Unlocking the Mysteries of Diastolic Function

Recommendations for Chamber Quantification: A Report from the American Society of Echocardiography’s Guidelines and Standards Committee and the Chamber Quantification Writing Group, Developed in Conjunction with the European Association of Echocardiography, a Branch of the European Society of Cardiology

2005 • 11,108 citations

Trends in Prevalence and Outcome of Heart Failure with Preserved Ejection Fraction

2006 • 3,991 citations

Doppler Tissue Imaging: A Noninvasive Technique for Evaluation of Left Ventricular Relaxation and Estimation of Filling Pressures

1997 • 2,998 citations

Burden of Systolic and Diastolic Ventricular Dysfunction in the Community

2003 • 2,930 citations

Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: the CHARM-Preserved Trial

2003 • 2,845 citations

Clinical Utility of Doppler Echocardiography and Tissue Doppler Imaging in the Estimation of Left Ventricular Filling Pressures

2000 • 2,755 citations

Endothelial-to-mesenchymal transition contributes to cardiac fibrosis

2007 • 2,029 citations

Outcome of Heart Failure with Preserved Ejection Fraction in a Population-Based Study

2006 • 1,906 citations

Changes in Arterial Stiffness and Wave Reflection With Advancing Age in Healthy Men and Women

2004 • 1,437 citations

The perindopril in elderly people with chronic heart failure (PEP-CHF) study

2006 • 1,393 citations

Evaluation of Diastolic Filling of Left Ventricle in Health and Disease: Doppler Echocardiography Is the Clinician’s Rosetta Stone

1997 • 1,271 citations

Noninvasive determination of age-related changes in the human arterial pulse.

1989 • 1,148 citations

Left atrial volume as a morphophysiologic expression of left ventricular diastolic dysfunction and relation to cardiovascular risk burden

2002 • 1,117 citations

Congestive Heart Failure in the Community

1998 • 1,109 citations

Effects of age and aerobic capacity on arterial stiffness in healthy adults.

1993 • 1,064 citations

Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy

2005 • 886 citations

Effective arterial elastance as index of arterial vascular load in humans.

1992 • 773 citations

Diastolic Heart Failure

2004 • 772 citations

Age- and Gender-Related Ventricular-Vascular Stiffening

2005 • 751 citations

Mathematical model of geometry and fibrous structure of the heart

1991 • 658 citations

Lisinopril-Mediated Regression of Myocardial Fibrosis in Patients With Hypertensive Heart Disease

2000 • 636 citations

Left ventricular diastolic dysfunction as a predictor of the first diagnosed nonvalvular atrial fibrillation in 840 elderly men and women

2002 • 629 citations

Myocardial Structure and Function Differ in Systolic and Diastolic Heart Failure

2006 • 628 citations

The Giant Protein Titin

2004 • 627 citations

Losartan-Dependent Regression of Myocardial Fibrosis Is Associated With Reduction of Left Ventricular Chamber Stiffness in Hypertensive Patients

2002 • 616 citations

Best method in clinical practice and in research studies to determine left atrial size

1999 • 543 citations

Phosphodiesterase Type 5 Is Highly Expressed in the Hypertrophied Human Right Ventricle, and Acute Inhibition of Phosphodiesterase Type 5 Improves Contractility

2007 • 527 citations

Cardiac Structure and Ventricular–Vascular Function in Persons With Heart Failure and Preserved Ejection Fraction From Olmsted County, Minnesota

2007 • 526 citations

Cardiomyocyte Stiffness in Diastolic Heart Failure

2005 • 513 citations

Left ventricular flow propagation during early filling is related to wall relaxation: A color M-mode Doppler analysis

1992 • 482 citations

Left Ventricular Structure and Function

2006 • 464 citations

Diastolic Heart Failure

2007 • 443 citations

Diastolic Stress Echocardiography: Hemodynamic Validation and Clinical Significance of Estimation of Ventricular Filling Pressure With Exercise

2006 • 390 citations

Prediction of risk for first age-related cardiovascular events in an elderly population: the incremental value of echocardiography

2003 • 377 citations

Global Diastolic Strain Rate for the Assessment of Left Ventricular Relaxation and Filling Pressures

2007 • 374 citations

Long-term effects of darusentan on left-ventricular remodelling and clinical outcomes in the Endothelin A Receptor Antagonist Trial in Heart Failure (EARTH): randomised, double-blind, placebo-controlled trial

2004 • 353 citations

Impact of left ventricular ejection fraction on estimation of left ventricular filling pressures using tissue Doppler and flow propagation velocity

2003 • 351 citations

Importance of hemodynamic response to therapy in predicting survival with ejection fraction ≤ 20% secondary to ischemic or nonischemic dilated cardiomyopathy

1990 • 347 citations

Effect of angiotensin receptor blockade and antihypertensive drugs on diastolic function in patients with hypertension and diastolic dysfunction: a randomised trial

2007 • 334 citations

Transmitral blood flow reflecting diastolic behavior of the left ventricle in health and disease. A study by pulsed Doppler technique.

