Airway Mucus: Basic Mechanisms and Clinical Perspectives

Effect of Aerosolized Recombinant Human DNase on Exacerbations of Respiratory Symptoms and on Pulmonary Function in Patients with Cystic Fibrosis

1994 • 1,473 citations

Na+ transport in cystic fibrosis respiratory epithelia. Abnormal basal rate and response to adenylate cyclase activation.

1986 • 561 citations

Bronchoalveolar lavage findings in cystic fibrosis patients with stable, clinically mild lung disease suggest ongoing infection and inflammation.

1994 • 525 citations

Marked Goblet Cell Hyperplasia with Mucus Accumulation in the Airways of Patients Who Died of Severe Acute Asthma Attack

1992 • 513 citations

The alveolar macrophage

1986 • 509 citations

Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in a human bronchial epithelial cell line.

1992 • 498 citations

Comparative effects of inhaled salbutamol, sodium cromoglycate, and beclomethasone dipropionate on allergen-induced early asthmatic responses, late asthmatic responses, and increased bronchial responsiveness to histamine*1

1987 • 497 citations

Activation by Extracellular Nucleotides of Chloride Secretion in the Airway Epithelia of Patients with Cystic Fibrosis

1991 • 495 citations

The Healing Hand: Man and Wound in the Ancient World

1992 • 481 citations

Pulmonary macrophages

1994 • 476 citations

Molecular cloning, sequence, and specificity of expression of the gene encoding the low molecular weight human salivary mucin (MUC7).

1993 • 461 citations

Changes in bronchial hyperreactivity induced by 4 weeks of treatment with antiasthmatic drugs in patients with allergic asthma: A comparison between budesonide and terbutaline

1985 • 458 citations

Molecular cloning and chromosomal localization of a novel human tracheo-bronchial mucin cDNA containing tandemly repeated sequences of 48 base pairs

1991 • 405 citations

Many pulmonary pathogenic bacteria bind specifically to the carbohydrate sequence GalNAc beta 1-4Gal found in some glycolipids.

1988 • 396 citations

NITRERGIC TRANSMISSION: NITRIC OXIDE AS A MEDIATOR OF NON‐ADRENERGIC, NON‐CHOLINERGIC NEURO‐EFFECTOR TRANSMISSION

1992 • 378 citations

A Pilot Study of Aerosolized Amiloride for the Treatment of Lung Disease in Cystic Fibrosis

1990 • 348 citations

Nontypable Haemophilus influenzae: A Review of Clinical Aspects, Surface Antigens, and the Human Immune Response to Infection

1987 • 329 citations

Oxidants, antioxidants, and respiratory tract lining fluids.

1994 • 295 citations

Regulation of secretory leukocyte proteinase inhibitor (SLPI) and elastase-specific inhibitor (ESI/elafin) in human airway epithelial cells by cytokines and neutrophilic enzymes.

1994 • 294 citations

THE IgA1 PROTEASES OF PATHOGENIC BACTERIA

1983 • 290 citations

Different mucins are produced by the surface epithelium and the submucosa in human trachea: identification of MUC5AC as a major mucin from the goblet cells

1996 • 282 citations

Differential regulation of protein kinase C isoforms in isolated neonatal and adult rat cardiomyocytes

1994 • 280 citations

Role of Ca2+-ATPases in regulation of cellular Ca2+ signalling, as studied with the selective microsomal Ca2+-ATPase inhibitor, thapsigargin

1990 • 276 citations

alpha 1-Antitrypsin: molecular pathology, leukocytes, and tissue damage.

1986 • 276 citations

Evidence for reduced Cl‐ and increased Na+ permeability in cystic fibrosis human primary cell cultures.

1988 • 265 citations

The lung in cystic fibrosis

1976 • 265 citations

Identification of an active disaccharide unit of a glycoconjugate receptor for pneumococci attaching to human pharyngeal epithelial cells.

