Cultured Rat Hepatocytes

Glutathione S-Transferases

1974 • 17,321 citations

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

HIGH-YIELD PREPARATION OF ISOLATED RAT LIVER PARENCHYMAL CELLS

1969 • 4,428 citations

Casarett and Doull's Toxicology: The Basic Science of Poisons

1992 • 3,276 citations

Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450

1985 • 1,272 citations

Casarett and Doull's toxicology: The basic science of poisons

1996 • 1,168 citations

Casarett and Doull's toxicology

2015 • 1,127 citations

Anatomy of the rat

1935 • 927 citations

Hepatocyte function and extracellular matrix geometry: long‐term culture in a sandwich configuration

1989 • 727 citations

Long‐Term in Vitro Function of Adult Hepatocytes in a Collagen Sandwich Configuration

1991 • 695 citations

Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes.

1993 • 671 citations

Metabolic zonation of the liver: Regulation and implications for liver function

1992 • 558 citations

Support of cultured hepatocytes by a laminin-rich gel. Evidence for a functionally significant subendothelial matrix in normal rat liver.

1987 • 547 citations

Cell-cell and cell-matrix interactions differentially regulate the expression of hepatic and cytoskeletal genes in primary cultures of rat hepatocytes.

1988 • 534 citations

Maintenance and reversibility of active albumin secretion by adult rat hepatocytes co-cultured with another liver epithelial cell type

1983 • 511 citations

Regulation of gene expression in adult rat hepatocytes cultured on a basement membrane matrix

1988 • 470 citations

PARENCHYMAL CELLS FROM ADULT RAT LIVER IN NONPROLIFERATING MONOLAYER CULTURE

1973 • 427 citations

Cyclosporin A drug interactions. Screening for inducers and inhibitors of cytochrome P-450 (cyclosporin A oxidase) in primary cultures of human hepatocytes and in liver microsomes.

1990 • 423 citations

Connective tissue biomatrix: its isolation and utilization for long-term cultures of normal rat hepatocytes.

1980 • 395 citations

Regulation of Hepatic Metabolism

1986 • 394 citations

Use of a low-speed, iso-density percoll centrifugation method to increase the viability of isolated rat hepatocyte preparations

1986 • 385 citations

Hepatocyte proliferation in vitro: its dependence on the use of serum-free hormonally defined medium and substrata of extracellular matrix.

1984 • 376 citations

Maintenance of differentiated rat hepatocytes in primary culture.

1985 • 358 citations

Regio- and stereoselective metabolism of two C19 steroids by five highly purified and reconstituted rat hepatic cytochrome P-450 isozymes.

1983 • 339 citations

Regulation of testosterone hydroxylation by rat liver microsomal cytochrome P-450

1987 • 330 citations

Primary monolayer cultures of adult rat liver parenchymal cells suitable for study of the regulation of enzyme synthesis

1974 • 321 citations

Changes in Liver-Specific Compared to Common Gene Transcription During Primary Culture of Mouse Hepatocytes

1983 • 316 citations

Omeprazole is an aryl hydrocarbon-like inducer of human hepatic cytochrome P450

1990 • 310 citations

Isolated Hepatocytes Preparation, Properties and Applications

1991 • 287 citations

Conditions affecting primary cell cultures of functional adult rat hepatocytes

1976 • 265 citations

Formation of extensive canalicular networks by rat hepatocytes cultured in collagen-sandwich configuration

1994 • 260 citations

Rat hepatocyte primary cell cultures

1977 • 239 citations

Comparative analysis of cytochrome P4503A induction in primary cultures of rat, rabbit, and human hepatocytes.

1995 • 233 citations

Isolated and cultured hepatocytes

1986 • 222 citations

Modulation of functional activities in cultured rat hepatocytes

1983 • 219 citations

Cell-extracellular matrix interactions can regulate the switch between growth and differentiation in rat hepatocytes: reciprocal expression of C/EBP alpha and immediate-early growth response transcription factors.

1994 • 199 citations

Some electrical and pharmacological properties of gap junctions between adult ventricular myocytes

1985 • 182 citations

Induction of cytochrome P-450 by glucocorticoids in rat liver. II. Evidence that glucocorticoids regulate induction of cytochrome P-450 by a nonclassical receptor mechanism.

1984 • 182 citations

PARENCHYMAL CELLS FROM ADULT RAT LIVER IN NONPROLIFERATING MONOLAYER CULTURE

1973 • 182 citations

Microfilament Dysfunction as a Possible Cause of Intrahepatic Cholestasis

1975 • 178 citations

Induction of cytochrome P-450 by glucocorticoids in rat liver. I. Evidence that glucocorticoids and pregnenolone 16 alpha-carbonitrile regulate de novo synthesis of a common form of cytochrome P-450 in cultures of adult rat hepatocytes and in the liver in vivo.