1982 • 332 citations

Usefulness of Left Atrial Volume in Predicting First Congestive Heart Failure in Patients ≥65 Years of Age With Well-Preserved Left Ventricular Systolic Function

2005 • 309 citations

The Effect of Alagebrium Chloride (ALT-711), a Novel Glucose Cross-Link Breaker, in the Treatment of Elderly Patients With Diastolic Heart Failure

2005 • 299 citations

Characteristics of left ventricular diastolic dysfunction in the community: an echocardiographic survey

2006 • 296 citations

Effects of Initiating Carvedilol in Patients With Severe Chronic Heart Failure

2003 • 295 citations

Diastolic stress echocardiography: A novel noninvasive diagnostic test for diastolic dysfunction using supine bicycle exercise Doppler echocardiography

2005 • 284 citations

Relationship of echocardiographic indices to pulmonary capillary wedge pressures in healthy volunteers

2000 • 249 citations

Persistence of Restrictive Left Ventricular Filling Pattern in Dilated Cardiomyopathy: An Ominous Prognostic Sign

1997 • 247 citations

Hemodynamic and Neurohumoral Effects of Selective Endothelin A (ET _A ) Receptor Blockade in Chronic Heart Failure

2002 • 233 citations

Prevention of Heart Failure in Patients in the Heart Outcomes Prevention Evaluation (HOPE) Study

2003 • 225 citations

Apex-to-Base Dispersion in Regional Timing of Left Ventricular Shortening and Lengthening

2005 • 220 citations

Regional ventricular wall thickening reflects changes in cardiac fiber and sheet structure during contraction: quantification with diffusion tensor MRI

2005 • 192 citations

Loading Manipulations Improve the Prognostic Value of Doppler Evaluation of Mitral Flow in Patients With Chronic Heart Failure

1997 • 182 citations

Time interval between onset of mitral inflow and onset of early diastolic velocity by tissue Doppler: a novel index of left ventricular relaxation

2003 • 176 citations

Left Ventricular Isovolumic Flow Sequence During Sinus and Paced Rhythms

2007 • 168 citations

Mechanisms of Disease: pathologic structural remodeling is more than adaptive hypertrophy in hypertensive heart disease

2005 • 166 citations

Annulus Paradoxus

2001 • 163 citations

Angiotensin-Converting Enzyme Inhibitors

2005 • 151 citations

The Irbesartan in Heart Failure With Preserved Systolic Function (I-PRESERVE) Trial: Rationale and Design

2005 • 139 citations

The Tip of the Iceberg

2008 • 137 citations

The pulmonary venous systolic flow pulse—its origin and relationship to left atrial pressure

1999 • 133 citations

Metoprolol controlled release/extended release in patients with severe heart failure

2001 • 132 citations

Estimation of Left Ventricular Filling Pressure with Exercise by Doppler Echocardiography in Patients with Normal Systolic Function: A Simultaneous Echocardiographic–Cardiac Catheterization Study

2007 • 126 citations

Aldosterone and Myocardial Fibrosis in Heart Failure

2000 • 124 citations

Zeisberg, E.M. et al. Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nat. Med. 13, 952-961

2007 • 123 citations

Contrasting Inotropic Effects of Endogenous Endothelin in the Normal and Failing Human Heart

2000 • 123 citations

Biphasic tissue Doppler waveforms during isovolumic phases are associated with asynchronous deformation of subendocardial and subepicardial layers

2005 • 103 citations

Effects of Quinapril on Left Atrial Structural Remodeling and Arterial Stiffness

2006 • 87 citations

Tolerability and dose-related effects of nebivolol in elderly patients with heart failure: Data from the Study of the Effects of Nebivolol Intervention on Outcomes and Rehospitalisation in Seniors with Heart Failure (SENIORS) trial

2007 • 85 citations

Comparison of Doppler echocardiography, color M-mode Doppler, and Doppler tissue imaging for the estimation of pulmonary capillary wedge pressure

2002 • 75 citations

Prescription of beta‐blockers in patients with advanced heart failure and preserved left ventricular ejection fraction. Clinical implications and survival

2006 • 73 citations

Statin‐Associated Pleiotropy: Possible Beneficial Effects Beyond Cholesterol Reduction

2006 • 61 citations

Chrome congestive heart failure

1994 • 53 citations

Haemodynamic insights into the effects of ischaemia and cycle length on tissue Doppler-derived mitral annulus diastolic velocities

2004 • 44 citations

Intraventricular early diastolic velocity profile during acute myocardial ischemia: A color M-mode Doppler echocardiographic study

1995 • 21 citations

Diastolic Heart Failure in the Elderly and the Potential Role of Aldosterone Antagonists

2006 • 21 citations

Cardiac effects of endothelin receptor antagonism in endotoxemic pigs

2007 • 17 citations

Doppler Tissue Imaging During Supine and Upright Exercise in Healthy Adults

2005 • 16 citations

Optimizing Treatment and Outcomes in Acute Heart Failure: Beyond Initial Triage

2006 • 15 citations