve Growth Factor

1985 • 483 citations

Differential expression of insulin-like growth factor genes in rat central nervous system.

1988 • 477 citations

Anterograde and Retrograde Transneuronal Degeneration in the Central and Peripheral Nervous System

1970 • 457 citations

Pathogenesis of Herpetic Neuritis and Ganglionitis in Mice: Evidence for Intra-Axonal Transport of Infection

1973 • 456 citations

Interleukin-1 is an astroglial growth factor in the developing brain

1988 • 442 citations

Nerve Growth Factor Gene Expression in the Developing Rat Brain

1986 • 436 citations

Effects of insulin, insulin-like growth factor-II, and nerve growth factor on neurite formation and survival in cultured sympathetic and sensory neurons

1986 • 426 citations

Reduction of the naturally occurring motor neuron loss by enlargement of the periphery

1976 • 425 citations

Neuronal death in the spinal ganglia of the chick embryo and its reduction by nerve growth factor

1981 • 407 citations

Environmental influences in the development of neural crest derivatives: glucocorticoids, growth factors, and chromaffin cell plasticity

1985 • 406 citations

Influences of peripheral nerve grafts on the survival and regrowth of axotomized retinal ganglion cells in adult rats

1988 • 402 citations

Nerve Growth Factor from Mouse Submaxillary Gland: Amino Acid Sequence

1971 • 401 citations

Distribution of neuronal receptors for nerve growth factor in the rat

1986 • 398 citations

The effects of wing bud extirpation on the development of the central nervous system in chick embryos

1934 • 389 citations

Placode and neural crest-derived sensory neurons are responsive at early developmental stages to brain-derived neurotrophic factor

1985 • 384 citations

Nerve growth factor and Alzheimer's disease

1986 • 378 citations

Fibroblast growth factor

1986 • 367 citations

Relationship between levels of nerve growth factor (NGF) and its messenger RNA in sympathetic ganglia and peripheral target tissues.

1984 • 359 citations

A diffusible agent of mouse sarcoma, producing hyperplasia of sympathetic ganglia and hyperneurotization of viscera in the chick embryo

1953 • 359 citations

Fibroblast growth factors promote the survival of adult rat retinal ganglion cells after transection of the optic nerve

1987 • 355 citations

Acidic and basic fibroblast growth factors promote stable neurite outgrowth and neuronal differentiation in cultures of PC12 cells

1987 • 353 citations

Regression versus peripheral control of differentiation in motor hypoplasia

1958 • 350 citations

Functional and structural changes in mammalian sympathetic neurones following interruption of their axons.

1975 • 348 citations

Trophic regulation of nerve cell morphology and innervation in the autonomic nervous system

1988 • 342 citations

Nerve growth factor mRNA in peripheral and central rat tissues and in the human central nervous system: Lesion effects in the rat brain and levels in Alzheimer's disease

1986 • 335 citations

Insulin and insulin-like growth factors in the CNS

1988 • 334 citations

Molecular Cloning and Expression of Neuroleukin, a Neurotrophic Factor for Spinal and Sensory Neurons

1986 • 332 citations

Characterization of nerve growth factor receptor in neural crest tumors using monoclonal antibodies.

1984 • 318 citations

Nerve growth factor protects adult sensory neurons from cell death and atrophy caused by nerve injury

1987 • 316 citations

Morphometric analysis of rat superior cervical ganglion after axotomy and nerve growth factor treatment

1976 • 311 citations

Selective Induction by Nerve Growth Factor of Tyrosine Hydroxylase and Dopamine-β-Hydroxylase in the Rat Superior Cervical Ganglia

1971 • 308 citations

Naturally Occurring Neuron Death and Its Regulation by Developing Neural Pathways

1982 • 306 citations

Expression and possible function of nerve growth factor receptors on Schwann cells

1988 • 304 citations

Trophic Stimulation of Cultured Neurons from Neonatal Rat Brain by Epidermal Growth Factor

1987 • 297 citations

Proliferation and differentiation of embryonic chick sympathetic neurons: Effects of ciliary neurotrophic factor

1989 • 297 citations

Localization of nerve growth factor receptors in cholinergic neurons of the human basal forebrain

1986 • 289 citations

Pharmacological effects of nerve growth factor and fibroblast growth factor applied to the transectioned sciatic nerve on neuron death in adult rat dorsal root ganglia

1987 • 285 citations

Nerve growth factor receptor molecules in rat brain.