1984 • 175 citations

Differential induction of rat liver microsomal UDP-glucuronosyltransferase activities by various inducing agents

1982 • 174 citations

Recent advances in the isolation of liver cells

1994 • 172 citations

Amino acid inhibition of the autophagic/lysosomal pathway of protein degradation in isolated rat hepatocytes

1980 • 172 citations

Phenobarbital induction of cytochromes P-450. High-level long-term responsiveness of primary rat hepatocyte cultures to drug induction, and glucocorticoid dependence of the phenobarbital response

1990 • 171 citations

The isoenzyme pattern of cytochrome P450 in rat hepatocytes in primary culture, comparing different enzyme activities in microsomal incubations and in intact monolayers

1990 • 162 citations

Posttranscriptional modulation of gene expression in cultured rat hepatocytes.

1984 • 161 citations

Induction of albumin gene transcription in hepatocytes by extracellular matrix proteins.

1990 • 157 citations

Expression of cytochrome P‐450 enzymes in cultured human hepatocytes

1990 • 157 citations

Cellular interactions promote tissue-specific function, biomatrix deposition and junctional communication of primary cultured hepatocytes

1988 • 148 citations

Influence of Extracellular Matrix Overlay on Phenobarbital-Mediated Induction of CYP2B1, 2B2, and 3A1 Genes in Primary Adult Rat Hepatocyte Culture

1993 • 140 citations

Long‐term maintenance of hepatocyte functional activity in co‐culture: Requirements for sinusoidal endothelial cells and dexamethasone

1986 • 140 citations

Omeprazole and lansoprazole are mixed inducers of CYP1A and CYP3A in human hepatocytes in primary culture.

1994 • 140 citations

Phalloidin-induced cholestasis: a microfilament-mediated change in junctional complex permeability.

1980 • 131 citations

Motility of bile canaliculi in the living animal: implications for bile flow.

1991 • 131 citations

Regulation of sexual differentiation in drug and steroid metabolism

1989 • 124 citations

Regulation of cytochrome P-450b/e and P-450p gene expression by growth hormone in adult rat hepatocytes cultured on a reconstituted basement membrane.

1990 • 108 citations

Long-term culture of hepatocytes: Effect of hormones on enzyme activities and metabolic capacity

1988 • 107 citations

Rat hepatocytes prepared without collagenase: Prolonged retention of differentiated characteristics in culture

1988 • 106 citations

Induction studies on the functional heterogeneity of rat liver UDP-glucuronosyltransferases

1982 • 97 citations

Long-term survival of functional hepatocytes from adult rat in the presence of phenobarbital in primary culture

1985 • 96 citations

Cultivation of adult rat hepatocytes on 3T3 cells: expression of various liver differentiated functions

1989 • 94 citations

A morphological study of differentiated hepatocytesin vitro

1995 • 94 citations

Reestablishment of cell polarity of rat hepatocytes in primary culture

1993 • 93 citations

Isolation of rat hepatocytes with EDTA and their metabolic functions in primary culture

1985 • 92 citations

Regulation of albumin synthesis by hormones and amino acids in primary cultures of rat hepatocytes

1987 • 91 citations

Expression of multiple forms of cytochrome P450 mRNAs in primary cultures of rat hepatocytes maintained on matrigel.

1993 • 91 citations

Modulation of xenobiotic-inducible cytochrome P450 gene expression by dexamethasone in primary rat hepatocytes

1995 • 89 citations

Rat hepatocyte cultures and co-cultures in biotransformation studies of xenobiotics

1993 • 87 citations

Rat Serum Carboxylesterase

1995 • 85 citations

Paradoxical transcriptional activation of rat liver cytochrome P-450 3A1 by dexamethasone and the antiglucocorticoid pregnenolone 16 alpha-carbonitrile: analysis by transient transfection into primary monolayer cultures of adult rat hepatocytes.