1983 • 248 citations

Efficacy and Safety of Short-term Administration of Aerosolized Recombinant Human Deoxyribonuclease in Patients with Cystic Fibrosis

1993 • 233 citations

ANTIOXIDANT PROTECTION: A FUNCTION OF TRACHEOBRONCHIAL AND GASTROINTESTINAL MUCUS

1984 • 231 citations

Tumor necrosis factor-alpha induces mucin hypersecretion and MUC-2 gene expression by human airway epithelial cells.

1995 • 223 citations

Erythromycin Inhibits Respiratory Glycoconjugate Secretion from Human AirwaysIn Vitro

1990 • 217 citations

Characterization of a Murine Model of Allergic Pulmonary Inflammation

1994 • 214 citations

Role of the physiochemical properties of mucus in the protection of the respiratory epithelium

1992 • 210 citations

Pathogenic Species of the Genus Haemophilus and Streptococcus pneumoniae Produce Immunoglobulin A1 Protease

1979 • 190 citations

Identification of Two Glycoforms of the MUC5B Mucin in Human Respiratory Mucus

1997 • 182 citations

Asialo GM1 is a receptor for Pseudomonas aeruginosa adherence to regenerating respiratory epithelial cells

1996 • 171 citations

Human respiratory tract secretions

1976 • 167 citations

Evidence that UTP and ATP regulate phospholipase C through a common extracellular 5'-nucleotide receptor in human airway epithelial cells.

1991 • 158 citations

STUDIES ON PULMONARY SECRETIONS. I. THE OVER-ALL CHEMICAL COMPOSITION OF PULMONARY SECRETIONS FROM PATIENTS WITH CYSTIC FIBROSIS, BRONCHIECTASIS, AND LARYNGECTOMY.

1963 • 154 citations

Structure and expression of the human polymorphic epithelial mucin gene: an expressed VNTR unit

1990 • 152 citations

VIP like immunoreactive nerves in human respiratory tract

1985 • 151 citations

Humoral Immune Response Patterns of Human Mucosae: Induction and Relation to Bacterial Respiratory Tract Infections

1992 • 150 citations

Tracheal mucous velocity in normal man and patients with obstructive lung disease: effects of terbutaline.

1974 • 149 citations

Heterogeneity of the carbohydrate chains of sulfated bronchial glycoproteins isolated from a patient suffering from cystic fibrosis.

1975 • 144 citations

Time course of release of catecholamines from individual vesicles during exocytosis at adrenal medullary cells

1995 • 144 citations

Regulation of human airway surface liquid

1995 • 142 citations

Quantitative evaluation of the development of tracheal submucosal glands in infants with cystic fibrosis and control infants.

1982 • 138 citations

Lung Defense Mechanisms

1976 • 137 citations

Molecular Mechanism of Mucin Secretion: I. The Role of Intragranular Charge Shielding

1987 • 136 citations

In vivo effects of recombinant human DNase I on sputum in patients with cystic fibrosis.

1996 • 135 citations

Interaction of pneumolysin-sufficient and -deficient isogenic variants of Streptococcus pneumoniae with human respiratory mucosa

1995 • 135 citations

Pseudomonas aeruginosa recognizes carbohydrate chains containing type 1 (Gal beta 1-3GlcNAc) or type 2 (Gal beta 1-4GlcNAc) disaccharide units

1991 • 135 citations

Antibodies to the cytoplasmic domain of the MUC1 mucin show conservation throughout mammals

1992 • 133 citations

Capsaicin and sensory neuropeptide stimulation of goblet cell secretion in guinea‐pig trachea.

1990 • 132 citations

Alveolar subphase pH in the lungs of anesthetized rabbits.

1981 • 127 citations

Erythromycin Inhibits Neutrophil Chemotaxis in Bronchoalveoli of Diffuse Panbronchiolitis

1994 • 125 citations

Mucus glycoproteins from ‘normal’ human tracheobronchial secretion

1990 • 125 citations

Levels of Free Granulocyte Elastase in Bronchial Secretions from Patients with Cystic Fibrosis: Effect of Antimicrobial Treatment Against Pseudomonas aeruginosa

1986 • 124 citations

Analysis of respiratory mucus glycoproteins in asthma: a detailed study from a patient who died in status asthmaticus.