1986 • 268 citations

Epidermal Growth Factor Immunoreactive Material in the Central Nervous System: Location and Development

1984 • 266 citations

Ultrastructural differences during embryonic cell death in normal and peripherally deprived ciliary ganglia.

1976 • 266 citations

The neurotrophic factor neuroleukin is 90% homologous with phosphohexose isomerase

1988 • 265 citations

The effects of nerve growth factor and its antiserum on the postnatal development and survival after injury of sensory neurons in rat dorsal root ganglia

1984 • 265 citations

Evidence that endogenous beta nerve growth factor is responsible for the collateral sprouting, but not the regeneration, of nociceptive axons in adult rats.

1987 • 265 citations

Implantation of tumors in the hind limb field of the embryonic chick and the developmental response of the lumbosacral nervous system

1948 • 263 citations

Expression of the insulin-like growth factor II gene in the choroid plexus and the leptomeninges of the adult rat central nervous system.

1988 • 262 citations

Purification of adult rat sciatic nerve ciliary neuronotrophic factor

1986 • 253 citations

Basic FGF induces neuronal differentiation, cell division, and NGF dependence in chromaffin cells: A sequence of events in sympathetic development

1988 • 252 citations

The response of chick sensory neurons to brain-derived neurotrophic factor

1986 • 251 citations

Expression of NGF receptor in the developing and adult primate central nervous system

1988 • 251 citations

Type-2 astrocyte development in rat brain cultures is initiated by a CNTF like protein produced by type-1 astrocytes

1988 • 249 citations

Nerve growth factor promotes cholinergic development in brain striatal cultures.

1985 • 245 citations

Insulin growth factors regulate the mitotic cycle in cultured rat sympathetic neuroblasts.

1988 • 239 citations

Development of sympathetic neurons in compartmentalized cultures

1982 • 239 citations

Decreased level of nerve growth factor (NGF) and its messenger RNA in the aged rat brain

1987 • 237 citations

The role of NGF in sensory neurons in vivo

1986 • 233 citations

A nerve growth factor-regulated messenger RNA encodes a new intermediate filament protein.

1988 • 232 citations

Neurotrophic Factors

1985 • 230 citations

A new method of destroying adrenergic nerves in adult animals using guanethidine

1971 • 222 citations

Experimental autoimmune model of nerve growth factor deprivation: Effects on developing peripheral sympathetic and sensory neurons

1979 • 220 citations

Reduction of Naturally Occurring Motoneuron Death in Vivo by a Target-Derived Neurotrophic Factor

1988 • 213 citations

The ontogeny of epidermal growth factor receptors during mouse development

1984 • 213 citations

Motoneuron death after sciatic nerve section in newborn rats

1984 • 213 citations

Effects of long-term nerve growth factor deprivation on the nervous system of the adult rat: An experimental autoimmune approach

1980 • 210 citations

Epidermal growth factor binding and mitogenic activity on purified populations of cells from the central nervous system

1982 • 206 citations

Studies in Developmental Neurobiology. Essays in Honor of Viktor Hamburger

1982 • 205 citations

Cell death of motoneurons in the chick embryo spinal cord. IX. The loss of motoneurons following removal of afferent inputs

1984 • 202 citations

Cell death of motoneurons in the chick embryo spinal cord. III. The differentiation of motoneurons prior to their induced degeneration following limb‐bud removal

1978 • 200 citations

Nerve growth factor stimulates the development of substance P in sensory ganglia.

1980 • 198 citations

Epidermal growth factor stimulates DNA-synthesis of astrocytes in primary cerebellar cultures

1981 • 197 citations

Association of 125I-nerve growth factor with PC12 pheochromocytoma cells. Evidence for internalization via high-affinity receptors only and for long-term regulation by nerve growth factor of both high- and low-affinity receptors.

1984 • 197 citations

Sympathetic Nerve Cell Destruction in Newborn Mammals by 6-Hydroxydopamine

1970 • 194 citations

Mouse glucose-6-phosphate isomerase and neuroleukin have identical 3′ sequences

1988 • 192 citations

Ganglion cell death during normal retinal development in the chick: Comparisons with cell death induced by early target field destruction

1979 • 189 citations

In vivo effect of brain-derived neurotrophic factor on the survival of developing dorsal root ganglion cells.

