Statin‐Associated Pleiotropy: Possible Beneficial Effects Beyond Cholesterol Reduction

Implications of Recent Clinical Trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines

2004 • 6,926 citations

Intensive versus Moderate Lipid Lowering with Statins after Acute Coronary Syndromes

2004 • 4,752 citations

Intensive Lipid Lowering with Atorvastatin in Patients with Stable Coronary Disease

2005 • 3,404 citations

From Vulnerable Plaque to Vulnerable Patient

2003 • 2,702 citations

Effects of Atorvastatin on Early Recurrent Ischemic Events in Acute Coronary Syndromes<SUBTITLE>The MIRACL Study: A Randomized Controlled Trial</SUBTITLE>

2001 • 2,473 citations

Paradoxical Vasoconstriction Induced by Acetylcholine in Atherosclerotic Coronary Arteries

1986 • 2,422 citations

Effect of Intensive Compared With Moderate Lipid-Lowering Therapy on Progression of Coronary Atherosclerosis

2004 • 2,346 citations

C-Reactive Protein Levels and Outcomes after Statin Therapy

2005 • 2,249 citations

From Vulnerable Plaque to Vulnerable Patient

2003 • 2,139 citations

PLEIOTROPIC EFFECTS OF STATINS

2004 • 1,860 citations

Pathophysiology of Coronary Artery Disease

2005 • 1,794 citations

Current Concepts of the Pathogenesis of the Acute Coronary Syndromes

2001 • 1,568 citations

Comparison of the efficacy and safety of rosuvastatin versus atorvastatin, simvastatin, and pravastatin across doses (STELLAR**STELLAR = Statin Therapies for Elevated Lipid Levels compared Across doses to Rosuvastatin. Trial)

2003 • 1,382 citations

The Lipid Research Clinics Coronary Primary Prevention Trial Results

1984 • 1,373 citations

Statin Therapy, LDL Cholesterol, C-Reactive Protein, and Coronary Artery Disease

2005 • 1,316 citations

Pleiotropic Effects of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors

2001 • 1,290 citations

Secondary Prevention by Raising HDL Cholesterol and Reducing Triglycerides in Patients With Coronary Artery Disease

2000 • 1,264 citations

New Concepts in Diastolic Dysfunction and Diastolic Heart Failure: Part I

2002 • 1,170 citations

Effect of Partial Ileal Bypass Surgery on Mortality and Morbidity from Coronary Heart Disease in Patients with Hypercholesterolemia

1990 • 999 citations

Pravastatin and the Development of Diabetes Mellitus

2001 • 854 citations

Influence of Pravastatin and Plasma Lipids on Clinical Events in the West of Scotland Coronary Prevention Study (WOSCOPS)

1998 • 804 citations

1995 Physicians' Desk Reference

1995 • 565 citations

Prior Statin Therapy Is Associated With a Decreased Rate of Severe Sepsis

2004 • 408 citations

High-Dose Atorvastatin Enhances the Decline in Inflammatory Markers in Patients With Acute Coronary Syndromes in the MIRACL Study

2003 • 403 citations

Atorvastatin for the Treatment of Mild to Moderate Alzheimer Disease

2005 • 392 citations

Statin therapy is associated with improved survival in ischemic and non-ischemic heart failure

2004 • 343 citations

Simvastatin Induces Regression of Cardiac Hypertrophy and Fibrosis and Improves Cardiac Function in a Transgenic Rabbit Model of Human Hypertrophic Cardiomyopathy

2001 • 341 citations

Can Low-Density Lipoprotein Be Too Low? The Safety and Efficacy of Achieving Very Low Low-Density Lipoprotein With Intensive Statin Therapy

2005 • 333 citations

Intensive cholesterol reduction lowers blood pressure and large artery stiffness in isolated systolic hypertension

2002 • 318 citations

Fluvastatin, a 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor, Attenuates Left Ventricular Remodeling and Failure After Experimental Myocardial Infarction