1995 • 123 citations

Isolation and structural characterization of low‐molecular‐mass monosialyl oligosaccharides derived from respiratory‐mucus glycoproteins of a patient suffering from bronchiectasis

1988 • 121 citations

The Carbohydrate Diversity of Human Respiratory Mucins: A Protection of the Underlying Mucosa?

1991 • 120 citations

The T84 human colonic adenocarcinoma cell line produces mucin in culture and releases it in response to various secretagogues

1990 • 117 citations

Modification of Na and Cl transport in canine tracheal mucosa by prostaglandins

1981 • 114 citations

Receptors in the Pseudomonas Aeruginosa Adherence to Injured and Repairing Airway Epithelium

1996 • 108 citations

Enkephalinase Inhibitors Potentiate Substance P-Induced Secretion of³⁵SO₄-Macromolecules from Ferret Trachea

1987 • 107 citations

Characterization of the binding of Pseudomonas aeruginosa alginate to human epithelial cells

1987 • 107 citations

Composition and control of secretions from tracheal bronchial submucosal glands

1979 • 107 citations

Ultrastructural immunocytochemical localisation of lysozyme in human bronchial glands.

1977 • 106 citations

Neuropeptide tyrosine (NPY): a newly discovered peptide is present in the mammalian respiratory tract.

1984 • 106 citations

Markers of Mucus Secretion and DNA Levels in Induced Sputum from Asthmatic and from Healthy Subjects

1993 • 104 citations

Biochemistry of airway mucus secretions.

1980 • 103 citations

Macromolecular Properties and Polymeric Structure of Mucus Glycoproteins

1984 • 99 citations

Characterization of a Mucin cDNA Clone Isolated from HT-29 Mucus-secreting Cells.

1995 • 96 citations

Effect of catecholamines on ion transport in dog tracheal epithelium

1979 • 95 citations

Comparative Morphology of the Airways in Asthma and Chronic Obstructive Pulmonary Disease

1994 • 94 citations

Amiloride Inhalation Therapy in Cystic Fibrosis: Influence on Ion Content, Hydration, and Rheology of Sputum

1993 • 93 citations

The role of mucus viscoelasticity in cough clearance

1987 • 93 citations

Production of the Pseudomonas aeruginosa neuraminidase is increased under hyperosmolar conditions and is regulated by genes involved in alginate expression.

1992 • 90 citations

Morphometric Analysis of Intraluminal Mucus in Airways in Chronic Obstructive Pulmonary Disease

1989 • 89 citations

Actin filaments mediate DNA fiber formation in chronic inflammatory airway disease.

1996 • 87 citations

COMPARISON OF MUCUS GLANDS IN THE TRACHEOBRONCHIAL TREE OF MAN AND ANIMALS*

1963 • 85 citations

Secretion of Neutrophil Attractant/Activation Protein by Lipopolysaccharide-stimulated Lung Macrophages Determined by Both Enzyme-linked Immunosorbent Assay and N-Terminal Sequence Analysis

1990 • 82 citations

Bacteria associated with obstructive pulmonary disease elaborate extracellular products that stimulate mucin secretion by explants of guinea pig airways.

1986 • 82 citations

Binding of nonmucoid Pseudomonas aeruginosa to normal human intestinal mucin and respiratory mucin from patients with cystic fibrosis.

1992 • 80 citations

Co-localization of vasoactive intestinal peptide- and substance P-containing nerves in cat bronchi

1988 • 73 citations

Dose-dependent in vitro effect of recombinant human DNase on rheological and transport properties of cystic fibrosis respiratory mucus

1995 • 73 citations

Effects of Orally Administered Drugs on Dynamic Viscoelasticity of Human Nasal Mucus

1990 • 70 citations

Differences in adhesion of Pseudomonas aeruginosa to mucin glycopeptides from sputa of patients with cystic fibrosis and chronic bronchitis

1989 • 68 citations

Dexamethasone Inhibits Respiratory Glycoconjugate Secretion from Feline AirwaysIn Vitroby the Induction of Lipocortin (Lipomodulin) Synthesis

1988 • 67 citations

Alteration of chloride secretion across canine tracheal epithelium by lipoxygenase products of arachidonic acid

1986 • 65 citations

Phospholipid composition and surface‐active properties of tracheobronchial secretions from patients with cystic fibrosis and chronic obstructive pulmonary diseases

1992 • 64 citations

[Long-term therapeutic effects of erythromycin and newquinolone antibacterial agents on diffuse panbronchiolitis].