1987 • 187 citations

Axonal Elongation in Peripheral and Central Nervous System Transplants

1982 • 186 citations

Spread of herpes simplex virus in peripheral nerves

1971 • 186 citations

Activation of Latent Herpes Simplex by Trigeminal Sensory-Root Section

1952 • 178 citations

Nerve growth factor receptor immunoreactivity in the nonhuman primate (Cebus apella): Distribution, morphology, and colocalization with cholinergic enzymes

1988 • 176 citations

Nerve growth factor enhances dendritic arborization of sympathetic ganglion cells in developing mammals

1988 • 171 citations

Latent Ganglionic Infection with Herpes Simplex Virus Types 1 and 2: Viral Reactivation in vivo after Neurectomy

1974 • 171 citations

The effects of nerve growth factor and its antiserum on synapses in the superior cervical ganglion of the guinea‐pig.

1978 • 169 citations

Nerve growth factor effects and receptors in cultured human neuroblastoma cell lines

1982 • 168 citations

The spatial and temporal pattern of beta NGF receptor expression in the developing chick embryo.

1985 • 163 citations

Regulation of microtubule protein levels during cellular morphogenesis in nerve growth factor-treated PC12 cells.

1988 • 160 citations

Different factors from the central nervous system and periphery regulate the survival of sensory neurones

1986 • 159 citations

Muscle-derived factors that support survival and promote fiber outgrowth from embryonic chick spinal motor neurons in culture

1986 • 157 citations

Nerve growth factor deprivation results in the reactivation of latent herpes simplex virus in vitro

1987 • 156 citations

Cell loss in the trochlear nucleus of the chick during normal development and after radical extirpation of the optic vesicle

1967 • 155 citations

Regulation of microtubule composition and stability during nerve growth factor-promoted neurite outgrowth.

1986 • 154 citations

Naturally-occurring neuron death in the ciliary ganglion of the chick embryo following removal of preganglionic input: evidence for the role of afferents in ganglion cell survival

1987 • 154 citations

Role of nerve growth factor in the adult dorsal root ganglia neuron and its response to injury

1984 • 152 citations

Retrograde transport of nerve growth factor (NGF) in motoneurons of developing rats: Assessment of potential neurotrophic effects

1988 • 151 citations

Characterization of nerve growth factor-dependent herpes simplex virus latency in neurons in vitro

1988 • 151 citations

Nerve growth factor induces the genes for two proteins related to a family of calcium-binding proteins in PC12 cells.

1988 • 148 citations

Cell death of motoneurons in the chick embryo spinal cord. VI. Reduction of naturally occurring cell death in the thoracolumbar column of terni by nerve growth factor

1982 • 147 citations

Binding characteristics of brain-derived neurotrophic factor to its receptors on neurons from the chick embryo

1988 • 142 citations

Neurite outgrowth from embryonic chicken spinal neurons is promoted by media conditioned by muscle cells.

1981 • 141 citations

Analysis of the effects of the antiserum to the nerve growth factor in adult mice

1971 • 140 citations

Nerve growth factor regulates both the phosphorylation and steady-state levels of microtubule-associated protein 1.2 (MAP1.2).

1988 • 139 citations

Quantitative histochemistry of brain acetylcholinesterase and learning rate in the aged rat

1986 • 136 citations

Pyruvate participation in the low molecular weight trophic activity for central nervous system neurons in glia-conditioned media

1985 • 135 citations

Motoneurons purified by cell sorting respond to two distinct activities in myotube-conditioned medium

1984 • 133 citations

PC12 cells express juvenile microtubule-associated proteins during nerve growth factor-induced neurite outgrowth.

1988 • 133 citations

Increased beta-nerve growth factor messenger RNA and protein levels in neonatal rat hippocampus following specific cholinergic lesions

1987 • 132 citations

Nerve Growth Factor

1977 • 130 citations

Somatic and behavioural postnatal effects of fetal injections of nerve growth factor antibodies in the rat

1981 • 125 citations

Developing dorsal root ganglion neurons require trophic support from their central processes: evidence for a role of retrogradely transported nerve growth factor from the central nervous system to the periphery.

1984 • 125 citations

Quantitative in vitro studies on the nerve growth factor (NGF) requirement of neurons

1977 • 120 citations

International Review of Neurobiology

1964 • 116 citations

Stability of numbers but not size of mouse forebrain cholinergic neurons to 53 months

1985 • 111 citations

Cell death of axotomized motoneurones in neonatal rats, and its prevention by peripheral reinnervation.

1987 • 110 citations

What, if anything, is a neurotrophic factor?

