Oncogene expression during progression of mouse mammary tumor cells; activity of a proviral enhancer and the resulting expression of int-2 is influenced by the state of differentiation.

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Purification of Mouse Immunoglobulin Heavy‐Chain Messenger RNAs from Total Myeloma Tumor RNA

1980 • 2,696 citations

STEROID RECEPTOR REGULATED TRANSCRIPTION OF SPECIFIC GENES AND GENE NETWORKS

1985 • 1,911 citations

Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome

1982 • 1,790 citations

Amplification of a Novel v- erb B-Related Gene in a Human Mammary Carcinoma

1985 • 1,064 citations

Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes

1984 • 906 citations

Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations

1983 • 719 citations

Sequence-specific binding of glucocorticoid receptor to MTV DNA at sites within and upstream of the transcribed region

1983 • 700 citations

DNA sequences bound specifically by glucocorticoid receptor in vitro render a heterologous promoter hormone responsive in vivo

1983 • 692 citations

Evolution of tumours and the impact of molecular oncology

1985 • 666 citations

Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15

1984 • 609 citations

A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma.

1985 • 607 citations

The experimental study of tumor progression: a review.

1954 • 522 citations

AMPLIFICATION OF c-erbB-2 ONCOGENE IN HUMAN ADENOCARCINOMAS IN VIVO

1986 • 400 citations

Amino-acid substitutions at codon 13 of the N-ras oncogene in human acute myeloid leukaemia

1985 • 372 citations

Tumorigenesis by mouse mammary tumor virus: Proviral activation of a cellular gene in the common integration region int-2

1984 • 356 citations

Tumorigenesis by mouse mammary tumor virus: Evidence for a common region for provirus integration in mammary tumors

1983 • 327 citations

Subfragments of the large terminal repeat cause glucocorticoid-responsive expression of mouse mammary tumor virus and of an adjacent gene.

1983 • 238 citations

Sequence, topography and protein coding potential of mouse int-2: a putative oncogene activated by mouse mammary tumour virus.

1986 • 234 citations

A possible mammary stem cell line

1978 • 230 citations

Structure and nucleotide sequence of the putative mammary oncogene int-1; proviral insertions leave the protein-encoding domain intact

1984 • 222 citations

A small region of the mouse mammary tumor virus long terminal repeat confers glucocorticoid hormone regulation on a linked heterologous gene.

1983 • 213 citations

Two proto-oncogenes implicated in mammary carcinogenesis, int-1 and int-2, are independently regulated during mouse development.

1986 • 211 citations

Hormonal response region in the mouse mammary tumor virus long terminal repeat can be dissociated from the proviral promoter and has enhancer properties.

1985 • 164 citations

Concerted activation of two potential proto-oncogenes in carcinomas induced by mouse mammary tumour virus

1986 • 137 citations

Transfection of the int-1 mammary oncogene in cuboidal RAC mammary cell line results in morphological transformation and tumorigenicity.

1987 • 116 citations

Glucocorticoid regulation of mouse mammary tumor virus: identification of a short essential DNA region.

1983 • 115 citations

Nucleotide sequence and expression in vitro of cDNA derived from mRNA of int-1, a provirally activated mouse mammary oncogene.

1985 • 110 citations

Correlation of Glucocorticoid Receptor Binding Sites on MMTV Proviral DNA with Hormone Inducible Transcription

1983 • 70 citations

Activation of cellular gene by mouse mammary tumour virus may occur early in mammary tumour development

1984 • 70 citations

Glucocorticoid regulation of mouse mammary tumor virus sequences in transgenic mice.

1985 • 58 citations

In vitro differentiation and progression of mouse mammary tumor cells.

1986 • 56 citations

The Use of cDNA Clones and Monospecific Antibodies as Probes to Monitor Keratin Gene Expression

1985 • 56 citations

Sarcomatous Change and Maintenance of Differentiation in Long-Term Cultures of Mouse Mammary Carcinoma

1961 • 45 citations

Nucleotide Sequence and Expression In Vitro of cDNA Derived from mRNA of int-1, a Provirally Activated Mouse Mammary Oncogene

1985 • 27 citations