1990 • 64 citations

The Role of Mucous Glycoproteins in the Rheologic Properties of Cystic Fibrosis Sputum

1990 • 64 citations

Density Gradient Study of Bronchial Mucus Aspirates from Healthy Volunteers (Smokers and Nonsmokers) and from Patients with Tracheostomy

1985 • 62 citations

Effects of oscillating air flow on the rheological properties and clearability of mucous gel simulants

1994 • 61 citations

Ca2+ and pH determine the interaction of chromaffin cell scinderin with phosphatidylserine and phosphatidylinositol 4,5,-biphosphate and its cellular distribution during nicotinic-receptor stimulation and protein kinase C activation.

1992 • 61 citations

Rheological and transport properties of airway secretions in cystic fibrosis‐relationships with the degree of infection and severity of the disease

1985 • 60 citations

Effects of two novel tachykinin antagonists, FK224 and FK888, on neurogenic airway plasma exudation, bronchoconstriction and systemic hypotension in guinea‐pigs in vivo

1993 • 60 citations

Use of ipratropium bromide nasal spray in chronic treatment of nonallergic perennial rhinitis, alone and in combination with other perennial rhinitis medications

1995 • 60 citations

Histochemical and autoradiographic investigation of the serous cells of the human bronchial glands

1970 • 60 citations

Sulfur-Dioxide-Induced Bronchitis in Dogs

1987 • 58 citations

Binding of Haemophilus influenzae to purified mucins from the human respiratory tract

1995 • 57 citations

Ipratropium bromide treatment of experimental rhinovirus infection

1988 • 55 citations

ATP-stimulated electrolyte and mucin secretion in the human intestinal goblet cell line HT29-C1.16E

1994 • 53 citations

The interaction of Streptococcus pneumoniae with intact human respiratory mucosa in vitro

1992 • 51 citations

The rheology of pig small intestinal and colonic mucus: weakening of gel structure by non-mucin components

1991 • 49 citations

‘Sensory‐efferent’ neural control of mucus secretion: characterization using tachykinin receptor antagonists in ferret trachea in vitro

1994 • 49 citations

Changes in epithelial secretory cells and potentiation of neurogenic inflammation in the trachea of rats with respiratory tract infections

1989 • 48 citations

Airway surface liquid thickness as a function of lung volume in small airways of the guinea pig

1994 • 45 citations

Establishment and characterization of a cell line derived from bovine tracheal glands

1986 • 44 citations

Isolation and structural characterization of novel sialylated oligosaccharide‐alditols from respiratory‐mucus glycoproteins of a patient suffering from bronchiectasis

1993 • 44 citations

Substance P Receptor-Mediated Secretion of Respiratory Glycoconjugate from Feline Airways in Vitro

1989 • 42 citations

Endothelin regulation of mucus glycoprotein secretion from feline tracheal submucosal glands

1992 • 41 citations

The control of mucin secretion into the lumen of the cat trachea by α- and β-adrenoceptors, and their relative involvement during sympathetic nerve stimulation

1982 • 39 citations

Bradykinin stimulates airway epithelial Cl- secretion via two second messenger pathways

1990 • 36 citations

The effect of an orally administered proteolytic enzyme on the elasticity and viscosity of nasal mucus

1988 • 36 citations

Platelet activating factor and tracheobronchial respiratory glycoconjugate release in feline and human explants: Involvement of the lipoxygenase pathway

1990 • 35 citations

Anaphylatoxin C3a enhances mucous glycoprotein release from human airways in vitro.