1988 • 108 citations

Isolation of embryonic chick motoneurons and their survival in vitro

1986 • 107 citations

Suppression of sprouting at the neuromuscular junction by immune sera

1984 • 105 citations

Outgrowth of sympathetic adrenergic neurons in mice treated with a nerve-growth factor (NGF)

1967 • 105 citations

Changes in the dendritic geometry of mouse superior cervical ganglion cells following postganglionic axotomy

1987 • 104 citations

A quantitative study of the developmental expression of nerve growth factor (NGF) receptor in rats

1987 • 102 citations

Target dependence of hypoglossal motor neurons during development and in maturity

1989 • 102 citations

Age‐related shrinkage of cortically projecting cholinergic neurons: A selective effect

1987 • 101 citations

Subunit structure of a high-molecular-weight form of the nerve growth factor from mouse submaxillary gland.

1967 • 100 citations

Similarities in development of substance P and somatostatin in peripheral sensory neurons: effects of capsaicin and nerve growth factor.

1981 • 100 citations

Reduction of experimentally induced neuronal death in spinal ganglia of the chick embryo by nerve growth factor

1984 • 99 citations

Expression of growth factor receptors in injured nervous tissue. I. Axotomy leads to a shift in the cellular distribution of specific β-nerve growth factor binding in the injured and regenerating PNS

1987 • 98 citations

A study of the de- and regenerative changes in the sympathetic nervous system of the adult mouse after treatment with the antiserum to nerve growth factor

1975 • 96 citations

Nerve growth factor antagonizes the neurotoxic action of capsaicin on primary sensory neurones

1983 • 95 citations

Biochemical effects of antibodies against nerve growth factor on developing and differentiated sympathetic ganglia

1978 • 94 citations

Fine structure of initial outgrowth of processes induced in a pheochromocytoma cell line (PC12) by nerve growth factor

1979 • 92 citations

The survival and growth of embryonic proprioceptive neurons is promoted by a factor present in skeletal muscle

1986 • 92 citations

Myelin phagocytosis in Wallerian degeneration of peripheral nerves depends on silica-sensitive,bg/bg-negative and Fc-positive monocytes

1986 • 92 citations

Short- and long-term effects of nerve growth factor on the sympathetic nervous system in the adult mouse

1975 • 91 citations

Guanethidine-Induced Destruction of Sympathetic Neurons

1984 • 91 citations

Neuronal growth factors produced by adult peripheral nerve after injury

1986 • 89 citations

Role of nerve growth factor in the development of rat sympathetic neurons in vitro. II. Developmental studies.

1977 • 88 citations

Expression of nerve growth factor receptor in human peripheral neuropathies

1988 • 86 citations

Functional and structural changes in mammalian sympathetic neurones following colchicine application to post‐ganglionic nerves.

1976 • 85 citations

Nerve growth factor (NGF) receptor expression in chicken cranial development

1987 • 85 citations

The synthesis of nerve growth factor (NGF) in developing skin is independent of innervation

1988 • 84 citations

Inhibition of Terminal Axonal Sprouting by Serum from Patients with Amyotrophic Lateral Sclerosis

1984 • 82 citations

Effects of antibodies to nerve growth factor on intrauterine development of derivatives of cranial neural crest and placode in the guinea pig

1983 • 79 citations

Fluorescence-activated cell sorting of embryonic mouse and rat motoneurons and their long-term survival in vitro

1987 • 78 citations

Regulation of the Synthesis of Nerve Growth Factor

1987 • 77 citations

The Developmental History of the Motor Neuron

1990 • 71 citations

Studies on the regulation of beta-nerve growth factor gene expression in the rat iris: the level of mRNA-encoding nerve growth factor is increased in irises placed in explant cultures in vitro, but not in irises deprived of sensory or sympathetic innervation in vivo.

1986 • 70 citations

Comparison of the effects of NGF, activators of protein kinase C, and a calcium ionophore on the expression of Thy-1 and N-CAM in PC12 cell cultures.

1988 • 69 citations

Short-latency local actions of nerve growth factor at the growth cone.

1983 • 68 citations

Ultrastructural Changes in the Rat Superior Cervical Ganglion Following Prolonged Guanethidine Administration

1971 • 67 citations

Immunochemical demonstration of reversible reduction in choline acetyltransferase concentration in rat hypoglossal nucleus after hypoglossal nerve transection

1978 • 66 citations

Immunization of adult rats against 2.5 S NGF: Effects on the peripheral sympathetic nervous system

1979 • 65 citations

The emerging generality of the neurotrophic hypothesis

1988 • 63 citations

Destruction of the sympathetic nervous system in neonatal rats and hamsters by vinblastine: prevention by concomitant administration of nerve growth factor

1978 • 63 citations

The effects of nerve growth factor (NGF) and antiserum to NGF on the development of embryonic sympathetic neurons in vivo

