Differential induction of rat liver microsomal UDP-glucuronosyltransferase activities by various inducing agents

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity test

1975 • 7,413 citations

The colorimetric estimation of formaldehyde by means of the Hantzsch reaction

1953 • 4,357 citations

Substrate-inducible Microsomal Aryl Hydroxylase in Mammalian Cell Culture

1968 • 1,691 citations

Glucuronidation of Drugs and Other Compounds

2019 • 807 citations

The O-Dealkylation of 7-Ethoxycoumarin by Liver Microsomes. A Direct Fluorometric Test

1972 • 634 citations

A simple and sensitive assay of 7-ethoxycoumarin deethylation

1978 • 600 citations

Properties of electrophoretically homogeneous phenobarbital-inducible and beta-naphthoflavone-inducible forms of liver microsomal cytochrome P-450

1976 • 536 citations

Drug-Induced Changes in the Liver Endoplasmic Reticulum: Association with Drug-Metabolizing Enzymes

1963 • 413 citations

Elevation of hepatic glutathione S-transferase activities and protection against mutagenic metabolites of benzo(a)pyrene by dietary antioxidants.

1978 • 338 citations

Conjugation Reactions in Drug Biotransformation

1980 • 314 citations

Regulation of three forms of cytochrome P-450 and epoxide hydrolase in rat liver microsomes. Effects of age, sex, and induction.

1981 • 304 citations

Glucuronic Acid Free and Combined

1966 • 298 citations

Determination of bilirubin glucuronide and assay of glucuronyltransferase with bilirubin as acceptor

1968 • 277 citations

Radioactive assay for aryl hydrocarbon hydroxylase. Improved method and biological importance

1977 • 265 citations

A reliable, sensitive, and convenient radioactive assay for benzpyrene monooxygenase

1975 • 236 citations

Effects of phenobarbital and 3-methylcholanthrene on substrate specificity of rat liver microsomal UDP-glucuronyltransferase

1973 • 229 citations

Purification of Rat‐Liver Microsomal UDP‐glucuronyltransferase

1979 • 219 citations

Functional heterogeneity of UDP-glucuronosyltransferase as indicated by its differential development and inducibility by glucocorticoids. Demonstration of two groups within the enzyme's activity towards twelve substrates

1978 • 170 citations

UDP‐glucuronyltransferase in Perfused Rat Liver and in Microsomes: Influence of Phenobarbital and 3‐Methylcholanthrene

1974 • 165 citations

Genetic regulation of UDP-glucuronosyltransferase induction by polycyclic aromatic compounds in mice. Co-segregation with aryl hydrocarbon (benzo(alpha)pyrene) hydroxylase induction.

1977 • 155 citations

Enzymatic conjugation of benzo(a)pyrene oxides, phenols and dihydrodiols with UDP-glucuronic acid

1976 • 139 citations

Demonstration of functional heterogeneity of hepatic uridine diphosphate glucuronosyltransferase activities after administration of 3-methylcholanthrene and phenobarbital to rats

1978 • 124 citations

Metabolism of benzo(a)pyrene-3,6-quinone and 3-hydroxybenzo(a)pyrene in liver microsomes from 3-methylcholanthrene-treated rats

1978 • 115 citations

Functional heterogeneity of UDP-glucuronyltransferase in rat tissues

1980 • 115 citations

Effect of 2(3)-tert-butyl-4-hydroxyanisole administration on the activities of several hepatic microsomal and cytoplasmic enzymes in mice

1979 • 99 citations

Biological reactive intermediates--II. Chemical mechanisms and biological effects.

1981 • 84 citations

An improved assay for steroid glucuronyltransferase in rat liver microsomes

1976 • 78 citations

Steroid and non-steroid UDP glucuronyltransferase: Glucuronidation of synthetic estrogens as steroids

1977 • 72 citations

Isolation and purification of bilirubin UDP‐glucuronyl‐transferase from rat liver

1980 • 68 citations

Separation of oestrone UDP-glucuronyltransferase and p-nitrophenol UDP-glucuronyltransferase activities

1978 • 67 citations

Trans-stilbene oxide: A new type of iducer of drug-metabolizing enzymes

1979 • 61 citations

Induction of rat hepatic epoxide hydratase by dietary antioxidants

1979 • 60 citations

trans-Stilbene oxide: An inducer of rat hepatic microsomal and nuclear epoxide hydrase and mixed-function oxidase activities

1978 • 53 citations

UDP-glucuronosyl transferase and the conjugation of benzo(a)pyrene metabolites to DNA

1978 • 53 citations

Steroid glucuronyltransferases of rat liver. Properties of oestrone and testosterone glucuronyltransferases and the effect of ovariectomy, castration and administration of steroids on the enzymes

1977 • 51 citations

Ethoxyquin as an inducer and inhibitor of phenobarbital-type cytochrome P-450 in rat liver microsomes

1977 • 47 citations

Morphine metabolism. I. Evidence for separate enzymes in the glucuronidation of morphine and p-nitrophenol by rat hepatic microsomes.

1974 • 41 citations

Long‐term effects of single and combined doses of DDT and PCB on drug‐metabolizing enzymes in rat liver

1977 • 41 citations

The Ah Locus. A Gene with Possible Importance in Cancer Predictability

1980 • 38 citations

Enhancement of Microsomal Drug Hydroxylation and Glucuronidation in Rat Liver by Phenobarbital and 3‐Methylcholanthrene in Combination

1974 • 37 citations

Release of mutagenic metabolites of benzo[a]pyrene from the perfused rat liver after inhibition of glucuronidation and sulfation by salicylamide

1981 • 35 citations

Increase in the hepatic glucuronidation and clearance of bilirubin in clofibrate-treated rats

1977 • 32 citations

Studies on bilirubin and steroid glucuronidation by rat liver microsomes

1975 • 30 citations

Increase of liver microsomal benzo(a)pyrene monooxygenase activity by subsequent glucuronidation

1978 • 25 citations

Modification of the mutagenicity of benzo(a)pyrene on bacteria by substrates of enzymes producing water soluble conjugates

1978 • 21 citations

Induction of rat hepatic UDP-glucuronosyltransferases by dietary ethoxyquin

1980 • 20 citations

Conversion of benzo[a]pyrene‐3,6‐quinone to quinol glucuronides with rat liver microsomes or purified nadph‐cytochrome c reductase and UDP‐glucuronosyltransferase

1980 • 19 citations

The positive inotropic effect of (?)-noradrenaline and (�)-isoprenaline after chemical sympathectomy: Evidence in favour of differences at a postsynaptic site

1981 • 18 citations

Action of transcription and translation inhibitors on the enhancement of drug hydroxylation and glucuronidation by 3-methylcholanthrene and phenobarbital

1974 • 18 citations

The interaction of foreign chemical compounds with the glucuronidation of estrogens in vitro.

1974 • 13 citations