1985 • 35 citations

Effects of erdosteine on sputum biochemical and rheologic properties: Pharmacokinetics in chronic obstructive lung disease

1990 • 32 citations

Effects of amphotericin B on ion and fluid movement across dog tracheal epithelium

1983 • 31 citations

Mucociliary transference rate and mucus viscoelasticity dependence on dynamic storage and loss modulus.

1979 • 30 citations

Constitutive hypersecretion and insensitivity to neurotransmitters by cystic fibrosis tracheal gland cells

1993 • 29 citations

Glycopyrrolate and Atropine Inhalation: Comparative Effects on Normal Airway Function^1,2

1984 • 28 citations

Ipratropium treatment for rhinorrhoea in patients with perennial rhinitis. An open follow-up study of efficacy and safety

1983 • 27 citations

Primary Structure Determination of Five Sialylated Oligosaccharides Derived from Bronchial Mucus Glycoproteins of Patients Suffering from Cystic Fibrosis

1984 • 27 citations

Three‐dimensional imaging of the mucus secretory process in the cryofixed frog respiratory epithelium

1991 • 26 citations

Loss and Ca²⁺‐Dependent Retention of Scinderin in Digitonin‐Permeabilized Chromaffin Cells: Correlation with Ca²⁺‐Evoked Catecholamine Release

1992 • 26 citations

Mucin secretion by T84 cells: stimulation by PKC, Ca2+, and a protein kinase activated by Ca2+ ionophore

1993 • 25 citations

Donnan mechanism of mucin release and conditioning in goblet cells: the role of polyions.

1989 • 25 citations

Viscous Airflow Through a Rigid Tube With a Compliant Lining: A Simple Model for the Air-Mucus Interaction in Pulmonary Airways

1993 • 25 citations

Stimulation of secretion into human and feline airways by Pseudomonas aeruginosa proteases

1991 • 24 citations

Mucous cells of the tracheobronchial tree in the ferret

1982 • 23 citations

Secretory Process of Mucus-Secreting Cells in Mouse Colonic Mucosa Studied by Rapid Freezing and Freeze-Substitution

1987 • 22 citations

Endothelin‐1 inhibits pre‐stimulated tracheal submucosal gland secretion and epithelial albumin transport

1991 • 21 citations

Characterization of tachykinin receptors in ferret trachea by peptide agonists and nonpeptide antagonists

1993 • 20 citations

Mucous gel transport in a simulated cough machine: Effects of longitudinal grooves representing spacings between arrays of cilia

1994 • 19 citations

Phenotypic Marker Expression during Fetal and Neonatal Differentiation of Rat Tracheal Epithelial Cells

1993 • 16 citations

Observation of the secretion on the surface of the bronchioles with the scanning electron microscope.

1975 • 16 citations

Ferret tracheal mucus rheology, clearability and volume following administration of substance P or methacholine

1993 • 15 citations

THE SHERRINGTON SCHOOL OF PHYSIOLOGY

1957 • 13 citations

Effects of the PAF-Antagonist CV-3988 on Paf-Induced Changes in Mucus Secretion and in Respiratory and Circulatory Variables in Ferrets

1987 • 13 citations

Bacterial pneumonia stimulates macromolecule secretion and ion and water fluxes in sheep trachea

1987 • 11 citations

Rheological Properties and Hydration of Airway Mucus

1997 • 9 citations

[Clinical effects of low-dose and long-term erythromycin in diffuse panbronchiolitis with chronic respiratory failure].

1993 • 8 citations

Regulation of secretion in cultured tracheal serous cells by protein kinases A and C

1991 • 8 citations

Histopathological studies on paranasal mucosa from patients treated with erythromycin.

1994 • 7 citations

[Effect of erythromycin on mucociliary transport and clinical symptoms in patients with sinobronchial syndrome].

1993 • 7 citations

Mechanisms Controlling Airway Ciliary Activity

1997 • 3 citations

Experimental Induction of Goblet Cell Hyperplasia In Vivo

1997 • 3 citations

The Microanatomy of Airway Mucus Secretion

1997 • 1 citations