1992 • 84 citations

Regulation by dexamethasone of P-glycoprotein expression in cultured rat hepatocytes

1993 • 84 citations

Phase I and phase II xenobiotic biotransformation in cultures and co-cultures of adult rat hepatocytes

1990 • 81 citations

Studies on the maintenance of cytochromes P‐450 and b₅, monooxygenases and cytochrome reductases in primary cultures of rat hepatocytes

1985 • 80 citations

Attachment and long term survival of adult rat hepatocytes in primary monolayer cultures: Comparison of different substrata and tissue culture media formulations

1986 • 79 citations

Enhancement of liver cell gap junction protein expression by glucocorticoids

1994 • 77 citations

Long‐term effects of physiological oxygen concentrations on glycolysis and gluconeogenesis in hepatocyte cultures

1985 • 77 citations

Apparent maintenance of cytochrome P 450 by nicotinamide in primary cultures of rat hepatocytes

1979 • 75 citations

Effects of Extracellular Matrix on Hepatocyte Growth and Gene Expression: Implications for Hepatic Regeneration and the Repair of Liver Injury

1990 • 74 citations

Insulin inhibition of protein degradation in cell monolayers

1980 • 73 citations

Glucocorticoid regulation of the rat cytochrome P450c (P450IA1) gene: Receptor binding within intron I

1989 • 72 citations

Amino acid and energy requirements for rat hepatocytes in primary culture

1982 • 68 citations

Effects of dexamethasone on albumin and collagen gene expression in primary cultures of adult rat hepatocytes

1985 • 68 citations

Carrier-mediated uptake of pravastatin by rat hepatocytes in primary culture

1992 • 65 citations

Induction of cytochrome P-450 in cultured rat hepatocytes. The heterogeneous localization of specific isoenzymes using immunocytochemistry

1989 • 64 citations

Hepatocellular phenotypein Vitro is influenced by biophysical features of the collagenous substratum

1991 • 63 citations

Hormonal regulation of albumin gene expression in primary cultures of rat hepatocytes

1995 • 62 citations

Influence of medium composition and culture conditions on glutathione S-transferase activity in adult rat hepatocytes during culture

1988 • 60 citations

Co-cultures of hepatocytes with epithelial-like cell lines: Expression of drug-biotransformation activities by hepatocytes

1991 • 60 citations

Direct effect of insulin on albumin gene expression in primary cultures of rat hepatocytes

1985 • 60 citations

Maintenance and induction in co-cultured rat hepatocytes of components of the cytochrome P450-mediated mono-oxygenase

1993 • 55 citations

Drug metabolizing enzymes in rat hepatocytes co-cultured with cell lines

1990 • 54 citations

Accumulation of organic anion in intracellular vesicles of cultured rat hepatocytes is mediated by the canalicular multispecific organic anion transporter.

1993 • 54 citations

Induction of cytochrome P-450 and 5-aminolevulinate synthase activities in cultured rat hepatocytes.

1990 • 52 citations

Bile canalicular membrane pathology in cytochalasin B-induced cholestasis.

1977 • 52 citations

Heterogeneity of rat liver parenchyma in cholesterol 7α-hydroxylase and bile acid synthesis

1991 • 49 citations

Demonstration by in situ hybridization of the zonal modulation of rat liver cytochrome P-450b and P-450e gene expression after phenobarbital.

1988 • 46 citations

Expression of differentiation of rat foetal hepatocytes in cellular culture under the action of glucocorticoids: Appearance of bile canaliculi

1973 • 44 citations

Cytochrome P450 activities in pure and co-cultured rat hepatocytes. Effects of model inducers

1994 • 43 citations

Primary hepatocyte culture: Is it home away from home?

1988 • 42 citations

Differential modulation of P-glycoprotein expression by dexamethasone and 3-methycholanthrene in rat hepatocyte primary cultures

1994 • 42 citations

Biphasic regulation of cytochrome P450 2B1/2 mRNA expression by dexamethasone in primary cultures of adult rat hepatocytes maintained on matrigel

1994 • 41 citations

Differential stabilization of cytochrome P-450 isoenzymes in primary cultures of adult rat liver parenchymal cells

1991 • 39 citations

Accumulation of organic anion in intracellular vesicles of cultured rat hepatocytes is mediated by the canalicular multispecific organic anion transporter

1993 • 37 citations

Transient induction of cytochrome P450 1A1 mRNA by culture medium component in primary cultures of adult rat hepatocytes

1993 • 37 citations

Rat adult hepatocytes in primary pure and mixed monolayer culture

1991 • 37 citations

The Glucagon-Insulin Antagonism and Glucagon-Dexamethasone Synergism in the Induction of Phosphoenolpyruvate Carboxykinase in Cultured Rat Hepatocytes

1983 • 37 citations

Divergent effects of cycloheximide on the induction of Class II and Class III cytochrome P450 mRNAs in cultures of adult rat hepatocytes

1990 • 36 citations

Drug metabolizing enzyme activities in rat liver epithelial cell lines, hepatocytes and bile duct cells

1991 • 35 citations

Dependency of the in vitro stabilization of differentiated functions in liver parenchymal cells on the type of cell line used for co-culture