2002 • 309 citations

Statin Therapy May Be Associated With Lower Mortality in Patients With Diastolic Heart Failure

2005 • 301 citations

Effect of the HMG-CoA Reductase Inhibitors on Blood Pressure in Patients With Essential Hypertension and Primary Hypercholesterolemia

1999 • 281 citations

Statin Treatment After Onset of Sepsis in a Murine Model Improves Survival

2005 • 281 citations

Improvement of Left Ventricular Remodeling and Function by Hydroxymethylglutaryl Coenzyme A Reductase Inhibition With Cerivastatin in Rats With Heart Failure After Myocardial Infarction

2001 • 264 citations

Effect of Statin Use Within the First 24 Hours of Admission for Acute Myocardial Infarction on Early Morbidity and Mortality††A complete list of participating hospitals is available from ClinTrials Research, 1100 Weston Parkway, Cary, North Carolina 27513.

2005 • 244 citations

Statin therapy is associated with lower mortality among patients with severe heart failure

2004 • 183 citations

A statin in the treatment of heart failure? Controlled rosuvastatin multinational study in heart failure (CORONA): Study design and baseline characteristics

2005 • 158 citations

Simvastatin Blunts Endotoxin-Induced Tissue Factor In Vivo

2005 • 149 citations

Statin Use and Survival Outcomes in Elderly Patients With Heart Failure

2005 • 128 citations

Relationship Between Uncontrolled Risk Factors and C-Reactive Protein Levels in Patients Receiving Standard or Intensive Statin Therapy for Acute Coronary Syndromes in the PROVE IT-TIMI 22 Trial

2005 • 117 citations

Statins, Inflammation, and Sepsis*

2003 • 111 citations

Hydroxymethylglutaryl Coenzyme A Reductase Inhibitor Simvastatin Prevents Cardiac Hypertrophy Induced by Pressure Overload and Inhibits p21 ras Activation

2002 • 110 citations

The effect of cholesterol lowering on carotid and femoral artery wall stiffness and thickness in patients with familial hypercholesterolaemia

2000 • 106 citations

Cardiac Systolic and Diastolic Dysfunction After a Cholesterol-Rich Diet

2003 • 106 citations

Neuronal Nitric Oxide Synthase Mediates Statin-Induced Restoration of Vasa Nervorum and Reversal of Diabetic Neuropathy

2005 • 103 citations

A pilot study with simvastatin and folic acid/vitamin B12 in preparation for the Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH).

2000 • 96 citations

The Effect of Simvastatin Treatment on the Amyloid Precursor Protein and Brain Cholesterol Metabolism in Patients with Alzheimer’s Disease

2005 • 95 citations

Early Time to Benefit with Intensive Statin Treatment: Could It Be the Pleiotropic Effects?

2005 • 84 citations

Effect of bezafibrate on incidence of type 2 diabetes mellitus in obese patients

2005 • 83 citations

MANAGEMENT OF HYPERCHOLESTEROLEMIA

2000 • 77 citations

Pharmacologic Options for Aggressive Low-Density Lipoprotein Cholesterol Lowering: Benefits Versus Risks

2005 • 75 citations

Statin Use and Fracture Risk

2005 • 74 citations

Lipid research clinics coronary primary prevention trial: Results and implications

1984 • 70 citations

Disease-free intervals after partial ileal bypass in patients with coronary heart disease and hypercholesterolemia: report from the Program on the Surgical Control of the Hyperlipidemias (POSCH)

1995 • 70 citations

Rosuvastatin Reduces Platelet Activation in Heart Failure

2005 • 63 citations

Statins Induce the Regression of Left Ventricular Mass in Patients With Angina

2004 • 36 citations

The Lipid Research Clinics Coronary Primary Prevention Trial: design, results, and implications

1991 • 27 citations

Statins and osteoporosis: myth or reality?

2004 • 10 citations