Effects of two novel tachykinin antagonists, FK224 and FK888, on neurogenic airway plasma exudation, bronchoconstriction and systemic hypotension in guinea‐pigs in vivo

Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons.

1991 • 1,760 citations

A Potent Nonpeptide Antagonist of the Substance P (NK ₁ ) Receptor

1991 • 875 citations

ASTHMA AS AN AXON REFLEX

1986 • 676 citations

Neuropeptides in the Respiratory Tract: Part I

1991 • 453 citations

A substance P antagonist inhibits vagally induced increase in vascular permeability and bronchial smooth muscle contraction in the guinea pig

1983 • 443 citations

Inflammatory mediators and asthma.

1988 • 408 citations

Release of Multiple Tachykinins from Capsaicin-sensitive Sensory Nerves in the Lung by Bradykinin, Histamine, Dimethylphenyl Piperazinium, and Vagal Nerve Stimulation

1988 • 408 citations

Tachykinin receptor types: Classification and membrane signalling mechanisms

1991 • 342 citations

Protection against bradykinin-induced bronchoconstriction in asthmatic patients by neurokinin receptor antagonist

1992 • 187 citations

Correlation between evans blue dye and radiolabeled albumin in guinea pig airways in vivo

1989 • 179 citations

Pharmacological profile of a high affinity dipeptide NK₁ receptor antagonist, FK888

1992 • 146 citations

Neuropeptides in the Respiratory Tract: Part II

1991 • 141 citations

Effects and interactions of sensory neuropeptides on airway microvascular leakage in guinea‐pigs

1988 • 134 citations

In vivo evidence for tachykininergic transmission using a new NK-2 receptor-selective antagonist, MEN 10,376.

1991 • 129 citations

Relative potencies of neurokinins in guinea pig trachea and human bronchus

1987 • 124 citations

Effects of tachykinins on mucus secretion in human bronchi in vitro

1989 • 123 citations

OPIOID INHIBITION OF NEURALLY MEDIATED MUCUS SECRETION IN HUMAN BRONCHI

1989 • 118 citations

Inhibition of neurogenic plasma exudation in guinea‐pig airways by CP‐96,345, a new non‐peptide NK₁ receptor antagonist

1992 • 107 citations

Cigarette smoke-induced airway oedema due to activation of capsaicin-sensitive vagal afferents and substance P release

1983 • 106 citations

Tachykinin Receptors and Noncholinergic Bronchoconstriction in the Guinea-Pig Isolated Bronchi

1991 • 97 citations

Direct evidence that capsaicin-induced plasma protein extravasation is mediated through tachykinin NK1 receptors

1991 • 94 citations

Tachykinin receptors in the guinea-pig isolated bronchi

1991 • 79 citations

FK 224, a novel cyclopeptide substance P antagonist with NK1 and NK2 receptor selectivity.

1992 • 71 citations

Receptors mediating tachykinin‐induced contractile responses in guinea‐pig trachea

1991 • 71 citations

Effects of FK224, a novel compound NK1 and NK2 receptor antagonist, on airway constriction and airway edema induced by neurokinins and sensory nerve stimulation in guinea pigs.

1992 • 65 citations

Cigarette smoke-induced airway oedema is blocked by the NK1 antagonist, CP-96,345

1991 • 60 citations

Release of tachykinins by histamine, methacholine, PAF, LTD4, and substance P from guinea pig lungs

1991 • 59 citations

Regional and time-dependent effects of inflammatory mediators on airway microvascular permeability in the guinea pig

1989 • 57 citations

Inhibition of tachykinin-induced hypotension in dogs by CP-96,345, a selective blocker of NK-1 receptors

1991 • 42 citations

Plasma exudation and oedema in asthma

1992 • 42 citations

In vivo pharmacology of [βAla8]neurokinin A-(4-10), a selective NK-2 tachykinin receptor agonist

1990 • 38 citations

Neurogenic inflammation in the airways: characterisation of electrical parameters for vagus nerve stimulation in the guinea pig

1990 • 18 citations