1980 • 63 citations

Reactivation of latent herpes simplex virus infection of the autonomic nervous system by postganglionic neurectomy

1978 • 62 citations

Time course and distribution of motoneuronal loss in the dorsal motor vagal nucleus of guinea pig after cervical vagotomy

1987 • 61 citations

Ultrastructural changes in sympathetic neurons of newborn and adult mice treated with nerve growth factor

1971 • 60 citations

Nerve growth factor increases substance P, cholecystokinin and vasoactive intestinal polypeptide immunoreactivities in primary sensory neurones of newborn rats

1982 • 59 citations

Survival of isthmo-optic neurons after early removal of one eye

1984 • 59 citations

Guanethidine-induced destruction of peripheral sympathetic neurons occurs by an immune-mediated mechanism

1983 • 58 citations

Expression of nerve growth factor receptor during human peripheral nerve development

1988 • 56 citations

Effects of exposure to nerve growth factor antibodies on the developing nervous system of the rat: An experimental autoimmune approach

1980 • 56 citations

NEURONAL–GLIAL INTERACTIONS

1986 • 55 citations

Light and electron microscopic studies on the excessive growth of sympathetic ganglia in rats injected daily from birth with 6-OHDA and NGF.

1975 • 55 citations

Purification of a human red blood cell protein supporting the survival of cultured CNS neurons, and its identification as catalase

1986 • 55 citations

Target organ regulation of sympathetic neuron development

1977 • 55 citations

Protection from guanethidine-induced neuronal destruction by nerve growth factor: Effect of NGF on immune function

1985 • 50 citations

The effect of target organ removal on the development of sympathetic neurons

1976 • 49 citations

Neurite-promoting activities for embryonic spinal neurons and their developmental changes in the chick

1984 • 49 citations

Principles of neural development

1986 • 48 citations

Polypeptide growth factors and the CNS

1986 • 47 citations

Effects of autoimmune NGF deprivation in the adult rabbit and offspring

1982 • 45 citations

Nerve Growth Factor in Neuronal Development and Maintenance

1987 • 45 citations

Increased formation of preganglionic synapses and axons due to a retrograde trans-synaptic action of nerve growth factor in the rat sympathetic nervous system

1983 • 45 citations

Structural gene for beta-nerve growth factor not defective in familial dysautonomia.

1984 • 44 citations

Nerve growth factor changes the relative levels of neuropeptides in developing sensory and sympathetic ganglia of the chick embryo

1985 • 43 citations

Cell surface Thy-1-cross-reactive glycoprotein in cultured PC12 cells: modulation by nerve growth factor and association with the cytoskeleton

1985 • 39 citations

Ultrastructural sequence of embryonic cell death in normal and peripherally deprived trochlear nucleus

1978 • 38 citations

Suppression of thein vitro andin vivo cytotoxic effects of guanethidine in sympathetic neurons by nerve growth factor

1974 • 38 citations

Dissociation between effects of nerve growth factor on tyrosine hydrolase and tubulin synthesis in sympathetic ganglia

1974 • 38 citations

Immunosympathectomy: Lack of evidence for a complement-mediated cytotoxic mechanism

1980 • 33 citations

Substrate-bound nerve growth factor promotes neurite growth in peripheral nerve

1987 • 33 citations

Nerve growth factor prevents vinblastine destructive effects on sympathetic ganglia in newborn mice.

1977 • 33 citations

Purification of bovine glia maturation factor and characterization with monoclonal antibody

1985 • 31 citations

Retrograde transport of NGF by early chick embryo spinal cord motoneurons

1988 • 28 citations

6-Hydroxydopamine Potentiates Acute Herpes Simplex Virus Infection of the Superior Cervical Ganglion in Mice

1979 • 23 citations

The effects of drugs which destroy the sympathetic nervous system on the retrograde transport of nerve growth factor

1979 • 22 citations

Some studies on the mechanism of action of antibodies to nerve growth factor

1979 • 19 citations

Effect of destruction of the postganglionic sympathetic neurons in neonatal rats on development of choline acetyltransferase and survival of preganglionic cholinergic neurons

1977 • 19 citations

DNA polymorphisms for the nerve growth factor receptor gene exclude its role in familial dysautonomia.

1986 • 18 citations

Intraocular herpes simplex virus injection in neonatal rats induces sympathetic nerve cell destruction: Effect of nerve growth factor

1987 • 13 citations

Sympathetic neuronal destruction in macaque monkeys by guanethidine and guanacline

1987 • 10 citations

The Biology of Nerve Growth Factor in Vivo

1988 • 5 citations