1992 • 35 citations

Phenolsulfonphthalein (phenol red) metabolism in primary monolayer cultures of adult rat hepatocytes

1982 • 34 citations

[32] Hepatocyte culture in study of P450 regulation

1991 • 34 citations

The activity of UDP-glucuronyltransferase, sulphotransferase and glutathione-S-transferase in primary cultures of rat hepatocytes

1986 • 33 citations

The effects of dexamethasone on metabolic activity of hepatocytes in primary monolayer culture

1980 • 32 citations

A fluorometric assay for quantitating phenol sulfotransferase activities in homogenates of cells and tissues

1987 • 32 citations

Induction of monooxygenase and UDP-glucuronosyltransferase activities in primary cultures of rat hepatocytes.

1986 • 32 citations

Sulfotransferase gene expression in primary cultures of rat hepatocytes

1996 • 32 citations

Hepatocellular uptake of peptides by bile acid transporters: relationship of carrier-mediated transport of linear peptides with renin-inhibiting activity to multispecific bile acid carriers

1991 • 30 citations

Effect of phenobarbital on the expression of glutathione S‐transferase isoenzymes in cultured rat hepatocytes

1989 • 29 citations

Effects of dietary lipid and phenobarbitone on the distribution and concentration of cytochrome P‐450 in the liver studied by quantitative cytochemistry

1981 • 27 citations

Relationship between hepatic metabolism of chlorpromazine and cholestatic effects in the isolated perfused rat liver.

1980 • 27 citations

Comparison of glucocorticoid-mediated changes in the expression and function of rat hepatocyte gap junctional proteins

1994 • 27 citations

Effects of dimethylsulphoxide on phase I and II biotransformation in cultured rat hepatocytes

1990 • 26 citations

Regulation of RNA degradation in cultured rat hepatocytes: Effects of specific amino acids and insulin

1993 • 23 citations

Effect of Tissue-Culture Substratum and Extracellular Matrix Overlay on Liver-Selective and Xenobiotic Inducible Gene Expression in Primary Rat Hepatocytes.

1994 • 23 citations

Modulation of fetal and neonatal rat hepatocyte functional activity by glucocorticoids in co-culture

1985 • 23 citations

Human and dog, but not rat, isolated hepatocytes have decreased foreign compound-metabolizing activity compared to liver slices.

1989 • 22 citations

Transcriptional‐ and post‐transcriptional‐dependent regulation of glutathione S‐transferase expression in rat hepatocytes as a function of culture conditions

1992 • 22 citations

Sulfation of acetaminophen in isolated rat hepatocytes. Relationship to sulfate ion concentrations and intracellular levels of 3'-phosphoadenosine-5'-phosphosulfate.

1988 • 22 citations

Evidence from dwarf rats that growth hormone may not regulate the sexual differentiation of liver cytochrome P450 enzymes and steroid 5 alpha-reductase.

1991 • 21 citations

Enantioselective induction of peroxisomal proliferation in CD-1 mice by leukotriene antagonists

1992 • 20 citations

Comparative cytotoxicity of angiotensin-converting enzyme inhibitors in cultured rat hepatocytes

1993 • 20 citations

Sulfation and glucuronidation of acetaminophen by cultured hepatocytes reproducing in vivo sex-differences in conjugation on matrigel and type 1 collagen

1991 • 20 citations

Regulation of glutathione S‐transferase gene expression by phenobarbital in cultured adult rat hepatocytes

1991 • 19 citations

Factors Affecting Secretory Protein Production in Primary Cultures of Rat Hepatocytes

1993 • 18 citations

The hepatic glucocorticoid domain: evidence for early and late hormone-mediated changes in the synthesis of individual protein gene products

1985 • 17 citations

Effects of cytochrome P450-inducing agents on the monooxygenation of testosterone in long-term cultures of hepatocytes from male and female rats

1989 • 15 citations

Enalapril hepatotoxicity in the rat

1992 • 15 citations

Studies on carotenoid metabolism. XI. The site of conversion of cryptoxanthin to vitamin A in the rat.

1951 • 13 citations

Xenobiotic-modulated expression of hepatic glutathione S-transferase genes in primary rat hepatocyte culture

1993 • 12 citations

Formation and secretion of glycolithocholate-3-sulfate in primary hepatocyte cultures.

1985 • 11 citations

Taurine and glycine conjugation and sulfation of lithocholate in primary hepatocyte cultures

1989 • 7 citations

Phenol sulfotransferase activity in rat liver parenchymal cells cultured on collagen gels.

1992 • 7 citations