Phosphodiesterase Type 5 Is Highly Expressed in the Hypertrophied Human Right Ventricle, and Acute Inhibition of Phosphodiesterase Type 5 Improves Contractility

Right Ventricular Function and Failure

2006 • 1,179 citations

Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy

2005 • 886 citations

Oral Sildenafil Is an Effective and Specific Pulmonary Vasodilator in Patients With Pulmonary Arterial Hypertension

2002 • 589 citations

A Comparison of Oral Milrinone, Digoxin, and Their Combination in the Treatment of Patients with Chronic Heart Failure

1989 • 561 citations

Tissue distribution of phosphodiesterase families and the effects of sildenafil on tissue cyclic nucleotides, platelet function, and the contractile responses of trabeculae carneae and aortic rings in vitro

1999 • 522 citations

Use of sildenafil (Viagra) in patients with cardiovascular disease

1999 • 452 citations

Dichloroacetate Prevents and Reverses Pulmonary Hypertension by Inducing Pulmonary Artery Smooth Muscle Cell Apoptosis

2004 • 436 citations

The right ventricle in pulmonary hypertension

2005 • 424 citations

Structure, Localization, and Regulation of cGMP-inhibited Phosphodiesterase (PDE3)

1997 • 418 citations

Intestinal Secretory Defects and Dwarfism in Mice Lacking cGMP-Dependent Protein Kinase II

1996 • 405 citations

Long-Term Treatment With Oral Sildenafil Is Safe and Improves Functional Capacity and Hemodynamics in Patients With Pulmonary Arterial Hypertension

2003 • 381 citations

Sildenafil versus Endothelin Receptor Antagonist for Pulmonary Hypertension (SERAPH) Study

2005 • 379 citations

Complete reversal of fatal pulmonary hypertension in rats by a serine elastase inhibitor

2000 • 373 citations

Effects of sildenafil citrate on human hemodynamics

1999 • 369 citations

Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension

2005 • 355 citations

Antiproliferative Effects of Phosphodiesterase Type 5 Inhibition in Human Pulmonary Artery Cells

2005 • 354 citations

Right Ventricular Myocardium Derives From the Anterior Heart Field

2004 • 349 citations

Hemodynamic Effects of Sildenafil in Men with Severe Coronary Artery Disease

2000 • 286 citations

Differences in hemodynamic and oxygenation responses to three different phosphodiesterase-5 inhibitors in patients with pulmonary arterial hypertension

2004 • 285 citations

A Stimulatory Role for cGMP-Dependent Protein Kinase in Platelet Activation

2003 • 265 citations

Cardiac phosphodiesterase 5 (cGMP‐specific) modulates β‐adrenergic signaling in vivo and is down‐regulated in heart failure

2001 • 228 citations

Ventricular expression of brain natriuretic peptide in hypertrophic cardiomyopathy.

1993 • 209 citations

HEMODYNAMIC EFFECTS OF SILDENAFIL IN MEN WITH SEVERE CORONARY ARTERY DISEASE

2000 • 197 citations

Effect of sildenafil on the acute pulmonary vasodilator response to inhaled nitric oxide in adults with primary pulmonary hypertension

2002 • 171 citations

Sildenafil Inhibits β-Adrenergic–Stimulated Cardiac Contractility in Humans

2005 • 167 citations

Sympathetic Activation by Sildenafil

2000 • 123 citations

Role of sodium‐calcium exchange in activation of contraction in rat ventricle.

1993 • 98 citations

B-type natriuretic peptide: a myocyte-specific marker for characterizing load-induced alterations in cardiac gene expression.

1998 • 88 citations

Use of Sildenafil for Safe Improvement of Erectile Function and Quality of Life in Men With New York Heart Association Classes II and III Congestive Heart Failure

2004 • 86 citations

Sildenafil citrate does not affect cardiac contractility in human or dog heart

2003 • 64 citations

An evidence-based approach to the management of pulmonary arterial hypertension

2006 • 57 citations

A Fluorescence Polarization Assay for Cyclic Nucleotide Phosphodiesterases

2002 • 49 citations

Effect of 1-(3-chloroanilino)-4-phenylphthalazine (MY-5445), a specific inhibitor of cyclic GMP phosphodiesterase, on human platelet aggregation.

1984 • 47 citations

Effects of Sildenafil (Viagra) on Human Myocardial Contractility, In Vitro Arrhythmias, and Tension of Internal Mammaria Arteries and Saphenous Veins

2003 • 43 citations

An evidence-based approach to the management of pulmonary arterial hypertension

2006 • 35 citations

Hypothyroidism Decreases the ATP Sensitivity of K ATP Channels from Rat Heart

1998 • 33 citations

Functional effects of C-type natriuretic peptide and nitric oxide are attenuated in hypertrophic myocytes from pressure-overloaded mouse hearts

2004 • 20 citations

The Diagnosis and treatment of pulmonary hypertension

1992 • 18 citations

cAMP modulates cGMP-mediated cerebral arteriolar relaxation in vivo

2004 • 16 citations